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E4818722701004181123
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VNITŘNÍ4268043010746106127172220280301
LÉKAŘSTVÍ748804301074185130188236280325378400
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Vnitř12458043010771118137165191
Lék1456804301074083122
2021;1597804301074487129168178
67(1):1794804301074486106145163178
e43–e481991804301074490131177223269314
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DOBRÁ42522701004899145190239
RADA67922701004493142188
Nutriční42533701005189116141157188225241
podpora68233701003776115153192217252
v950337010035
časné10013370100306594132167
fázi11853370100195586102
kritického13033370100335975102118148182217254293
stavu16123370100295692128166
–1794337010038
zaostřeno184933701003066105134161187222260299
na216433701003671
množství225133701005997136167197225263279
energie254633701003573108132170185220
a2782337010034
bílkovin28323370100375369104141177193231
15.425553085366883
Uehara5215540834478116148169202
M,7385540835266
Plank819554083334779117147
LD,981554083297586
Hill108255408342577287
GL.1184554083417387
Components12865540833874132171210248283321343370
of16715540833554
energy17415540833169104125163195
expenditure19515540833263102138176215230252290311345
in23115540831250
patients2376554083366991106141178200227
with2619554083486386124
severe27585540832358901254256540832155
sepsis4956540832560100126141167
and6786540833169108
major8016540835689104142164
trauma:980654083214275113171203215
a121165408331
basis1257654083387197112138
for1411654083175576
clinical150365408330456098113145178193
care.1712654083306384118130
Crit185865408339607598
Care1971654083397293127
Med.21146540835388128141
1999;2270654083346499134147
27(7):2433654083336682117136148
1295–1302.2597654083336397131167198228263296308
doi:10.1097/00003246-199907000-00015.42575408338769210413416517820824027530832836239843447050353656860462765868872375979482786089693295699310301066109811281140
16.425853085366985
Kreymann528854083355791123182214252290
G,8338540834659
Grosser9088540834667104131158193214
S,11378540833548
Buggisch12008540833775114153168195227265
P,14808540833742
Gottschall15378540834685107131159191229261277292
C,18448540834255
Matthaei19148540835789111135174206241256
S,21858540833548
Greten22488540834667101124158196
H.24598540834660
Oxygen25348540834981114153188226
consumption277585408333701094259540832663121160182198236274
and7149540833775114
resting844954083255986109125163202
metabolic10619540836297120152192230246261293
rate1370954083255880114
in14999540832058
sepsis,15729540833166105132147173186
sepsis17739540833166106132147173
syndrome,19629540833163102141162200258293305
and22829540833775114
septic24119540833166106128143175
shock.26019540833269108140170185
Crit2801954083456682104
Care4251054083407394128
Med.56810540835590129143
1993;7261054083346499132144
21(7):8851054083346681115135147
1012–1019.10471054083346697127162193224256286297
doi:10.1097/00003246-199307000-00015.1359105408338779210413416517820924027530832836239843447050353656860462765868872475779182485789392995399010261062109411241136
17.4251153085366876
Puthucheary5181154083357295133171203241276308329363
ZA,8961154083388195
Rawal100711540833668119152167
J,119011540832437
McPhail124211540835587123160192208223
M,148011540835569
et156411540833557
al.16361154083334861
Acute171211540834273111134167
skeletal18951154083265690106141163196211
muscle212211540835895122154169204
wasting234111540835184111134149187226
in258311540831553
critical2651115408332536991107138171187
illness2853115408315314251254083155387114141
[published5811254083165694133149164190228262302
correction8981254083296687109143176200215253291
appears120412540833069108144176197224
in144312540831350
JAMA.150912540832161117159173
2014;311(6):625.16971254083326698129141176207234249282300312348381416428
Padhke,214012540833364103141171205217
Rahul237312540833365103141156
[corrected25441254083164683105126160193217251290
to284912540832057
Phadke,42513540833573105144174208220
Rahul]].66013540833669107144160179198210
JAMA.88613540832464119161176
2013;107713540833468100130142
310(15):12341354083346597116148178196208
1591–1600.14571354083356597129162193224259295308
doi:10.1001/jama.2013.278481.17801354083387792104134165178209240276308330346378436468482518552583613626662695728765801833842
18.4251453085356783
Cerra5191454083397292113145
FB,6781454083296274
Siegel7671454083284276114148162
JH,9441454083206476
Coleman10341454083367287121177208245
B,129314540833244
Border13511454083326990126160180
JR,15461454083205568
McMenamy162914540835081135169205237293322
RR.19661454083316680
Septic206114540832862100121135166
autocannibalism.22421454083286486121153185221258272310342356370395451464
A2720145408337
failure277214540831547617611242515540832053
of49315540833452
exogenous5601554083306197135169206243280306
nutritional8801554083347192113128150164201238270284
support.11791554083235997135173194217230
Ann142415540833774111
Surg.15501554083296585122135
1980;16991554083316094128140
192(4):18541554083316092109141157169
570–580.20371554083316395132165198232244
doi:10.1097/00000658198010000-00015.22961554083347186981261571691992292632953143473824174524875225545874251654083346499135166198234270306330367403439471501513
19.4251753085377186
Hartl53417540834579102128144
WH,695175408366113127
Jauch83817540833266105139179
KW.1033175408343106117
Metabolic1167175408363100123158199239256272306
self‑destruction14891754083347187108130172208237261284324358383399439479
in198517540832262
critically20631754083396279102119152187203219252
ill23321754083223855
patients:240317540834781104121157197220249262
origins,26821754083456885125142181209223
mechanisms42518540835894128167200239255282341368
and80918540833877117
therapeutic94218540832767103125159199235274297313346
principles.13041854083456783122155171211228264291305
Nutrition.162518540835190113135152175191230269283
2014;192418540834075108140152
30(3):20921854083407696131148161
261–267.226918540834075106139172207240247
doi:10.1016/j.25321854083448399112143175188220252285317343360373
nut.2013.4251954083387598111147181213243255
07.6961954083346673
019.7841954083346696107
20.4252053085367287
Losser5262054083316995122157178
MR,72020540835389103
Damoisel83820540834577135173188214249265
C,111820540833952
Payen11862054083346696131169
D.137020540834456
Bench‑to‑bedside144120540833469107140178200222259283323358398424439478513
review:19692054083205486102136188201
Glucose21852054083435996129165192227
and242720540833169108
stress25512054083254869103130157
conditions2723205408330671061451604252154083223775113140
in58021540831553
the6482154083226095
intensive7582154083155374108146172187220254
care10272154083316485120
unit.11622154083377590113126
Crit1303215408340617799
Care.14182154083397293127140
2010;157321540833468100131144
14(4):231.17332154083346584117135147182217247257
doi:10.1186/cc9100.20052154083387692104134165178209236267303328356387423455486523535
21.4252253085367082
Losser5222254083316995122157178
MR,71622540835389103
Bernard8352254083357091130162183221
C,107122540834053
Beaudeux113922540833570102139178213251282
JL,14372254083235569
Pison15212254083354976114152
C,168922540833952
Payen17562254083356797132170
D.194122540834556
Glucose20122254083435997129166193228
modulates225522540835795135172188220242275302
hemodynamic,25722254083377213016920824027931142523540835772103116
metabolic,55623540835589111144183221237252283296
and86723540832967105
inflammatory987235408313506784116173230262284320342375
responses13782354083185178116155193219253280
to167323540831956
lipopolysaccharide17442354083122765104143181197229255288320350388420441456495529
in228823540831250
rabbits.23532354083185089128144166193207
J2575235408321
Appl261123540833978117132
Physiol2758235408333701001274252454083155369
(1985).5092454083185080115149168179
1997;70324540833464100132142
83(5):8612454083346886119138150
1566–1574.10262454083346498134172203233266296309
doi:10.1152/jappl.1997.13502454083387792104134165178209236266300326342374414453469482513543578611617
83.19832454083346880
5.1566.20792454083344676106141176190
22.4252553085367288
Marik53225540835487108124154
PE,7012554083387184
Bellomo8002554083387489104142201239
R.105425540833953
Stress11232554083355678112138165
hyperglycemia:130325540834172111147168206222253285319377392424436
an175425540833573
essential18422554083376491126164185201233248
survival21052554083306788123138171204219
response!.23402554083235784123162200227262277290
Crit26452554083436480102
Care.27632554083437597131143
2013;17(2):305.42526540833468100130141171201217251269281316351385397
doi:10.1186/cc12514.8372654083387692104134165178208236267303328356387418448483514545558
23.4252753085367287
Elke5272754083334878112
G,65427540834356
van72627540833164102
Zanten84327540833770108129163201
AR,10602754083407690
Lemieux116527540833165123138172210241
M1422275408353
et149127540833355
al.15622754083314659
Enteral16362754083327091125146179195
versus18462754083316586114151177
parenteral20382754083387192127165186220241274290
nutrition23432754083377497118134156172210248
in260627540831452
critically2673275408331526890105137170186201233
ill4252854083153045
patients:4852854083437698113148186208236248
an74828540833775
updated83828540834281120153174208248
systematic11012854083316390113147205237259275306
review14232854083255991107142193
and163128540833775114
meta‑analysis176028540836297119152174207245277292324351366392
of216728540834261
randomized22442854083255896135173232247276310349
controlled260928540833572111132154191207222257296
trials.425295408322435991106132146
Crit586295408340617699
Care.7002954083407394128140
2016;85629540833468100131143
20(1):10152954083346887119133145
117.1176295408334629197
doi:10.1186/s13054-016-1298-1.12882954083397792104134165178209236268303328352382412447481516539576608639663694723758793815846855
24.4253053085367289
Peterson5353054083357094129151180220260
SJ,8113054083376376
Lateef9043054083357093128165185
OB,110630540835189103
Freels12253054083375893130147174
S,141630540833651
McKeever148330540835992129165201235271293
L,179330540833550
Fantuzzi186030540833667106129169199232249
G,212630540834762
Braunschweig22053054083396296135175202236275327363380420
CA.264230540834387103
Early27623054083367193111144
Exposure42531540833367107148176214237272
to71431540832462
Recommended79331540833774108146206265301341381418458
Calorie12683154083427693133156173209
Delivery149331540834884101118152187210246
in175531540831756
the18283154083236399
Intensive19443154083175679114154182198232267
Care22283154083427699134
Unit237931540834685101125
Is252131540831744
Associated258231540834372100140174190224247282323
With4253254083577599138
Increased5803254083155488111146179207244285
Mortality88132540835595118144178195211235270
in116832540831454
Patients12383254083366992109145184207236
With14913254083587599139
Acute164632540834174113137173
Respiratory183532540833672100141158180215238276299334
Distress21863254083466390115137173201229
Syndrome.243232540833264104144167205265302315
JPEN27643254083246195141
J425335408324
Parenter4663354083367092128167190225248
Enteral7313354083347396131154188205
Nutr.95233540834686110132144
2018;111333540833571104137150
42(4):12803354083356988123141155
739–747.145133540833672106145178210243251
doi:10.1177/0148607117713483.17193354083397996109140173187219248279315336372405437475511548582616645676712746777814851887901
25.4253453085367387
Arabi5333454083416295135150
YM,69934540834095108
Tamim82234540833866124139197
HM,1034345408349104118
Dhar116734540835189122143
GS132534540834982
et142234540833962
al.14993454083375265
Permissive15803454083407395153168194221236268303
underfeeding189834540834280119154176197232267307322360399
and231234540833775114
intensive24413454083205880113151178193225260
insulin27163454083205884121137151189
therapy4253554083226095116149188219
in66035540831755
critically730355408334557193108140173188204235
ill9813554083173247
patients:10433554083417496111146184206233246
a1304355408334
randomized13543554083235694133171229244273307347
controlled171635540833471109131152190205221255295
trial.2026355408324466193109122
Am2163355408343101
J2280355408326
Clin23213554083435873111
Nutr.244735540834785107129139
2011;260235540833670102130138
93(3):27553554083377088121138150
569–577.42536540833468102140174207242248
doi:10.3945/ajcn.110.005074.6883654083387692104134165178213247282315339369385417455468499526558571606642676710743773786
26.4253753085367187
Zusman52937540833874101158191229
O,77337540834859
Theilla84737540833473108123138153186
M,104837540835569
Cohen113237540834178116151190
J,133737540832537
Kagan138937540833670109141179
I,158337540831629
Bendavid162737540833672110149181213228267
I,190937540831629
Singer19533754083344886125160181
P.215037540833641
Resting22063754083367198121137175214
energy243537540833573108129167199
expenditure,2650375408335661061411792182334253854083226081115127
calorie5673854083326480118139155190
and77238540833270109
protein8973854083386097119153168206
consumption111838540833269107133171228268290305343381
in151538540831552
critically1583385408331526890106138171186201233
ill18313854083153045
patients:18923854083397193109143181203231243
a2150385408332
retrospective2198385408321557798136162201237269294309341376
cohort258938540833168107145167191
study.279638540832649874253954083387080
Crit520395408340617799
Care.6353954083407294128140
2016;79039540833468100131144
20(1):9493954083346888119134146
367.111039540833469102108
doi:10.1186/s13054-016-1538-4.12333954083387692104134165178208236267303328352382412446481516539576608639662693723756791813850862
27.4254053085367179
Oshima51740540834774111126184216
T,74840540833039
Deutz80240540834378116138169
NE,9864054083427588
Doig10894054083438297135
G,124040540834154
Wischmeyer13094054083557197129167225260291325346
PE,16704054083336578
Pichard17634054083334779117149170208
C.198640540833851
Protein‑energy20524054083335390112146161198221257295330351389420
nutrition24884054083357295116131154169207245
in274840540831250
the28134054083195792
ICU42541540831556100
is54041540831945
the6004154083266499
power71541540834381132167188
couple:91841540833673111150166201213
A1147415408345
hypothesis120741540834273113151173212247273288314
forming15374154083226081140155193232
analysis.178441540833674107122154181196222235
Clin20354154083445974112
Nutr.216241540834987109131141
2016;231941540833872104135147
35(4):24824154083387189122139151
968–974.264841540833974110147181214245257
doi:10.1016/j.clnu.2015.4254254083387692104134165178208240272303328344357389404442480493529563595625637
10.10774254083346678
016.11714254083346697110
28.4254353085367187
Al‑Dorzi5254354083415678124162184214229
HM,76943540834296109
Albarrak8934354083385392125145167199229
A,113743540833852
Ferwana12044354083306384137169207239
M,145843540835165
Murad153843540835189109142181
MH,173443540835195108
Arabi18574354083385992130146
YM.201843540833286100
Lower213343540832966116150171
versus23194354083296384110147173
higher25074354083355088126160181
dose27034354083357399134
of285243540833453
enteral4254454083347294127149182197
caloric6374454083316479117139154186
intake8394454083135173106136170
in102444540831452
adult109144540833170108123145
critically1252445408330516789105137170185200232
ill14994454083142944
patients:15594454083377092107142180202229242
a1816445408331
systematic18624454083265885108142200232254269301
review21794454083195486102136187
and238244540833169108
meta‑analysis.250544540835792114147169201239272287319346361387400
Crit425455408340617799
Care.5394554083407394128140
2016;69545540833468100131143
20(1):8544554083346887119134145
358.101545540833467101114
doi:10.1186/s13054-016-1539-3.11454554083387692104133165177208236267302327352382412446480515538576607639662693723756789813845858
29.4254653085367285
Gunst52446540834482120146169
J,70946540832134
Van75846540833364102
den87646540833570108
Berghe10004654083336889127165200
G.121646540834155
Intensive12864654083135172106144170185218252
Care15534654083387192126
Nutrition169446540834380103124140163178216254
and196446540832967106
Post‑Intensive20854654083337097120140156194216249288314329361395
Care24964654083377091125
Recovery.263746540833368100137169204225259269
Crit425475408340617799
Care5394754083407394128
Clin.6834754083405570108121
2018;81947540833468100131143
34(4):9784754083346989122139151
573–583.114447540833468102138172206240253
doi:10.1016/j.ccc.2018.14124754083387692104134165178208240272303328344357389420451464500534566597610
06.20384754083347083
004.213647540833471107119
30.4254853085367287
Gunst53348540834482120146169
J.71848540832841
Recovery77448540834075108145177211232266
from10564854083234582140
critical1212485408336577395110142175191
illness‑induced1418485408319344987122149176197213251290327360393433
organ186648540834264102134172
failure:2053485408323577287125146180192
the22614854083266499
role23764854083256278113
of250448540834261
autophagy.25814854083367496133173211244283315325
Crit425495408340617799
Care.5394954083407394128140
2017;69549540833468100129139
21(1):8494954083346681113127139
209.100349540833469104115
doi:10.1186/s13054-017-1786-y.11334954083387692104134165178208236267302327352382412446480516539576608637656686716749785808840850
31.4255053085366981
https://www.nobelprize.org/prizes/medicine/2016/press‑release/.5225054083385983123150162189209260314367378417455494530546585606622651685697735757795821859880896925959986101210681103114211581190120512431278130413391373140514361461149815201554158116071628165016851700173517671793182818551860
32.4255153085367186
de52651540833873
Cabo61451540833972111150
R,77951540833549
Mattson84351540835386107132159198236
MP.10955154083538994
Effects12045154083325170104137161188
of140851540833655
Intermittent14795154083135173106128186201224248282320341
Fasting18365154083316087110125163202
on205451540833674
Health,214451540834378109125147185198
Aging,23575154083407994132171183
and255651540833068108
Disease.26795154083446086121153179214226
N425525408345
Engl48552540833370109125
J625525408324
Med.66552540835489129142
2019;82252540833468100130143
381(26):98052540833569101116150183202213
2541–2551.120952540833469104134167199234266297306
doi:10.1056/NEJMra1905136.15315254083387691104133165177208240274308333379412439494515548578608644678709739773787
33.4255353085367186
Gunst53053540834482120146169
J.,7155354083273952
Vanhorebeek78253540833970109147185206240280315351381
I,117853540831831
Van122453540833970108
den134853540834176114
Berghe14775354083397495133171206
G.169953540834761
The177553540833675110
role19005354083246177112
of202753540834160
autophagy21025354083357395132172211243282314
in243153540831856
recovery25025354083245891128160194215249
from27675354083214381139
critical425545408331526891106138171186
illness.626545408315304583118145172185
ICU82654540831556100
Management94154540835587125158197232289325363384
&1340545408337
Practice13925454083325285118142157189223
2017;1630545408334681001291756545408313
17:17845454083346474
134–136.18735454083346499137168198232245
34.4255553085367388
Kroemer5325554083355795130188223244
G,79255540834760
Mariño86755540835891112127165203
G,108655540834760
Levine116255540833468101116154189
B.136655540833952
Autophagy143455540834481103140180218251290322
and177155540833573112
the18995554083246398
integrated20125554083185677111150172205226260300
stress23275554083295274108135161
response.25045554083245885123162201227262274
Mol279455540835796112
Cell.4255654083407489104117
2010;55856540833468100131144
40(2):7175654083347090124142154
280–293.88656540833468103141173207240252
doi:10.1016/j.molcel.2010.11535654083397792104134166178209240272303328345358416455470502536552565601635667698711
09.18795654083346980
023.197556540833467101114
35.4255753085357084
Watanabe52157540835787108140177209247282
E,81757540833042
Muenzer87457540835188122159188221242
JT,11305754083215563
Hawkins120857540834172122152168205230
WG145357540835497
et156457540833153
al.16315754083294456
Sepsis170257540832964102128142167
induces18845754083124987124155188214
extensive21135754083316185118155181195227260
autophagic23885754083286587123162199231269283314
vacuolization27175754083296192129166425585408315305992114129167206
in64658540831250
hepatocytes:71258540833570109142164201233267292325352365
a1092585408329
clinical1137585408329445997112144177192
and134458540833068107
laboratory‑based14665854083134584123144177199236258292314354387413448488
study.19695854083244785124156166
Lab215058540832963102
Invest.22675854083135182116143166180
2009;89(5):549–246258540833266102137150185219238272290302338373406443
561.4255954083346899108
doi:10.1038/labinvest.2009.8.5485954083397792104134165178209240273308333349382421436474506540567590603639673709745756791805
36.3047553085367286
Vanhorebeek31495540833666103141178199233271306341370
I,35345540831527
Gunst35765540834381118144166
J,37575540832435
Derde38075540834680101138172
S399455408333
et40415540833456
al.4112554083314658
Insufficient4185554083155278114132150168199214248285306
activation4506554083326386101133165186201238276
of47965540833856
autophagy4867554083326991127166204235274305
allows518755408331466198148175
cellular5376554083326579941313047654083154667
damage31286540833667124156194229
to33716540831955
accumulate3441654083296091128185222236268289322
in37786540831149
critically384165408329496486100132164179193224
ill4080654083112640
patients.4135654083366889104138175196223236
J438565408322
Clin4421654083385266103
Endocrinol45396540833067105143175195210247285300
Metab.48546540835286108140178190
2011;5059654083316495122130
96(4):5204654083316684116133144
E633–5363654083306396129164
E645.30477540833366102134146
doi:10.1210/jc.2010-2563.3207754083387590101130161173203232263294317333364377412446477507531561595629662673
37.3047853085367079
Hermans31398540834479100159191229255
G,34108540834154
Casaer3480854083377097130165186
MP,3681854083528893
Clerckx3789854083385388109140170204
B400885408333
et40568540833254
al.4126854083294557
Effect4199854083304968102135159
of43738540833555
tolerating4443854083195672107128161183198236275
macronutrient47338540835587120141178217254277298314348386408
deficit5156854083367188105137152175
on53468540833573
the5435854083195792
development30479540833873105140155193233291326364386
of34489540833756
intensive‑care3520954083145273107145172186219253276310343364398
unit3934954083367490112
acquired40619540833264102139155176210249
weakness:43269540835084116146186221247274287
a462895408331
subanalysis46759540832663102135173205221252279294320
of50119540833756
the5082954083226095
EPaNIC51929540833368100145160201
trial.540895408322435991106119
Lancet304710540833165103135169191
Respir32531054083367197136152173
Med.344110540835590129143
2013;359910540833468100130141
1(8):37561054083344983101113
621–629.38841054083346799132169202236247
doi:10.1016/S2213-2600(13)70183-8.41471054083387691104133165177208240271302328360394429460490512543576612648668699729746778811843874908929965979
38.30471153085367288
Casaer31521154083407399132167189
MP,33561154083569296
Mesoltten346811540835691118156172194219252291
D.377411540834758
Nutritional384711540834784107128144167182220258291306
Failure:4168115408334647994132153187199
An438311540834280
Adaptive447911540834281113152174190222256
Response47511154083377299137176215241276
to504211540832461
Critical51181154083426378101116148181196
Illness?5330115408316314684119146173197
ICU304712540831556100
Management316212540835487125157196231289324362384
&3561125408336
Practice36121254083325386118142158190223
2013,385112540833468100130142
13:40081254083346475
98–101.409912540833469106137168200209
39.30471353085367185
Arabi31501354083416295134150
YM,331513540833893107
Al‑Dorzi34371354083445982129167189220235
HM,3688135408346102115
Sadat381813540833669108140162
M.399513540835771
Protein40821354083385896117151166204
intake43021354083175576109139174
and449113540833573112
outcome461813540834078101131168227262
in489513540831855
critically4966135408334557193108140173189204236
ill52171354083173348
patients.52801354083427496112146184206234247
Curr30471454083407698119
Opin318214540834686102139
Clin33371454083395469107
Nutr345914540834582105126
Metab360114540835489111144183
Care.37991454083407394128140
2020;395414540833468101135148
23(1):41171454083346987119133145
51–58.42771454083346598132166179
doi:10.1097/MCO.0000000000000619.44721454083377591103133164177207239274307327382422468479514551587623659695731767803840876912948984101410441055
40.30471553085367489
Hoffer315315540834482102121156177
LJ.33451554083336073
Protein34331554083375795117150165203
requirement36521554083225695133148169203261296334356
in402315540831754
critical4093155408333546992107139172187
illness.4296155408316314684119146172186
Appl449715540834382122138
Physiol465015540833774105132147185201
Nutr486615540834684107128
Metab.500915540835691114147186198
2016;522315540833569101132145
41(5):53831554083366681115133145
573–576.304716540833468102138172205237250
doi:10.1139/apnm-2015-0551.33131654083387691104133165177208236266299322353392430488511542576607638660697731763794804
41.30471753085366880
Rooyackers314117540833573112143176208238272293320
O,347617540834556
Sundström354717540833067105144170193214251309
Rehal387217540833267105137153
M,404017540835265
Liebau41201754083294579118151188
F,432417540833035
Norberg437517540834280101141176197235
Å,462617540833852
Wernerman469317540835588109148182204262294332
J.504017540832234
High50891754083425796133
protein52381754083365794116150165202
intake54561754083125030471854083225485119
without31811854083516689127165203226
concerns?.342218540833168107139173194232259283293
Crit3730185408340617799
Care.38441854083407394128141
2017;21(1):106.400018540833468100129139174206221252267279308340376389
doi:10.1186/s13054-017-1699-9.44041854083387692104134165178209236267303328352382412447481516539576608637656687718752787811845856
42.30471953085366983
Casaer31401954083407196128161181
MP,33351954083508488
Wilmer34361954083546882138172191
A,364119540833750
Hermans37051954083407493150181217242
G,396119540834052
Wouters402719540835388125146178198223
PJ,42641954083314960
MesottenD,433819540835084109146166189221258313322
Van46741954083326198
den478619540833467104
Berghe49041954083316584121157191
G.510919540834052
Role51751954083316883116
of530519540833351
disease53701954083344872106136304720540832660
andmacronutrient312120540832865102170201232252288325361382402416450486507
dose36412054083357297131
in378620540831148
the38482054083185588
randomized39502054083184986124160217231259291329
controlled429320540832864101121141177191205238277
EPaNIC45842054083296393137151190
trial:478820540831939538498108
a4910205408329
post49532054083357298120
hoc508620540833572103
analysis.52032054083286596110140166179204216
Am543320540833894
J3047215408324
Respir30852154083346893131145164
Crit3263215408339587394
Care33712154083387089122
Med.350721540835387125137
2013;187(3):247–255.36582154083326595124134163192224239271287297331362392423453487518528
doi:10.1164/rccm.201206-0999OC.4200215408337748899127157168198224254289312330360390446458493525556584617651673709743777811858898909
43.30472253085367186
Koekkoek315322540833572108138170207243273
WACK,3441225408362101140175189
van364622540833568106
Setten37682254083367193118151190
CHC,397322540834488129142
Olthof41302254083516790128166185
LE,43312254083356881
Kars44282254083397293121
JCNH,456422540832869114159171
van475122540833568106
Zanten487322540834174112134168206
ARH.509422540834581126139
Timing524922540833653111126164203
of546722540834161
PROTein304723540833570118150181196234
INtake32962354083145982114145179
and349023540833169108
clinical3613235408330456098113145178193
outcomes38222354083367496127164222257284
of412223540833655
adult419223540833170108123145
critically4353235408330516689104136169184200231
ill46002354083132843
patients46592354083377092107142180201229
on490423540833674
prolonged49932354083385997113151189228263303
mechanical53112354083569112416219430472454083385385117133
VENTilation:319524540834074119153170185218239255293331343
The355424540833776111
PROTINVENT368024540834075123155171217253288332366
retrospective40622454083255981103140167206241274298313346380
study.44582454083305391130162172
Clin46462454083445974112
Nutr.477324540835087110131142
2019;493024540833973105135148
38(2):50932454083397392126144156
883–890.526424540833974108145181215251263
doi:10.1016/j.clnu.2018.30472554083387692104134165178208240272303328344357389404442480493529563595626639
02.37022554083346779
012.37962554083356696109
44.30472653085367490
de315226540833873
Koning324026540833572111126164203
MLY,345826540835486117126
Koekkoek359926540833472107138169207242272
WACK,388726540835796135170185
Kars40872654083346889116
JCNH,421926540832464109154167
van440126540833164102
Zanten451926540833770108130163202
ARH.473626540834076121135
Association48862654083416995133166181213235250288327
of522826540833756
PROtein530026540833469117141175190228
and304727540833270109
CAloric31712754083388096134156171203
Intake33892754083135172105135169
and357427540832967106
Clinical36962754083375267105120152185200
Outcomes391227540834483105136173231266293
in422027540831351
Adult428627540833977114130152
SEPTic44532754083316398132149181
and464927540832967106
Non‑Septic477127540834280119141173208247269284316
ICU51022754083135498
Patients52152754083336586102136174196224
on545427540833573
Prolonged30472854083355693109147186225259299
Mechanical336128540835489122160192230245277310326
Ventilation:370228540833568106127143158190212227265304316
The403328540833271106
PROCASEPT415528540833469117158201235267303336
Retrospective45072854083357092113151177216252284309324356391
Study.49132854083325391130162172
JPEN51002854083246092137
J5252285408324
Parenter52912854083356688122160181215236
Enteral30472954083337092126147180195
Nutr.325829540834482105126136
2020;341029540833468101135148
44(3):35732954083347191124141153
434–443.374229540833466102139176213245258
doi:10.1002/jpen.1663.40152954083387792104134165178209240276309336352391427465478509540576609622
45.30473053085367185
Preiser31473054083355588103128163183
JC,33453054083246477
Wernerman343630540835890111149183204261293330
J.378130540832436
Provision38323054083355592123138163177215252
of409930540833856
Nutrients417030540834582104124139173211231258
to444330540832258
the45163054083225993
Acutely462430540834172109131164179210
Ill.4849305408314294356
Introducing4919305408315537394131170206238252289328
the52613054083226094
„Baby53703054083205789127158
Stomach“30473154083335389147179210247267
Concept.332831540834481119150183222243256
Am3598315408346103
J3716315408328
Respir375931540834074100139153174
Crit39483154083446479101
Care40643154083447697130
Med.420931540835893132144
2017;436831540833872103132141
196(9):452331540833969103122154171182
1089–1090.472031540833869104137174205235270305317
doi:10.1164/rccm.50523154083428094106135166178208235265301325344375405462475
201705-0919ED.30473254083346899127160193214251285317346379424434
46.30473353085357287
Koekkoek314733540833471106135165202237266
KWAC,342833540833191129167179
van36223354083286097
Zanten373433540833567104125157194
ARH.394333540833873117130
Nutrition408733540834278100121136158172209247
in434933540831148
the44123354083195690
ICU:45173354083125194106
new463733540833569119
trends47703354083194073110148174
versus49583354083296283109145171
old‑fashioned51443354083344987108127160186222237274311345384
standard30473454083275185125165199221261
enteral332434540834080102137160194210
feeding?.35503454083256097138154194234260270
Curr383634540834684107129
Opin398134540835496112151
Anaesthesiol.414834540834888121158186210249286314329369386399
2018;456434540834076109141154
31(2):47343454083417389124143155
136–143.490634540834071107146179211245258
doi:10.1097/518034540834585101114145177191223256292326347
ACO.0000000000000571.304735540834180125137172208244281317353389425461497533569606640673706715
47.30473653085367079
Heyland314336540834479111127159197236
DK,33943654083478398
Stapleton35073654083345588127143178200237276
R,379836540833751
Compher386436540834279137177215250271
C.415136540834155
Should422136540833472110148164203
We443936540835992
Prescribe45473654083365791118150172187226262
More482436540835695116150
Protein49903654083375794116150165203
to520836540832461
Critically52843654083426378101116148181196211243
Ill30473754083153045
Patients?.31073754083366789104139177199227251261
Nutrients.338337540834582105126142177215236264278
2018;10(4):462.367637540833468100131143173205224257275287321357390403
doi:10.3390/nu10040462.40943754083387792104134165178213246280315340376414444475511548584620656689702
48.30473853085367490
Preiser31523854083355690105131166187
JC.33553854083236477
High34483854083435897135
protein35993854083385997118152167205
intake38203854083145173106136170
during40053854083387697112150189
the42103854083215994
early43193854083346587102134
phase446838540833977109136171
of465438540833756
critical4726385408330516790105137170185
illness:4926385408314304583118144171183
yes51253854083306491
or523238540833658
no?.530538540833775100110
Crit5430385408339607698
Care.30473954083407394128140
2018;320239540833569101132144
22(1):33613954083346986118132144
261.35213954083346798107
doi:10.1186/s13054-018-2196-5.36433954083387792104134165178209236267303328352382412447481516539576608639662693724754790813847859
49.30474053085367184
De314340540834580
Waele323740540835585120135169
E,342140540833042
Malbrain34784054083518398137158190205242
MLNG,373540540835183127171184
Spapen393440540833068100138173211
H.416040540834154
Nutrition422940540834178100121137158173211248
in449240540831249
Sepsis:455640540833064103129143169181
A4752405408338
Bench‑to‑Bedside480540540833267104136173195217254276313347386412426465499
Review.53194054083326798114148198208
Nutrients.304741540834582105126142177215236264278
2020;334041540833468101135148
12(2):35034154083356482116134146
395.366441540833467101113
Published379341540833572111127142168206241281
2020408941540833468101135
Feb423941540833367106
2.436041540833447
doi:10.3390/nu12020395.44224154083387792104134165178213246280315340376414444474508541575608641675687
50.30474253085367084
Greig31434254083436497111148
PD,33054254083327686
Elwyn34054254083294393126163
DH,35824254083428698
Askanazi36944254083376493125162193221236
J,394442540832132
Kinney39904254083314783120154184
JM.41884254083217487
Parenteral42904254083316282115152172205225256271
nutrition45754254083347092112127148162199236
in482542540831248
septic48884254083225694115129160
patients:50624254083356788102135172193219230
effect53074254083304968101132155
of547642540833452
increasing30474354083145182102135165190204240278
nitrogen3339435408334486989125163197234
intake.3587435408311486899128161172
Am377343540833794
J3881435408321
Clin39164354083365064100
Nutr.40304354083417899119128
1987;41734354083305993124133
46(6):43204354083316583115132143
1040–1047.44774354083306195130167196226261292297
doi:10.1093/ajcn/46.4788435408334718697125155167196226260291314344358388425450480515527
6.532943540833143
1040.53864354083306095130141
51.30474453085367082
Thiessen31454454083337287122148175210248
SE,34084454083336578
Derde350244540834580102140175
S,369244540833345
Derese375344540834580102136162197
I3966445408315
et399644540833456
al.40684454083314760
Role41434454083367490125
of428344540833756
Glucagon43554454083446097129162201239278
in464844540831553
Catabolism47164454083407395127167205221236262320
and505144540833270109
Muscle517644540835492118151166201
Wasting53924454083578911530474554083223774113
of317545540833554
Critical3245455408337587396111143175190
Illness3451455408312274280114141168
and363445540832967106
Modulation375545540835290129167182214236251288327
by409745540833667
Nutrition.417945540834280102124139162177214253266
Am446045540833896
J4571455408322
Respir46084554083336895133149170
Crit4793455408337587496
Care49044554083387091125
Med.504445540835287126139
2017;51994554083316597126136
196(9):53504554083326297116148166178
1131–1143.30474654083346292123156186214245278290
doi:10.1164/rccm.201702-0354OC.33534654083387691103133165177208236267303328348379410468481517551583612645678699736769802837886927940
52.30474753085367187
Meijer315547540835590105120155176
AJ.33474754083467385
Amino3448475408346104119157195
acid36594754083376984123
regulation379747540832660100137153185207222260299
of411147540834362
autophagosome41884754083377597134174213245284322349388446481
formation.46844754083246283142174196211249288301
Methods500147540835994117155193233259
Mol527647540835998114
Biol.54054754083405694110123
2008;445:89–109.304748540833468104140152187224256267302337374405436472482
doi:10.1007/978-1-59745-157-4_5.35454854083387692104133165177208240276308328362395429451482501535567600631663685716746780798835871907919
53.30474953085367287
NICE‑SUGAR315549540834561102136158190234279321358
Study35284954083386098138171
Investigators,37144954083205991126153177192232265287324346374388
Finfer41174954083385392111146168
S,430149540833851
Chittock43684954083458499122147184218248
DR,463249540835188102
et475049540833962
al.48284954083375366
Intensive49104954083205981115154180196229264
versus51894954083377294122160186
conventional539149540833774113304750540833266104126141179217250265
glucose33275054083395592124161188223
control356550540833269108129151188204
in378450540831654
critically3853505408332546992107139172187202234
ill41025054083163146
patients.41645054083397294109144182204231245
N4424505408346
Engl448550540833472111126
J4626505408325
Med.466750540835590130143
2009;482550540833569105141153
360(13):499450540833569105124156186203215
1283–1297.52245054083366599133169200230264297303
doi:10.1056/NEJMoa0810625.30475154083387692104134165178208240274308333379412439494532565601636668700735769804816
54.30475253085367388
AVERT315152540834174108144178
Trial3344525408333506698113
Collaboration34735254083407793108140179218240273295310348386
group.38755254083385996135174186
Efficacy4077525408333506886118151183217
and430952540833270109
safety44345254083265978113135169
of461852540833857
very46905254083326788122
early48275254083356688103135
mobilisation497852540835796135151166181207240262277315354
within53475254083516789127142180
24304753540833466
h3128535408340
of318353540834059
stroke32575354083295273111141175
onset344853540833978104139161
(AVERT):36245354083216296130165199221233
a3872535408334
randomised39225354083225594133171229244270305345
controlled428253540833370109130152189205220255294
trial.4592535408324456193108121
Lancet.472853540833467105137171193207
2015;495053540833670102132143
386(9988):510853540833771106125158193228264282294
46–541753540833672110
55.30475454083346779
doi:10.1016/S0140-6736(15)60690-0.314154540833876921041341651782082402723033283613964274594945185565886236576767087387567918268628969329569931005
55.30475553085367185
Rist31455554083355177100
VT,32605554083347180
Weiss335555540835588104130156
E,352755540833043
Eklund35855554083316077115153192
M,379255540835266
Mosenthin387355540835290117152190212250265303
R.419155540833348
Impact425455540831270109142175199
of446855540833554
dietary45385554083355185108140161195
protein47495554083365895117151166204
on496855540833573
microbiota505755540835570102123160200215253275308
composition538055540832966124304756540833977104119141157195233
and329656540833270109
activity34205654083326489104136152175208
in364456540831552
the37125654083226095
gastrointestinal38225654083397198121142179195233254288315338353391423439
tract42765654083224477109133
of442456540833857
piglets44965654083395594109144166194
in470556540831553
relation47745654083215570102124139177216
to500556540832259
gut50795654083397799
health:519356540833873105121143181193
a5402565408332
review.54495654083215530475754083324782133144
Animal.32065754083418095152185200213
2013;7(7):1067–1078.343457540833469100130142175191226245257287318354387419450482514548561
doi:10.1017/S1751731113000062.40105754083387792104134165178209240272301321354385414447478508542573600628658692729765801837870882
56.http://main.poliquingroup.com/ArticlesMultimedia/Articles/Article/2646/Three_Situations_In_Which_A_High‑Protein_Diet_Is_A_Bad_Idea.aspx.30475853085367186313358540833858811201311571762312632763133253644024174314685055195565946146506877257367678038608859229429659791010102410581084113811751189121012241281131513541367139814241460148015041518154915631597162216471683170317271741177217861820184518791911194719822006204120802100213321672202223622492270230723392359237330475954083377499135151188224279316330361397433476513558572609646667703722758778810824861896943957990101110471063108811241167120412401272131013451361139914321463147515071532157015991611