1617
HLAVNÍ506722701005185134178232252
TÉMA533422701003981147194
Souhrn285733701003776114152176215
pozičního308833701003776107122153190206245284
dokumentu338833701003776110149209244282309347
České375133701003973103137171
pneumologické393833701003875111149209248263302341356386421455
a4409337010034
ftizeologické4459337010022446092126165181220258273304338372
společnosti484733701002967106122157188226265294322338
2020–2021520133701003375109151191223266299326
|5584227010018
239561722701006197139
/35298043010757
Vnitř36058043010771118137165192
Lék3816804301074184122
2021;3958804301074386128167177
67(4):4155804301074485105147168183
230–2394357804301074488132180219263305
/46828043010757
VNITŘNÍ47598043010791152172217266326346
LÉKAŘSTVÍ5126804301074185131189236281326378400
www.casopisvnitrnilekarstvi.cz42580430107651332012142542953293774274464795215705896176436927117307748128548809159449871007102310631101
6.4255530853652
Martin4925540835385106131146184
RJ,692554083336072
Bel779554083346984
EH,879554083307487
Pavord982554083336596134155194
ID11915540831358
et12655540833254
al.1334554083304558
Defining1408554083437896113151166204243
severe1666554083245991126147181
obstructive18625540833675102125146185217241256289323
lung2200554083135189128
disease2343554083365177112144171206
in25645540831351
the2630554083205893
biologic2738554083375290106144425654083385385
era:526654083335588100
an6416540833270
endotype-based7266540833472111150172205245281304344377403438478
approach.12196540833271111132170203235273286
Eur1520654083336991
Respir1626654083357097136152173
J.18146540832437
2019;18666540833468100130143
54:2024654083357082
1900108.21216540833464100136168200235248
7.4257530853645
Barnes485754083387192131166193
PJ.693754083375769
Inflammatory77775408318567390122180238270292329350384
mechanisms11777540835994127165197235251277334361
in15537540831755
patients1623754083417496111146184205233
with1871754083536991130
chronic2016754083337193130168183215
obstructive22477540833979105129150188220245260292327
pulmonary2589754083417995152190229261282316
disease.425854083385379114146173208220
J66085408324
Allergy700854083415671106127165198
Clin913854083405570108
Immunol.10368540831573131168206244260273
2016;13258540833468100131143
138(1):1483854083356599118150164176
16–27.16748540833466103135168174
8.4259530853551
Tashkin491954083305783119149165202
DP,707954083427782
Wechsler8039540835487118156181196230250
ME.1068954083518496
Role1179954083327085119
of13139540833452
eosinophils1380954083316995109146183222260274289314
in17099540831148
airway1772954083294364116148178
inflammation196595408312496682114170227258279294331369
of23489540833553
chronic2416954083286586122160174205
obstructive263695408334739912114217921123424942510540833266
pulmonary5061054083397792150188227259280314
disease.8361054083385379114146172207220
Int10711054083155374
J1161105408324
Chron12001054083407899136175
Obstruct139010540834787113137158196228253
Pulmon16581054083357288145183222
Dis.18951054083466187101
2018;201110540833468100131143
13:21701054083346475
335–349.226010540833568101137169205238249
9.42511530853649
Singh4901154083385391130168
D,67311540835162
Kolsum7501154083407894120157215
U,98111540834960
Brightling10561154083416278117155176192207245284
CE135511540834678
et144911540833961
al.15261154083375265
ECLIPSE160711540833778109125161194226
investigators.18481154083205890124151174189228261283320341369382
Eosinophilic224611540833875102117155193233272287302317349
inflammation26101154083205876931251832412734251254083223775113
in55412540831452
COPD:62212540833985121166179
prevalence8161254083396195127160175210248280314
and114512540833270109
clinical1270125408331466199114146179194
characteristics.148012540833169101122155187211245266282308331347379406420
Eur19151254083336990
Respir20211254083357097136151173
J.220912540832437
2014;226112540833468100131143
44(6):24191254083347191124142154
1697–700.258812540833466100132165196230266278
10.4251353085366984
Polosukhin5241354083337085123150187217256271309
VV,8481354083337381
Richmond9451354083334880118175213252291
BW,125113540833390100
Du136613540834381
RH146213540833378
et155513540833254
al.16241354083294558
Secretory16971354083306597118152174211233267
IgA19791354083125192
Deficiency20861354083437896113145160194232264298
in239913540831250
Individual24641354083125089104137152191228260276
Small275513540833087119135150
Airways4251454083415677130162193220
Is66014540831238
Associated7131454083386692130163178209231264304
with10321454083476385123
Persistent11701454083336687114128154177211248270
Inflammation1455145408312506784116173231263284299337375
and184514540833067106
Remodeling.196614540833368125163202237252267305344356
Am233814540833895
J2449145408321
Respir24851454083336894133148169
Crit2669145408338587496
Care27801454083377091125
Med.42515540835490129142
2017;58315540833468100129139
195(8):7371554083346499116150168180
1010–1021.9321554083346698129167198229262294303
11.4251653085366678
McDonough51816540835688134173211249287326364
JE,8981654083255872
Yuan98516540833671104142
R,114216540833751
Suzuki120816540833471100138169185
M1408165408356
et147916540833558
al.15521654083334861
Small-airway162916540833391123139154176208223244298331361
obstruction200616540833878104128149187219244259297335
and235716540833371110
emphysema248216540833593132171201228263321354
in285116540831654
chronic4251754083316990128166181213
obstructive65317540833877104127148187219243258291325
pulmonary9941754083387692149188226258280314
disease.13231754083385379114146173208220
N1558175408345
Engl161817540833371110125
J1758175408324
Med.179817540835489129142
2011;195517540833468100128136
365(17):210717540833468102120151181200212
1567–1575.23341754083356599132164195225258291303
12.4251853085366985
Elbehairy5261854083345090126165198214235270
AF,8121854083427683
Ciavaglia9111854083415789122155195211227259
CE,11861854083427589
Webb129118540835992132173
KA148018540833681
et157718540833558
al.16511854083334963
Canadian173018540834174113146186202234273
Respiratory201918540833772100140156178211234272294329
Research23641854083367299135168190221260
Network.264018540834682105158197219250266
Pulmonary4251954083357389147186225258280315
Gas75619540834275103
Exchange8751954083316496134167206246281
Abnormalities117219540834080119158180239272288304327343378406
in159419540831352
Mild16621954083526984124
Chronic18021954083387799137176191224
Obstructive204219540834586113137159198231256272305340
Pulmonary23981954083347187146185224257279313
Disease.272719540834460871231554252054083266275
Implications51620540831574113130146178212234250289328355
for8872054083195880
Dyspnea98320540834679107147186222254
and125320540833371111
Exercise138020540833367101123155171197233
Intolerance.16292054083165477114131166188222261294328341
Am1986205408341100
J2102205408325
Respir21432054083367299139155177
Crit23362054083406278102
Care24542054083407496130
Med.260020540835591131145
2015;276120540833570102133145
191(12):4252154083346598114146177195208
1384–1394.64921540833565100137175207238272308321
13.4252253085366883
Garcia-Rio52322540834881102133148180203240255293
F,83222540833642
Miravitlles8902254083587495128159175198213228263290
M,119522540835972
Soriano12832254083367596112144182220
JB151822540832965
et159822540833861
al.16742254083365264
EPI-SCAN17542254083377286109140181224269
Steering20382254083375892127148164202241
Committee.229422540834481140197213235259293328341
Systemic26502254083376693117150208223255
inflammation425235408315537087119177235267289304342381
in82123540831856
chronic8932354083357394131170185217
obstructive112523540834181107130152190222246262294329
pulmonary14692354083428196154192230263284318
disease:18022354083425783118150177212224
a2042235408335
population-based209323540833877117155170202224239277316338378411438473512
study.26212354083305391130162172
Respir2808235408339744252454083266581102
Res.5422454083357097111
2010;66824540833468100132144
11:8282454083346270
63.9142454083346780
14.4252553085366984
King5242554083334987126
PT.6652554083336776
Inflammation756255408313506885117174232264286301339378
in114925540831250
chronic12142554083296788125163178210
obstructive144025540833474101124145183215239255287321
pulmonary17762554083377590148186224256277311
disease21032554083355076111143170204
and232325540832967106
its24442554083123562
role25222554083185571106
in264325540831250
cardiovascular270825540832962831211361744252654083326591123161176209230
disease6702654083385379114146173208
and89326540833270109
lung10172654083155391130
cancer.116226540833164102134168189200
Clin13772654083405570108
Transl15002654083335083121147163
Med.167826540835489129142
2015;183526540833569100130141
4(1):1992265408334538599111
68.21192654083346983
15.4252753085367086
Kim52827540834260119
HC,66427540835093107
Mofarrahi788275408361101122157179202237277293
M,109827540836176
Hussain119127540835090117145180197236
SN.144427540833985100
Skeletal156027540833971106123160184218235
muscle1812275408363103130164181217
dysfunction204627540834578107128168208241267284323363
in242627540832161
patients250327540834680103120156196219248
with27682754083577498138
chronic4252854083317193132172188221
obstructive66328540834081109133156196229255272306341
pulmonary10212854083418197156196236270292328
disease.13652854083415785121154182219232
Int16142854083175780
J1710285408327
Chron175328540834382104143183
Obstruct195328540834990118143166205239264
Pulmon22342854083387693152192231
Dis.24822854083486592107
2008;260628540833672109146160
3(4):27832854083365690109122
637–658.42529540833469103137175210246261
16.4253053085366985
Chen52530540834179114152
YW,69230540833697107
Ramsook81430540833669126153191230260
AH,10903054083418699
Coxson120430540834178108136174213
HO143230540834593
et154030540833557
al.16123054083334861
Prevalence16883054083365791123156171206244276310
and201330540833371110
Risk21383054083365278108
Factors22613054083336295119156177205
for24813054083195778
Osteoporosis257430540834875981321712102492713084253154083264167
in50731540831553
Individuals5753154083155392107140155194232264280306
With8963154083577396134
COPD:104531540834086122167180
A1240315408341
Systematic12973154083326289112146204236258273305
Review161731540833671103119153205
and183731540833270109
Meta-analysis.196131540835590112145167199237270285317344359385398
Chest.237531540834078113139163176
2019;256631540833468100130143
156(6):27253154083346498117150168180
1092–1110.42532540833466101134168199227254286298
17.4253353085366876
Lu51733540833168
Y,60133540833543
Feng65933540833266104143
L,81833540833144
Feng87833540833266104143
L1036335408331
et108333540833356
al.11543354083314760
Systemic12293354083326289112146204219251
inflammation,1495335408315527087119177235267289304342380393
depression190433540833772111133167194220235273312
and223133540833270109
obstructive235533540833776103126148186218242258290324
pulmonary269533540833876921491884253454083387091125
function:5653454083195795128152167205243255
a836345408332
population-based88334540833977117155171203224240278316339379412438473513
study.14113454083264987126158168
Respir15953454083357097136151172
Res.17833454083357097111
2013;190934540833468100130141
14:20663454083346577
53.21583454083346780
18.4253553085366985
Hersh52535540834984105132170
CP,7113554083447984
Make81035540835992122156
BJ,9813554083406577
Lynch107335540833664103135173
DA126135540835090
et136635540833961
al.;1442355408337526578
COPDGene153535540834490126171216251290325
and187535540833674113
ECLIPSE200435540833777108124159192225
Investigators.22443554083195789123150173188227259281318340367380
Non-emphysematous26403554083498712614818424242536540833977108135170228260282319357383
chronic8243654083347293131169184216
obstructive105536540834181107130152190222246262294329
pulmonary13993654083428096153191230262283317
disease17323654083415683118149176211
is195836540831844
associated20183654083356288126159174206228262301
with23353654083536992130
diabetes24803654083425789128163186220246
mellitus.274236540836095111126141425375408322608699
BMC54037540833590131
Pulm6863754083357288145
Med.84737540835489129142
2014;100437540833469100131143
14:11633754083346577
164.125537540833466102115
19.4253853085366982
Agusti52238540834179117143166181
A,71938540834054
Bel7883854083357086
E,88938540833245
Thomas94938540833272110168200227
M1191385408354
et126038540833456
al.13313854083314760
Treatable14063854083324983115137170209225259
traits:1681385408321427590113140153
toward184938540832158109142163201
precision20663854083385993126141167182220258
medicine234038540835691131146178193231266
of262138540833756
chronic26933854083306889126165180212
airway4253954083324768121154185
diseases.6253954083385480115147173208235249
Eur8893954083326990
Respir9943954083367198137152173
J.118339540832436
2016;123539540833468100131143
47(2):13933954083346783117135147
410–419.15553954083346496134171201231242
20.4254053085367287
Franssen5274054083335386124150177212250
FM,7924054083328699
Alter9074054083415679112134
P,105640540833540
Bar11114054083366990
N1216405408345
et127640540833457
al.13484054083324760
Personalized14244054083356990117155194226241256285320359
medicine179840540835893133148180195233268
for20814054083195678
patients21744054083397294109144182203231
with24204054083516789127
COPD:256340540834085121166179
where27584054083508912442541540832155
are4954154083325387
we?59741540835185110
Int7234154083145274
J812415408324
Chron8524154083407798136174
Obstruct104241540834686113136158196228252
Pulmon13094154083367388146184223
Dis.15474154083456187100
2019;166341540833468100130143
14:18214154083346577
1465–1484.191441540833465101135171202233269305318
21.4254253085367082
Bigna5224254083365190128160
JJ,6974254083254961
Kenne77342540833569107145180
AM,96842540834197110
Asangbeh109442540834169102140179218253292
SL140142540833263
et148042540833456
al.15514254083324860
Prevalence16274254083355690122155170205243275309
of195142540833857
chronic20234254083316991128166181213
obstructive225242540833776103126148186218242258290324
pulmonary25924254083387792150188226259280314
disease4254354083385379114146173208
in64843540831451
the7154354083205993
global8244354083375290130163178
population101743540833877116155170202224239277316
with13484354083496587126
HIV:14894354083435895107
a1611435408331
systematic16574354083265986109143200233255270302
review19744354083205486102136188
and217743540833169108
meta-analysis.230043540835691114146169201239271287319346360387400
Lancet271543540833164102134168190
Glob4254454083446098137
Health.57844540834479111126148187200
2018;79344540833468100131143
6(2):9524454083345387105117
e193–e202.10844454083346494127163199234268301313
22.4254553085367287
Bui5274554083337085
DS,6274554083427587
Burgess7294554083337091129163189216
JA,9604554083216174
Lowe104945540832966116150
AJ121445540833865
et129445540833153
al.13624554083294457
Childhood14344554083377489104143180218256295
Lung174445540832965103141
Function190045540833066103135159174211249
Predicts21644554083335387126140172196223
Adult240245540833876113128150
Chronic25674554083377595132170185216
Obstructive2798455408345844254654083264971109141165181213247
Pulmonary6884654083347187144183221253274309
Disease10124654083446086121153179214
and124246540833169108
Asthma-Chronic13654654083406891130187220242285323344381420435467
Obstructive184746540834686113136157196228252267300334
Pulmonary21964654083357287145183222254275309
Disease25204654083456187122153180215
Overlap2750465408347801141364254754083154786
Syndrome.52747540833262101140161198256291304
Am84647540834199
J960475408324
Respir10004754083357097136151172
Crit1188475408340617699
Care13024754083407394128
Med.144547540835590129143
2017;160347540833468100129139
196(1):175747540833565100119151165177
39–46.194947540833568105142178192
23.4254853085367287
Broström5284854083355693120143164202260
EB,8034854083326780
Akre8984854083407093127
O,104048540834657
Katz-Salamon11124854083346890120142173206222254312350388
M1516485408353
et158448540833356
al.16554854083314659
Obstructive172948540834686113136157195228252267300334
pulmonary20784854083387691149187226258279313
disease24064854083375379114146172207
in262848540831452
old26954854083365291
age280148540833170105
among42549540833290128166205
individuals6464954083145291106139155194231263279305
born9664954083397899138
preterm.11194954083396095117151172230244
Eur13784954083326990
J1483495408325
Epidemiol.15234954083337187126161219234272288301
2013;183949540833468100130141
28(1):19964954083346887118133145
79–85.215649540833467105141175187
24.4255053085367187
Byrne5275054083417395134170
AL,7125054083467892
Marais82050540836092114147162188
BJ,10245054083416577
Mitnick11175054083607598136152184214
CD134750540834591
et145350540833962
al.15305054083375366
Tuberculosis161150540833872111147168200238253292319333360
and198650540833776115
chronic21165054083377596134173188220
respiratory23515054083266188127143164197219256278312
disease:26795054083435885120152179214227
a425515408332
systematic4725154083265986109143201233255270302
review.7895154083215587103138189200
Int10045154083155374
J1094515408324
Infect11335154083155372106139163
Dis.13115154083466187101
2015;142751540833468100130141
32:15835154083356780
138–146.16785154083346498135166197233247
25.4255253085367287
Hayden52752540834376106145180218
LP,7605254083306670
Hobbs84652540834381121160187
BD,10485254083348091
Cohen115552540833875114149187
RT135752540833468
et144052540833355
al.;1511525408330465971
COPDGene159852540833884120165210245283318
Investigators.19325254083135183117144167182221253275312334361374
Childhood23225254083387691107145183222260300
pneumonia2637525408338761111492072454255354083385385
increases5255354083195789110144176203238265
risk805535408325416797
for9175354083236082
chronic10145354083367495132171186218
obstructive124753540834281108131152191223247262295329
pulmonary15915354083448297155193232264285319
disease:19255354083435884119151177212225
the21655354083266499
COPDGene228053540834489126171216251289324
study.26205354083305391130162172
Respir2808535408339744255454083266581102
Res.5425454083357097111
2015;66854540833468100130141
16:8245454083346678
115.9175454083356292104
26.4255553085367187
Greulich52755540834667101139154169201239
T,78255540833443
Nell8405554083468197112
C,96755540834255
Hohmann103755540834684123180213251289
D1341555408347
et140355540833658
al.14765554083344962
The155455540833473108
prevalence16775554083406296128161177212250282315
of200855540833958
diagnosed20815554083405587126164202229264304
α1-antitrypsin24005554083396988120158180195218239273313340355392
deficiency280855540833974425565408317346681116154186219
and66056540833775114
its7895654083204270
comorbidities:87456540833673132170192231247286301323339373400413
results13025654083266086124139161189
from15065654083244683141
a1663565408337
large17155654083154768106141
population-based187256540834382122160175207229245282321343383416443478517
database.24055654083437597130169202229264276
Eur26965654083387495
Respir2807565408340754255754083266581102
J.54257540832437
2017;59457540833468100129139
49(1):7485754083356887119133145
1600154.90857540833466101137169199234247
27.4255853085367281
Guo52158540835088127
F,66458540833844
Kuang72358540834178111150189
JL.9285854083296276
Superoxide102058540833875115151173210241257296332
dismutase13675854083445986144182205239266301
gene168458540834379117153
polymorphisms185258540834584100132192231253293332347374432459
and232658540833876116
functional245758540832463102135159175213252285300
activity277358540833770951104255954083324770104
in54459540831957
chronic6165954083367495132170185217
obstructive84959540834181108131152191223247262295329
pulmonary11935954083438197154193231264285319
disease.15275954083425884119151177212224
Zhonghua176759540834280118156195233271303
Jie20855954083294479
He217959540834984
He227859540834883
Hu237759540834886
Xi247859540834358
Za255159540834275
Zhi.26415954083428095108
2011;276559540833872104132140
34(6):4256054083347089122140152
424–428.5936054083346698135172205239252
28.4256153085367389
Houghton53161540834988127167206228265304
AM.851615408347103117
Matrix98461540836194116138154185
metalloproteinases118561540836399122155171187225266288326348382398436469496532559
in176061540832059
destructive183461540834480107131153192224249265298333
lung21826154083215997137
disease.23356154083445986121154181217229
Matrix258061540836093116137153185
Biol.27816154083415795112125
2015;42562540833468100130141
44–46:58162540833471109145181194
167–174.7906254083346698131162191222234
29.4256353085367286
Ding52663540835166104143
Z,68563540834256
Wang75663540836294132171
K,94263540834055
Li101263540833752
J1079635408330
et112463540833961
al.12016354083375265
Association128163540834674101139172187219241256294333
between162963540834479102155189225263
glutathione19076354083435996119152173212227265303338
S-transferase22616354083376082104137175201221256277310337372
gene264863540834378116151
M1281563540835990
and42564540833270109
T154964540833871
polymorphisms6366454083438298130189227249288327342368426452
and110464540833674113
chronic12336454083367495132171186218
obstructive146664540834382109132154192224248263296330
pulmonary18126454083438297155193231264285319
disease21466454083435985120152178213
risk:2375645408325416797112
A2502645408346
meta-analysis.256364540835893115148171203241273289320425655408326416781
Clin5216554083405570108
Genet.64465540834479117152175188
2019;84765540833569100131143
95(1):10066554083346886117132144
53–62.116565540833467104141174187
30.4256653085367388
Miravitlles5296654083617698131163179202218233268295
M,84066540836074
Dirksen9296654083516788119149184223
A,116766540834761
Ferrarotti12446654083377293115149170208230255270
I1530665408320
et156666540833456
al.16386654083375366
European17206654083387596134174210242281
Respiratory201666540834176104143159180214236273295329
Society236166540833877110125160183217
statement:25946654083315488110144202238276298312
diagnosis4256754083385385124162201227242268
and70967540833573112
treatment8376754083254781113134193228266287
of114067540834160
pulmonary12156754083438197154193231263285319
disease15496754083425783118150177212
in177667540831956
α(1)-antitrypsin18486754083416092106129161199220236258280314354380395433
deficiency.22966754083427795112144159194232264297307
Eur26196754083377394
Respir272967540833974101140155176
J.42568540832437
2017;47768540833468100129139
50(5):6316854083356988122140152
1700610.7986854083356497133169199231243
31.4256953085366981
Burgel5226954083357294132167182
PR,7206954083336983
Laurendeau81869540833064101122156194234268300338
C,117169540833952
Raherison123869540833467105140162177203241280
C1533695408339
et158769540833355
al.16586954083304659
An173269540834078
attempt18256954083315377111169208230
at207069540833153
modeling213869540835694134169185200237276
COPD243069540833884120165
epidemiological261069540833372881271622202352734257054083155393108140172188
trends6287054083224377115154181
in82470540831553
France.8927054083325285123155189201
Respir11087054083367198136152173
Res.12967054083367198111
2018;142370540833468100131143
19(1):15817054083346484115130142
130.17387054083346499111
32.4257153085367086
Adeloye52671540833977111127164195229
D,77171540834253
Chua83971540833775112144
S,99871540833043
Lee10567154083296298
C1169715408337
et122171540833153
al.;1290715408329445769
Global13747154083415795134167182
Health157171540834276108123145183
Epidemiology17697154083306984123157215230267283321360392
Reference21767154083336886121142175213245278
Group24707154083416299137176
(GHERG).266171540831658103136171215233244
Global4257254083446098137170186
and62672540832967106
regional7487254083185292107145183215231
estimates994725408332588197154187208242269
of127872540833554
COPD134872540833783119164
prevalence:15277254083365892124157172207245277311324
Systematic18667254083306087110144201234255271303
review21847254083185285100135186
and238572540833068107
meta-analysis.250772540835590112145168200238270285317344359385399
J425735408324
Glob4647354083446098138
Health.61773540834479111127149187200
2015;83373540833468100130140
5(2):9897354083345286103115
020415.112073540833467101137167197209
33.4257453085367186
Koblizek52674540833977116132147176210241
V,78274540834048
Jarkovsky8467454083286081112149181208238272
J,113374540832840
Dusek118974540834987114149179
L,138374540833649
Benesova144874540833974112147174212244277
K,174174540833853
Svoboda180974540833768105145184223255
M,208074540835872
Brat21677454083396194115
K.229874540833954
The236774540833776111
Czechia249374540834475109142180195227
COPD273574540834489125170
mortality42575540835796117142175190205227261
rate7027554083205375109
declining,82675540833873106121136174189227266279
but11207554083397799
total12357554083215880113128
deaths137975540833873104126164191
increasing.15857554083155385106140172198213251290303
Eur19047554083326990
Respir20097554083367197136152173
J2197755408324
2020;223775540833468101135148
56(suppl24007554083346988113150190229245
64):26607554083357188100
434.277675540833466102114
34.4257653085367489
Vondra53076540834278117156178211
V,75776540834150
Malý82376540836093108140
M.97976540836074
Výrazný10697654083417496130159199229
vzestup131476540833768103130153192231
úmrtnosti1561765408343101122147186225252275291
na186876540834375
chronickou19597654083377596134173188221251289327
obstrukční230276540834383110133155194224256294309
plicní26277654083446076108146162
nemoc28047654083437942577540835796128
v569775408331
České61677540834073100130164
republice7967754083205493132171187202234267
v1079775408331
letech11267754083144972105138176
2013-2017.131777540833569100130152183217249278285
Studia16177754083325391130146178
Pneumol181077540833573108145203242257
Phthiseol.20837754083357294132147173208247263276
2019;237477540833468100130143
79(2):25327754083356887121139151
43–50.269877540833467103137171184
35.3047553085367186
Celli3148554083407490105120
BR,3283554083367286
Cote3384554083407799133
CG,3532554083408295
Marin36435540835487108124161
JM38205540832479
et39145540833457
al.3986554083324760
The40625540833272107
body-mass41845540833977117149171230262289315
index,4514554083155392127159172
airflow470255408332476888105143194
obstruction,49115540833877104127148187219243258296335347
dyspnea,5274554083387097136174209241254
and30476540833271110
exercise31736540834072106128159175201237
capacity34266540833670110143176191214248
index3690654083205998134166
in38716540832059
chronic3946654083367597134173189221
obstructive41836540834383110134156195227252268301335
pulmonary4534654083448399157196235268290324
disease.4874654083445986121154181216229
N511965408350
Engl51856540833876116131
J533265408330
Med.53776540836196137150
2004;30477540833468104141152
350(10):32157540833467101121152184202214
1005–1012.34447540833566102136173203235267297309
36.3047853085367288
Puhan31508540833370108140178
MA,33438540835294108
Garcia-Aymerich3466854083417495126141172195236265324359380395427465
J,39468540832234
Frey3995854083305083115
M412585408352
et41928540833254
al.4261854083294557
Expansion43348540833062102134172198213251289
of46388540833554
the4708854083195792
prognostic4815854083365895134172210236260275307
assessment5137854083295582117143170227262300322
of54748540833454
patients3047954083397293109143181203231
with3293954083526890129
chronic3437954083337192129168183215
obstructive36679540833979105128150188220244260292327
pulmonary4009954083407894151190228261282316
disease:4340954083405581116148175210222
the4577954083246297
updated46899540833978118150172206245
BODE49509540833785131164
index5130954083165493128159
and53059540833371110
the5431954083236196
ADO304710540834187135
index.31971054083155392127158172
Lancet.338510540833164102135168191204
2009;360410540833468105140153
374(9691):37721054083346697116149184218250264276
704–711.406410540833467103140172205232242
37.30471153085367079
Brat31421154083355790111
K,326911540833449
Svoboda333311540833263100140179218251
M,359911540835468
Hejduk36821154083447994133170200
K3898115408334
et394811540833356
al..Introducing401911540833147607389127149170207247284317332370409
a4443115408331
new449011540833772123
prognostic46291154083385997136174213239262278310
instrument49541154083145278102123161219254292314
for52831154083185677
long-53761154083145291130152
-termmortality3047125408321437697156225263285309342357372394427
prediction34891254083365892131146177201216254292
in379612540831350
COPD386112540833883118163
patients:40391254083366991106140178199227239
the42931254083195792
CADOT440012540833780125173205
index.46201254083125089123154168
Biomed48031254083334886144178218
Pap503612540833264103
Med515412540835286126
Fac52951254083305991
Univ54011254083417893126
Palacky30471354083356782115147177211
Olomouc327313540834763101160198236268
Czech355713540833970104137175
Repub.374713540833570110148187200
2020;396213540833468101135148
in412513540831553
press.41931354083396094121148161
doi:43701354083387691104
10.5507/bp.2020.035.44891354083346678113146180213233273312325361395428462474510543576588
38.30471453085367288
Qaseem315014540834679105140175233
A,339914540833954
Wilt34681454083567288110
TJ,35931454083325365
Weinberger367314540835689105143182217238277311333
SE402114540833164
et410014540833355
al.41701454083314659
Diagnosis42451454083445991130168207233248274
and453514540833068107
management465814540835688126158197232290325363385
of505814540833656
stable51291454083254881120136171
chronic53151454083306889126165180212
obstructive304715540833776103126147185217241256288322
pulmonary33851554083367489146184222254275309
disease:37091554083365177111143169204216
a3941155408329
clinical3985155408331466199113145178193
practice41931554083365890122146161193226
guideline44351554083357388126161176191229263
update471415540833473112144166199
for49291554083165374
the50181554083205892
ACP,512515540833978113117
ACCP,525715540833978115151155
ATS542715540833967101
and304716540833270109
ERS.317116540833368102115
Ann330216540834179117
Intern34341654083155374108129168
Med.361716540835590129142
2011;377516540833468100127136
155(3):39261654083346497114148165177
179–191.41181654083356497135166196228237
39.30471753085367185
Pellegrino3147175408335688499134173194210248286
R,344817540833549
Viegi35121754083355186126141
G,366817540834357
Brusasco37401754083345694120153180212249
V4004175408335
et405517540833356
al.41261754083314659
Interpretative42011754083135173107128168189223246278300315348382
strategies45991754083254870103124158198213247274
for48891754083175576
lung49811754083145189128
function51241754083185795127151166204243
tests.53821754083215581105132146
Eur30471854083336990
Respir31531854083357097136151172
J.334118540832436
2005;339318540833468104138149
26(5):35571854083346887120139151
948–968.372318540833470106143178213249262
40.30471953085367489
Brat31511954083396093115
K,328119540833853
Plutinsky33491954083395391114129167193223257
M,362119540835871
Hejduk37081954083478297136174204
K3927195408338
et398119540833759
al.40551954083355164
Respiratory413419540833974100139155176209231268289323
parameters44731954083417496129186221244278299326
predict48141954083426498137153184209
poor503819540834281119141
outcome519419540834179101132169227262
in547219540831855
COPD304720540833983118162
patients,32242054083356788102136173194221233
category34722054083275980113151188209242
GOLD372920540834086118162
201739062054083316495123
B.404420540833244
Int41032054083114869
J4187205408321
Chron42222054083377394130167
Obstruct440420540834382108130151188219242
Pulmon46612054083326882138176213
Dis.4889205408341568194
2018;49982054083316495125136
13:51492054083315970
1037–1052.52342054083316193124156186216249281293
41.30472153085366981
Agusti314321540834180117144167182
A.334021540834156
The341121540833372107
path35332154083397294132
to368021540832259
personalised37542154083397496123161200232247262288323363
medicine413221540835893132147179194232267
in441521540831452
COPD.448221540834086122167178
Thorax.467521540833372110132165197210
2014;490121540833468100131143
69(9):50592154083346887120138150
857–864.522421540833468102134170205242254
42.30472253085367086
Le314822540832963
Rouzic322722540833371109138154185
O,342822540834455
Roche349922540833271103141176
N,369022540834355
Cortot37612254083377496120157179
AB395522540833974
et404422540833254
al.41132254083304558
Defining41862254083437996113151166204242
the44442254083195792
„Frequent45512254083185272106145183218256277
Exacerbator“48432254083306396128161182222255276313335357
Phenotype521622540833270105143181203236276312
in304723540831553
COPD:311523540834085121166179
A3310235408341
Hypothesis-Free336623540834476116155177215250277291317338373392426462
Approach.384323540834180120142179212244282295
Chest.415323540834078113140163177
2018;434523540833468100131143
153(5):45032354083356598116149168180
1106–1115.46982354083346293129167198225253283295
43.30472453085367186
Chalmers314824540834583115130188223244271
JD,34352454083297585
Aliberti35362454083456176115150172196212
S,376324540833750
Filonenko38282454083375267105144179217247284
A4128245408345
et418824540833457
al.42602454083365265
Characterization434024540834482115136169201225259280296325358380395433472
of482724540834261
the490324540832765100
„Frequent50182454083255979113152190225263285
Exacerbator53182454083377010213416818930472554083397293130152
Phenotype“321425540833573108146184206240280315337
in356625540831452
Bronchiectasis.36342554083355694132164202217252285309342368383409423
Am407225540834199
J4186255408324
Respir42262554083357097136151173
Crit4414255408340617699
Care45282554083407394128
Med.467125540835590130143
2018;482925540833468100131143
197(11):49882554083346497113145173187199
1410–1420.52022554083346596127165196227260294306
44.30472653085377896
Koblizek316126540834283125143161192229262
V,344026540834455
Milenkovic35122654083638198136177210250284302337
B,386726540834358
Barczyk394226540834379103136170206240
A4199265408349
et426626540833761
al.43452654083395772
Phenotypes443526540834383121161203227263306344374
of482626540834667
COPD491126540834896135183
patients511126540834783107124162203227257
with538626540835876101142
a3047275408332
smoking309627540832786126158176215255
history33682754083415885110148171207
in359127540831958
Central366627540834379118141164198215
and389827540833575115
Eastern40302754083367199123158181221
Europe:42682754083367497135176213227
the451227540832565101
POPE463027540833988125159
Study.48062754083365998138172183
Eur50062754083367497
Respir512027540833975103144161183
J.532027540832842
2017;537827540833874107138149
49(5):30472854083346989124144157
1601446.322128540833668105138171209247261
45.30472953085367186
Kim314829540833451108
V,327229540833443
Han333029540834376114
MK,345929540835489104
Vance357829540833566104136170
GB376329540834379
et385729540833355
al.;3928295408330465971
COPDGene401529540833984120165210246284319
Investigators.43492954083145283117144167183222254276313334361375
The473929540833271106
chronic48602954083316990127165180212
bronchitic50882954083375996135167205220242258290
phenotype53932954083377611130473054083387698131171207
of326930540833757
COPD:334130540834085122167180
an353630540833270
analysis362130540833270102118149176191217
of385430540833756
the39263054083215994
COPDGene403630540834085121166211247285320
Study.43713054083335492131163173
Chest.455930540834078113140163176
2011;475030540833569100128136
140(3):490230540833465101120154171183
626–633.510030540833468101139177210243256
46.30473153085367489
Cheng315231540834179114152191
Y,335931540833644
Tu341831540833467
X,350131540833952
Pan356931540833668106
L3690315408332
et373831540833557
al.38103154083334962
Clinical38873154083415671109124156189204
characteristics410631540833371103124157189213247268284310333348380408
of452931540833958
chronic46023154083337192129167182214
bronchitic,48323154083396198137169207222244260292305
emphysematous51523154083359313217120122826332135430473254083225997123
and318532540833675114
ACOS331432540834584130162
phenotypes349232540834381116154193215248288324351
in385832540831957
COPD393032540834590126171
patients41163254083437698113148186208235
with43673254083557093131
frequent45133254083234579119156191229251
exacerbations.477932540833970103135169190230263284300338376402416
Int52103254083195779
J5304325408329
Chron534832540834482103141179
Obstruct304733540834787113137158196229253
Pulmon33153354083357288145184222
Dis.35523354083466187101
2017;366833540833468100130139
12:38233354083346476
2069–2074.391533540833468104138175207241273304316
47.30473453085367180
Tho314234540833978117
NV,32753454083508797
Park33873454083417395126
HY,35283454083508795
Nakano363934540835083113147186225
Y.387934540834150
Asthma-COPD39453454083467498137195228251294340377422
overlap438334540834375110132148180220
syndrome461934540833164104143165202261297
(ACOS):493134540832466106152185204216
A5163345408347
diagnostic52253454083395487126165204231254270302
challenge.304735540833169102117132167205244279291
Respirology.33533554083367198136152173210226264304336346
2016;371435540833569100132144
21(3):38733554083346681114132143
410–418.40323554083346496134171201232245
48.30473653085367490
Takiguchi31523654083356394110149186218256272
H,343936540834659
Asano351436540834371104142180
K.371036540833752
Asthma-COPD37783654083437194132190222245288333369414
overlap420736540834072106128143176215
syndrome443736540832961100139160197256291
(ACOS).474336540832162101147179198209
Nihon496836540834762100138177
Rinsho.51603654083385391118155194206
2016;538136540833771103134146
74(5):30473754083346584118136148
778–782.321037540833469102139171204238250
49.30473853085367285
Martinez-Garcia314738540835789110135150188223253274321353375406421453
MA,361538540835698112
Miravitlles37433854083567192125157173195211226261287
M.404638540835670
Bronchiectasis41313854083375996135167205220254287311344371385412
in455838540831654
COPD462738540834287124169
patients:48113854083407395110145183205232245
more507138540835998119153
than52403854083236193131
a5387385408333
comorbidity?543638540833168304739540835796117157172211226249283306
Int33693954083145274
J3458395408324
Chron34983954083407799136174
Obstruct368839540834786113136158196228252
Pulmon39563954083357287145183222
Dis.41933954083456187100
2017;430939540833468100129139
12:44633954083346477
1401–1411.455539540833465101133166197228258286295
50.30474053085367287
Polverino31494054083367388121155176192230268
E,343240540833347
Dimakou349440540834561119151181219257
K,376640540833550
Hurst383140540834582104131154
J,400040540832537
et405240540833457
al.41244054083324860
The420040540833372107
overlap432240540833870104125141173212
between45504054083397497150184219258
bronchiectasis48234054083396098136168206221256289313346372387413
and525140540833371110
chronic5376405408331699112830474154083375284
airway31464154083304566119151182
diseases:33434154083365177111143170204231243
state36024154083234679100134
of375141540833554
the38204154083195792
art39274154083305175
and401741540833067106
future41394154083155476114135169
directions.43234154083365172106138162177215253279293
Eur46314154083306687
Respir47344154083326794133148169
J.491841540832234
2018;49674154083326698128140
52(3):51234154083316482115132144
1800328.52824154083326298133166199232246
51.30474253085367082
Yu314442540833469
Q,322842540834559
Peng330242540833467105144
H,346242540834255
Li353242540833045
B3592425408334
et364142540833255
al.37114254083304558
Characteristics378442540833876109130163195219253274290316339354386414
and421342540833068107
related43354254083195369101123157196
factors45474254083164982106143164191
of475442540833555
bronchiectasis48244254083375896134166204219254287311343370385411
in525042540831351
chronic53164254083306889126165180212
obstructive304743540833777104127148186219243258291325
pulmonary33874354083397792150188227259280314
disease.37174354083385379114146172207220
Medicine395243540835489129144176191229264
(Baltimore).42314354083195588103125141198237258292310321
2019;456743540833468100130143
98(47):47254354083357089122154173185
e17893.49254354083346494127161194206
52.30474453085367288
Sánchez-Muñoz315144540833872111143182218248270327366404443472
G,363944540834964
Lopez-de-Andrés371944540833775115151181204245280304346385425447481509
A,424444540834661
Hernández-Barrera432144540835086108147180219258294324347384418440462497519553
V4890445408341
et494744540833558
al.50214454083375367
Bronchiectasis510444540834062100139172211227262296320354381397423
in304745540831553
patients31164554083397395111146185207236
hospitalized336845540833776104143160183216232248278313353
with37374554083506790129
acute388245540833164103126160
exacerbation405845540833467100133167189229263286302340379
of445345540833858
COPD452745540833986122168
in471145540831553
Spain:478045540833372106122160173
Influence4969455408315547289127162201234269
of525445540833757
mortality,532745540835796118144177304746540831530548899
hospital316246540833978105145161184218234
stay,34124654083275185116127
and355546540833372111
hospital368246540834079106146162185218235
costs39334654083327097121150
(2006-2014)40994654083205489126162187218253286317335
according44504654083346798136158197213251291
to475746540832361
gender.483446540834075114154189211222
PLoS507246540833769107139
One.522746540834988124137
2019;538046540833670103134147
14(1):30474754083346686118134146
e0211222.320947540833571105137165196231267280
53.30474853085367186
McDonald314848540835487132171209242257296
MN,3459485408354100113
Wouters358748540835793131154188209236
EFM,383948540833264118131
Rutten39854854083357395120154192
E4192485408332
et424048540833355
al.43114854083314659
It’s4386485408314365176
more447748540835896118152
than46444854083216092130
low478948540831553104
BMI:490848540833590106118
prevalence50414854083396094127160175210248280314
of537048540833756
cachexia544148540833164304749540833169104136151183
and324649540833169108
associated33704954083325885123156171203224258298
mortality368349540835796117142175190205228261
in396049540831452
COPD.402749540834086122167178
Respir42204954083367198137152173
Res.44094954083357097110
2019;453549540833468100130143
20(1):46934954083346888119134146
100.485449540833466102114
54.30475053085367388
Kwan315050540833685118156
HY,33225054083448088
Maddocks342650540835587126165203236266295
M,373650540835569
Nolan382050540834584100132170
CM400550540834196
et411650540833557
al.41885054083334861
The426450540833373108
prognostic43875054083396198137175214240264279311
signifikance47135054083274280118134151168198232270302335
of506450540833857
wieght513650540835167102141179201
loss53525054083155380107
in547450540831553
chronic30475154083316990128166181213
obstructive327551540833878104128149187220244259292326
pulmonary36165154083397893151189227260281315
disease39465154083395480115147173208
–4170515408335
related42215154083215571103125158198
cachexia:44345154083326597135170202217249261
a4711515408332
prospective47585154083396198125163199232256271304338
cohort511151540833269108146167192
study.53185154083275088127159169
J5503515408324
Cachexia304752540834073105143178209225257
Sarcopenia33195254083336687118155194230268283315
Muscle.364952540835593119151167201214
2019;387852540833468100130143
10(6):40365254083346685119137149
1330–1338.42005254083346497132170200230263298311
55.30475353085367186
Mokari-Yamchi314853540836099130164185201223256286344377415430
A,359453540834660
Jabbari367053540832962101141175196212
M,389753540836074
Sharifi398653540833876109130146164181
A4182535408347
et424453540833557
al.43175354083375265
Low439853540833774126
FEV1453953540833870109143
Is469753540832046
Associated475953540834674101140173188220242276316
With509153540836379102140
Increased52475354083205890112146178205240280
Risk30475454083355177107
Of316954540834667
Cachexia325154540833972104142177209224256
In352354540831452
COPD359054540833985121166
Patients.37715454083356788104138176198226239
Int40265454083145273
J4114545408324
Chron41535454083397798136174
Obstruct434254540834786113136158196228252
Pulmon46105454083347187144183221
Dis.48465454083456187100
2019;49625454083336799129142
14:51195454083346577
2433–2440.52115454083346698131167199231268304316
56.30475553085367288
Sanchez315055540833063101133171206235
FF,34005554083306268
Faganello34835554083305998130168203218233271
MM,3770555408352106120
Tanni39055554083305896134149
SE406955540833062
et414655540833254
al.42155554083294557
Anthropometric42885554083387697136157194233272330365387408424455
midarmmeasurements475955540835469108140161220290324356383420441475532567605627654
can542855540832962100
detect30475654083387395129162186
systemic32485654083276087110143201217248
fat-free3512565408319527494113135170205
mass373256540835891117144
depletion389156540833974113129164186202239278
in418456540831654
patients42535654083397294109144182204231
with45005654083516789127
chronic46435654083327091128166181213
obstructive487256540833877104127149187219243258291325
pulmonary52135654083397793150189227259280314
disease.30475754083385379114146173208220
Braz32825754083365790120
J3417575408324
Med345657540835590129
Biol36015754083355088104
Res.37215754083357097110
2011;384757540833468100127136
44(5):39985754083347191124142154
453–459.416857540833467100136173206238249
57.30475853085367180
Brat31425854083365790112
K,326958540833650
Svoboda333558540833263101140179219251
M,360158540835568
Zatloukal36855854083387192108146184214248263
J,396358540832537
Plutinsky40155854083365088110126164190220254
M,428458540835568
Volakova43685854083367288120150187219252
E,463658540833246
Popelkova469758540833572112147163193230262295
P,500758540833640
Novotna506358540834583115152174213245
B,532358540833649
Dvorak53875854083457911730475954083215485
T,314759540833847
Koblizek321059540834078118134150179214244
V.347059540834150
The353659540833878113
relation36655954083256076108130146184223
between390459540834480103156191227265
clinical41855954083375267106121153186202
phenotypes,440359540834483118157195218252292328355368
GOLD478759540834997130177
groups/stages497959540834465103141181208234259282316355390417
and541259540833776115
mortality304760540835796117142175190205227261
in332460540831856
COPD339560540834490126171
patients35816054083437697113147186207235
-3831605408325
a3871605408336
prospective39226054083396198125164199232256271304338
multicenter427560540836299115137152184218256278311333
study.46236054083305391130162172
Int48106054083195779
J4904605408328
Chron494860540834381102140178
Obstruct514160540835191118141162201233257
Pulmon54136054083397792304761540835796134
Dis.31966154083466187101
2021;331261540833469101133141
in346861540831553
press.35366154083396195121148162
58.30476253085367288
Ajmera315062540834460117153174207
M,337262540835771
Sambamoorthi345862540833669126166199256295333355380418433
U,390662540834758
Metzger397962540835893115146184219240
A4234625408344
et429362540833457
al.43656254083355063
Multimorbidity444362540835896111133149206245266306321360375398432
and489062540833573112
COPD501762540834388124169
Medication520262540835792132147179212234249287325
Receipt304763540833570103137152191213
Among3275635408344102140179218
Medicaid350863540835792132147179212227266
Beneficiaries378963540833874112147164181213228260281297332359
With41636354083607699137
Newly431563540834883134150181
Diagnosed45126354083486395134172211237272312
COPD.483963540834388124169180
Respir503563540833873100139154175
Care.52266354083427596130143
2015;538463540833771103133143
60(11):30476454083347089121149163175
1592–1602.32376454083346497130164195226262294307
59.30476553085367184
Jantunen31466554083245694116154192227265
J,342665540832436
Haahtela347765540834476109147168202218250
T,374265540833241
Salimäki3798655408332658196153186216232
J4046655408323
et408565540833356
al.41566554083314760
Multimorbidity423165540835492107129145202241262302318356372394428
in467465540831452
Asthma,47426554083406891129187219232
Allergic49906554083405671106127165180212
Conditions521765540834077115154170192207245284310
and304766540833270109
COPD317166540834287123168
Increase33546654083175587108142174201236
Disease36056654083476288123155182217
Severity,383766540833469101136157172195229238
Drug409166540834668106145
Use425266540834571106
and437366540833371110
Costs:449966540834178105128156168
The468266540833474109
Finnish48066654083344987125140166204
Pharmacy502566540833674106127186218250284
Survey.53246654083347193127162193203
Int30476754083155374
Arch31376754083416293131
Allergy32836754083415772107128166198
Immunol.349667540831573131168206245261274
2019;378567540833468100130143
179(4):39436754083346497116149167179
273–280.413767540833467101138169203238251
60.30476853085367388
Spyratos315068540833371103125158179216243
D,340868540834556
Haidich34806854083437691130145177215
AB,37106854083417789
Chloros38156854083397793131152190216
D4047685408345
et410768540833456
al.41786854083324760
COPD425468540833985121166
screening44356854083265879113149187202240279
program:47296854083396098137158191249261
What500668540835796128150
is517168540831440
appropriate522768540833170110132169208230246278304769540832255
target31186954083215475113148171
group33046954083385996135174
population?349369540833977117155171203225240278316341
Respiration.38496954083367197136152173206228243281319333
2017;419769540833468100129139
94(1):43516954083357090122136148
74.45146954083346577
61.30477053085366981
Ulrik3143705408347628399129
CS,32877054083437789
Løkke339270540833472103134169
A,357670540834458
Dahl364970540834880119134
R3798705408338
et385270540833659
al.,3926705408335506376
TOP401770540833582118
study41507054083295290129161
group.432670540834162100138177189
Early45317054083356889105137
detection46837054083417698132165189204242281
of497970540834059
COPD505470540834288124169
in523870540831855
general530970540834176114149170203218
practice.30477154083396093125150165197230243
Int33057154083155374
J3395715408324
Chron34347154083407899136175
Obstruct362471540834787113137158196228253
Pulmon38927154083357288145184222
Dis.41297154083466187101
2011;424571540833468100128136
6:439671540833547
123–127.44587154083356499136166196229235
62.30477253085367187
Jiménez-Ruiz31497254083233996131169204234256293330346375
CA,35397254083398296
Andreas365072540834078117138172204231
S,389672540833244
Lewis395672540833064115131157
KE412872540833468
et421272540833355
al.42827254083314659
Statement43577254083315285107140198233271293
on466572540833675
smoking475572540832583121152168206245
cessation50167254083306390117150172187225263
in529572540831351
COPD536272540833884120165
and304773540833270109
other31717354083386098133154
pulmonary33407354083397793150189227259281315
diseases36707354083385379114146173208235
and392073540833270109
in404473540831553
smokers411273540832784123153188209236
with43637354083516789127
comorbidities450673540833168126165186226241280295318333368395
who491673540835189127
find50597354083173472111
it518573540831537
difficult5238735408338537290107140177193215
to546873540832259
quit.30477454083387691113127
Eur31897454083336990
Respir32947454083367198137152173
J.348374540832436
2015;353574540833468100130140
46(1):36917454083347089121135147
61–79.38537454083346598129163173
Další46037589011061108131169193
literatura481475890110244779125158204236287320366
u51997589011051
autora5269758901104597129179212258
a41207729011046
na4184772901105298
www.casopisvnitrnilekarstvi.cz430177290110671372082272683143524034574805185656186416737057587818058528989459781016104910971121114311841226