[Essential phospholipids in the treatment of hepatic encephalopathy].

R Brůha, Z Marecek

Vnitr Lek 2000, 46(4):199-204

THE AIM: To evaluate the effect of treatment with intravenous essentiale phospholipids in patients with liver cirrhosis and hepatic encephalopathy grade III-IV.PATIENTS AND METHODS: 12 patients with hepatic encephalopathy grade III-IV due to decompensated liver cirrhosis, age 35-67 years, were randomized to two groups: Essentiale 2.0 g i.v. daily was given to 6 patients in combination with standard therapy for 2 weeks; 6 patients had only standard therapy. The patients were followed up for 90 days. The diagnosis of hepatic encephalopathy was based on clinical examination, psychometrical tests and neurophysiological examination-EEG and evoked potentials.RESULTS:...

[Thallium scintigraphy of the myocardium in evaluation of patients with insulin resistance syndrome and microvascular angina pectoris].

J Lepej, D Spisiaková, J Hrnciar, J Okapcová, M Szentivanyi, P Kurray

Vnitr Lek 2000, 46(4):205-212

Insulin resistance syndrom (IR) is often associated with the syndrome of microvascular angina pectoris (MVAP) or with coronary artery disease (CAD). The authors quantified distribution and washout of 201Tl in heart (C), lungs (L) and liver (H) to evaluate the results 201Tl stress (s) and redistribution SPECT in 50 patients. They compared 2 groups of patients with laboratory verified IR (MVAP and CAD) and control group (CG) of patients with normal coronarography without any symptoms of IR. In Patients with IR and MVAP were found significantly more frequent local perfusion abnormalities then in CG. The index sL/C calculated by ROI analysis is significantly...

[Gastric emptying in diabetics].

S Lacigová, Z Rusavý, J Mindlová, M Malinková, J Záhlava

Vnitr Lek 2000, 46(4):213-217

UNLABELLED: The authors evaluate gastric emptying in diabetic patients and follow up selected factors which may influence it.METHOD: In a group of 25 type 1 diabetics selected at random (12 women and 13 men), mean age 40.5 years +/- 11.6 SD (range 21 to 57 years) with a duration of diabetes of 17.8 +/- 7.9 years (minimum 4, maximum 35 years) with a mean value of glycosylated haemoglobin of 8.71% +/- 1.82 (minimum 7.2, maximum 12.2%) the authors assessed: the time of gastric emptying by scintigraphic follow up of the progress of solid food (rice labelled with 99mTc). 2. The correlation of gastric emptying and time factors (age, duration of diabetes)...

[The bioartificial liver--an alternative in the treatment of acute liver failure].

J Smrzová, J Lata, V Simánek, J Ulrichová

Vnitr Lek 2000, 46(4):218-224

One of the therapeutic approaches in acute liver failure is the use of an artificial system replacing hepatic function--bioartificial liver. Its application is the most perspective in fulminant liver failure during preparation for transplantation of the liver (so-called bridge to transplantation) or in case of a non-functioning hepatic graft, and to reduce the mortality and morbidity of patients with acute liver failure where transplantation is not indicated or where a suitable graft was not found. The authors discuss briefly the construction of these systems, analyze different indications of treatment and its results, obscure questions and perspectives...

[Treatment of Hodgkin's disease using the German Study Group protocol. Personal experience and results].

J Marková, J Kocová, B Malinová, J Stríteský, D Feltl, V Diehl

Vnitr Lek 2000, 46(4):225-231

UNLABELLED: The article present an evaluation (02/1999) of the study of primary treatment of Hodgkin's disease (HD) according to the third generation of the German Hodgkin's Disease Study Group (GHSG), and our experience with this treatment strategy. HD7 study of early stages HD showed better results (fewer relapses) for combined chemo and radiotherapy than for radiotherapy alone (2x ABVD + extended field radiotherapy compared to extended field radiotherapy alone). HD8 study of intermediate stage HD did not show any difference between chemotherapy 2x (COPP + ABVD) combined with radiotherapy extended field, or involved field. Due to the long-term consequences...

[Can we foresee the end of the alphabet in viral hepatitis?].

J Ehrmann, I Krc

Vnitr Lek 2000, 46(4):232-234

There is a number of viruses which may cause acute or chronic liver damage. Only some of them belong into the group of hepatotropic viruses and only the latter are the cause of acute or chronic viral hepatitis. So far we know seven hepatotropic viruses. The virus of hepatitis A (HAV), virus of hepatitis B (HBV), virus of hepatitis C (HCV), virus of hepatitis D (HDV), virus of hepatitis E (HEV), virus of hepatitis G (HGV) and Transfusion-Transmitted-Virus (TTV). For HAV and HEV orofaecal transmission is typical, the others are transmitted by the parenteral route. All cause acute hepatitis. Only HAV and HEV infections develop into the chronic stage....

[Characteristics of still unknown hepatotropic viruses and a clinical picture of the disease].

J Ehrmann, I Krc

Vnitr Lek 2000, 46(4):235-239

So far seven hepatotropic viruses were identified. They are described by letters A,B,C,D,E, G and TTV. The virus of hepatitis F is so far speculative. Virus of hepatitis A and E are transmitted by the orofaecal route and cause only acute hepatitis. The remaining hepatotropic viruses are transmitted by the parenteral route and have a longer incubation period than viruses A and E. The infection with the virus of hepatitis B develops into the chronic stage in about 10% and that of virus C in 50-90%. At least one third of chronic carriers of the virus of hepatitis B or C develop within 10-20 years liver cirrhosis or hepatocellular carcinoma. The objective...

[Corticosteroids in the treatment of rheumatic diseases].

S Alusík

Vnitr Lek 2000, 46(4):240-242

The author describes the use of corticosteroids in the treatment of rheumatic diseases. He mentions different indications, incl. controversial vones, the problem of dosage and undesirable effects of treatment.

[Topical therapy with corticosteroids in rheumatology].

S Alusík

Vnitr Lek 2000, 46(4):243-245

The author summarized when and how to use steroid-injection therapy. He mentions indications, contraindications, complications and the controversial uses of the local treatment.

[Recommendations for accreditation in internal medicine].

I Duris, J Murin, S Kinova,

Vnitr Lek 2000, 46(4):247-252

[Comments on "Recommendations on accreditation in internal medicine" by the Slovak Society of Internal Medicine].

K Horky

Vnitr Lek 2000, 46(4):253-254