1002
KAZUISTIKY512322701004696138190209248289309356404
Liver35443370100314884119143
cirrhosis3703337010030456994132171201216245
and396433701003471110
pregnancy:40903370100376196135173207245276313330
a4437337010033
case44873370100296593129
report46323370100245997136160189
and483833701003371110
review49643370100235894110145198
of517833701003858
literature5252337010015305792116151178216241275
|5584227010018
E315617227010066102131
/34868043010757
Vnitř35628043010771118137165192
Lék3773804301074184122
2021;3915804301074386128167177
67(e3):4112804301074485105146190211225
e24–e274357804301074487127174221264306
/46828043010757
VNITŘNÍ47598043010792152173218266326347
LÉKAŘSTVÍ5126804301074285131189236281326379401
www.casopisvnitrnilekarstvi.cz42580430107651332012142542953293774274464795215705896176436927117307748128548809159449871007102310631101
in42562301071965
metabolic509623010770113140180229277296314353
and88162301073784132
hormonal103262301074492118191238286326344
derangements139562301074588113154201249292365408455481515
that192962301072471111137
lead20856230107165998146
to225062301072470
anovulation233962301073784131171218236276302320367415
and277362301073784132
amenorrhea425763010741114159207255282309358402442
presumably88776301075279122156203276317367386426
because133376301075297138180227260305
of165776301075175
hypothalamic-pituitary175176301075189140189217265305324365439457497520571590618666685713754781824
dysfunction2594763010752921261512002482884259030107284795143
(5,5889030107287084
6).6919030107487083
For79490301074593120
example,93390301074887129202252271315330
hypogonadotropic128390301075190141190240288337377427475502529576626646686
hypogonadism198990301075190141190240288337377427445478551
as256090301074578
well2658903010768112131150
as282790301074578
elevated425104301074463107148189216259309
levels754104301072266107150169202
of976104301075175
estrogen1071104301074781110137184234278326
are1417104301074471114
seen.1550104301073882127175191
Hyperestrogenemia17611043010760100151196222265299328355402452496544588662680721
occurs2501104301075293132180206240
due27611043010753100144
to425118301072875
aromatization519118301074874121196237264283319362389408456505
of1043118301075579
weak11421183010771115155193
androgens1355118301074796145172219269313361394
from1769118301073058105179
the1968118301073583127
portal21151183010756106133164205224
circulation235911830107476592131179198238265284332381
and2760118301074796145
consequently425132301074087135168213262310354402429448488
ovulation933132301074888136155196223242290338
is1291132301071951
prevented.1362132301075076119160203252278321371387
Women17691323010773119193238286
with2075132301076483112160
alcoholic2254132301074160100147196244264282322
hepatitis2596132301074892142184211229258276309
have425146301074889128171
early616146301074181107126166
menopause.8021463010771115163211261303350383427442
In1263146301071664
alcoholic134714630107375697143192240260278318
patients1685146301074688115134177225252287
between1991146301074792120187230275323
20–402334146301074083131178223
years2577146301073680120146180
old,2777146301074464113129
decreased425160301074993134161204244277321371
numbers8161603010753100174223268295329
of1165160301075276
follicles126116030107287695114132173192235269
and1550160301074593143
no17131603010752101
corpora1833160301074592119169218245287
lutea2139160301072472100142182
are2341160301074672115
seen.2476160301073882127175191
These2687160301074696140174218
changes425174301074088128176226269303
are748174301073764106
reversible874174301072366107150176210228278297341
because1235174301074691132173221254298
fertility155217430107216490121140159177205247
is1819174301071648
restored1887174301072366100129175202245295
after220117430107386193135161
liver238217430107163475118145
transplantation.25461743010725529314117422324228333142518830107286996115163212228
Full672188301073985104122
sexual814188301073075114162203222
development1056188301074589130173193241291365409457484
returns156018830107236694142168217250
within1830188301076281109157175223
320731883010741
years2134188301073679120146180
of2334188301074569
transplant242218830107255293141174224243284332358
(11,280018830107216195106
12).425202301074481104117
Successful561202301074996136175218251285309358377
pregnancies958202301075683126176224265313353372416449
can1427202301074788136
be15832023010756101
achieved1703202301074888136155198239282332
in2055202301072573
anovulatory2148202301074795143184232251292319366392436
cirrhotic260320230107476592119167216243262302
patients425216301075091118137180228255290
with734216301076281109157
assisted911216301073871104122155184226276
reproductive1207216301072366115142189239286327357376416460
technology.1686216301072567108156204252272320370410422
Concomitant2127216301074995144184230304323351392440467
diseases261321630107466597141181214258292
and425230301074189138
nutritional583230301074896124151170198217265313354373
deficiencies976230301074993117136177195239287328346390424
may14192303010774115154
also159223030107416093141
impair1753230301071992142183202228
fertility200123030107236793124143162180208251
(11).227223030107246398115128
Pregnancy565244301074571115165214255303344387
is972244301072659
also1050244301074867100149
associated1219244301074881115164206224265293335386
with1625244301077291120168
an1813244301074897
increase1929244301072674115142185226260304
in2253244301072674
portal23472443010756106133165206226
pressure2592244301075784128162195243270313
(8).42525830107246689102
Portal547258301074490117148190209
hypertension775258301074886137182208239282330363381429478
develops1273258301074892133176195243293327
as1620258301074073
a17132583010740
result1773258301072669103150169197
of1989258301074771
several2080258301073377118161188229248
etiologies.234825830107437189137157205255274318351368
Liver2736258301074059100143169
cirrhosis42527230107416087115165215249268302
is747272301072660
the827272301073585130
most9782723010782131166196
common1194272301074896171247296346
cause1561272301074790138172218
of1799272301075681
portal19002723010757108136167210230
hypertension.2150272301075695147193221253296346379398448497514
Other2685272301076899148193221
causes,425286301074082129162206240256
like70128630107224078121
extrahepatic842286301074786117144185234278327369396415455
portal13172863010753102129160201220
vein1557286301074487106153
obstruction,17302863010751101135164191239280310329377425441
non-cirrhotic2191286301075199148176219237264291339388415434474
portal26852863010753102129160201220
fibrosis,42530030107234290116161193211242257
portal701300301074593119148188206
vein92630030107367896142
thrombosis,108730030107237095141213261309341358390405
Budd–Chiari1510300301074188135183228280327344383408427
syndrome,1955300301073069117165190236308350364
infection233830030107156183125165194212259306
or2662300301074470
congenital2750300301073681128425314301074993141160188229248
hepatic693314301074993143184211230271
fibrosis98331430107254594121168202220252
contribute1255314301074188136163190209259307335378
significantly1652314301073553102150169193213253294342369388428
to2100314301072975
non-cirrhotic2195314301074998146174217236262289338386413432473
portal26873143010751100127158199218
hypertension425328301074886136181207238280328360378426474
(NCPH).918328301072177129173228251264
Mostly12023283010766114147176195235
liver145632830107163475118144
function1619328301072069117157187205253301
is1940328301071548
much20073283010770117157205
better2231328301074791119149191217
preserved2468328301074673115149192219262305355
in2842328301071663
women4253423010764111183226273
with717342301076179107154
NCPH8903423010753104147201
and1110342301073784132
pregnancy1261342301074672114163210249296336377
is1657342301071547
spontaneous1723342301073078126173199239286329377424456
in2198342301071562
these2279342301072471114147190
women24883423010761107180223270
(13).277734230107205995116128
Numerous5653563010757104177221247294342374
hemodynamic959356301074588161210259299348388461479519
and1498356301073785134
physiological1651356301074695133166184232251299349367407448467
changes2137356301073784125172221265298
occur2455356301074485123171197
during2671356301074693119138185234
pregnancy.425370301074976119169216257304345387399
One8433703010757106150
of1012370301074569
the1100370301072573117
earliest1236370301074180107126144188221250
changes1505370301073785125173222266299
is1824370301071648
an1892370301073785
increase1996370301071664104130173213246290
in2305370301071663
plasma2388370301074666106139212253
output2660370301074593121170218246
by425384301074988
40–50%.533384301074085133175217284301
Maternal8533843010767107134176202250290309
cardiac1181384301073778104152170210250
output1450384301074592120169217245
increases1714384301071663103129172211244288321
by2054384301074685
30–50%2159384301074083131173215282
due2461384301074592135
to2616384301072470
increase2706384301071562103129171425398301074174118
in563398301071967
stroke65039830107346390137176219
volume888398301074189109156230274
and1181398301074290139
the1340398301072877121
heart1481398301074893133159190
rate.169139830107276896138153
There1864398301074292136162205
is2089398301071952
a21613983010741
decline2222398301074993134153171219264
in2505398301072067
systemic2592398301073475109138181254273313
vascular425412301074183117158206226267293
resistance738412301073477112130163193235283324367
as1125412301074882
a12274123010748
result1295412301072770104152171200
of1515412301075579
the1614412301073584128
progesterone1762412301075785132183228262291334361409458503
effect2285412301075074102146188219
and2524412301074896146
development26904123010756101142186425426301071967117191236284311
of755426301074771
placental846426301074867108148191239266307326
vascular1192426301073981114155202221262288
beds.1500426301074893143176193
As1712426301075187
a18184263010740
result1877426301072770103150169197
of2094426301074670
all218442630107395877
of2281426301074670
these2371426301072674118152196
changes,2587426301073887127175225269302318
there425440301072875119145188
is632440301071648
a6994403010738
profound756440301075076123146194241289338
alteration111344030107385684126152193220239286334
in1467440301071563
the1549440301072572116
systemic1685440301073070104133175248266306
hemodynamics,2010440301074589162210259299348388461479519554569
resulting259944030107236599145164191210257306
in425454301071967
a5114543010738
hyperdynamic568454301074987137182209257297346386460478518
state1106454301073159101128170
with1296454301076281109157
increased1472454301071664104131174214247291341
pulse1832454301074795114146190
pressure.2042454301074773116150183230256299314
These2375454301073989133166210
changes2605454301073785126173223267300
can425468301074082130
worsen5744683010769116143177222270
portal8644683010752102129160201220
hypertension1104468301075190140185212243285333366384432481
in1605468301072270
pregnant1694468301075380123173221262310337
patients2051468301075394121140184232259294
with2365468301076887115163
portal25484683010753102129160201220
hypertension2788468301075190425482301075095121152195243276294342391
and835482301074290139
significantly994482301073553102150168192212253294342369388428
increase1442482301071967108134177217251295
the1756482301072977122
risks189748230107284780117154
of2070482301074973
variceal2163482301074183109128169211251270
hemorrhage2453482301074993167215242269318359408452
(4).42549630107246587100
Because545496301074892133175222255300
TIPS864496301074565110151
is1035496301072154
a11094963010743
rare117249630107276895138
situation132949630107365583131171198217265314
in1663496301072169
connection1751496301074390138186231272302321369418
with2188496301076887115163
pregnancy,2371496301075279122172220261309350392403
we27944963010768111
cannot425510301074082130178226253
assess698510301074478111155189222
the940510301073180124
possible10845103010753102135169187236256300
effect140451030107477198141183213
on16375103010751100
the1756510301073280124
placental1900510301075373113154196245271313332
bed.2251510301075499149165
According2435510301075796135182209257275323373
to2827510301073278
available425524301074181122141159200250269313
literature75852430107214068110137178205253280323
there1100524301073078123149192
is1312524301072153
limited1385524301072140113132160202252
data1657524301075192119160
about1837524301074392142190218
patients2075524301075193120139183231258293
who23875243010767116164
have2571524301075091131174
had2765524301075091140
TIPS425538301074262107149
during593538301075198124144192241
pregnancy.854538301075178120171219259307348390402
No12765383010759107
effect140353830107456896139181211
on1634538301074997
TIPS1751538301074363108150
patency1921538301075192119162210251293
has2234538301074990123
been2377538301075196140189
reported2585538301072871121170197228270320
in425552301071967
a5115523010742
few573552301072568133
patients,726552301075092119138182230257292307
but1053552301075199127
only1200552301074998117157
a13765523010742
moderate14385523010774122172216243285312354
increase1812552301072068108135178218251295
in2127552301072068
the2214552301072977121
flow235555230107254795160
velocity2535552301074285104152194212240283
in2838552301071967
the425566301072876120
portal565566301075099126157198217
vein,802566301074084102150166
the987566301072876121
stent,1127566301073463105154180197
and1343566301074189139
the1501566301072876121
hepatic1641566301074993142184211230270
artery193156630107416798141167210
(14).2161566301072463102124137
The565580301074394139
most7245803010782132166196
common941580301074795171246296346
cause1307580301074890139173218
of1546580301075580
maternal16465803010782124152196223273315335
death20015803010757102143171220
in2242580301072675
liver233758030107274688132159
cirrhosis251758030107486794122172222256275309
is2846580301072660
massive4255943010775116150184202244288
upper7335943010755106156202229
gastrointestinal982594301075698132161188236256304332375409439458507548567
bleeding1570594301075777121167218237285335
usually1926594301075588136177197216256
due22025943010757105150
to2372594301073582
esophageal2474594301075185134185235276326371412431
varices425608301074182109128168211244
(15,68960830107216198112
16).821608301074180102115
The956608301073989133
risk110960830107234275113
of1242608301074468
bleeding1330608301074767110155205224272321
from167160830107214895169
varices1860608301073879106125165208241
has2121608301074586119
been2260608301074792136185
estimated2464608301074175104123196237264306356
at2840608301073865
20–27%425622301074385132171211286
among7306223010737109156204252
pregnant1001622301074571113162209248295321
women13416223010760107179222269
with1629622301076179106153
cirrhosis;180162230107365480106153201233251282296
however,2116622301074492155197237279304315
this245062230107247189121
increases2590622301071562101127168207240283315
to425636301072874
62–78%519636301074991134174216293
if832636301072347
esophageal899636301074882130180229270319363403422
varices1341636301074587113132173215249
are1609636301074672115
present1744636301075481124158202250277
(3,204063630107297186
6).214663630107487084
The2249636301074796141
mortality24096363010778127154185226245264292334
rate2763636301073173100142
from42565030107245198172
variceal617650301074182108128168210251270
bleeding906650301075069113158208227275324
is1250650301071851
between1321650301074994122189233278326
2%16666503010744122
to1807650301072875
6%19016503010744122
(5).204265030107246689102
All216465030107527190
pregnant2273650301075077120170218259307334
women26266503010765113187231279
with425664301076686115164
cirrhosis60966430107486794122172221255274308
should937664301074190139188208258
have1215664301075698138183
an1418664301074897
initial153666430107267494122142183203
screening1759664301074182110153199248267316367
endoscopy,21466643010751100151200235276324375415427
which25946643010772122141182231
is2846664301072659
recommended425678301072770111157231305349397447491541
during986678301075199125144192241
the1247678301073079123
early1390678301074686112132172
second1582678301073680121168216266
trimester186767830107315877150194228257300326
or2213678301075077
before2310678301075297121168195238
pregnancy.256867830107527912217222026130942569230107408294
Pregnant539692301074874117167215256304331
patients889692301075394122140184232259294
at1203692301074371
risk129369230107304982119
for1432692301072674101
variceal1553692301074385111130171213253272
bleed1845692301075372116161211
should2076692301073684132181199249
receive2344692301073073114156175216259
primary262369230107538099172213239282
prophylaxis,425706301075077124174223261281321361380413429
with874706301076584112160
either105470630107436290138183209
endoscopic1283706301074391141189223263310360379419
variceal1722706301074182109128168211251270
ligation201170630107193887128155174222270
or2301706301074875
beta-blockers.2395706301075095123164192243262311352390433459494510
Although425720301075372100148196245294342
there787720301072573117144186
has993720301074686120
been1132720301074792137185
a13377203010738
reported1395720301072669119168195226268318
association1733720301073871105153194213253280299347396
of2149720301074569
beta-blockers2237720301074792120161190240260308349387430457491
with2748720301076281109157
intrauterine42573430107196692118158205233274300319366409
growth853734301074571117180211258
retardation113073430107236592133158206245272290337385
and1534734301073784132
neonatal1686734301074487135183223249290308
bradycardia,2013734301074672113161201240280306353371411426
nonselective2458734301074492140172215234277317347365405447
beta-blocker425748301075095122164192243262310352390433459
therapy904748301073078122149190240279
can1203748301074284132
be1354748301075297
used1471748301075083127177
as1668748301074376
variceal1764748301074384111130170213253272
bleeding2055748301075272116161211229277326
prophylaxis2401748301075279126176225263283324364383415
in2836748301072169
pregnancy425762301075077120170218258306347389
(17).834762301072564101126139
In992762301072068
women10807623010766113187232280
with1380762301076584113161
an1560762301074290
episode1670762301074494113146194244288
of1978762301074973
acute2070762301074282130158201
variceal2291762301074183109128168211251270
bleeding2581762301075070114158208227275324
during425776301074996123142190239
pregnancy,684776301075380123173221262310350393404
treatment1108776301073158100141168242286334361
should1489776301073684133181200249
be1758776301075297
focused1875776301072774116163196240290
on21857763010751100
the2305776301073179123
resuscitation2448776301072972106153186227245273315342361409457
and304762301074189138
hemodynamic320562301074993167216266306355396469488528
stabilization375362301073463105154173192211247289317335383432
of420562301074973
the429762301072977121
mother,4438623010775123150199243269281
antibiotic473962301074290116135185204252279298338
prophylaxis,509762301075178125175223262282322362381414430
and304776301074087134
endoscopic320076301073986134180213252297345364402
therapy.362176301072470113138179227265276
The391576301073886129
mainstay4062763010769108126172204232272309
of439076301074366
treatment44757630107234990129155227270316342
remains483676301072264135175192239270
endoscopic512576301073986134180212252297345363402
variceal304790301074081106125164205244263
ligation33299030107153381120147165212259
(13).36079030107205996116129
The375590301073886129
use390390301074476119
of404190301074467
vasopressin412790301073778110157206232274307339357404
is455090301071547
not461690301074491118
recommended475390301072264105150223295338385433476525
during529790301074591117136182231
pregnancy3047104301074976119169216257304345387
due3453104301074693137
to3609104301072571
the3700104301072472116
risk383610430107234274112
of3967104301074569
arteriolar405510430107386495137163182230249289316
vasospasm4390104301073879112160193242283316389
and4799104301073785134
an4952104301073886
increased5057104301071664104130173212245289339
risk541610430107234274112
of3047118301074872
placental3139118301074867108149191239266307326
abruption,3485118301073989116164214241260308357372
myocardial38771183010772111158200241267316334375394
infarction,429011830107186589131157196227246294342358
peripheral4667118301074893120139189237282308350369
ischemia505511830107185091139183257275316
and5390118301074088137
hypertension.3047132301074887137182209240282330363382430478494
The3561132301074190135
use3715132301074780124
of3859132301074670
octreotide3949132301074688118145188237264283332376
is4345132301071750
controversial4415132301073885134160187234274318344378397437456
(13).489113230107226299120134
Third5044132301074191109135184
generation5247132301074892140184211253304714630107284795143
cephalosporins3210146301073981131180220239288321370419446466514547
can3776146301073981129
be3925146301074893
used4038146301074679123173
for423114630107237097
prophylaxis4348146301074875122172221260280320360379412
against4779146301074090130149197230259
spontaneous5057146301073382131180207248296340389437470
bacterial3047160301074989128157199224242281299
peritonitis3365160301074589114133160205252270297314346
in3730160301071561
the3810160301072471113
event3942160301073979121167193
of4154160301074366
a42391603010737
variceal4294160301074080105123162204242260
bleed4573160301074564107150199
but4790160301074692120
fluoroquinolones492816030107204187134160206254300318364411430477524567599
are3047174301074167110
contraindicated3177174301074693141168195237255303352371411453480522572
in3769174301072573
pregnancy3862174301075582125175223264312353395
(13).4277174301073069107128141
TIPS4438174301074868113155
is4612174301072558
contraindicated4690174301074692141168195236255303352371411452479522572
during52821743010755102129148196245
pregnancy3047188301075076119169217257305346388
due3454188301074693137
to3611188301072571
the3702188301072472116
risk383818830107234375113
of3970188301074569
fetal405818830107216492133152
radiation4229188301072465114133173200219267315
exposure.4564188301074080130179212259285328342
The4926188301073988132
placement5078188301074666106147189262306354381
is5479188301071548
considered3047202301074085133165183231274300342391
only3457202301074492110149
if3625202301071639
the3683202301072472115
medical38172023010770113162180219260278
treatment411420230107255193132158231274322348
or4481202301074470
the4570202301072472115
endoscopic4704202301074087136183216255301350369408
procedures5131202301074672118159200249296322364397
fail304721630107246684103
to3170216301072874
control3264216301074087135162189236256
the3539216301072876121
variceal3679216301074182109128168211251270
hemorrhage3969216301074892166214241268317358407451
(2,444021630107246682
13).4541216301074482103116
Another31872303010753102152181230276304
complication3512230301074088163214235255297339368388437487
in4020230301071969
these4110230301072777123158203
women43342303010765114190235285
is4640230301071953
hepatic4714230301074894145188216236278
decompensation5013230301074995137185261311358407442485304724430107284898148
leading3216244301072773114165186235286
to3523244301073684
hepatic36282443010757102154197225246288
encephalopathy.39372443010751101143187238289331351401453496525574614628
This45862443010750101121155
can4763244301074891141
occur4925244301075698139188216
during51622443010757106134155204255
all543824430107497090
stages3047258301073464107157203238
of3306258301075681
pregnancy3408258301075886130182231273322364408
but38372583010758107137
often3995258301075681114158207
occurs4223258301075698139188215251
after4495258301074974107150178
an4694258301074998
episode48132583010752103123157207259304
of5138258301075681
variceal5240258301074992119140182225267287
bleeding.3047272301074969113158208227274324340
The3407272301073989133
basis3560272301074789122141174
of3754272301074569
treatment384327230107255295135163236281329356
is4219272301071649
using428827230107457897145194
both4502272301074796123172
lactulose469427230107165797128176195243277321
and5035272301073886136
antibiotic5191272301073886113132181201249277296336
therapy.3047286301072878124153196248289303
According33712863010761103144192221271291341393
to3785286301073685
available3891286301075091135155175218270291337
literature,424928630107284878122150194223273301346362
the4632286301073787133
preferred4786286301075987132158203231260305357
antibiotic5165286301074999128148200221271300320362
therapy3047300301072877123151194245285
is3353300301072256
Metronidazol34303003010772118147175224274293344386425473494
to3945300301073078
Rifaximin,404430030107486994138179199274294343360
because4425300301075298141184233267312
Metronidazol47593003010772118147175223273293344386424473494
is5274300301072155
safer5350300301073679104149177
in3047314301071968
pregnancy.3136314301075886130182231273323365408421
Renal3579314301075398148190210
dialysis3810314301075777119139181216235269
is4101314301072660
the4182314301073686131
modality43343143010782132183225245265295339
for4694314301073180108
hepato-renal48233143010756102153196224272303332376426468488
shutdown.53323143010742911401693047328301074999165215232
Terlipressin3301328301074989117138158208237281316351370420
is3742328301072660
contraindicated3823328301074896146174203246266315366386427470498542594
in4438328301072676
pregnancy4535328301075786130181231273322364408
as4964328301074883
it5068328301072756
may51453283010782124164
exert5330328301075293137165197
oxytocic3047342301074887131164212255275316
effect338434230107457099144186218
(13).3623342301072566105128142
Liver3187356301074160101145172
transplantation3379356301073562104152186236256297345372414442461509558
is3957356301072659
considered4036356301074794144177195245290316360410
in4467356301072573
patients4561356301075698126145189238265300
with4881356301077292120169
advanced5070356301074898140182230271314365
liver54553563010726443047370301074184111
disease3178370301075574107151192225270
before34673703010757102126174201244
pregnancy.3731370301075683127177225266314355397410
Liver4160370301074767108151178
transplant4358370301073461103151184234254294343370
recipients4747370301073477118137187206250298325360
possess51273703010757106140173218251285
an5432370301074796
improved3047384301071992142169216256299349
quality3416384301075097138157176204246
of3682384301074973
life,377538430107203862106120
their3915384301072977121140166
hormonal4101384301074998125199247296337356
imbalance4476384301072094143185204244293333376
return487138430107287199147173222
to5113384301072975
a52083843010742
normal5270384301074896123198238257
state,3047398301073463104132174189
ovulation3256398301075495144163204231250298347
resumes,3623398301073376110157231275309325
and3968398301074896146
pregnancy4134398301075683126177225266314355397
may45513983010781122161
ensue4732398301075098131179223
(8).497539830107307395109
In5104398301072574
our51973983010755103130
case,5347398301074788122166181
our3047412301074896122
patient’s3189412301074788115134178226253271302
pregnancy3511412301074976119169217258306346388
was39194123010762103137
unplanned,4075412301074593142162202250298342392408
so4503412301073078
we46014123010762105
did4726412301074665114
not4859412301074694121
consider5000412301073784132165183232276303
a53224123010738
liver538041230107183778121147
transplantation.304742630107285596144177226246287335362403430449497546562
There3187440301074292137164207
is3414440301072659
limited3493440301072544118137165208259
data3772440301075597124166
about3958440301074797147196224
an4202440301074896
intercurrence4318440301072674101144171211259285313356405446489
of4827440301075479
alcohol-induced4926440301074767107154204252272300321369419467508550601
liver304745430107193880123150
cirrhosis321745430107476693121170219253272305
and3542454301074896147
lymphomas3709454301072566141192241290365406440
in4169454301072674
the4263454301073584129
literature,441245430107264473116143185213261288332346
consisting4778454301074895144178196229259278326376
mostly51744543010781131165194213254
of5448454301075579
case3047468301074082115159
reports3226468301072972122171198229264
(18–22).3509468301072767106152192236258271
The3800468301074594138
evidence3958468301074787107156200248289331
of4309468301075074
the4403468301073079123
possible45464683010752101135168186236255299
causal4865468301074384132165207226
connection5110468301074390138186231272302321369418
of3047482301074872
these3138482301072573117151195
two3352482301072592140
diseases351148230107466597141181214258292
is3823482301071548
thus3890482301072573120153
low.4063482301071664128141
Alcohol4224482301074968109155204252271
consumption4515482301073783132165212285334362380428477
is5011482301071649
known5079482301073585133197246
to5345482301072471
be5435482301074792
a30474963010741
risk310849630107264578116
factor3243496301072568108138185212
for347549630107257299
developing3594496301075094135178198246296315363412
cancers4026496301074283131172214241275
of4321496301074973
the4414496301072977121
oral4555496301074976118137
cavity,4712496301074183122142170212224
pharynx,49564963010751100140167210259298315
larynx,529149630107206187130180219236
esophagus,3047510301074477126176225265315362395411
liver,347851030107193778122148160
colon,3657510301074187107155204219
rectum,3896510301072669111141189262278
and4194510301074189138
female4352510301072367140181200244
breast4616510301075077119160193222
(23).4858510301072366110131144
Alcohol3187524301075372112159207256275
consumption3482524301074289138171218291341368387435484
and3985524301074391141
the4146524301072978122
risk428852430107284780118
of4425524301075074
lymphoid4519524301072161136185234283302351
malignancies48895243010776117136154203252292340381399443477
was53865243010767108141
evaluated3047538301074484126145192233260303353
in3419538301071967
two3506538301072895143
large366853830107196086135179
prospective3866538301075077124158207252293323342383426
cohort4312538301074087135184211242
studies.4574538301073362110160178222256272
One48665383010760109154
of5039538301074872
the5131538301072876120
studies5271538301073362110160178222256
found3047552301072472121169219
a32865523010748
slightly335455230107345371121169197216257
increased3631552301072574114141185225259304354
risk400555230107345386124
of4149552301075580
developing42495523010756100141185204253304323372421
plasma4690552301075777118152226267
cell4977552301074790109128
neoplasms51255523010756100150200220261295369402
(multiple3047566301072495143161189208258277321
myeloma,33885663010771109152172220294335351
lymphoplasmocytic3758566301071656131180229277328347388421494543584626657676716
lymphoma)4494566301071656131180229277352392414
and4928566301073886135
chronic5083566301073785111158207226266
lymphocytic53685663010717571313047580301074997145185227257275315
leukemia3381580301071659106143185258276315
in3715580301071663
alcohol379758030107375595141189236255
drinkers.407158030107467190137174217242276292
Nevertheless,4382580301075497137180206236283327345389422454470
both4871580301074694121168
of5058580301074468
the5145580301072471115
studies5279580301073058105154172215248
failed304759430107246685104148198
to3265594301073481
prove3366594301075684131171215
a36015943010747
statistically3668594301073363104131150183212231272313332351391
significant4079594301074059108156175199219259301349376
association4475594301074881115163205223264291310358407
between49025943010756102130197241286334
alcohol5256594301074867107154203252271
consumption3047608301074088137170218292342370389437486
and3553608301074897147
incidence3720608301072574115133183228276317360
of4100608301075579
LBL4199608301074893134
or4353608301075583
other4456608301075482131175202
aggressive4678608301074898148175218252286304346389
lymphomas5087608301072667142192241290365406440
(24,3047622301072467107121
25).3188622301074488111124
Conclusion30476474013856118182232266330382415477541
Cirrhosis318766430107506894120167214247264296
in3502664301071561
pregnancy3582664301074672113162209248295334375
is3976664301071547
a40426643010736
complex4097664301073985157205224267305
situation442166430107304774121160186204251298
which47386643010761108126165211
requires4968664301072365113159177203244277
a52646643010736
multidisciplinary531966430107721191371641823047678301074968100141160209229247295336362405
approach.3472678301073887137164211253293341358
Neonatal3849678301075599148197237265306325
risks419467830107234375113149
are4363678301073864107
increased4490678301071664104131174214247291341
as4851678301073871
well49426783010762106125143
as5105678301073871
maternal,51966783010771112139181208257297316331
which30476923010765114132172220
includes3287692301072270110129176226270303
mainly36106923010777117136184203243
bleeding3873692301075272116160210229277326
(due4219692301072773121165
to4403692301073178
variceal4500692301074485112131171214254273
bleed,4792692301075372116161211227
splenic5038692301073786106150198216257
artery5314692301074470101144170213
aneurysmal3047706301074189133181207250284357398417
rupture,3484706301072675124152200226269284
postpartum3787706301075099133162212253280311359432
bleed)4239706301075069113158208232
or4491706301074875
liver458670630107193778121148
failure.475470630107236584103150176219234
We31877203010774117
demonstrated33247203010756101175224274307336364406433476527
the3871720301073584129
successful4020720301074088129168211246279305354374
pregnancy4414720301075684127178227268317358401
in4835720301072574
a49297203010748
37-year-old4997720301074485109149193234261285336356406
female542372030107317530477343010774116135180
patient,3247734301075699126145190238266282
who,35497343010773122171186
despite37557343010756101135185204233276
having4051734301075596137157205255
an4326734301074897
irregular444373430107255280123174222241282309
menstrual47727343010781126175209238265314355375
cycle5167734301074790130149194
and5381734301074897147
one3047748301074897141
episode3208748301075099119151200250294
of3522748301075478
acute3620748301074788136164207
bleeding3846748301075676120165215234282331
from4197748301073058105179
esophageal4396748301075084132182231272321365405424
varices4840748301074789115135175217251
in5111748301072573
the5204748301073482127
past,5350748301075798132161177
managed30477623010774114163203253297347
the3413762301073482126
entire3559762301074998124143169212
course3791762301074693141167201246
of4056762301075478
pregnancy4154762301075582125175223264312352395
without4568762301077190118166215263291
any4879762301074695133
bleeding5032762301075575119163214232280329
due53817623010755102146
to3047776301072874
TIPS.3141776301074161106148164
She3325776301074088132
gave3477776301074889128172
birth366877630107496894125174
to3861776301072774
a39547763010740
healthy4014776301074892133151179228266
baby4300776301074890140179
with4499776301076483111159
physiological4678776301074997136170188236256304354373413454473
measures,51717763010773117157190237264307340356