Vnitřní lékařství 8/2020

HLAVNÍ TÉMA Změny farmakokinetiky léčiv u obézních pacientů | 471  / Vnitř Lék 2020; 66(8): 465–471  /  VNITŘNÍ LÉKAŘSTVÍ www.casopisvnitrnilekarstvi.cz „ BMI – body mass index „ BSA – tělesný povrch „ CG – Cockroft a Gault „ CKD‑EPI – Chronic Kidney Disease Epidemiology Collaboration „ CL – clearance „ C max – maximální koncentrace „ dTT – diluční trombinový čas „ eGFR – odhadovaná glomerulární filtrace „ IBW – ideální tělesná hmotnost „ INR – mezinárodní normalizovaný poměr „ LBW – tukuprostá tělesná hmotnost „ LMWH – nízkomolekulární hepariny „ NAFLD – nealkoholická steatóza jater „ NASH – nealkoholická steatohepatitida „ NOAC – nová perorální antikoagulancia „ TBW – celková tělesná hmotnost „ T 1/2 – eliminační poločas „ Vd – distribuční objem LITERATURA 1. Cheymol G. Effects of obesity on pharmacokinetics implications for drug therapy. Clin Pharmacokinet, 2000; 39(3): 215–231. 2. Kunešová M. Obezita – etiopatogeneze, diagnostika a léčba. Interní medicína pro pra‑ xi, 2004; 9. 3. 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