847
REVIEW42522701004486135155197270
ARTICLES71022701004591132151192226269309
Is42533701001645
autoimmune4863370100347198137152212272310347383
pancreatitis88533701003772110141165200234261277304320349
a1250337010034
risk13003370100233968102
factor14183370100205586114152177
for16113370100205882
pancreatic170933701003873110141165200235261277307
adenocarcinoma?203333701003372107145184215250274305320357396456491521
E1019522701004170115
|325227010043
VNITŘNÍ4268043010746106127172220280301
LÉKAŘSTVÍ748804301074185130188236280325378400
/11688043010757
Vnitř12458043010771118137165191
Lék1456804301074083122
2021;1597804301074487129168178
67(1):1794804301074486106145163178
e9–e131991804301074488135181219256
/22678043010757
www.casopisvnitrnilekarstvi.cz442680430107651332012142542953293774274464795215705896176436927117307748128548809159449871007102310631101
Je42556701503699
autoimunitní561567015064133180247281381450518552600669703
pankreatitida1302567015068133201269319382447494529576611680745
rizikovým208456701504982138172240305370441542
faktorem2663567015048112179229296344408509
adenokarcinomu3209567015064133196265332400464513567602670737838906
pankreatu?4152567015068133201269319382447495563613
Imunoglubulin425793012326112168226283341367423482539565591648
G41094793012373128
asociované124279301235899156202228284334385442494
nemoci1757793012364116201258304329
tvoří210779301234295150186212
skupinu2339793012349100157216242299356
chorob,2716793012351109165201258317340
které307679301235896147183235
charakterizuje3332793012351109159195246297335386422448493549576628
vysoká3980793012358111153210261313
hladina431479301236490141199225282333
imunoglobulinu4668793012332117174231288346372429487545571596654710
G45399793012373128
(IgG4)42593301233055113180235263
v708933012353
krevním78293301235390142192250276361
séru,116493301234395132189213
zvýšený1397933012348101154196248305354
obsah1772933012358117159210268
lymfocytů206093301232879164196253299351389446
a2527933012353
plasmatických260093301236187139180265316351376421472525569626
buněk3247933012361118175227278
s3546933012344
IgG4361193301232886154208
v3839933012353
parenchymu3913933012361112148200257302360408494551
některých4484933012360111163201252288341385442
orgánů494793301235894152203260317
a5284933012353
storiformní53589330123448013642510730123366193150186271328354
fibróza.800107301233866124160217261313338
Nejčastěji11581073012374126153198249291327378404430
postiženým16091073012364121163198224269321379427513
orgánem2142107301236399156207265316402
je2564107301233385
pankreas.26701073012364116173224261313364405430
Hovoříme31211073012373130180235271296381433
o35751073012362
autoimunitní36581073012357114149205230315372430455490547573
formě4251107301233895131216268
pankreatitidy,45401073012364116173224261313364399424459484543593613
která5174107301235794145182232
se54271073012348100
rozlišuje425121301233692137163189230287314365
na8111213012361112
dva9431213012362113164
typy.1128121301233891150199219
1.1367121301235777
typ1464121301233991151
s16351213012346
vysokým17011213012355108149206257311396
obsahem21181213012360119160212269321406
IgG42545121301233088155209
v27751213012354
pankreatickém28501213012362113170221259310361396422467517568653
parenchymu35241213012362113149200258303360409495551
je4096121301233082
významně41991213012354107154212263348405457
častější4677121301234899141177228254296322
než50201213012360112157
2.5198121301235783
typ5301121301233991151
a54721213012354
má4251353012385136
zásadní581135301234598139191249307332
odlišnost,9341353012356115141167209266323364400424
i13791353012326
pokud14251353012359116167225283
jde1729135301232785137
o18871353012356
přítomnost1964135301235995120155211296354410452487
extrapankreatických24721353012352102140175226285336393444481533584619644689740793837895
postižení.33871353012359116157193218264316373399423
V4251493012360
obecné5061493012358117170215273324
rovině851149301233895144171228280
platí,1151149301236188139173199223
že1395149301234799
chronický15151493012347104140196254279324375428
zánět19641493012347100157209244
patří22291493012361112147182208
mezi24581493012387139184210
rizikové2689149301233863108134185240290340
faktory3050149301233486137174230266319
vzniku33901493012353100157183234291
karcinomu.37021493012353105140185211268325410467491
Chronická42131493012361118154210268293338389441
pankreatitida46751493012361112169220257309360395420455481539590
je5286149301232981
tak5388149301233789140
akceptovaným4251633012351102145196255291347397448505553639
rizikovým1084163301233965109135186242291345430
faktorem1535163301233586137175231267318404
vzniku19591633012354101158184235292
pankreatického22721633012361113170221258310361396421466517567625682
karcinomu.29741633012354106141186212269326411468492
Je3486163301234395
otázkou,3601163301236095147192243299356380
zda40021633012348106157
toto4180163301233793129185
platí4385163301236288139174199
i46051633012329
o46541633012360
autoimunitní47341633012354111146202227312369426452487544570
pankreatitidě53241633012362113170425177301235188140191226251286311370422
(AIP),868177301232891117173201223
která1111177301235087138175225
má13571773012383134
některé15121773012355107158196247283335
mediátory18681773012383135194220271305361397450
zánětu2339177301234395152204240297
shodné2656177301234098154213270322
s29991773012340
pankreatitidou30601773012356108165216253305356391416451476535591649
sporadickou,3729177301234099156192243301327372422478535559
a43091773012349
jakou4378177301232676127183240
roli4639177301233390116142
hraje4801177301235691142168220
přítomnost5042177301235793118153209294352408450485
imunoglobulinu4251913012326110167225281339365422481538564589647703
G4.11491913012367121145
Naprostá4252053012368119178214270312347399
většina8452053012351102137180206263314
prací1179205301236096146191217
s14172053012342
touto1480205301233692149184240
tematikou1741205301233587172223258283334389446
jsou2208205301232869126183
kazuistická24122053012352103149206231273309334379430482
sdělení,29142053012343101153180232289315339
přesto3274205301235995147189225281
však,3575205301235293145196222
a38182053012351
to3890205301233692
i40022053012327
na40492053012358109
základě4179205301234598149176227285337
vlastních4537205301235278129171206263289334391
zkušeností,4949205301234597154196248306362404440465489
si5459205301234268
dovolujeme4252193012358115164220246303329381467519
tvrdit,964219301234295131190215250275
že12602193012351103
existuje13842193012358108134176211268295346
vztah17512193012357104141193250
mezi20222193012391143189214
autoimunitní22572193012357114149205231316373430455491548573
formou2851219301233895131216273330
pankreatitidy32022193012364116173224261313364399424459485543594
a38162193012357
pankreatickým38942193012365116174225262314365399425470521574659
karcinomem,45742193012357109145190215273329414466552576
který5171219301235795146182235
se54262193012349101
objevuje4252333012356115142193244301328379
obvykle8252333012360119169222274301353
v11982333012355
prvních1273233301236298152210235280337
dvou16312333012361113168225
letech1877233301232981117168214271
od21682333012360119
stanovení2308233301234581132189246296346404430
diagnózy2758233301236288139196253310354407
AIP.3185233301236894150163
Významný33692333012363114161219270355412460
je3850233301233082
rovněž3953233301233995145203255300
fakt,4274233301233586137175200
že44942333012349101
u46152333012361
skupiny4696233301234596154212238296344
osob50612333012360101158217
s52982333012345
AIP,5364233301236793150163
která425247301235087137173222
je668247301232374
klinickoumanifestací76224730123467398154179223273327383484534590615646697738773824868893
IgG41675247301232279145199
asociovaných1894247301234687143188212268317367423470513569
onemocnění,24832473012353109160244300344400451508533556
byl30592473012355103129
nalezen32082473012353103128179223274330
dokonce35582473012354110160214271315365
vyšší3943247301234799140180205
výskyt41682473012347100140190242280
nádorových44682473012353103160216251306355407450506
onemocnění49952473012352108159243299343400450507532
extrapankreatických,4252613012352102140175226285336393444481533584619644689740793837894919
než13642613012358109155
tomu1539261301233591176233
bylo17932613012358108134191
v20042613012351
pankreatu20762613012358110167218255307358393449
samotném.2546261301234293178235270327379465489
Diferenciální425275301236995128180216268327372398449475533559
diagnostika1004275301236692143201259316358394419470523
AIP1547275301237198154
od17222753012364123
karcinomu18662753012358110146192217275332418475
pankreatu23622753012366117175226264316368403460
může28422753012393150195248
být31102753012366116154
někdy32852753012365117169226277
problematická,35832753012366102159219245297383435470495541592644668
protože42722753012366102159195251296349
tato4641275301234395130186
onemocnění48482753012364122174260317363420473531557
se54262753012349101
mohou4252893012385142199256313
projevovat759289301235591148174226276331381432467
obě12462893012354113165
jako1432289301232475126181
fokální1634289301232985137188214271297
pankreatické19522893012355107164215252304355390415460511561
léze.2534289301232375120172195
IgG42750289301232482149203
je2974289301232476
považován30702893012356113163214259316365416473
za3564289301234295
užitečný36792893012354100126161212258315364
pro4063289301235692149
diagnostiku4232289301235681132190247304345381406457514
AIP,4767289301236187143156
avšak4944289301234897139190241
hladiny5206289301235480131189215272321
IgG4425303301232684152206
mohou6523033012391148206262320
být9923033012366115153
mírně11663033012391117153210262
zvýšené14493033012352105158200252310362
i18313033012333
v18843033012358
případě19633033012365101127185237295347
adenokarcinomu23313033012357116168225282333385421466491548605690747
pankreatu.30993033012365116174225262314365400456480
Hladiny36003033012374100151210235293341
IgG43962303301233391158212
přesahující41953033012365101153195247304361388413458484
dvojnásobek46993033012365116172198255306348405463516567
horní52873033012364121157214240
hranice425317301235792143199225269320
jsou765317301232465122178
u9643173012353
pacientů10383173012355106150175227284318374
s14333173012338
adenokarcinomempankreatu14923173012347105156214270321372407452477534590675726811886937994104510811133118412181274
vzácné.2787317301234793145190247298322
Byly31293173012354104130180
však3330317301234788139190
zdokumentovány35403173012342100156207264348400457491547596647704752
případy4312317301235591116174225283333
současného4665317301233995152197248289346397454511
projevu5196317301235591147173224274331
karcinomu4253313012351103138183209266323408465
pankreatu9103313012359110167218255307358393450
a13803313012351
AIP,1452331301236390146159
a16323313012351
proto1703331301235995152187243
ani19663313012351108134
tato2121331301233586121177
možnost23193313012385141186244300342378
by27173313012359108
neměla28463313012357109194246272324
být31903313012359108146
opomíjena.33573313012356115172257283310362420470495
AIP425345301236490146
patří5923453012358110144180205
mezi8183453012385137182208
stav,1047345301234277129178198
jenž1265345301232779137182
vyžaduje14683453012350104151203261318345397
pravidelnou1885345301235995146195221279331358415472529
dispenzarizaci,2435345301235883125184236294339391427452497550595620644
a31003453012351
to3171345301233591
i32833453012326
z33293453012345
pohledu33953453012358116173199251310367
možné37833453012384141186244295
kancerogeneze.40993453012351103160205256292349407459517568614665689
Klíčová425362301235885111155211261312
slova:758362301234874130180231254
chronický10393625012145100132187243266310357407
zánět,1467362501214999154205238259
kancerogeneze,17473625012153103158203252285339396446502553596646666
autoimunitní24343625012154109142196220303357413436469524547
pankreatitida,30033625012163111167213247297345378401434457513562583
chronická36073625012151106138193248272316363412
pankreatitida,40403625012163112167214248298346378401434458514562583
adenokarcinom46443625012155111162217272320369401446469524579663
pan‑53283625012163111167199
kreatu,425376501214781131179211266287
immunoglobulin7333765012124107190245300355412435490547603626649704
G4.14583765012165117138
Introduction425409401383296141188251315379429474508570634
IgG4-related565426301071969126171200228271290331358400451
disease1035426301075675107152192225270
(IgG4-RD)132442630107314999156201230277336358
can1702426301074788136
be18584263010756101
linked197942630107264492130173224
with2222426301077291119168
many24094263010781122170208
organs,2637426301075582130171219252268
such425440301073380120168
as613440301073770
the703440301072472116
biliary83944030107466584102142168211
tract,106944030107255193133163179
liver,126844030107163475117144155
salivary144344030107307290109149191217260
gland1722440301074664105152201
and1943440301073885134
lacrimal209744030107165696123142215255274
glands,2390440301074665105153202235250
kidney,2660440301073555104151195235246
prostate,425454301074975121154182223249291305
lungs,749454301071562109157189204
breast,972454301074672114153186214230
thyroid,1221454301072471109136182200248263
pericardium,1503454301074690116134174214240287305351423438
lymph1961454301071554127176224
nodes2204454301074491140183216
and2439454301073784133
skin259145430107306686133
(1,274345430107205969
2).283145430107406274
Cancer565468301075193141181224250
tissue83546830107264477111158202
can1056468301073880128
also120446830107385790138
be1362468301074792
infiltrated147446830107176588108126154181223250292342
by1836468301074887
IgG41943468301071766123168
plasma2131468301074767108141214255
cells,240646830107388099118151167
however2592468301074695160203244287313
this42548230107297998132
infiltration578482301072676100121141170198241270290339390
is988482301072761
usually1070482301075690139181201220262
with1353482301077394123173
variable1547482301074992119140181233254299
density18674823010757103153187206236280
and2168482301074998150
counts2338482301074997147197225261
of2620482301075681
IgG42722482301072678136183
plasma425496301075069110143216257
cells.702496301074183102121153170
There892496301074292136163206
is1117496301072052
no1189496301074997
association1306496301074175108156198216257284303351399
with1725496301076585113161
typical1906496301072871121140181222241
IgG4-RD2167496301071969126171200247306
histological2492496301074968100129176196244294313353394413
markers.4255103010774114141179222249283300
This745510301074695114147
fact911510301072870111141
poses10725103010754103136180214
the1306510301073280124
question,14505103010753100144178207226274323338
if1808510301072347
synchronous1874510301073879128169217243290339387435468
carcinoma2362510301074486112151170218266340381
and2763510301074593142
IgG4-RD425524301071968125171199246305
represent750524301072972122149191225269318344
a11145243010743
true1177524301073157106150
association1346524301074477110159200219259286305353402
or1767524301075178
a18645243010744
non‑specific19275243010751100148176210259304346364388408448
pericancerous2395524301075297124143183225273313356382429477510
IgG4425538301071968125171
reaction;615538301072770110151181200248296311
this94553830107287695128
remains1092538301072770144184203251284
unresolved1396538301074795122165198247266307351401
(3).181653830107246788101
The565552301074292137
autoimmune722552301074896124171190264338386435480
form1221552301073179106181
of1422552301075579
chronic1521552301074795122169219237278
pancreatitis1819552301075799147188215258299326345374393426
is2265552301072558
a23435523010748
relatively241155230107337796137164184225269288329
rare2759552301073476102146
disease425566301074968100145185218262
characterized707566301074492133159201241272314341360396439489
initially121656630107237189117136176195214254
by1490566301075393
the1602566301073280125
presence1746566301075481124158202250290333
of2099566301075175
an2194566301074593
obstructive23075663010752102135164191239280310329370413
icterus,274056630107236393136425580301072777110127
lymphoplasmatic572580301072768144195245294345366407442516558586606647
infiltration,1239580301072675100120139168196238266286335385401
storiform1660580301074171119147167191240268344
pancreatic20245803010758100150191218262304331351392
parenchyma24375803010757100127171220262311351427469
fibrosis42559430107244393120167200219251
with696594301076887115164
intraparenchymatous87959430107227097124166215257283326374415463501576617644690739772
venulitis,1670594301074487135183202220248267300316
and2005594301074593142
further2167594301072775102133181225252
an2438594301074593
abundant2550594301074494142190240280329355
presence425608301075077120153197246286329
of773608301075276
immunoglobulin869608301072295169216265313363382430480528547566614
G415026083010760105
(IgG4)162760830107284696152198219
in1866608301072270
serum,1956608301073781108156230245
with2221608301076988116164
an2405608301074593
increase2517608301072371111138181221254298
in2835608301072270
IgG4-positive425622301071968125171199250299333351379398439482
plasma927622301074868108142215256
cells1202622301073982101120152
in1374622301071765
the1459622301072675119
parenchyma.1597622301074990117160208248296335410450467
A20836223010752
typical2154622301072770120139180221240
feature2414622301072265105133181207250
is2684622301071750
a27536223010740
favourable2813622301072264425636301074087134159200249268311
response75563630107236497146194241273317
to1091636301072469
steroid118063630107295799125171189237
therapy1436636301072472115141181230268
(4),17236363010720618295
which18376363010761108126165212
is2069636301071547
reported2135636301072365113161187218259308
as2462636301073770
one2551636301074491134
of2705636301074367
the2791636301072471114
diagnostic425650301074866105153199246278306324363
criteria.80765030107356179106147173191230245
In1071650301071562
the1151650301072471114
pathogenesis1283650301074686112159206254297343386419436467
of1769650301074366
autoimmune1854650301073783110155173244316362408451
pancreatitis2324650301074585132171196238277303321348366397
(AIP),274065030107207088132153165
the425664301072876120
multifactoriality5656643010775123142170188212254295325372399418458477496524566
of1151664301075074
the1244664301073078122
process1386664301075178125166209242276
is1681664301072154
a17546643010743
characteristic1816664301074290131157199239270312339358391420438479
feature2314664301072569109136184211254
to2587664301073076
which26836643010766115134174222
autoimmunity,425678301074087114160179251323370417435462504515
genetic959678301074588136179206224264
and1242678301073784132
environmental1394678301073987125144170216264336379426453493512
factors1925678301072061101130176202236
contribute.2180678301073682130156182201249296324366380
As2579678301074983
noted,2681678301074492119160209224
the425692301072774117
autoimmune561692301073783110155174245317363410453
form103369230107196691164
of1216692301074367
pancreatitis1301692301074686133172198239278305323350368399
is1719692301071547
the1785692301072370113
clinical191769230107365472118136175215233
manifestation21696923010769109155173196238271299339365383430477
of2665692301074467
a27516923010736
set280669230107307299
of425706301074872
diseases51770630107466497141181215259292
referred82970630107246790134160188231281
to1129706301072572
as1220706301073872
IgG4-RD.1311706301071666123168197244303316
These1647706301073989133166211
diseases187770630107466598142182215259293
are2190706301073864107
characterized2317706301073785126152194234265307334353389432482
by2819706301074786
a4257203010741
high485720301074563112159
presence664720301074673115149193240280322
of1006720301074468
plasma1094720301074665105138211251
cells136572030107377998116148
and1533720301073785134
positivity1686720301074695128146174193233253280323
of2028720301074468
IgG42116720301071564121166
not2301720301074593120
only2440720301074593112151
in2611720301071563
blood2693720301074766114162212
serum,425734301073376101149220235
but679734301074592120
also81773430107375587134
in970734301071561
cells105073430107367796113145
of1214734301074366
parenchymatous1299734301074686111153200239286323396436462507554586
tissues.190473430107244273106151194227243
In2165734301071662
addition,2246734301073785133151178196243290305
the2570734301072370113
disease270273430107456394137176425748301073478
is522748301071749
closely591748301073857105138183202242
associated853748301073871105153194213253280323373
with1246748301076281109157
an1423748301073987
increase1529748301071764105132174215248292
in1841748301071664
interferon-1192574830107166491133160187230257304352380419
(INF-1),236474830107213997138165204221235
which26187483010763111130170218
is2856748301071649
produced425762301074975121170217256298347
by791762301074584
plasmacytoid894762301074564104136208248288329359405423472
dendritic1385762301074488135183209227254273312
cells.171676230107367896114146162
Increased1897762301071562102128170209241284333
INF-12249762301071672113138176
production2444762301074672118167213253282301348395
is2858762301071547
one425776301074795138
factor582776301072061100130175201
in802776301071662
the883776301072471115
pathogenesis1017776301074586112159207255298345389421439471
of1507776301074367
AIP1593776301074866110
(5).17227763010720628496
In1837776301071662
addition1918776301073786134152179197244292
to2229776301072469
the2317776301072471114
autoimmune2450776301073784111157175247319365412455
form304741230107247198172
of3239412301074771
pancreatitis,3330412301074991139179206249289316335363382414430
INF-13780412301071976117144183
(usually3982412301072368101148189208227267
alpha)4268412301074159109157198220
is4508412301071851
known4578412301073888136201250
to4847412301072874
be4941412301074994
an5055412301074088
important5163412301071891141190217248289337364
factor3047426301072466106137183210
in3277426301072371
the3367426301073281125
development3512426301075397137181200248298372416465491
of4023426301075276
other4119426301075279128172198
autoimmune4337426301074592121167186260333381429473
diseases,4830426301075371104148188222266300316
such5165426301073885126174
as5358426301074579
in5456426301072371
those3047440301072877126160205
with3272440301077292120169
systemic3461440301074182117146189264282323
lupus3804440301072674124173207
erythematosus4031440301075177121153202246321362390437471518552
(SLE)4603440301073171111153178
(6).480144030107317496110
Attention4931440301076087118161209237256304354
in5305440301072574
the5399440301073584128
pathogenesis3047454301074990117165213262306354397431448481
of3547454301074568
AIP3635454301074967112
is3766454301071648
also383345430107385789137
given3989454301074664104147195
to4203454301072571
genetic4293454301074689137181208227266
and4579454301073785134
immunological4732454301071688161208256304323371420438478519538
factors5289454301072162102132178205239
(7).304746830107246892105
Interesting317246830107186692135161204238267286334383
results3575468301072568102149168196231
have3825468301074788128171
been4016468301074893138186
reported4222468301072568118167194225267317
by4559468301074988
a46674683010739
Japanese4726468301073071120162210254288332
study,5077468301073362110159200211
which53084683010764112131171219
described3047482301074993127167194213263307358
as3424482301074578
a35224823010744
possible35864823010753103136169188237257301
new3906482301075297162
genetic4087482301075397145189217236276
factor4383482301072769110140187214
HLA46174823010760100155
serotype4792482301073781108155182225275320
DRB151324823010762108154194
04055345482301074894139182
and3047496301074088136
DRB13202496301075499145184
04013405496301074085130169
(8).35934963010720628496
However,37084963010753101164207247289315326
this405449630107247189121
undoubtedly4194496301074491140187234283310352401419458
interesting467249630107156288130156198231259277324373
result506449630107236598144162190
has5273496301074484117
not5409496301074492118
yet3047510301074083111
been3177510301075398143191
confirmed3388510301074390139162182208282327377
by3785510301075292
further3897510301072675102133181225252
studies.4168510301073766114164182226260276
People4464510301074991140190209253
with4737510301076888116164
AIP4921510301075674119
demonstrate5060510301075296170219267300329356398425467
a30475243010741
high3108524301075068117165
level3293524301072165105149168
of3481524301074973
antibodies.3574524301074290117136186235285303347381398
Positive3991524301074794127145173192233276
antinuclear4287524301074391118136184232272291335375402
antibodies4708524301074391118137186235285304348381
were51095243010767110137180
found5308524301072673122170219
in3047538301071966
40%3133538301074085152
of3305538301074468
patients,3392538301074788115133177224251285301
antibodies3713538301073785111130179228277296339372
against4105538301073786127145192225254
anhydrase4378538301073885133171219246287320364
II4761538301071634
and4815538301073785134
PSTI4968538301074283126146
(pancreatic5134538301072070111159199225268308334353393
secretory3047552301073478119145188216262289332
trypsin339955230107255194145178197244
inhibitor)3663552301071664112130179199227273300322
in4005552301071664
55%4088552301074182146
and4254552301073886135
against4409552301073787127146194227255
lactoferrin468455230107165797127174198241268295314362
in5066552301071563
as5149552301073871
many52395523010771112160198
as5457552301073871
75%3047566301074485149
(9).32165663010722638699
Environmental3335566301074088127147173220269342386434461503522
factors3876566301072264105135182209243
include4139566301071765106124172221265
the4424566301072675119
long‑term4562566301071866115164192220263289364
action4945566301074080111129177226
of5191566301074670
certain5281566301073881107138180198246
substances,3047580301073481130164193234282323365399415
such3481580301073481122170
as3670580301074174
mineral3764580301077492140184211253272
oils405558030107486786118
and4193580301074189138
certain4351580301074083109140182200248
polymers.4619580301074999118158233277304338355
The30476054013861124183
classification3265605401385083144197248281326360411471516549612676
of39766054013862107
autoimmune41186054013860124169232264358451515579638
pancreatitis47916054013864124188239285344405450483528561613
In3187622301071967
2012,3274622301074386126163178
recommendations3472622301072568110156230304348396446486513532580629662
were41546223010763107133176
published4350622301074997147166185217265309359
regarding4729622301072568118159186234252300350
the5098622301072775120
nomenclature52376223010747961702142623047636301074059100127175201244
of3311636301074670
AIP3400636301075170115
(10).3535636301072261101124137
There3692636301074089134160203
are3915636301073965108
thus4043636301072674121154
two4217636301072693141
types4378636301072668119164198
of4595636301074670
AIP.4685636301075170115120
Type4825636301074074125170
1,5015636301074252
also508763630107395890139
referred524563630107256892135162189232282
to3047650301072876
as3143650301074882
lymphoplasmatic3245650301072667143193243292343364405439513555583602643
sclerosing3908650301074182102147174222256275323374
pancreatitis4302650301075799148190217261301329349377397430
(LPSP),4752650301073172118160205227241
is5014650301072559
reported5093650301073477128178206237281332
to5445650301073582
be3047664301075095
an3161664301074492
autoimmune3273664301074492120167186259333380428472
form3765664301072774101176
which39606643010769117136176224
is4204664301072255
a42786643010744
manifestation43426643010777118166184208252286315356383402450498
of4860664301075175
IgG44955664301072272129174
associated5149664301074477110159200219259286328379
pancreatitis.3047678301075091139180206249289317335363382415432
Type3498678301074579130175
236936783010746
is3759678301072154
not3833678301075199126
associated3979678301074477110159200218259286328378
with4377678301076887115163
IgG4-RD4560678301072271128173202249308
and4888678301074391140
is5048678301072254
designated5122678301075296129148197245285312355405
as3047692301074175
idiopathic314269230107257594142192234262310329370
duct35326923010756103144175
centric3727692301074790138165192212252
pancreatitis3999692301075799147188215258299326345374393426
(IDCP)4445692301073049107160205228
(11).4692692301073171106124137
Key4849692301075295135
characteristics5004692301074796137163205246277320346366399428447488523
and3047706301074191141
differences3208706301075776101129173200244293335378412
between36417063010757103131200245290339
type4001706301073578130176
141977063010751
and4269706301074897147
type4437706301073578130176
246337063010751
autoimmune4705706301074896125173192267342391440485
forms5210706301073179107183217
of5447706301075580
pancreatitis3047720301075091139180206249289317335363382415
are3482720301074167110
shown3612720301073381129194243
in3875720301071966
Table3961720301074277127146190
141717203010744
(adapted4234720301072463112153202230272323
according4576720301074182120167194242261309358
to4954720301072874
Webster50487203010774116165199228270297
(11)).536472030107246498116137150
Autoimmune30477454013871134179242274368461525589648
pancreatitis37307454013864124188239285344405450483528561613
and43787454013860124189
pancreatic46027454013863124188238285344405449482533
cancer51707454013850110174225283330
An31877623010753101
important3308762301072093142192219250291339366
issue369376230107205387134178
is3890762301072053
the3963762301072977121
existence4104762301074584104136165208256296339
of4463762301074973
a45557623010742
relationship461776230107287190131158177225273306354373422
between5059762301075195123191234279327
the5406762301072977121
autoimmune3047776301074291120168188263338387437482
form3550776301073079107184
of3754776301075681
pancreatitis38557763010758101150192219264305333353382401435
and4310776301074998149
pancreatic44807763010757100150191219263304333352394
cancer,4894776301074891140182226253265
similar5180776301074160135155174216243
to5444776301073583