602
PŮVODNÍ42522701004395143193242296315
PRÁCE75522701004489137177218
Th1,4253370100367598113
Th255433701003675109
a679337010034
Th177293370100367598126
lymfocytyu87133701001551112133171202240269307346
autoimunitních12333370100347198137152212250287303329368383414451
tyreopatií17003370100266489124163202237263279295
E2619022701004179121
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VNITŘNÍ4268043010746106127172220280301
LÉKAŘSTVÍ748804301074185130188236280325378400
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Vnitř12458043010771118137165191
Lék1456804301074083122
2021;1597804301074487129168178
67(8):1794804301074486106148171185
E23–E281999804301074286130176220265307
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www.casopisvnitrnilekarstvi.cz442680430107651332012142542953293774274464795215705896176436927117307748128548809159449871007102310631101
Výsledky425594013870135185218277342405472
Zaznamenali56576301074890127176216290334382423442460
jsme104576301071648122166
množství1230763010771119167203238267311330
statisticky158076301073059100127146179208226267304347
významných194776301073881119168209282330368408456
korelací,242376301073582109152171211252270286
které272876301073566108135178
zde42590301073685129
ale57390301074160104
neuvádíme,69790301074892140181223272291364409423
protože114090301075077124151198233276
byly143690301075089109149
velmi160590301074083103176195
slabé18199030107345393143188
až202790301074078
slabé,21249030107345393143188202
kdy234690301073887127
|r|24939030107194564
<2577903010753
0,4000.265090301074459103148194240255
Uvádíme425104301075697139188207280325
pouze769104301075099147184227
korelace1016104301073885112155175215256298
středně133410430107336289132182230274
až1628104301074078
velmi1725104301074184103177195
silné,194010430107345271118163177
kde2137104301073886130
|r|228710430107194564
≥23711043010754
0,40002444104301074459103148194240
(13).2704104301072363101122135
V5651179011055
souboru639117901104597150205258291344
pacientů10021179011060108150174222275308360
s13821179011044
E06314451179011054104155203
jsme1667117901103271149197
zjistili188311790110487397136169193217242
tyto2144117901103887123174
statisticky2338117901104478125158182221254278320367416
významné27741179011052102425131901104093139216268315
korelace:758131901104696129176200246287333355
Mezi5651463010769112149167
Th751146301073887
a8571463010737
Tc913146301073872
lymfocyty1004146301071555128151197237279309351
(r1374146301072043
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-0,5605,150514630107236983127169213255268
p17921463010746
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0,0000),192514630107405598143188232255268
celk.221214630107367796133150
T23811463010738
a24381463010737
B24941463010741
lymfocyty2554146301071655128151198238279310351
(r425160301072447
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-0,4877,56116030107236984127172213256261
p8421603010746
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0,0000),97616030107405599144189234256269
Th11265160301073887123
a14081603010737
Th171464160301073887124160
lymfocyty1643160301071655129152199239281312354
(r2016160301072044
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0,4346,214816030107415598139183228243
p24101603010746
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0,0000),254516030107405498143188233256269
Tc2833160301073873
a4251743010741
Th1485174301073989126
lymfocyty630174301071656131154201243285316358
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0,4124,1142174301074156100137175215229
p13911743010746
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IRI182017430107156180
a19201743010737
Th11977174301073988125
lymfocyty2122174301071656130153201242284315358
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p4251883010750
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0,0000),572188301074762107152198244267280
celk.872188301074486106143161
T10531883010746
lymfocyty1118188301072363138161209250293324366
a15041883010745
NK15681883010762106
buňkami16941883010754102150188230303322
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p24741883010754
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0,0000),2624188301074863108153199245268281
paměť.425202301075091165209237253
Th698202301074191
a8092023010741
Th1869202301074292129
lymfocyty1018202301071858133157204245288319362
(r1399202301072448
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0,7982,1540202301074358102144188230245
p18052023010750
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0,0000),1947202301074459104149195241264277
naiv.2244202301074889107148160
Th2424202301074291
a25352023010741
Th12595202301074292129
lym‑2744202301071959133161
focyty304762301072471112154185227
(r329462301072145
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-0,7995,34286230107247186129171215258271
p3719623010746
=3785623010750
0,0000),385562301074156100145191236259273
Tc414762301073974
lymfocyty424062301071656130154201242284315357
a4617623010738
NK467462301075499
buňkami479362301074694142179221295313
(r512662301072044
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-0,4014,52606230107247185129174214253267
p3047763010750
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0,0000),319276301074661106151197243266279
Tc349176301074479
a3590763010743
celk.365276301074385105142160
T3832763010744
lymfocyty389676301072161136159207248290321364
(r428076301072650
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0,4551,442576301074661105146187226237
p4681763010752
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0,0000),482976301074661105151197242265279
Th512876301074493
a5241763010743
celk.530476301074285104141160
T5483763010744
lymfocyty304790301071961137161210252296328372
(r343990301073156
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0,4135,359890301075167112151190232247
p3865903010757
=3943903010761
0,0000).402590301075167113160207254277291
Mezi4337903010778123161181
subpopulacemi453990301074189140191242293343362404446489565584
lymfocytů514390301072768144168217260303335384
a30471043010741
hodnotami31081043010755103154202250278319393412
TSH,3539104301074992147163
FT3,3722104301074893138153
FT4,3895104301074893132147
anti‑TG4061104301074896123142170208262
a43431043010747
anti‑TPO4410104301074796123142169207254314
jsme4744104301072659132177
nalezli4941104301075595114159196216234
jen5195104301072670118
slabé5333104301074059100149194
statisticky3047118301073463104131150183212230271308351
významné3418118301073881120169209283331375
korelace3813118301073582109152171212253295
(|r|41281183010721406685
<42331183010750
0,4000).4303118301074156100145191237260273
Korelace4595118301074290117160179219260302
zjištěné491711830107335372104133175223268
u52041183010745
jednot‑5269118301071660110158206234258
livých304713230107193779122161209
pohlaví3276132301075099148167207247266
zde3562132301073685129
s37101323010734
ohledem3763132301074897116160210254328
na4110132301074989
rozsah4219132301072673109144186234
textu4473132301072870110141189
neuvádíme,4681132301074993141182223273291365409424
protože5124132301075077124151198233276
ref.542013230107266993107
meze30471463010774118155198
lymfocytů3265146301071959134157205246288319367
se3652146301073378
obvykle3749146301074898139182221241285
uvádějí4054146301074889130180224242261
bez4335146301074994131
rozlišení4486146301072774109129147180224272290
pohlaví.4796146301075099148167207247266282
Statisticky3187159801124983133168195235270297340391442
významný36481598011255107152208257337392440
rozdíl4106159801124296140196222250
mezi43751598011285135179206
kontrolním46001598011256109164198235289316371397477
souborem50961598011246100155211265301351431
a30471738011248
souborem3113173801124598152207261296345424
pacientů35551738011260109151176225279313367
s39401738011246
E06340041738011254106157207
jsme4236174301071952126171
nalezli4426174301075596115160197217235
u46811743010755
Th14756174301074898136
(p4912174301073081
=50131743010760
0,0270),5093174301075166111152194236259273
Th25386174301074898142
(p3047188301072474
=31411883010753
0,0309)3214188301074459103145189233255
a34891883010741
Th173550188301074291129165
lymfocytů3735188301071959134157205246288320367
(p4122188301072474
=42161883010753
0,0070)4289188301074459104149190232255
(Obr.4564188301072382132159172
1).475618830107436174
U31872018011261
kontrolního3265201801124696149182217269294347371426477
souboru3760201801123688140194246280332
jsme4110201801122362139187
zjistili431520180112386489128162187212237
tyto4570201801122978113165
statisticky4753201801123568116149175214247272313362412
význam‑5182201801124494137191238315345
né30472158011252100
korelace:316521580112469713218020625429534235082163010716
Mezi35432163010766110147166
Th3729216301073887
lymfocyty3836216301071655129152200240282313355
a42112163010737
NK4268216301075498
buňkami4385216301074795142179221294313
(r4717216301072144
=47812163010750
-0,5936,485021630107247185129170210253269
p51382163010746
=52042163010750
0,0120),5273216301074156100139176219242255
mezi30472303010774118155174
Th3241230301073988
lymfocyty3349230301071656131154202243285316359
a37272303010738
FT33785230301073983128
(r3933230301072145
=39982303010750
-0,5218,406823030107237185130171211250266
p43532303010747
=44202303010750
0,0317),4490230301074156100142181217242255
mezi47652303010771115152171
Tc4956230301073974
a50492303010738
B51072303010742
lymfocyty5169230301071656131154201243285316359
(r3047244301072447
=31142443010749
-0,7059,318324430107237084127168210250262
p34642443010746
=35302443010750
0,0015),359924430107405599144183220242256
mezi38742443010770113150169
Tc4062244301073873
lymfocyty4154244301071655129152199239281312354
a45272443010737
FT34584244301073881126
(r4729244301072144
=47932443010750
0,4880,486224430107405598143187231245
p51272443010746
=51922443010750
0,0469),526124430107415599144189231253266
mezi30472583010774118155174
Tc3241258301074782
a33432583010746
celk.3408258301074688107145163
T35912583010747
lymfocyty3657258301072464139163210251294325368
(r4044258301072953
=41172583010759
0,6008,4195258301074964109154200245261
p44752583010755
=45502583010758
0,0108),4628258301074964109149188233255269
mezi49172583010778123160179
Th5116258301074796
a52322583010746
celk.5298258301074587107144162
T54802583010747
lymfocyty3047272301071959134157205246288320362
(r3429272301072145
=34942723010751
0,5115,3565272301074156100139174211225
p38102723010747
=38772723010751
0,0358),3947272301074257101143184228250263
mezi42302723010771116153172
celk.442227230107378099137155
T45962723010740
lymfocyty4655272301071757131155202244286317360
a50352723010738
NK5093272301075499
buňkami5212272301074795143181223297315
(r3047286301072448
=31152863010753
-0,7260,318728630107277489132175218263278
p34842863010749
=35532863010753
0,0010),3626286301074358103149189228251264
mezi39102863010773118155174
IRI410428630107186383
a42072863010740
B42672863010745
lymfocyty4331286301071959133157205246288319362
(r4713286301072347
=47802863010753
0,6968,4853286301074358103146190235251
p51242863010749
=51932863010753
0,0019),5266286301074358102148188226248262
mezi30473003010774118155175
B32423003010752
lymfocyty3313300301072666141164212253296327370
a37033003010747
FT43770300301074893132
(r3921300301073155
=39963003010760
-0,6724,407630030107338196141182226266280
p43763003010756
=44523003010760
0,0031),4532300301075166110156198237255268
mezi48203003010780125162181
dvojitě5021300301075697144164182210253
neg.5294300301075499149165
T54793003010748
lymfocyty3047314301071959134157205246288320362
a34293143010745
Treg3494314301074667110160
(r3674314301072852
=37463143010758
-0,4949,382431430107317893137179224266278
p41223143010754
=41963143010758
0,0434),4273314301074964108154195240261275
mezi45683143010778122159178
IRI476631430107236988
a48743143010745
FT34939314301074690136
(r5094314301072953
=51663143010759
-0,5489,524431430107317893138182228271283
p30473283010750
=31163283010758
0,0225),3194328301074863108149193237260273
mezi34873283010778122159179
Th13685328301074696133
a38383283010745
Treg3903328301074667110160
lymfocyty4083328301072363138161209250292323366
(r4469328301072852
=45413283010757
0,5798,4618328301074863108150192236252
p48893283010754
=49633283010758
0,0147)5040328301074964108148187227252
a53113283010745
me‑53763283010778122151
zi3047342301073757
Treg3125342301075072116168
lymfocyty3314342301072667144169218261304337381
a37153423010749
anti‑TPO3785342301074998126146175214262324
(r4130342301073156
=42073423010761
0,4955,4289342301075268113156201243258
p45673423010758
=46463423010762
0,0431),4728342301075268114161204244262277
mezi50253423010783128167187
naiv.5233342301075698118160173
Th54263423010750102
a30473563010740
Th13106356301073886122
lymfocyty3247356301071554127149196236277307348
(r3614356301072043
=36763563010749
-0,7614,374435630107236983125164201239253
p40153563010746
=40803563010749
0,0004),414835630107395497141186230251264
mezi44313563010769112148166
paměť.4616356301074586157200228243
Th4878356301073786
a49823563010737
Th15038356301073886122
lymfocyty5179356301071554127149196236277307348
(r3047370301072448
=31153703010753
0,7612,3188370301074459102142180218233
p34413703010749
=35103703010754
0,0004).3583370301074459104149195241263276
Diskuze30473954013872105157220284336394
Mezi31874123010771117155175
Th133834123010749100138
a35424123010748
Th1736114123010749100139176
lymfocyty3808412301072667144168217259303335379
jsme4207412301072760135181
nalezli4408412301075698118163201221241
pozitivní46694123010758108144164193213255305325
korelaci.5014412301074694122166186228270289305
Je5340412301073884
to5444412301073583
v30474263010741
rozporu3109426301073381117169219246296
s34254263010741
literaturou,348642630107264574117144187215264291339388404
která3910426301074577120147190
uvádí,4120426301075597140190209225
že4365426301074488
cytokin4473426301074791123170209230279
Th147724263010750100138
lymfocytů4931426301072667142167215257300332381
IFN‑γ5332426301072669126155195
inhibuje3047440301071967115133183231250294
diferenciaci336144030107486791135161204252293311352392411
Th173792440301074191128165
lymfocytů3977440301071959133157205246288319367
(10).4364440301072464103126139
Tab.3047473401135092144170
3.3244473401135277
Referenční3348474301074482105142167204250287333350
meze37144743010769107144181
pro3911474301074268112
Th1,4039474301073784119130
Th24186474301073784124
a43264743010742
Th174384474301073885120154
lymfocyty4554474301071652124146190228267295334
v49044743010735
plné4955474301074362108146
krvi5117474301073460101119
od5252474301074288
195356474301073975
let544747430107165480
věku,3047485301073875111157172
upraveno3236485301074591117159197234281326
podle3578485301074591137156194
(15)378848530107246195117
Subpopulace307849900984287135183229277323345386423464
Th307850900984289
lymfocytů318350900982162131157203241283314360
Referenční399549900984688114157186228275312358380
meze4391499009868110147189
Jednotka495049900983174122168214243284326
Th1307852130953782115
lymfocyty321152130951753119141183220258286324
6,66–8,0141335213095395394134177218232272308
%5084521309559
Th2307953330953782120
lymfocyty321753330951753119141183220258286325
4,86–5,9841355333095395294134177215228265305
%5084533309559
Th17307954530953782115148
lymfocyty324554530951753119141183220258286325
9,50–11,4741265453095395090129172207238248287323
%5084545309559
Tab.3047581801135093144171
4.3245581801135279
Referenční3351582701074482105142168205251288334352
meze37195827010769107144181
pro3916582701074369113
Th14045582701073784120
a41815827010743
Th24240582701073784125
lymfocyty4381582701071653124147191229268296336
v47335827010735
plné4784582701074362108146
krvi4946582701073561102120
u50825827010744
japonských5142582701071560106152198228263303340386
dospělých,3047593701074590120165203221258295341357
upraveno3420593701074591117160198235281326
podle3762593701074691138156194
(16)397259370107246198119
Subpopulace307860740984287135183229277323345386423464
Th307861740984289
lymfocytů318361740982162131157203241283314360
Referenční399660740984688114157186228275312358380
meze4392607409868110147189
Jednotka495260740983174122168214243284326
Th1323362970953782115
lymfocyty336662970951753119141183220258286324
13,1–29,541476297095397386121158194232244284
%4983629709559
CD4+505962970954698139188
Th1323364170953782115
lymfocyty336664170951753119141183220258286324
26–53419164170953977120158196
%4987641709559
CD3+506364170954698134182
Th2323165370953782120
lymfocyty336965370951753119141183220258286325
1,6–3,841776537095394989132169182223
%4983653709559
CD4+505965370954698139188
Th2323166570953782120
lymfocyty336966570951753119141183220258286325
0,9–2,541786657095395390133168182222
%4987665709559
CD3+506366570954698134182
Tab.3047702201135093144171
5.3245702201135479
Referenční3351703001074482105142168205251288334352
meze37197030010771110147183
pro3919703001074571115
Th1,4050703001073987122133
Th24199703001074087127
a43437030010745
Th174404703001074087122156
lymfocyty4576703001071956127150194232271299339
u49317030010745
čínských4992703001073856102131167206243289
dospělých,5297703001074591121165203304771400107195693138154
upraveno3217714001074691117160198235281326
podle3560714001074591137155193
(17)377071400107236095118
Subpopulace307872780984287135183229277323345386423464
Th307873780984289
lymfocytů318373780982162131157203241283314360
Referenční399572780984688114157186228275312358380
meze4391727809868110147189
Jednotka495072780983174122168214243284326
Th1307875010953782115
lymfocyty321175010951753119141183220258286324
0,43–39,6241217501095395392129170207244256296334
%4981750109559
CD4+505775010954698139188
Th2307876210953782120
lymfocyty321676210951753119141183220258286325
0,27–3,5741407621095395393131167204217257295
%4981762109559
CD4+505776210954698139188
Th17307877410953782115148
lymfocyty324477410951753119141183220258286325
0,22–2,6241387741095395393133172207221261299
%4981774109559
CD4+505777410954698139188
Obr.4252339011362114150173
1.625233901135478
Rozdíl731234801074489123167186205
mezi9522348010772110147165
souborem1133234801073176122167213239275347
s14962348010731
dg1543234801074691
E0631650234801074081123163
a18292348010745
kontrolním1890234801073782128153179223241288306377
souborem2283234801073175121167212238275347