1056
PŘEHLEDOVÉ42522701004388130181216258306358404446
ČLÁNKY88722701003973122176223272
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a652337010034
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terapie10033370100256084120158173209
dyslipidemie122833701003773103118133171187225260320336371
a1615337010034
hypertenze:166533701003773111147171200235273305339354
kdy203533701003471108
ji215933701001429
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dlouhodobě27193370100375391129167206245284322358
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4022422701004087
|326227010043
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výhodu240662301073679126173222268
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u1471763010749
pacientů154076301075092132151195243270318
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věku215376301074184122171
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cílové8839030107375575123162205
hodnoty110790301074592142189237264306
LDL‑CH143290301073794134152205261
a1712903010737
k1768903010735
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riziko151710430107335289108146193
ev.1730104301074990102
nežádoucích1852104301075498135177227275323364382422470
účinků.2342104301075494113161199247261
Naopak26231043010764105153203245283
pozdně4251183010751102139189239284
zahájená730118301074488138180200246296338
terapie1089118301073579107150201222267
u13771183010756
pacientů14531183010758102144163209259287336
ve1810118301074994
vysokém1924118301074994129179220264340
riziku228511830107345593113152202
AS25081183010761105
KVO26341183010753105166
již282111830107274684
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agresivnější769132301074089115158192210251300344363396414
terapii120313230107266995137186205224
vyššími1447132301073982116149167241259
dávkami1726132301074889128167209283301
statinů2047132301073261103130149196244
a23101323010740
kombinací2370132301073684158207227274315356374
více276413230107395999141
antihypertenziv425146301074088114132179217267311337367409456493511552
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většinou1192146301073779106140158205252300
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hůře2340146301074591116158
tolerována.251714630107247089133159205244285332372388
Závěr4251714013862123184242288
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velmi68220230107367896167185
významně885202301073678115163202274320363
riziko12662023010722407694130176
AS1460202301074890
KVO.1568202301074088147159
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systolického2485202301072969101129174192210248285326373420
krevního304762301073865107147195213262309
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10363062301074482
%3731623010766
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hladiny387562301074866106154172219257
LDL‑C415062301074098137155208
také437762301072868105147
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%4710623010767
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KVO537562301074493152
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45311276301073979
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Pacientům344076301074078117134176222247292363
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DLP430576301075392135
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dosažením4241903010754102134175211253301318391
cílových46519030107456383130170212251298
hodnot4968903010753101150197245271
LDL‑CH5258903010746103143161214269
i30471043010719
krevního3086104301074472116157206224275323
tlaku342910430107345394132181
a36291043010748
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adherence4797104301074898146191217260309350392
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k30471183010738
této3104118301073476104150
léčbě.3273118301072568109158202216
Samozřejmostí3508118301074889162210245272314332405453486515533
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měla41741183010780124142182
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životního5189118301074261101148175223241290338
stylu,3047132301073360101119164178
racionální3243132301072262100117163210248266311328
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u38591323010743
kuřáků3920132301073379104143179225
zanechání4163132301073172118160199245284330346
kouření.4527132301073479125149190236253267
Nutná4812132301075298124171209
je5040132301071456
komunikace5114132301073378150195241258294334373413
lékaře304714630107196298139164206
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a37071463010737
jeho3762146301071558105152
edukace.3932146301073988134171212251292305
Včasná4256146301074178118150197236
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je4893146301071558
v49691463010736
souladu5024146301072976123141180228274
i53161463010715
s53491463010730
nej‑5397146301074487104130
novějšími3047160301074896135177195227244317335
odbornými34001603010751100149197223271309382400
doporučeními3819160301075299148196223270310351398416488506
pro4344160301075278125
prevenci4487160301075379121161203250290308
AS4814160301075597
KVO.4930160301074896155168
Aby51171603010756105143
terapie527916030107307298138187205248
splnila3047174301073482101148165183223
svůj3288174301073172120137
účel3444174301074585126144
–36071743010742
snížení366817430107307795131173220237
rizika39241743010724427896133174
AS4117174301075092
KVO,4228174301074290149162
musí44091743010770117149166
být4594174301074785115
dlouhodobá,4728174301074664111159206253303350399440455
a52021743010738
je5258174301071759
proto5336174301074773119146191
klíčové,304718830107385875114160199241255
aby3321188301074695133
pacient3473188301075596136154196244270
tuto3761188301073481108154
léčbu3934188301072468108156204
trvale4156188301073460103143161204
a43791883010747
pravidelně4444188301075682123161180228271290337380
užíval.4842188301075490108148189207222
V50821883010752
tom5153188301073379152
může53241883010779126161203
významně3047202301074183121169209281328372
pomoci3437202301074997171218259276
využití3732202301074082130166184211229
fixních398020230107224180127145184231
kombinací4230202301073783157205223270310350368
statinů4616202301073361102128146193239
s48742023010732
antihypertenzivy.4925202301074087113131178216265310335365407454490508549591602
LITERATURA426226001234978134189250318368438498567
1.42524200853648
Perk4872421083356990120
J,62324210832335
De67324210834479
Backer7682421083346799129163184
G,96824210834255
Gohlke103924210834281119135165199
H1253242108343
et131124210833355
al.13812421083314659
European14552421083326889127166202234272
Guidelines17422421083428196135169185200238273300
on205724210833674
cardiovascular21472421083306284122137175207240266299336352384405
disease25672421083375278113145172207
pre‑27892421083375993116
vention42525210833266104126141179217
in65825210831654
clinical7272521083334863101116148181196
practice9392521083406295127151166198232
(version11862521083205286107134149187226
2012).142725210833670102132149160
The160325210833473108
Fifth1727252108334496893131
Joint18732521083266480118139
Task20282521083346288118
Force21622521083347193124157
of233525210833958
the24082521083246297
European25202521083347192129169204236274
So‑28102521083347295
ciety4252621083314681103137
of57726210833958
Cardiology6502621083417495133148186202240280312
and97726210833371110
Other110326210834871109144166
Societies128426210833372104120154177192227253
on155326210833876
Cardiovascular16452621083417495133148186218251277310347363395416
Disease20762621083476288123155182217
Prevention23082621083365791123158196217232270309
in263226210831654
Clinical27012621083415671109124156189204
Practice4252721083355689121145160192226
(constituted6662721083184784123149172188210248271304344
by102527210833769
representatives11092721083195393114148175210248270303324340372406433
of155827210833655
nine16282721083365189124
societies17682721083246395110145167183217244
and202827210833068107
by215027210833869
invited2234272108314528399121155194
experts).244427210833264103139160185213230241
Eur27002721083316889
He‑280427210834378101
art4252821083325378
J518282108324
2012;55728210833569100130143
33:7152821083346778
1635–1701.8092821083346599132168199228262293303
2.42529200853652
WHO.498292108358103151163
Global67729210834965103143176192
atlas8842921083375975107134
on103329210834381
cardiovascular11302921083366991129144183215248275307345361393414
disease15602921083435885120152179214
prevention178929210834466100133167206227243281320
and212429210833775115
control225429210833774112134156193209
2015.247929210833973105136148
Available264229210834777110126141173213229264
from:4253021083184078136148
https://www.world‑heart‑federation.org/cvd‑roadmaps/.589302108337598312214916218820926031336737742746548650254156360263766969071573575478982886388491793995499210311044108211041142116811971231126912921314135113841423148115131552157916051611
3.42531200853651
Thoenes49131210833372110146184219246
M,75231210835468
Bramlage8353121083355689147163195234269
P,111931210833540
Zhong117431210833775113152191
S1380312108332
et142831210833456
al.14993121083324760
Hypertension157431210834476116151173197231269296310348387
control197631210833168106128149187203
and219431210833170109
cardiometabolic23183121083316485123138176234269292325364403419433465
risk:2799312108320366292106
a425322108332
regional4723221083215594110148186218234
perspective.7213221083397495123162197230254269302336348
Cardiol10853221083397294132147185201
Res13013221083357097
Pract14143221083355588120145
2012;157432210833468100130142
2012:173232210833468100129142
925046.188932210833468103137173209222
4.42533200853651
Neaton49233210834580112133170209
JD,7163321083247081
Blackburn8123321083365183116146186224246284
H,111233210834356
Jacobs11843321083245688125164191
D1391332108345
et145133210833456
al.15223321083324760
Serum15983321083326788127184
cholesterol179833210833169107123158185208242263300316
level21293321083155082116132
and227633210833270109
mortality240033210835896118142175190205228261
findings26773321083173471110126163202229
for4253421083185678
men51834210835793131
screened6643421083265880114149187222262
in94134210831553
the10093421083226095
Multiple112034210835492107130145184200235
Risk13703421083365177107
Factor14933421083326294118155177
Intervention16853421083155374108129164198236258273311350
Trial.2050342108333506698113126
Multiple219134210835593108130146185201236
Risk24423421083355177107
Factor25643421083336294119156177
Inter‑27563421083155375109130149
vention42535210833266104126141179217
Trial658352108332496597112
Research7863521083357097132164185216254
Group.105535210834466103141180193
Arch12633521083416293131
Intern14103521083145274108129167
Med159335210835489129
1992;173735210833464100133145
152:18983521083346497109
1490–1500.20233521083346598134172203233267303316
5.42536200853650
Shepherd49236210833270105145183218239277
J.78536210832537
The83836210833373108
West96136210835892118142
of111836210833857
Scotland119136210833366103124140172210249
Coronary14563621083407799136175207228262
Prevention17343621083365690123157195217232270308
Study:20583621083335492131163177
a2250362108333
trial2298362108323446092107
of242136210833857
cholesterol249436210833270108124159186209243264301317
re‑28263621083225679
duction42537210833876108132147185224
in66437210831553
Scottish73237210833265102123148163189227
men.97437210835893131144
Am113337210834199
J1248372108324
Cardiol12873721083407394132147185201
1995;150337210833565100134145
76:16633721083346679
113C–117C.17573721083346292132160191219248286300
6.42538200853652
Ford4973821083327091129
I,64238210831932
Murray68938210835997118140173204
H,90838210834861
McCowan98538210835991132169220253291
C1291382108345
et135138210833861
al.14273821083365265
Long‑Term150738210833673112151173203234255313
Safety18363821083376988123145179
and203038210833674113
Efficacy2159382108337557390122155188221
of239538210834261
Lowering247238210833673124158180195233272
Low­275938210833674125147
‑Density42539210832168103141168182205239
Lipoprotein6793921083294483122162183221243276291329
Cholesterol102439210833775113129164191214248269306322
With13613921083557294132
Statin15083921083315284106122159
Therapy:168339210833069104125158197229242
20-Year19413921083316689122153185206
Follow‑Up2162392108330688499137188210256295
of247239210833554
West254139210835589115139
of269539210833554
Scot‑276439210833163100122141
land4254021083154785124
Coronary5644021083407799136175207228262
Prevention8414021083365690123157195216232270308
Study.11654021083325391130162172
Circulation13524021083405677108145161193215230268306
2016;167440210833468100131143
133:18334021083346497108
1073–1080.19564021083356699133169200231267302315
7.42541200853645
Sever48341210833267100134155
PS,6534121083336679
Dahlof74741210834375113129167186
B,94841210833346
Poulter100941210833370108123145179200
NR,12254121083427892
et133241210833254
al.14014121083304558
Prevention14744121083335488120154192214229267305
of179441210833555
coronary18644121083296687124163195216250
and212941210833068107
stroke22514121083244768106136170
events24374121083316498136157185
with26374121083486486124
ator‑27774121083295188109129
vastatin4254221083326591114147169184222
in66242210832058
hypertensive73542210834373113149170195228266293308340374
patients11254221083437698113148186208235
who137642210835594132
have152342210834375107141
average167942210833769103124157196231
or192542210834364
lower‑than‑average200542210831957108143164184206245277315337370401435457490529564
cholesterol258442210833674112128163190213247268305321
concentrations,42543210833168107139172211232254286308324362400426439
in88043210831553
the9494321083226095
Anglo‑Scandinavian106043210834280119134172196227259292330369384422455486502534572
Cardiac16474321083417495133149181213
Outcomes187543210834886109140177235270297
Trial2187432108334516799114
–2316432108336
Lipid23684321083324787102141
lowering252443210831654105140161177215254
arm279343210833354112
(ASCOT‑LLA):4254421083196094134180212230263295339358370
A810442108341
multicentre86644210835895110133148180214252273295329
randomised12104421083215492131169227243269304343
controlled156944210833168106128149186202217252292
trial.1876442108322435991106119
Drugs201044210834667106145171
2004;219644210833468105141153
64:23644421083347183
43–60.246244210833467103140176188
8.42545200853653
Gupta49945210834483123146179
A,69445210834761
Mackay77145210836194127157192223
J,101045210833042
Whitehouse1068452108363103118141176215254293319355
A1439452108347
et150245210833962
al.15804521083375366
Long‑term166245210833775115154177200235257316
mortality1994452108363102124150183199214237272
after22824521083375682116138
blood243645210834461100139180
pressure­263145210834567102129156194216251274
‑lowering4254621083213878130166188204243283
and72446210833877118
lipid‑lowering858462108320367692132155173212264300322338377417
treatment12914621083285085118141201237276298
in160546210832160
patients168146210834579101117153192215243
with19404621083577497136
hypertension209246210834476117153175201236275302318357397
in250546210832059
the258046210832767103
Anglo­269946210834787127143182206
‑Scandinavian4254721083215285118156195210248280312327359398
Cardiac8384721083457899137152184216
Outcomes107047210835290113144181239274301
Trial13864721083385571103118
(ASCOT)15204721083236498139184217239
Legacy177447210833671110143175208
study:19984721083315492131163177
16-year21904721083397094126160192213
follow‑up2419472108323617792130181204242282
results27164721083266087124139162189
of42548210833757
a497482108332
randomised5444821083215492131169227242268303343
factorial9024821083195284108145167182214230
trial.1147482108322435991106119
Lancet128148210833265103135169191
2018;148848210833468100131143
392:164648210833468101113
1127–1137.17754821083346291124157188215245277284
9.42549200853649
Ference4864921083326586120157189222
BA,7234921083327386
Bhatt82449210833371102124147
DL,9864921083437488
Catapano10894921083376990123161193231269
AL137349210833869
et145749210833153
al.15254921083294456
Association15964921083386692129161176208229244281319
of193049210833453
Genetic199849210834176113148170184216
Variants2229492108333638499131168189216
Related24604921083336782114135169208
to268249210831956
Com‑275349210833773131152
bined4255021083395492127167
Exposure60750210833770109148175212233267
to89050210832663
Lower96850210833673124159180
Low‑Density116350210833674125147194229268294309331365
Lipoproteins15435021083365291130169191228250284299337363
and192150210833775114
Lower205050210833673124159180
Systolic22455021083386794118154170185217
Blood24785021083405593132172
Pressure26655021083406095121148185206240
With4255121083577496134
Lifetime5745121083324767101123139196231
Risk8215121083355177107
of94351210833756
Cardiovascular10155121083407394132147185217250276309346362394415
Disease.14455121083466187122154181216228
JAMA168851210832464120162
2019;186551210833468100130143
322:202451210833466101114
1381–1391.21535121083346498130163194224257289299
10.4255220085356882
Ference5185221083326585117154185217
BA,7495221083327184
YooW,84752210833264102169178
Alesh10395221083375185110147
I1200522108311
et122552210833052
al.12915221083284254
Effect1359522108329476598130152
of152652210833351
Long‑TermExposure159152210832864101138159188217237294337368406444469505525557
to216352210831853
Lower223052210832864113146166
Low‑Density241052210832864113134180214250275289310343
Lipo‑27675221083274279117139
protein4255321083385894115147161198
Cholesterol63753210833672109124157183205237257293307
Beginning95953210833165103117153190204240278
Early1251532108329608095125
in139053210831248
Life1452532108328426093
on155953210833471
the16445321083185588
Risk17465321083324671100
of186053210833351
Coronary19265321083367192127164195215248
Heart218853210834074104124147
Disease23505321083415580114144169203
AMendelian2567532108337102136172210243258271302339
Randomization42554210833567104142179236250279311332346383421
Analysis.86054210833875106121151177191216229
Journal11045421083205895115153184198
of131754210833452
the13845421083185589
American148754210833895129149164195227264
College17655421083377388102136174208
of198854210833352
Cardiology20545421083376989126140177192229268299
2012;23675421083316495124135
60:25175421083316577
2631–2639.26095421083316396126158188221254286296
11.4255520085366679
Ference5245521083326788122160193226
BA,7665521083408196
Majeed87755210836092108143178218
F,111055210833844
Penumetcha116955210834074112150208243266296335367
R1551552108341
et160755210833962
al.16845521083375366
Effect17655521083385776110143167
of194855210834262
naturally20255521083437597135156189205220252
random22925521083265997137175233
allocation25415521083375267106138171193209247285
to284255210832764
lower42556210831553104138160
low‑density60056210831351102124165200238264279301335
lipoprotein9515621083122767105145167204226259275312
cholesterol127956210832967105121156183206240261298314
on160956210833573
the16985621083195893
risk1806562108319346090
of191256210833554
coronary19825621083296688125163196217251
heart224856210833671103124148
disease24125621083365177112144171206
mediated263356210835590130145177199233272
by42557210833970
polymorphisms5105721083407995126185223245285323338364422448
in97457210831553
NPC1L1,104257210834682122154182212221
HMGCR,1278572108345100145185221235
or152857210833860
both:160357210834079101139151
a1769572108333
21817572108335
×1868572108342
21926572108335
factorial19765721083195385109146168183215231
Mendelian222257210835590128167202218233265303
randomizati‑25405721083225593132170228243273306328343365
on42558210833776
study.5165821083264987126158168
J700582108324
Am73958210834199
Coll8535821083407793108
Cardiol9775821083397293132147185201
2015;119358210833468100130141
65:13495821083346879
1552–1561.14435821083356597130164195225260290299
12.30472420085366884
Ference31472421083326688122160192226
BA,33882421083367791
Julius3494242108325637893131157
S,366724210833346
Mahajan372824210835588126158173205243
N3987242108345
et404824210833457
al.41202421083324861
Clinical41962421083415671109124156189204
effect44152421083355574108141165
of459524210833857
naturally46682421083387092130151184200215246
random49302421083215492131169228
allocation51732421083334863101134167188204242280
to546924210832259
lower304725210831553104138160
systolic32222521083306289113150165180212
blood34502521083425896135174
pressure36402521083426498125151188209244
beginning389925210834278117132170208223261300
before42152521083427897134156190
the44202521083266499
development453425210834277109143159197237295330368390
of493925210834160
hypertension.501425210834272112148169194227266292307345383396
Hy‑542625210834779101
pertension30472621083397495120154192218233271310
2014;337226210833468100131143
63:35302621083346879
1182–1188.36252621083346293126160191219250285299
13.30472720085366883
Authors/Task314727210834178101139177199226252288316343373
Force35352721083347193124157
M,370827210835569
Guidelines37922721083458398137172188203240275302
ESCCfP,411027210833367108146165202207
Societies433227210833472105120155177192227254
ESCNC.460127210833468108153194207
2019482427210833569101131
ESC/EAS497027210833468109136170212246
guidelines52322721083397692130165181196234269296
for30472821083185678
the31402821083226095
management325128210835890128160199234292327365387
of365328210833857
dyslipidaemias:37262821083387097113127167182221253288346361393420432
Lipid41742821083324786102140
modification433028210835896136151169185218250272287325364
to470928210832259
reduce47842821083215595132164198
cardiovascular49972821083326586124139177209242269301339354386408
risk.5420282108321376393107
Atherosclerosis304729210834162100135157194221253268303324361388403429
2019;349129210833569100131143
290:365029210833468104117
140–205.378229210833465101139171205239251
14.30473020085366884
Mach314430210835486118156
F,331530210833036
Baigent33663021083336680119154191213
C,359430210833750
Catapano36593021083387092124163196234272
AL394630210833870
et403130210833153
al.41003021083294457
201941723021083316597127
ESC/EAS431430210833064104131164207240
Guidelines45703021083417893132167182197234269296
for48813021083165375
the49713021083195792
management507830210835486124156195230287322360381
of547430210833554
dyslipidaemias:30473121083376894109123161176214245279335349380406418
lipid3479312108312266479117
modification361031210835491130144161178209240261276313350
to397531210831854
reduce40443121083175088125156189
cardiovascular42473121083286080117132168199231257288325339370391
risk.4652312108318335887101
Eur47673121083306585
Heart486731210834074105126149
J5031312108321
2020;50663121083316496129141
41:52223121083316068
111–188.53053121083305784115145175210222
15.30473220085366883
Benner314632210833571109147182203
JS,33643221083255769
Glynn34493221083446091130168
RJ,36323221083366375
Mogun372232210835593133171209
H3946322108344
et400632210833456
al.40783221083324760
Long‑term415332210833269108147169191225246305
persistence44733221083397596123138164187221259291325
in481332210831553
use48813221083386499
of499532210833857
statin50673221083275083105120158
therapy52403221083226095116149189220
in547532210831553
elderly30473321083345088123145160192
patients.32553321083387193108143181203230244
JAMA351433210832464120162
2002;369133210833468104137150
288:385633210833468103116
455–461.39873321083346799136172209239248
16.30473420085366985
Monane314734210835493131164202237
M,339934210835468
Bohn348234210833574112150
RL,36483421083356781
Gurwitz374434210834482103156172194225
JH398534210832468
et406934210833456
al.41403421083324760
The421634210833271106
effects43383421083335372106139163191
of454434210833757
initial4616342108314526790105137153
drug47843421083385997136
choice493634210833169107122154188
and513934210833270109
comorbi‑526334210833269127165187226242264
dity30473521083385376109
on317235210834078
antihypertensive32653521083357394110147178218254275300333371398413445479
therapy37603521083246297118151190222
compliance:399735210833471129168184199231269301335347
results43603521083235784121136159187
from45623521083214380138
a4716352108334
population‑based476535210834281120158174206228243281319342382415441476516
study52963521083295290129161
in547235210831755
the30473621083226095
elderly.31573621083345089123145161192202
Am337536210834199
J3489362108324
Hypertens352836210834576116152173198231270296
1997;383936210833465100133142
10:39973621083346578
697–704.409136210833468101133165198234247
17.30473720085366775
Skoupá31353721083326299136175207
J.335737210832234
Dlouhodobá34063721083435896134171209248286325357
adherence377837210832968105140161194232264297
ke409037210832760
kardiovaskulární41653721083276081119134171203235261291328343375396434449
farmakoterapii46293721083164869127159189226247280301334373388403
v5047372108328
České50903721083387197127160
republice52653721083185291128167183197229262
na304738210833870
příkladu31323821083396076107124156195233
amlodipinu338038210833290105143183198237253290328
a3723382108332
atorvastatinu.37703821083325491112147180207230263284300338375388
Kapitoly417438210833468107123145182198230
z4419382108328
kardiologie44633821083296384122137175191229269284319
2011;479738210833468100128136
3:494838210833446
63–67.500938210833468104142174181
18.30473920085366985
Chapman314839210834078110149207240278
RH,34413921083358193
Benner355039210833570108146181202
JS,37683921083245668
Petrilla38523921083356891112128143158190
AA405739210834184
et415739210833356
al.42283921083324760
Predictors43033921083355690130145177201238259287
of460539210833756
adherence467739210833170108143165199237269303
with49953921083506688127
antihyperten‑51373921083327091106144175215251272296330368391
sive30474021083264174108
and317040210833270109
lipid‑lowering3294402108315306985124146162200251286307323361400
therapy.37094021083226095116149188219229
Arch39544021083416293131
Intern41004021083155375108130168
Med428440210835489129
2005;442840210833468104138149
165:45934021083346599110
1147–1152.47184021083346293125157188216246279292
19.30474120085366982
Kettani31464121083356991116149187202
FZ,33634121083337184
Dragomir346341210834668101140178236251272
A,375141210834156
Cote382241210834178100133
R3971412108336
et402241210833557
al.40954121083324861
Impact417141210831674113146178202
of438841210833858
a4461412108333
better45094121083407598122156177
adherence470141210833372110145166200238270304
to502041210832360
antihypertensi‑50954121083337193108146176216252273298332370396411433
ve304742210833266
agents312842210833271106144166193
on333742210833775
cerebrovascular34284221083316586120159181218250283309342379395427448
disease38914221083385480115147173208
for41144221083195678
primary42074221083396176134166187221
prevention.44444221083386094126161199220236274312325
Stroke47844221083335476113143178
2009;497742210833468104139152
40:51454221083347083
213–220.52434221083346696132163198232245
20.30474320085357084
BohmM,314343210833572109165230243
Schumacher34014321083296097133189220251288322342
H,375843210834052
Laufs38254321083286097115142
U3981432108340
et403643210833052
al.41024321083294355
Effects4172432108329476699131154180
of436743210833452
nonpersistence443443210833471108146180200227241266288321358389421
with48704321083466183120
medication500443210835488126140171203224238275312
on533143210833371
out‑54164321083347192111
comes304744210833167124158184
in324644210831148
high‑risk33094421083344987124146167182207236
patients35604421083356889103137174195222
with37974421083476284121
cardiovascular39334421083286080117132169200232258289326341372393
disease.43404421083355075109140166200212
AmHeart456744210833794150184215235259
J4841442108321
2013;48774421083316495124135
166:50274421083316196107
306–314514944210833165100137168198228
e307.53924421083316498130135
21.30474520085367082
Shin31464521083327085123
S,328545210833446
Jang33474521083255795134
S,349745210833446
Lee355945210833367102
TJ367745210833455
et374745210833558
al.38204521083334962
Association38974521083427097135168183215237252290328
between42414521083407598151185221259
non‑adherence451545210833977116138171210248283304338376408442
to497245210832360
statin50484521083275083105120158
and522145210833472111
hospi‑534745210833977104143159181
talization3047462108322547085114147169184222261
for33234621083175576
cardiovascular34154621083296283122137175207240266298336352384405
disease38354621083375278113145172207
and405746210833068107
all‑cause4180462108330456183117149187213248
mortality444446210835694115140173188203226259
in471946210831351
a4785462108331
national48314621083366890105143182214230
cohort.507646210833067105143165190203
Int52944621083145273
J5382462108323
Clin54214621083385368106
Pharmacol304747210833573105126184217249286302
Ther336447210833372107128
2014;350847210833468100131142
52:36664721083346780
948–956.376147210833470106143178212246259
22.30474820085367288
https://www.sukl.cz/modules/medication/detail.php?code=0093013315148210833859831231501621892092603143673784054424734895025345655936496877277647808148418679239589981013104510781100111511531191121712531288131013431358137313861426146515041529155815951634166917131750178618211854188819201950
&5116482108337
tab=texts51684821083185190134156190222246274
23.30474920085367287
https://www.sukl.cz/modules/medication/detail.php?kod=014807031504921083385983123150162189209260314367378405442473489502534565593649687727764780814841867923958998101310451078110011151153119112171253128813101343135813731386142614651504152915581596163516781715174717781814184918821915
&5080492108336
tab=texts51324921083185190134156190221246274
24.30475020085367186
https://www.sukl.cz/modules/medication/detail.php?code=0016054314950210833859831231501621892092603143673784054424734895025345655936496877277647808148418679239589981013104510781100111511531191121712531288131013431358137313861426146515041529155815951634166917131750178618181849188419181954
&5118502108336
tab=texts51695021083195291135157191222247274
25.30475120085367287
Lund314851210833168106145
TM,33095121083318699
Torsvik34245121083306486113146162192
H,363151210834356
Falch37025121083306075107145
D3863512108343
et392151210833355
al.39915121083304558
Effect40655121083315068103136160
of424051210833555
morning431051210835694115154169207246
versus45715121083306486113150176
evening47635121083326498137152190229
intake50075121083135172105135169
of519251210833554
simvasta‑52625121083243996128161187211243266
tin30475221083223775
on313752210833977
the32305221083236196
serum33415221083286384122180
cholesterol353652210833371109125160187210244265302318
level38705221083165183117133
in401852210831654
patients40875221083417495111145183205233
with43355221083526890128
coronary44795221083326991128166199220254
artery47485221083335579113134168
disease.49325221083395480115147174209221
Am5168522108343101
J5284522108326
Cardiol53255221083417495133149187202
2002;304753210833468104137150
90:32125321083347083
784–786.331053210833468104141173206242255
26.30475420085367187
Hermida314954210834479100159174213245
RC,34095421083357689
Crespo35135421083396094121160199
JJ,37275421083234759
Dominguez‑Sardina380154210834583142157195234271306336357389422443481496534566
M4383542108353
et445254210833355
al.45225421083314759
Bedtime459754210833469109131147204239
hypertension485254210833667107143164188222260287301339378
treatment52455421083214276108130188223261283
improves304755210831572111133170202237263
cardiovascular33265521083316485123138176208241268300338353385406
risk3748552108320366292
reduction:38555521083215595132164188204242280292
the41635521083215994
Hygia427355210834476114129161
Chronotherapy44505521083397798136174212234272307329362401432
Trial.4897552108333506698113126
Eur50385521083337091
Heart514455210834479111132157
J5316552108324
2019.535655210833468100130141
27.30475620085367180
Emberson314256210833390129165186213252290
J,344756210832436
Whincup349856210835796111149181219258
P,377156210833540
Morris382656210835492114136151177
R4019562108334
et406956210833355
al.41405621083314659
Evaluating42155621083326396112149181203219256295
the45265621083215994
impact463556210831472111144176201
of485156210833756
population492256210833877117155170202224240277316
and525356210833170109
high­53775621083375291129151
‑risk3047572108321435986116
strategies31795721083315576110132166206222257284
for34795721083236183
the357857210832766101
primary36955721083446682140173194229
prevention393957210834567101134168207229244283322
of427657210834363
cardiovascular43555721083367091130145184216249276309347363395417
disease.47875721083445986121154181216229
Eur50315721083387597
Heart514357210835086118139164
J5323572108329
2004;536857210834074111148160
25:30475821083346980
484–491.314258210833470107144181214246255