671
PŮVODNÍ497922701004395143193242296315
PRÁCE530922701004489137177218
Th1,39443370100367598113
Th2407333701003675109
a4198337010034
Th1742483370100367598126
lymfocyty439033701001551112133171202240269307
u4713337010037
autoimunitních47663370100347299137153212250288303330368384414452
tyreopatií52343370100256489123163201236263279294
|5584227010018
E235617227010066104139
/35258043010757
Vnitř36018043010771118137165192
Lék3812804301074184122
2021;3954804301074386128167177
67(8):4151804301074485105147170184
E23–E284355804301074287131177220265307
/46828043010757
VNITŘNÍ47598043010791152173217266326347
LÉKAŘSTVÍ5126804301074185131189236281326378400
www.casopisvnitrnilekarstvi.cz42580430107651332012142542953293774274464795215705896176436927117307748128548809159449871007102310631101
Th1,4259870275122248374436
Th29329870275128254388
a13919870275122
Th1715559870275128254379502
lymfocyty21299870275651943814725986988289221053
u42512470275122
autoimunitních58912470275122249339464529716844972103811271256132314231551
tyreopatií221212470275902213134325586878088979641030
Karolína4251635013768126168232262293357415
Absolonová,8631635013772137185249279343408472528586616
Petr15011635013764120161204
Matucha,17271635013793152192257307372430459
Ivan2208163501373290148212
Šterzl2443163501375998156199251283
Endokrinologický4251789013354114176236287325350410470496557618644692743798
ústav,12461789013361104140194244261
Oddělení15311789013375138200255281336396421
klinické1976178901335178103163188237288341
imunoendokrinologie,234017890133261171772372973534144765365876246507107707968579189439981020
Praha3383178901335993146206259
Mezi4252298012183135180204
nejčastější6502298012168120144190240280315366390430454
orgánově11262298012166100157207264320369419
specifická15672298012151109161208232262289335383433
autoimunitní20222298012160116150206230315371428452486543567
onemocnění26102298012167124176262319366423474532555
patří31872298012169119152186210
autoimunitní34182298012160116150206230315372429452486543567
tyreopatie.4007229801214495130181238297347380404456476
Zaměřili45052298012167118203255288312336359
jsme4886229801213575161213
se51202298012151103
na52452298012167117
vý‑53832298012160112144
znam4252438012144101150235
stanovení682243801214882132189245293344401424
Th1,11282438012158116160176
Th213262438012158116167
a15152438012156
Th1715932438012158116161205
lymfocytů1819243801213280167196253299350387443
u22842438012163
autoimunitních23692438012157113146202225311367423447481537561606663
tyroiditid3053243801214192126182206264287321345402
(AT).3477243801213698142174193
Soubor36912438012158115171229286320
tvořilo4032243801214293149182206229286
13643392438012160106157
léčených4518243801213183129179236283328384
pacientů49242438012165115161184236293326382
v53272438012157
pl‑5405243801216690122
ném4252578012157108193
klinickém639257801215580103159182227274324409
rozvoji1069257801214096138190244268291
AT13822578012169112
(241516257801213585134
mužů,16712578012192148191247268
prům.1960257801216598154239260
věk22412578012156106153
41,024162578012158104120172
±26092578012168
16,826982578012159106127181
let2900257801213081115
a30362578012156
11231132578012159101146
žen,32802578012150101157178
prům.3479257801216598154239260
věk37602578012156106154
44,639352578012159113134186
±41432578012167
17,642312578012159103114166
let).4418257801213182116143162
Kontrolní46012578012162116173205238294318374397
soubor50192578012147103159217273306
tvo‑5347257801214091146180
řilo42527180121345881138
175852718012161106
zdravých7122718012153111144194242293338395
mužů11292718012194150194251
(prům.1401271801213896130187272294
věk17162718012159109157
44,018952718012161116137190
±21072718012170
5,02198271801216281134
let).2354271801213385119146165
Ke25412718012164115
statistickým2677271801215084135168191231266289335383435521
výpočtům32202718012158110169226273309365451
jsme3692271801213474159211
použili39252718012167124181225249273296
Box‑Coxovu42432718012164121168197260315362417465522
transformaci4787271801214376126182222253310343429479525548
dat,53572718012166116149170
t‑testy42528580121336092141179212261
a7072858012154
Pearsonovu7812858012159107154185225279334388434489
korelační12902858012153106138187210257301355377
analýzu.16882858012154108155178224269323343
Subpopulace20512858012155109165221276332387409456500548
lymfocytů2619285801213077160188242287335371425
jsme3064285801213069151200
stanovili3284285801214679127181236282305327349
průtokovou3653285801216395150182235281334380433488
cytometrií.4161285801215199135188271320353384407429449
Zjistili4630285801216284106144177199222244
jsme4894285801213069151200
statisticky5115285801214578126158180218251273317362412
významné425299801214898142196243326380429
korelace8752998012152104136185208255299347
mezi12422998012188138180203
Th14652998012155110
a15952998012154
Tc1669299801215592
lymfocyty1781299801212976159187241285334369418
(r2219299801213463
=23022998012164
-0,5605,2387299801213590109161210261311329
p27362998012162
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0,0000),2903299801215776126178230282308326
celkovými3249299801215098121166219265315398420
T36892998012155
a37642998012154
B38382998012159
lymfocyty3917299801212976159187241285334369418
(r4355299801213462
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-0,4877,4523299801213590109159211259309318
p48612998012162
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0,0000),5028299801215776127179231283308326
Th153742998012155110153
a4253138012148
Th174933138012148103146188
lymfocyty702313801212167150178232277326361410
(r1132313801212655
=12073138012157
0,4346,1284313801214968119167218270289
p15943138012154
=16683138012158
0,0000),1746313801214968118170222274300318
Tc2084313801214885
a21893138012146
Th122553138012148103146
lymfocyty2421313801212168151179233278326361410
(r2851313801212755
=29263138012158
0,4124,3004313801214968119163206253272
p32973138012154
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0,0000),3449313801214968118170222274300318
IRI378731380121227498
a39053138012146
Th139713138012148103146
lymfocyty4137313801212168151179233277326361410
(r4567313801212655
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-0,4076,4720313801212882101152203251297317
p50573138012155
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0,0000),5209313801214968119171223275301318
celk.425327801214593116161183
T6283278012152
lymfocyty700327801212572155183237282330365414
a11353278012150
NK12053278012167121
buňkami13463278012159113167213261343365
(r1732327801213058
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-0,8175,1892327801213386105158204246293311
p22243278012158
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0,0000),2384327801215372123175227279305322
paměťovými27263278012159107189238271324370420503525
Th32713278012152107
a33983278012150
Th134693278012151106149
lymfocyty3638327801212672155183237282331366415
(r4073327801213059
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0,7982,4234327801215372121169220269288
p45423278012159
=46213278012161
0,0000),4703327801215372122174226278304322
naivními50453278012157104127174229251333356
Th54213278012151107
a4253418012148
Th14933418012150105148
lymfocyty661341801212470154182236280329364413
(r1094341801212957
=11723418012159
-0,7995,1251341801213185104153202253302320
p15913418012157
=16683418012160
0,0000),1748341801215170121173225277303320
Tc2089341801214987
lymfocyty2196341801212470153181235280328364413
a26293418012148
NK26973418012166119
buňkami28373418012157111165211259341363
(r3220341801212958
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-0,4014,3378341801213084103154206252296316
p37143418012157
=37913418012160
0,0000),3871341801215170121173225277303320
Tc4211341801215088
a43193418012148
celk.4387341801214593116161183
T45903418012150
lymfocyty4660341801212470154182236280329364413
(r5093341801212957
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0,4551,5250341801215271121170217262277
p4253558012157
=5023558012155
0,0000),577355801214766117168220272298315
Th9123558012146101
a10333558012144
celk.1097355801214188111157178
T12953558012146
lymfocyty1361355801211965148176230275323358407
(r1788355801212453
=18613558012155
0,4135,1936355801214766116160204251269
p22253558012153
=22983558012155
0,0000).2373355801214766117169220272298315
Stanovení2709355801214575123177231277325379401
subpopulací3130355801213589144200255311365387434478500
lymfocytů3650355801211965148176230275323358412
je4082355801212069
pomůckou41713558012153108190243287333385439
při4630355801215385107
diagnostice4757355801215274121176230284322355376420468
a52453558012144
léčbě5309355801211968113168218
autoimunitních4253698012148102134187209291345400422454508530574628
chorob,10733698012148102156188242298316
pomáhá14103698012160115197244299346
objasnit17763698012158114137184222276298330
klinické212736980121507496150172216261309
projevy2457369801216092145168217264314
onemocnění27913698012158113162245299343398447501524
a33353698012151
může34063698012187141183232
doplnit36583698012159114170193247269301
interpretaci3979369801212781112161193249281330362410454476
běžně44753698012160110152206256
stanovovaných4751369801214376124178232278331377425479523566620
au‑53923698012151105135
toprotilátek.425383801213386142174228260282304351382431477499
Může9443838012178132174223
pomoci11873838012155110193247292313
určit,1521383801215384128149182202
zda1743383801214196143
jde1906383801212379128
o20543838012153
fázi2127383801212876118141
destrukční22883838012154104142175207261307349403426
(Th1,2734383801212678133176191
Th17,29453838012148103146188198
Tc3163383801214886
lymfocyty),3269383801212268151179233278326362411436454
nebo37433838012154103159214
protektivní3977383801215587141172221267302324371426448
(Th24446383801212678133182
lymfocyty,4648383801212268152180234278327362411426
protilátky).5094383801215587141173195217264295341390416433
Klíčová425400601235885111155211261312
slova:758400601234268124174225248
autoimunitní10274008012148103136190214297351407430463518541
tyreopatie,1590400801213383116166222279328360383433453
cytometrie2064400801214595131185269319353385409459
průtoková,2544400801215790145179233280334381429450
pomocné30154008012157113197252298353403
T34394008012150
lymfocyty.3510400801212471156185240285335371421437
Th1,4254260015067134201234
Th26964260015068135206
and9404260015064133201
Th1711794260015067135202268
lymphocytes14844260015034103203272340407461530580643698
in22194260015034103
autoimmune23594260015064133180247281382482550619682
thyreopathies30784260015048116184233296363432497544613647710766
Among4254458012161143196251306
themost751445801212882131230284322354
common1125445801214193175257311365
organ-specific1510445801215182137183237268306362411456477506531574
autoimmune2104445801214497129182204285367420474524
diseases2648445801215173111160207245294332
are3000445801214475124
autoimmune3144445801214397129181203285367420474523
thyreopathies.3687445801212983127159208262318365397450472521559579
We42864458012180127
have4433445801215198143191
focused4644445801212478122176214263319
on49834458012150105
the5108445801212882131
impor‑52594458012119101156211242268
tance425459801213381135179227
of672459801215482
Th1,7754598012148104146161
Th29564598012149104153
and11304598012147101157
Th1713074598012148104146189
lymphocytes1516459801212369152208263317362410446494532
in2068459801212377
autoimmune21654598012147101133186208291373426481530
thyroiditis2715459801213287131164217240295317349371409
(AT).3145459801212786128159176
The33414598012149104154
cohort3515459801214496151205237272
consisted3807459801214497151189211249282331387
of4214459801215482
1364316459801215094143
treated4480459801213263112159191239295
patients47954598012156104135157207261293332
in5147459801212377
the5244459801213286136
full5400459801212883105127
clinical42547380121456789143165209257279
course724473801214194148180219268
of1013473801215078
AT1112473801215799
(24men,1231473801212573120220269324344
mean15954738012179129176230
age1845473801214499149
41.0±16.82014473801214791106157216258304324376
years2410473801214391138170209
and2639473801214499154
1122813473801214888131
women,29644738012170123206255310330
mean33144738012179129176230
age3564473801214499148
44.6±17.637334738012147100119170229271314324375
years).4128473801214391138170209233250
The43994738012145101150
control4569473801214194148180211265288
group4877473801215283137191247
consisted5144473801214194148186208246279328384
of425487801215583
17528487801215093
healthy6414878012154104151173205259304
men9654878012182132186
(mean11724878012127106156203257
age14494878012147102152
44.0±5.016214878012150103122173232282301351
years).1992487801214695142173213236254
Box-Cox22664878012153108152180241293338
transformation2624487801213263111165203232286318401448479502556610
of3254487801215482
the3357487801213186135
data,35124878012155102134182202
t-tests373448780121325991140178211251
and40054878012147101157
Pearson4182487801215299146178217271326
correlation4528487801214497129161209232279311333387442
analysis49904878012147101148171217256277316
were53264878012172121152201
used425501801215593143199
for644501801212882114
statistical778501801213871119150173211243266309357379
calculations.1178501801214391113157211233280312334388442480501
Lymphocyte1699501801214687170226281335379428463512
subpopulations2231501801213891147203258314369391438470492546600638
were28905018012172120152201
determined31115018012155104137185217300322376426482
by36135018012155101
flow3734501801212853107179
cytometry.3933501801214492128181263313345377426442
We43955018012183130
found4545501801212882136190246
statistically4811501801213871119150172210243265309357379401448
signif‑5279501801213860115169191220248
icant425515801212367115169200
correlations646515801214396128160209232279310332386441479
between11455158012156106139214262312367
Th15325158012149104
and16565158012147102157
Tc1834515801214886
lymphocytes1940515801212369152208263317362410445494532
(r2492515801212857
=25695158012158
-0.5605,2648515801212983103155205256305323
p29925158012155
=30685158012158
0.0000),3146515801215170120172224276302320
total3486515801213285117165187
T36935158012149
and37625158012148102157
B39405158012153
lymphocytes4013515801212369152208263317362410446494532
(r4566515801212756
=46425158012158
-0.4877,4721515801212984103153205253302312
p50535158012156
=51295158012159
0.0000),5208515801215069120172224276302319
Th14255298012150105148
and5935298012151106161
Th177745298012153108151194
lymphocytes988529801212673156212267321365414449498536
(r1544529801213260
=16255298012162
0.4346,1707529801215574124172223275295
p20225298012160
=21025298012163
0.0000),2185529801215473124176228280306323
Tc2528529801215391
and26395298012151105161
Th128205298012153108151
lymphocytes2991529801212773156212267321366414450498536
(r3548529801213160
=36285298012163
0.4124,3711529801215473123168211258277
p40085298012160
=40895298012162
0.0000),4171529801215574124176228280306324
IRI4515529801212780103
and46395298012151105161
Th148205298012153108151
lymphocytes4991529801212773156212267321366414449498536
(r425543801212857
=5025438012157
-0.4076,580543801212882101151203250296316
p9175438012154
=9915438012157
0.0000),1068543801214968119171223275301318
total1407543801213083115163185
T16125438012148
lymphocytes1680543801212167151206261315360409444492531
and22315438012146100155
NK24075438012163116
cells2544543801214290113135173
(r2737543801212655
=28125438012157
-0.8175,2889543801212983102154200242289308
p32175438012154
=32915438012157
0.0000),3369543801214868118170222274300318
memory37075438012181130213267299348
Th40755438012148103
and41985438012146100156
Th143745438012147103145
lymphocytes4540543801212167150206261315360408444492530
(r5091543801212554
=51655438012157
0.7982,5243543801214868117165216265284
p4255578012157
=5025578012156
0.0000),579557801214867117169221273299317
naive916557801215299121169217
Th11535578012146102
and1275557801214599155
Th114505578012146102144
lymphocytes1615557801212066149205260314359407443491530
(r2165557801212554
=22395578012156
-0.7995,2315557801212882101150199249298317
p26525578012153
=27265578012156
0.0000),2802557801214867118170222274300317
Tc3139557801214784
lymphocytes3243557801212167150206261315360408444492530
and3794557801214599154
NK39695578012162116
cells4105557801214189112134172
(r4298557801212553
=43725578012156
-0.4014,4448557801212881101151203249293312
p47815578012153
=48545578012157
0.0000),4931557801214867118170222274300317
Tc5268557801214784
and53725578012145100155
total425571801213386117164187
T6325718012145
lymphocytes696571801212066148203258312356404439487525
(r1241571801212452
=13135718012155
0.4551,1388571801214665115163210255270
p16785718012152
=17505718012155
0.0000),1824571801214766116168219271296314
Th21585718012145100
and2277571801214498153
total2450571801212881113160182
T26525718012145
lymphocytes2717571801211965148203257311355403438486524
(r3261571801212453
=33335718012155
0.4135,3408571801214766116159202250268
p36955718012153
=37685718012154
0.0000).3842571801214766116167219271296313
The41755718012145100149
determination43445718012152101133181212295317370417448470523578
of4941571801215179
lymphocyte5039571801212066148203258312356404439487
subpopulations425585801214093149205260316370393440471493547602640
is1085585801212462
an11675858012149103
aid1291585801214870126
in1437585801212478
the1535585801213488138
diagnosis1693585801215779126181235289327349387
and21015858012148103158
treatment2279585801213465114161193275325379411
of2710585801215583
autoimmune28145858012148102134187209292374427482531
diseases,3365585801215780118167214252302340360
helps37455858012156106129184223
to3988585801213387
clarify4095585801214567114146168197246
the4362585801213387137
clinical451958580121456789143166209257280
manifestations48195858012184131185207235285323356404435457511566604
of5443585801215684
the425599801213387137
disease582599801215880118167215253302
and9045998012150104160
can1084599801214694148
complement1252599801214799182238261310392442497528
the1800599801213589138
interpretation1958599801212579111159191247279328360408440462516571
of2549599801215684
commonly2653599801214799182264318373396442
determined31155998012158107140188220303325379429485
autoantibodies.36205998012150103135188236290322344399454510533582620641
It4281599801212557
can4358599801214694148
help45275998012157106129185
determine47325998012158107139188219302325379428
whether51805998012175130180212266316348
the425613801213387137
phase5826138012156111158196245
is848613801212260
destructive9286138012156105143176208262306341363410458
(Th1,1406613801212879134177192
Th17,16186138012149104147189199
Tc1837613801214986
lymphocytes)1944613801212269152207262317361410445493532556
or2520613801215486
protective2626613801215688141173221266300322370418
(Th23064613801212779134183
lymphocytes,3268613801212269152207262316361410445493532552
antibodies).38406138012147101133155210265321344393431455473
Key4256306012358108158
words:6046306012374130166224266290
autoimmune9156308012148103136190214297380435490540
thyroidopathy,1477630801213388133167221245301356414462495550595611
flow2110630801212955110183
cytometry,2314630801214595131185269319353385436452
helper27876308012155106130186237270
T30796308012149
lymphocytes.3149630801212471156212268323369419455504544565
Úvod4256754013874137198262
Autoimunitní565692301075399128174193267314362381409458476
tyreopatie1061692301073477104147196246288315334378
(AIT)1459692301073082101144172
jsou1650692301072659107155
časté,1825692301074788121150193208
postihují20526923010756106139168187235283301320
asi239269230107478099
525106923010751
%25816923010772
popu‑26736923010756105156204232
lace,425706301071961102145160
u6057063010755
žen681706301074387136
po8377063010757107
menopauze9647063010782127176225276318367404448
až1432706301074886
201538706301075295
%.1654706301077391
Patří1765706301075394122149168
sem1954706301074085160
autoimunitní2134706301074897125173192267315364383412461480
tyroidi‑2634706301073579107155174224243271
tida304767830107284796136
(AT)3203678301073082118145
a33686783010747
Graves‑Basedowova3434678301076289131170214247273320362395440490538603650691732
(GB)4186678301072983129151
tyreotoxikóza.4357678301073376103146195223269307327364412447489506
AT4882678301075995
se4996678301074084
dále5100678301075495114158
dělí5277678301075599118136
na5433678301075494
Hashimotovu,3047692301075695127174191263310336382421468483
juvenilní,3548692301071662102144190208226272290305
poporodní,3871692301074693142190216261310357374389
silentní,427969230107294765107154180227244259
atrofickou,455769230107376388134157176215252298344359
fibrózní,493569230107203886112158192240257272
Riedlovu5226692301074159102150168215254301
a30477063010741
léky3108706301072569107150
indukovanou3278706301072573122170208255295337385433481
tyroiditidu3779706301073477104151170220238266285334382
–41807063010752
po42517063010756106
léčbě4376706301072670111160205
cytokiny4601706301074689120166205225273312
IFN‑γ4932706301072667123152191
(interferon514370630107304896123165192219262289336384
KORESPONDENČNÍ42574060954092133171210249303355407445496542593610
ADRESA105374060954799140178216262
AUTORA:133374060954795134186227276291
Mgr.1642740609562106130142
Karolína180174060954078102144162179222258
Absolonová,207774060954691121165182226269313349386401
Ph.D.,24957406095408397151163177
kabsolonova@endo.cz269074060953371116146189207250294337373411469509552597640654690725
Endokrinologický42575260953780124168202227245288331349392437454490524563
ústav,10057526095437298136171181
Odd.120475260955499143158
klinické13797526095345369112129165199238
imunoendokrinologie163475260951783125168212252295339383417443460503546564607652669708
Národní42576460955188111154199242258
8,70176460953953
11077276460953970106
0089576460953980
Praha99376460954063100144180
11191764609539
Cit.43547406095466388103
zkr:44747406095336792108
Vnitř459974060954183100125149
Lék476674060953674109
2021;489274060953978115150159
67(8):50697406095397694132153166
E23–E28525274060953878117158197237276
Článek45307526095466399142182216
přijat47637526095456986103139164
redakcí:494475260952462107144178213230243
27.52057526095397683
8.530575260953954
2021537775260953978115150
Článek43487646095466399142182216
přijat45817646095456986103139164
po476276460954488
recenzích:48687646095246299137180214231267310323
4.520976460953953
11.52797646095397181
2021537776460953978115151