549
REVIEW493422701004486135155197270
ARTICLES521922701004591132151192226269309
Is338333701001645
autoimmune34443370100347198137152212272310347383
pancreatitis384333701003772110141165200234261277304320349
a4208337010034
risk42583370100233968102
factor43763370100205586114152177
for45693370100367498
pancreatic468333701003873111141165200235261277308
adenocarcinoma?500733701003472107145184215250275305320357396457491521
|5584227010018
E95617227010066108
/36098043010732
Vnitř36608043010771118137165192
Lék3871804301074184122
2021;4013804301074386128167177
67(1):4210804301074485105145162177
e9–e134407804301074387134181218255
/46828043010757
VNITŘNÍ47598043010791152173217266326347
LÉKAŘSTVÍ5126804301074185131189236281326378400
www.casopisvnitrnilekarstvi.cz42580430107651332012142542953293774274464795215705896176436927117307748128548809159449871007102310631101
CORRESPONDING42574130954697138179218256295349401453471522573
AUTHOR:101574130954795134186240281296
Lumír132974130953577143160184
Kunovský,153074130954082125169205235269308318
M.D.,186674130956278131143157
Ph.D.,20417413095408297150163177
lumir.kunovsky@gmail.com223574130951760126142166178213256299342378409443481538583649686702719734770812878
Department42575330955292136174197225291331374398
of84175330954264
Gastroenterology92375330955087117143167209249292317355379421439482527563
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Internal16457533095176084122146190226244
Medicine,1906753309562102147164200217260299313
University223675330955093110147185209240257282320
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Medicine,754765309562102147164200217260299313
Masaryk108476530956299129167191229264
University,136576530955193110147186210240257282321331
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00223976530953980
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Czech251976530954680119156199
Republic273676530954080124167212229246282
Citation:43687413095466388125150167210253267
Vnitř465274130954183100125149
Lék481974130953674108
2021;494574130953978115150159
67(1):51227413095397694130146159
e9–e13529974130953978120162195229
Received:487475330954080117155172209248293306
30.51987533095397892
1.530775330953950
2020537475330953978115153
Accepted:482876530954782117155200225263308321
28.51677653095397792
11.52777653095397080
2020537476530954078115154
Is425987027565169
autoimmune6669870275121249339464529716903103111591278
pancreatitis20159870275129250378479572691812902969105811251229
a33169870275121
risk3479987027593157262388
factor3939987027591210311402526619
for4251247027586212304
pancreatic801124702751292503784795726918129029681069
adenocarcinoma?1942124702751212503694976237248459381040110512331359154616671762
Lumír4251635013756120215245287
Kunovský1,7341635013768130195258315362422482121516430803651
2,127916430803654
3,134616430803613831635013729
Petr14341635013764120161204
Dítě1,16601635013777108148206185916430803651
4,192316430803619611635013729
Martin20121635013793152194236267332
Blaho4,2366163501376697155220284265016430803654
5,271716430803627541635013729
Jana28051635013745103168226
Dvořáčková5,30531635013777136198240297347407470526584363616430803653
6,370216430803637401635013729
Magdalena37911635013793152216282341371429495553
Uvírová6,43661635013775133164206269326384475116430803647881635013729
Marie48391635013793152194223282
Přecechtělová1,4251785013764105163214272322387427485516580637695111217930803651
3,117617930803612131785013729
Petr12641785013764120161204
Jabandžiev3,14901785013745103169228292358411442500557204517930803653
7,211117930803648
8,217217930803622101785013729
Hana22611785013776134199257
Mašková1,25401785013793152200260322379437297017930803651
3,303417930803630701785013729
Bohuslav31211785013766130195259307338396453
Kianička3,3596178501376899157222252302362420401617930803653
9,408217930803641171785013729
Pavel41681785013764121177234265
Janeček2,44551785013745103168226277335395485317930803654
3,492017930803649571785013729
Michal4251935013793124174239297327
Eid3,77519350137588915592919430803653
10,9951943080367010661935013729
Arnošt11171935013772113178241289329
Martínek4,14691935013793152193236267332390451191819430803654
51985194308036
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University30152089013371131156209262298342367403457
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Czech44172089013364113167217277
Republic47172089013360115177238300326350399
2Department4252246078334582239013373129191244280319410465526561
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University35362539013371131156209262298342367403457
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University13882839013371131156209262298342367403457
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Czech27712839013364112167217277
Republic30712839013359114177237299325350399
6CGB4252996078334592989013364131190
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a.1216298901335376
s.,131529890133446790
Ostrava,14282989013376119156191244295348370
Czech18222989013363112167217277
Republic21222989013359114177237299325350399
7Department4253146078334583139013373129191244280319410465526561
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University16443139013371131156209262298342367402457
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Brno,2524313901336096157217238
Brno,2785313901336095156216237
Czech30463139013364112167217277
Republic33463139013359114177237299325350399
8Central4253296078334593289013364117178213248301327
European8093289013354112148207270326378438
Institute1271328901332686129166191226286322376
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Technology,17863289013354102152212272332358419481533550
Masaryk23593289013389142184238273328380
University,27623289013371131156209262298342367403457474
Brno,3260328901335995156216237
Czech35203289013364113167217277
Republic38213289013359114176237299325350398
92nd425344607833458343901335651234460783673
Department6083439013373129191244280319410465526561
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Internal1307343901332787122176212273325350
Medicine,16813439013388144206231280305365420442
Department21463439013373129191244279319410465526561
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Gastroenterology,28453439013371125167204239299354415450504540599625686747800817
St.3685343901335488111
Anne’s38203439013367127188243265304
University41473439013372132157209263299343367403458
Hospital,46283439013372132175237262298351377399
Brno,5050343901336095156217238
Czech4253589013364113167217277
Republic7253589013360115177237299326350399
10Department425374607833644913739013373129191244280319410465526561
of1075373901336192
Hematology,11903739013372128219271307366392452514566583
Oncology17963739013376138187245271331393445
and22653739013353113175
Internal2463373901332787122176212273325350
Medicine,28373739013388144206231280305365420441
University33023739013371131156209262298342366402457
Hospital37823739013372133175237262298352377
Brno,4182373901336096157217238
Brno,4443373901336095156217238
Czech47043739013364112167217277
Republic50043739013359114177237299325350399
Immunoglobulin4253973012124107190245300356412436491548603627650705
G4-related11513973012164117150184234258306338388445
diseases1617397301215680119169217256307346
(IgG4-RD)1985397301212851107172224258314381407
are2414397301214880130
a25653973012148
group2634397301215689143199255
of2911397301215483
diseases3016397301215679118169217256306346
characterized33833973012145100148180229274309358391415457507565
by39693973012157103
high4093397301215679135190
serum4304397301214090123178262
levels4587397301212374121170194233
of4842397301215483
immunoglob‑49473973012123106189244299354411434490547580
ulin425411301215579101157
G46034113012164117
(IgG4),741411301212851107173225251270
increased1032411301212378123156206254293343401
lymphocyte1454411301212371155212268323368418454504
and19794113012148103160
plasma2160411301215781129168251299
cell2480411301214594118141
with2642411301217498131186
IgG42849411301212481146198
positivity30684113012157113152175208231280303336386
in3475411301212479
the3575411301213389139
parenchyma37354113012157106138188244289344389473522
of4278411301215584
some4383411301214095178229
organs,4633411301215588144192247286307
and49614113012149104160
storiform5143411301213973127160184213268301385
fibrosis.425425301212955111144198237259298319
The7654253012146102152
most9384253012179134173206
frequently1165425301212659109165220270325357380427
affected1613425301214473105155200235284341
organ1975425301215184139186241
is2237425301212059
the2317425301212984134
pancreas.24724253012153101156201233282330369390
This28834253012146101124163
is3067425301212059
an31464253012145100
autoimmune3267425301214498131185208290373427482532
form3820425301212680113196
of4037425301215180
pancreatitis,41384253012153101156201233282330362385418440479500
which46594253012170125148192247
can4927425301214189144
be50924253012153103
divided5216425301215376124147204253310
into425439301212379111165
two6114393012137112167
types:799439301213686144195234254
Type1075439301215394151203
1,1299439301215470
which13904393012177133156201256
is1667439301212766
significantly1754439301214366121177200229255300349404436460507
more22824393012187142175225
common25284393012148102185269324380
than2929439301213691139195
Type3145439301215394151203
2,3369439301215475
is3465439301212666
high3552439301215982137193
in3766439301212782
IgG43869439301212784149201
in4091439301212782
the4194439301213792142
pancreatic43574393012161109165210242292340372395440
parenchyma48184393012161109142192247292347393477525
and53644393012152107164
shows425453301214095150223262
a7084533012149
fundamental778453301212985140197245328379434467515539
difference1338453301215780109142192225275330375424
in1784453301212378
the1883453301213489139
noted20434533012156111144193250
presence2315453301215689139179229285330379
of2715453301215584
extra‑pancreatic2820453301215098133166214246304353408453486536584616639684
disorders.3525453301215680119174207263313346387408
In425467301212479
general,5254673012160111166217250298322342
chronic8884673012149104137191247270315
inflammation1224467301212883112138186269352401433456511567
is1812467301212867
a19004673012152
risk1973467301213761100146
factor2141467301213382127162216249
in2411467301212883
the2515467301213792143
development26794673012160111158208232287344427478534566
of3266467301215988
carcinomas.3375467301214998131175198253308392440479500
Chronic38964673012162117150204260283328
pancreatitis42454673012161110165210242292340373396429452491
is4757467301212867
an48454673012152108
accepted4974467301215297141190247280329386
risk538246730121366099146
factor425481301212978123158212245
for691481301212984117
the829481301213288138
development9884813012156106154203227282339423473529561
of1571481301215483
pancreatic16754813012156105160205238288336368391436
cancer.2132481301214493148193242275291
The24454813012149105155
question26224813012155110160200234257312368
is3011481301212262
whether30944813012173128179212267318351
this3466481301213288111150
also3637481301214771110165
applies38234813012148104162186209259298
to4142481301213387
autoimmune42504813012148102135189213296379434489540
pancreatitis48114813012156105160205237287335368391424447486
(AIP),5318481301212888112165191209
which4254953012174129153197252
has6994953012153101140
some860495301213792176226
mediators11084953012180131188211259292346379419
of1548495301215382
inflammation1651495301212176105131179263346394426449504560
in2232495301212176
common2330495301214296179262318373
with2725495301217194128183
sporadic2929495301213793149182231287311355
pancreatitis,33064953012154103158203235285333366389422445484505
and38324953012146101158
what40114953012171127175207
role4240495301213084109159
the4420495301213186136
presence4577495301215588138177228283328377
of4975495301215382
IgG45078495301212278143195
plays.5295495301215478126172211233
The4255093012150106157
vast6035093012151100139173
majority7975093012187135159214247270303353
of1171509301215988
the1280509301213792143
work14445093012177131164211
on16765093012159115
this1812509301213792115154
topic1987509301213791148172216
consists22255093012148102157196219258292333
of2579509301215988
case2688509301214897136187
reports,2896509301213686143199232268308329
yet,32475093012150100133154
even34225093012154102151206
based36505093012160109148198256
on39275093012158114
our40625093012159114147
own42305093012158131187
experience,44385093012154101159210243266316372417466486
we49455093012177127
would50935093012177132187210267
like538150930121275097146
to425523301213387
say533523301213988133
that687523301213287135168
there876523301213287137170220
is1117523301212262
a12005233012147
relationship1268523301213181105153185209264319358414437493
between17825233012156107140216266317372
the2176523301213187137
autoimmune23345233012147102135189212295379433489539
form2894523301212883116200
of3115523301215483
pancreatitis32195233012156104160205237287335368391424447486
and37265233012147102159
pancreatic39065233012156104160205237287335367390435
cancer,4362523301214493148193242275291
which46745233012172128151196251
usually4946523301215493148196219242290
occurs5257523301215399143197230270
in425537301212379
the525537301214096146
first69253730121376396136170
two8835373012141117171
years10755373012155104152185225
after1322537301215584121170203
diagnosis1546537301216487135191247302341364404
of1971537301216291
AIP.2083537301216992146155
Also2260537301216891131186
significant2467537301214770126181205234260305354410442
is2930537301213170
the3021537301214096146
fact3189537301213685130165
that3376537301214095143176
the3573537301214096146
group3741537301216395150205262
of4025537301216291
people41375373012164115171229253303
with44625373012180104137193
AIP,4676537301216892145154
who48525373012181137192
is5065537301213170
a51565373012155
clinical523353730121527598153176221270294
manifestation4255513012183132187210239290329363412444467522578
of1024551301215584
IgG4-RD,1129551301212480145197231287354372
was15225513012173122161
found1704551301212984139194251
to1976551301213387
have20845513012155103150199
an23045513012148103
even2428551301215098147202
higher2651551301215679135190240273
incidence2945551301212378123146203253309354403
of3369551301215584
extrapancreatic3474551301215097133165214270319374419452502550582605650
cancer4145551301214593149194243275
than4442551301213287135191
in4654551301212378
the4753551301213388139
pancreas49135513012156105160205238288336375
itself.530955130121235697147171200219
Differentiating425565301216791120153203237287342375398446479502557614
AIP1060565301216992146
from1227565301213670125209
pancreatic14575653012164113169214247297345378401446
cancer19245653012152101156202251284
can22295653012152101157
sometimes24075653012147102186237271294377428468
be28965653012164115
problematic3033565301216497152209233284368416449472517
since3571565301214770125171220
these3812565301214096146186237
diseases4070565301216487126177225265315355
can44465653012152101157
both46245653012164120153209
present4854565301216497147187238293326
as5201565301215695
focal5317565301213792138187210
pancreatic4255793012157106161206238288336369392436
lesions.883579301213080120143198253292314
IgG41218579301213187152204
has14445793012162110149
been16145793012164115166221
considered18575793012151105161200222279329362412469
useful23475793012162102152182238261
for2629579301213691124
AIP2774579301216892145
diagnosis,2940579301216386134190245301340363402423
however,33845793012162117190240287336369385
IgG43790579301213188153205
levels4016579301213081128177201240
can42785793012151100155
be44545793012164115
slightly459057930121467093148204236259307
elevated,4918579301215781131179227260309366387
as5326579301215594
in5441579301213086
the425593301213388139
case585593301214493132183
with789593301217397130185
pancreatic9965933012156105160205238287336368391436
adenocarcinoma.14535933012148105155211266311360393437460515570654702723
IgG42197593301212480146198
levels2416593301212374121170194233
of2670593301215584
over27765933012154101150183
twice29815933012132108132177226
the3228593301213388138
upper33885933012155111168220252
limit3662593301212346129152185
are3869593301214880130
rare4020593301213381114163
among42055933012148131186242298
patients45245933012157105138161211267299340
with4885593301217397130185
pancreatic50915933012157106161206239288336369392437
adenocarcinoma.4256073012148105155211266312360393437460515570654702723
However,11696073012172127200249297346379395
cases15856073012151100139189229
of1835607301216190
simultaneous1946607301214669152207230263312367418474529568
presentation2535607301216396146186236292324373405428483539
of3095607301216190
pancreatic32076073012163111167212244294342374397442
cancer36706073012151100155200249282
and39736073012155110166
AIP4161607301216790144
have43266073012161109156205
been45526073012163114165221
documented47946073012162118163218301352407440489546
and53626073012154109166
should425621301214095150205229285
not7316213012156111144
be8966213012157108
neglected.10256213012156106163186237282317367424445
AIP425635301216185138
is584635301212363
a6686353012148
condition737635301214599154211234267290345401
where11596353012174130180213263
regular1443635301213383139194218266298
follow‑up1762635301212984108132187260291348404
is2187635301212463
mandatory,22716353012184132187244292324378411461477
including2770635301212378123146201258281336392
from3183635301213063118201
the3405635301213489139
perspective35656353012157108141182238289335370393441491
of4077635301215584
possible41826353012157113152191214271295345
cancerogenesis.4548635301214594149194243276330387437493544583606645666
Key4256521012358107156
words:6016521012371126161219260282
chronic901652301214499130184239262306
inflammation,1227652301212075103129176258340388419442496551571
carcinogenesis,1819652301214189121164187241295351401456505544566605626
autoimmune2465652301214598131184207289371425480529
pancreatitis,30156523012153101155200232281328360382415437476496
chronic3532652301214195127181236258302
pancreatitis,38556523012153101155200231281328360382415437476496
pancreatic43726523012153101155200231280328360382426
adenocarcinoma,48196523012144100150205259304352383427449504558641688709
immunoglobulin4256663012123106190244300355412435490547603626649704
G4.11506663012165117138