774
PŘEHLEDOVÉ42522701004388130181216258306358404446
ČLÁNKY88722701003973122176223272
Preleukemické42533701004065100115151188223257317332362397431
fúzne8723370100205890128163
gény105133701003773111147
typické121433701002564102118148182217
pre14473370100376196
akútnu155933701003469107134172210
myeloidnú178533701005995130146184200238275313
leukémiu21143370100155088122157217232270
E1220422701004170106
|325227010043
VNITŘNÍ4268043010746106127172220280301
LÉKAŘSTVÍ748804301074185130188236280325378400
/11688043010757
Vnitř12458043010771118137165191
Lék1456804301074083122
2021;1597804301074487129168178
67(e5):1794804301074486106147191213228
e9–e122042804301074387135181218255
/23178043010777
www.casopisvnitrnilekarstvi.cz442680430107651332012142542953293774274464795215705896176436927117307748128548809159449871007102310631101
8.4256380853652
Kosik492639083347298113143
P,6516390833438
Durdik7056390834482104142157187
M,9076390835467
Skorvaga989639083326299121156189228260
M,12646390835467
Klimova1347639083345065123161193226
D.15886390834556
Induction1659639083145291129161185200238277
of19516390833656
AML20226390834096128
Preleukemic2165639083345589105139177207241299314346
Fusion2527639083316794109147185
Genes27276390834379117152178
in4257390831553
HSPCs4937390834476111151179
and6877390833270109
DNA8117390834591132
Damage9587390834577135168207241
Response1215739083357097136174213239274
in15057390831452
Preleukemic1572739083355590105140178208242300315347
Fusion1934739083326995110148186
Gene21367390834378116151
Positive2303739083357198113135151183217
Samples.25367390833265123162178212239253
Antioxidants28047390834179425839083223775105121160192230251279
2021;7198390833569102133141
10(3),876839083346585118136147
481.10388390833470102112
9.4259380853649
Laguna‑Olmos4909390833568107145183215238288304361400427
M93293908357
et10059390833759
al.1079939083355164
Leucemia11589390833569106139172230245277
mieloide14519390836075110126164179218253
aguda17199390833574112151183
y191793908334
pre‑eclampsia1967939083426397120157189205237295334361375407
coexistente.23909390833471107138154180203237275296330342
Algunas27489390834459981364251039083387096
dificultades537103908337527087119157172195228267301328
diagnósticas.8811039083375284123161200226250265297330356370
A1266103908341
propósito13221039083386097137176202217240277
de161410390833772
un170210390833674
caso.17921039083316390128141
Revista194810390833570102118144167200
chilena21631039083316984100134172205
de238310390833873
obstetricia247110390833776103126160182204219251266298
y2785103908330
ginecologia28301039083385342511390833873105142158196236251283
2020;72311390833468101135148
85(2):8871139083346885119137149
155–161.10511139083356597133164195226235
10.4251238085367085
https://ghr.nlm.nih.gov/gene/AML152512390833859841231501621892102452833043153543694274404794945325455846226546777137487868218478849409721002
[cit.154212390831848648699
2021-02-18]165712390833468101132151188221241272303321
11.4251338085366781
Krejci5231339083365995112145161
O,70113390834860
Wunderlich77813390835896135176212235252268302341
M,113613390835569
Geiger12221339083448198138174197
H.143613390834459
p53151213390833974108
signaling16371339083264383122156173189228269
in192313390831554
response19941339083215684125165205233269
to228013390832260
increased23571339083155488110146179207243284
DNA265813390834693135
damage28101339083397242514390835791132168
sensitizes61014390832662102129146170186217252280
AML1-ETO90714390834198132163183219255303
cells12271439083316683100127
to137114390832260
stress‑induced14481439083265174109137165188205244285324357392433
death.189814390833875108131171185
Am.2100143908341100115
J.223214390832438
Hematol228714390834481140174197235252
2008;255614390833570108144158
111(4),27311439083346392109143162174
2190–2199.4251539083346799136175208241273309322
12.4251638085366884
Oo52416390834584
Z623163908336
M,67416390835366
Illendula755163908313284378116155193208240
A,101116390833953
Grembecka10791639083426397155194230263293326
J.142116390832234
A1470163908339
tool15251639083195695111
compound165116390832966124163202240278317
targeting19841639083195273111146169184222261
the22601639083205893
core23681639083296688122
binding25051639083375290129144182221
factor27421639083164981105142164
Runt42517390833573111133
domain57317390834180138170185223
to81217390832562
disrupt8891739083415783104142181203
binding11081739083425795134149187226
to134917390832662
CBFβ142717390834379112149
in159117390831856
leukemic16621739083195391121155213228260
cells.1938173908334688499125138
Leukemia209217390833569106137171229244276
&2383173908336
lymphoma243517390831143102141179218276308
2018;275917390833771103134146
59(9),4251839083346686118136147
2188–2200.5881839083346596132169200235269305318
13.4251938085356781
Zahedipour52119390833467104138176191229266304324
F,86019390832934
Ranjbaran90919390833264101115153185206238275
R,119819390833346
Behzad125919390833266103131164202
A1476193908337
et152819390833152
al.15951939083284355
Development166519390834276108141156193231288322360380
of206019390833453
Flow21271939083294380130
Cytometry‑Fluorescent22721939083366387123180214236257290311344358395432453486512543576613634
In42520390831553
Situ4932039083304567105
Hybridization61320390834274114135151189205234267289304342380
(Flow‑FISH)10092039083164863101152174208223255298317
Method134220390835287109147185225
for15822039083165475
Detection167220390834379101135167191207244283
of197020390833554
PML/RARa204020390833286118146182225261294
Chromosomal23492039083387596134192230257295353385401
Translocation276520390833047801184252139083264179112145167182220258
in69921390831755
Acute76921390834476113136170
Promyelocytic9542139083385996154185219235273306339364379411
Leukemia138121390833468106136170228243275
Cell16712139083437792107
Line.17942139083344987122134
Avicenna19442139083437490122155193231264
J.222321390832739
Med.227821390835792132145
Biotechnol24382139083385492113147180218256294310
2017;276321390833771103133142
9(2):4252239083345387105117
104–108.55722390833566102140170202237251
14.4252338085356782
Lallemand‑Breitenbach,522233908328617590123180211248286307343364397411433466503541573604641653
V.118923390833341
PML124523390833284115
nuclear137523390833470101116150180201
bodies.159023390833673112126160186199
Cold18032339083377388125
Spring19432339083296788103139177
Harb21352339083407292131
Perspect22802339083326485111149183215238
Biol2533233908332468398
2010;26462339083316495125137
2(5).2798233908331478097108
15.4252438085366882
Matt52224390835284106130
S,66724390833043
Hofmann7252439083428099157189227265
T.100524390833039
G.106024390834155
Crosstalk11302439083375895121148171203219248
between13932439083377294147181216254
p53166224390833670103
modifiers178024390835493132147164181216237264
at205924390832951
PML212524390833386118
bodies.225824390833675114129164190204
Molecular247724390835290106140173210225257278
&2771243908335
cellular282124390832861425253908315306783115136
oncology57625390833876108145161199239271
2018;86225390833468100131143
5(3).10212539083345285102113
16.4252638085366985
Wang,52526390835688126165177
G,71826390834255
Tian7892639083314880118
Y,92226390833442
Hu97926390834380
Q.107526390834557
PML/RARa114726390833487119147184227263295
blocks14582639083375391124154183
the16562639083205893
differentiation1765263908336517190124146180218239255287308324362400
and218026390833169108
promotes23032639083375996154193214248275
the25932639083205994
proliferation27022639083375996112127146180425273908321547591129167
of60727390833656
acute67827390833062100123157
promyelocytic8502739083375996154185219235273306339364379411
leukemia12772739083134886116150208223255
through15472739083205980117155194232
activating17942739083316387102135168190205243282
MYB209127390835388125
expression223127390833364104126160186213228266304
by255127390833768
transcriptional263427390832142751131391721932092484252839083223775113146161
and60128390833270109
epigenetic7262839083347388127162200235257273305
regulation10462839083215594132147179201216254293
mechanisms.135428390835893125163196234249275332359372
J.174228390832436
Cell.17942839083407389104117
Biochem19262839083365189122160195252
2019;219428390833468100130143
120(2):23522839083346498118152170182
1210–1220.25492839083346495127165196226260294307
17.4252938085366876
Zhu51729390833674112
H644293908343
H,70229390834255
Yang77329390833363101140
M928293908353
C,99629390833952
Wang106329390835687125164
F.124229390833137
Identification12952939083135287125147162180197229261283299336375
of168529390833655
a1756293908330
novel180129390833674106140156
NUP98–RARA197229390834388123158193230267310346389
fusion2377293908316558196134173
transcript25652939083204174112139171192208247269
as284929390833057
the4253039083226095
14th5353039083346560130430491335
variant6513039083326586102134172193
of86030390833756
acute93130390833264102125158
promyelocytic11053039083386097156186221236274307340365381413
leukemia.15333039083155087117152209225257270
Am.181830390834199112
J.194630390832436
Hematol199830390834479137169191228244
2020;225730390833468101135148
95(7):24203039083356986121141152
E184–E186.25883039083326495131169203234265301314
18.4253138085366985
Testi5253139083316289112127
A668313908339
M,72231390835367
Biondi8043139083344987126165180
A,99931390834054
Coco106831390833875108145
F1228313908331
L1274313908330
et132031390833254
al.13903139083304558
Protocol14633139083345592114151183220236
for17153139083165476
the18063139083205893
treatment19153139083204175107129187222260282
of221231390833655
newly228231390833671122138170
diagnosed24673139083375284123161199226261301
acute27833139083306210042532390832255
promyelocytic4963239083386097155186220236274307340365380412
leukemia9243239083154987117151209224256
(APL)11963239083186095126145
in135732390831452
children.1425323908331698499138159193231245
Blood16853239083355189128167
2005;186832390833468104138149
106(2),203232390833466102121154172184
447–453.223132390833471103136172205238251
19.4253338085366982
Soignet5223339083316984123161196219
S756333908330
L,80233390832943
Maslak86033390835285111127159189
P,106433390833338
Wang111733390835587125164
Z1296333908336
et134733390833254
al.14173339083294558
Complete149033390833875133172188223245279
Remission178433390833368126141168194209247285
After20853339083395883116138
Treatment22383339083304882113135193228266288
of254133390833555
Acute261133390833970108131164
Promyelocytic.2791333908333549142534390835788122138176209242267282314328
NEJM76834390834578104159
1998;9433439083346499134147
339:110534390833467100113
1341–1348.12343439083346499129162193223258294308
20.4253538085367287
Burnett5273539083347293131166189213
A755353908339
K,81035390833347
Russell8733539083337197124159174189
N1078353908343
H,113635390834255
Hills1206353908342587388114
R1335353908334
K.138435390833348
Myeloid144835390835284118134172187226
Leukaemia168935390833064102132165200258273305
Working201035390835592113144160198237
Group.226235390834264101139178191
Arsenic24683539083396088123161176208
trioxide2691353908320415795125141180215
and42536390833270109
all‑trans549363908332476284107128161199226
retinoic790363908320547792130168184216
acid10213639083326479118
treatment11543639083214377109131189224262283
for14533639083185577
acute154536390833264102124158
promyelocytic17193639083386097155186220236274307340365380412
leukaemia21463639083155088118151186244259291
in245236390831553
all25203639083324762
risk2598363908320366292
groups27053639083385996134173200
(AML17):42537390831960116149179208228240
results6813739083256087124140163190
of88737390834362
a965373908337
randomised,10173739083265998137176234249276311351364
controlled,139637390833774113135156194210225260300313
phase172437390834483116143178
31917373908340
trial.1972373908327496597113126
The211337390833878113
Lancet224137390833771109142176198
Oncology245537390835291123161177215255287
2015;275837390833974106136147
16(13):4253839083346584116146163175
1295–1305.6153839083346498133169200230264298310
21.4253938085367082
Platzbecker5223939083375284106136176212244274308330
U,86739390834556
Avvisati93839390834373108124150183205220
G,117439390834558
Cicconi12473939083425789120157195210
L.147239390833347
Improved153439390831674113135172204238278
outcomes182739390833977100130167225260287
with21303939083526790128
retinoic2273393908322567894132170185217
acid25063939083336580119
and264039390833371110
arsenic276639390833354811164254039083385385
trioxide525403908323446098128144182217
compared75840390833269127166199221255294
with10674039083526890128
retinoic1211403908322567893131169185217
acid14434039083336580119
and157840390833371110
chemotherapy170340390833270105163202223262297318351390421
in214040390831553
non‑high‑risk220940390833877115138176192230268291313328355384
acute260940390833365103125159
promyelocytic2783403908340629930476390835788122138176209242267282314
leukemia:3377639083185391121155213228260272
final3665639083213875108123
results3803639083255986123138161188
of40076390834160
the4082639083266499
randomized4196639083255896135173231247276310349
Italian‑German456163908318417389104136174196242278299358390428
APL040650046390834581112146182218254
trial.527363908326476395110123
Am.541163908345103116
J.30477390832437
Clin.3099739083405570108121
Oncol32357390834786118155171
2017.34217390833569100130136
22.3047838085367288
Bernard3150839083367293131164185223
O,33888390834859
Berger3463839083367192130165186
R.36658390833650
Molecular37318390835593109144177214230262283
basis4029839083407399114140
of41858390833857
11q234257839083356398132167
rearrangements4439839083225688109130163201240275333368406428456
in49108390831553
hematopoietic49798390833873131163185222261300316350373388420
malignant541483908358913047939083153069107139177198
proliferations.3261939083386097113128147182203236258273311350376389
Genes36669390834479117152179
Chromosomes3860939083407899136195233260298356391418
Cancer42939390834073111143177198
1995;13:4507939083346499133144174204216
75–85.47389390833467103139173185
23.30471038085367287
Balgobind31491039083336681120158198213251290
B3454103908333
V,350210390833443
Raimondi35601039083336580138176215254269
S3844103908330
C,388910390833851
Harbott39551039083427495134173195219
J4189103908322
et422610390833254
al429510390833045
Novel435510390834381113147162
prognostic45331039083365795134172210237260275307
subgroups485510390832461100140161198236275302
in517210390831250
childhood5237103908329678297136174212250290
11q23/MLL‑rearranged30471139083346297131166190245277309324346380412433455488526565600639
acute370111390833466104126160
myeloid387611390835990125140178194233
leukemia:41241139083165189119153211226258270
results44101139083225683120136158186
of461111390833958
an468511390833371
international47711139083175576110131170202224239277315348363
retrospective51501139083225678100137164203238271295310343377
study.30471239083264987126158168
Blood32311239083355189127167
2009;341312390833569105140153
114(12),35811239083346293112144174192203
2489–2496.379912390833566102137174206238271306320
24.30471338085367186
Kuntimaddi314813390833674112133148206239278317332
A,349513390834256
Achille356713390834273111127142157192
N3774133908346
J,383513390832638
Thorpe388813390833473111133173208
J.411213390832537
Degree416513390834682121142176212
of439213390833958
recruitment44651339083225689110149164186244279317339
of481913390833958
DOT1L489213390834795128161189
to509613390832360
MLL‑AF9517213390835587119135176209243
defines54301339083397430471439083173472107134
level31961439083185385119135
of334614390834059
H3K79342114390834781116151184
di-36201439083415779
and371414390833573112
tri‑methylation3841143908325466284143178200238269285317339354392431
on428714390834079
target43811439083245778117151174
genes457014390834176114149176
and476114390833573112
transformation48881439083254679117144164201223281314335351389427
potential.533114390834180102136174304715390832237698497
Cell31601539083397389104
Rep327915390833671110
2015;340415390833468100130141
11:35601539083346271
808–820.364615390833469105142178212246258
25.30471638085367287
Rowley314916390833371122138173204
JD.33681639083226879
The346216390833069104
critical3581163908329506688103135168183
role37791639083195671106
of390016390833554
chromosome39701639083286687124182220247285343378
translocations43631639083204174112138153191223256278293331369395
in477416390831250
human483916390833572130162200
leukemias.50541639083134785115149207222253280293
Annu.536316390833876114151164
Rev.304717390833570103113
Genet317517390834479117152174
1998;33651739083346499134147
32(1),35271739083346784116130141
495–519.368417390833467101137171202232243
26.30471838085367187
Tonks314918390833367105135164
A,332918390834054
Tonks339918390833266105135164
A3578183908341
J,363418390832436
Pearn368518390833569101122160
L3861183908331
et390718390833456
al.39791839083314659
Expression405418390833265104126160187213228266305
of437418390833756
AML1-ETO444618390834096128158176211246292
in475418390831452
human482118390833875133165203
myelomonocytic504018390835787122137176234272311349382415440455487
cells3047193908331658196122
selectively31841939083256075110143167182215249265296
inhibits34961939083135189104143159181209
granulocytic37201939083375891129167182220253286311326358
differentiation4094193908337527190125146180218240255287309324362400
and451019390833068107
promotes46331939083375996154192214248275
their49231939083205994109130
self‑renewal.5068193908325607695115137171209244296328344357
Leukemia544019390833064304720390833767101159174206
2004;326920390833468104140152
18(7):34372039083346584118138150
1238–1245.36022039083346499133170201231263296308
27.30472138085367180
https://ghr.nlm.nih.gov/gene/RARA314221390833859841231501621892102452833043153543694274404794945325455846226546777137487868218478849269621005
[cit.416321390831848638699
2021-02-18]427721390833569102133152189222242273304322
28.30472238085367288
Nunes315022390834987125160187
V3352223908340
S,340822390833749
Moretti347322390835997119153175199214
N3703223908349
S.376722390833750
Nuclear383322390834986119134169201222
subcompartments:407022390833168107140177235274307328353411446484506533546
an463122390833674
overview.472122390834173108129164179214265276
Cell50122239083457894109
biology51362239083435997113151191223
international5374223908319577811213330472339083387092107145183216231
2016;329323390833469100132144
41:34522339083346573
2–7.354023390833569101107
29.30472438085367286
Wood3148243908363100139178
A3342243908346
M,340324390836073
Garza‑Gongora349224390834982103134167190236275314353391413446
AG,395424390834689102
Kosak407224390834078104138168
A.425524390834761
A4332243908346
crowdsourced43932439083375896147185212250288310341375414
nucleus482324390834380113128163201227
:5066243908317
understanding509824390834381120155177204227260298337353391430
nuclear304725390833877110126161194216
organization327925390834366105138177193222257279295334374
in366825390832160
terms37442539083276283143170
of393025390834464
dynamically400925390834577117150210225258292308324356
networked438125390834480103157196218249285325
protein472225390834567105128162178217
function,495525390832464103136161176215255268
BBA523925390834178120
2014;537525390834075108140152
ISSN30472639083154779124
1874-9399.31862639083346598129152187219253288299
30.30472738085367287
Lang314927390832962100139
M,330327390835265
Jegou33832739083225796134172
T,357027390833039
Chung362427390833875113150189
I,382827390831325
Three‑dimensional38682739083306990124159182222237295329367393408446484516531
organization44142739083355794127164179208241263278316354
of478327390833554
promyelocytic48522739083365895153183217233271303336361376408
leukemia52752739083124785114148206221253
nuclear304728390833875107123157189210
bodies.327328390833877117132167193207
J.349528390832537
Cell.35472839083407490105118
Sci36802839083326580
2010;377528390833468100132145
123(3):39352839083346499117150168179
392–400.413028390833467100135171207243256
31.30472938085356880
Lausten‑Thomsen31422939083296198124147180217239268307344402427462499
U,365629390834151
Madsen372229390835183122147182219
HO,39562939083418899
Vestergaard40692939083336591114147168205237268289326
TR441029390833066
et449129390833153
al.45592939083284356
Prevalence46302939083325285117149164198236267300
of494529390833453
t(12;21)[ETV6-RUNX1]-positive501329390831937689811014417518920623927331334636840544849330473039083387085107147186213228250265298332
cells3395303908331648095121
in353230390831452
healthy359930390833873105120142181211
neonates.382630390833772111149182203237264278
Blood41193039083355189128167
2011;430230390833468100127136
117:44533039083346291101
186–189.457030390833465100138169200234245
32.30473138085367186
Wayne314931390835990121160195
AS,33593139083427689
Baird34633139083366984105143
K,362231390833650
Egeler368831390833371106122157178
RM.388131390833692106
Hematopoietic400231390834580138170192229269308323358380395427
stem44453139083275084141
cell4602313908332668196
transplantation47143139083224477115141180196228266288320342357395434
for51633139083195779
leukemia.52573139083165188118153210226258271
Pediatr304732390833569108123155177198
Clin32613239083405570108
North338432390834583105129167
Am356732390834199
2010;368132390833468100132144
57:38413239083346777
1–25.39343239083346798133145
33.30473338085357084
Oliansky31463339083445974105142168197230
DM,339033390834296109
Rizzo35143339083324776106142
JD,36713339083216677
Aplan37623339083387692123160
PD.39373339083327687
The403933390832967101
role41553339083185470104
of427333390833453
cytotoxic43413339083286185121142178207222254
therapy46093339083195690111143181212
with48363339083476284121
hematopoietic497233390833468125156177213252290305339360375406
stem53933339083234578135
cell3047343908331658196
transplantation31583439083264780118145183199232270291324346361399437
in361134390831956
the36833439083266499
therapy37973439083266499120153193224
of403634390834261
acute411234390833668106129162
myeloid429034390836192126142180196234
leukemia45403439083195491121156213229261
in481634390831957
children:48883439083357388104143164198236248
an515134390833674
evidence­52413439083387086125160198230264287
‑based30473539083216194120155195
review.32573539083215587103138189200
Biol34723539083355189105
Blood35923539083355189128167
Marrow377535390835487108130167218
Transplant40083539083335083121147186202234272294
2007;431735390833468105137147
13:44793539083346476
1–25.45703539083346799134145
34.30473638085367388
Rosenthal315136390833574100135173195233266281
J,344736390832436
Woolfrey349836390835894133149168190224256
AE,37693639083417487
Pawlowska387136390833567118133171223250279313
A4199363908341
et425536390833456
al.43273639083314659
Hematopoietic440236390834378136169190227267306321356378394426
cell4843363908331648095
transplantation49543639083214275113140179194227265286319341356394433
with54023639083506688126
autologous30473739083326992129145183222261299325
cord33873739083316890128
blood35303739083395593132171
in371737390831452
patients37843739083397294109143182203231
with40303739083516689127
severe41723739083266193128149183
aplastic43703739083327187119146169184216
anemia:460137390833270105163178210222
an483937390833169
opportunity492437390833776116155176201239277292315348
to528837390832158
revisit53613739083215587103129144166
the30473839083226095
controversy315738390832966104126147185217251272299332
regarding35043839083185292124145184199237276
cord37953839083296687125
blood39363839083365290129168
banking412038390833669107137154191230
for43663839083165375
private44563839083375874106139161195
use.46663839083356196109
Pediatr479038390833366106121153175196
Blood50013839083334987126165
Cancer518238390833770108140174195
2011.53933839083316597125134
35.30473938085367085
Ballen3147393908333668196130168
K3330393908332
K,337739390833247
Verter34393939083336586111144165
F,361939390833036
Kurtzberg36703939083326990114144184219240278
J.396339390832133
Umbilical401239390834198137152167182213246261
cord42883939083296586124
blood44273939083365290128167
donation:460939390833673112144165180218256268
public489239390833674112128143174
or508139390833556
private?51523939083365873105138159193217
Bone538439390833371109144
Marrow304740390835487108130167218
Transplant32814039083324982120147186201234272293
2015;359040390833468100130140
50:37464039083346881
1271–1278.38424039083356497130163194224256290303
Rádi26259090423164309462539
vám85759090423138283519
pomáháme14315909042315730654268884699112261371
v285759090423138
on-line305159090423151309398475550709852
vzdělávání395959090423138262415559636782913105812161292
Získejte283810101765690137196256288333393
také6998101017642103163222
nové9448101017663125181240
aktuální12078101017658117162228289322388421
informace1651810101762895136198240339400447508
a21828101017657
kredity2262810101765798159223256301358
v26438101017654
rámci27208101017639100199245278
celoživotního30218101017643104136199249281338399444510543609672
vzdělávání37168101017653104168229261323378438504536
➜432581040216134
https://online.solen.cz4482810101761161612062713183523924334955625946276937547868338969289891056108911361187
2388364550435153307
on-line4376873017060124161192223288346
kurzů8056873017058121162212275
a11036873017059
kongresů11846873017058117181243284342388451
7200232172180435153307460613
účastníků23917635017063109170215259323354412474
160239864550435153307460
přednášek23736873017063104162224289348393452509
134073272180435153307460613
vydaných5417635017055114174234298351394458
certikátů10227635017045103145191222290348409451514