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cardioverter1080174301074788115163182230270313340371414440
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(ICD1978174301073049101158
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20191448188301075194134172
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Pacing712202301074686127146193243
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the2313216301073180124
incidence2457216301072270110129178222270311353
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extrasystole826230301075191121148190224265299329375395440
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X‑ray1012258301075276104145184
(Figure121625830107276887136183210253
1).148825830107486578
The1586258301074595139
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a7302723010740
moderate7892723010773121171216242284311353
restriction1162272301072568102131158177217247266314363
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capacity.760286301074283133174215233262304316
In1096286301072068
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2019,1505286301074588128165178
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2552609286301074589130
ng/l2759286301074493126146
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30%.1041300301074083149165
The1225300301073886129
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image2052300301071587127175218
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Figure2689300301073755103149175217
2.425314301074459
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another766314301073785133160207251277
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2020,1913314301074183124166181
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204586328301075194141
ng/l747328301074595128148
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25%.1443328301075195160178
At1641328301075986
another1747328301074897146173222267294
follow‑ap,206132830107307898117166231260301351365
in2446328301072674
May25413283010777118157
2021,2718328301075195137177187
the425342301072876120
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NT‑proBNP8493423010761104127177204251297355400
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1801431342301074886131
ng/l1582342301074493126146
and1748342301074492142
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was20973423010769110143
30%.2260342301074791158175
Subjectively,2455342301074592142161205246276295336379399439450
the425356301072877121
patient566356301075799126145189238265
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good,10433563010755104154204220
has1283356301075596129
no14323563010756104
chest1556356301074796140174204
pain,1779356301075799118166182
tolerates1981356301073481101146172214242285319
normal23203563010755104131206247266
physical26063563010757106145179197238280299
exertion425370301074483126152183202249298
without742370301076281109157205253281
difficulty.104337030107466488115135175223241269312324
The1386370301073988132
patient1538370301074688115134177225252
is1809370301071649
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by2150370301074686
a22553703010738
cardiologist2312370301073779105153171219239287337355388417
with2748370301076281109157
the425384301072876120
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of1215384301074872
regular1306384301072770120167186227253
blood1579384301074969117166216
pressure1815384301075077120153187234260303
checks2138384301074088132173211247
and2405384301074189138
adequate2563384301074190134184232272300342
physical425398301075098137171189229271290
activity735398301074181112130171191219262
and1016398301074290139
the1175398301072876120
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treatment:187639830107285598138165239283331358375
beta‑blocker,2271398301075095122164192243262310352390433459471
ACE27623983010753102143
inhibitor,425412301071966113131179198225271298309
eplerenone,753412301074089108151177219266314361405419
vitamin119141230107375683124196214261
D14714123010755
and1545412301073784133
furosemide.169741230107206894140173216289307355398412
The2129412301073887130
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is2545412301071547
a26114123010738
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a10344263010737
heart1091426301074588128154185
transplant,129542630107255293140173222241282329356372
which16864263010762110129168216
currently1922426301073684110137179227254273312
is2254426301071548
not2321426301074593120
indicated2461426301071563112130170211238280330
for281042630107216895
good425440301074997146196
functioning.641440301072675123164194213261309328376425441
Possible1102440301074894127161179228248292
barriers1414440301075294120147167210237271
in1705440301072169
the1794440301073078122
future1936440301072675103151178221
include2176440301072270110129176226270
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of425454301074872
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gene657454301074993141185
for86245430107237198
CADASIL9794543010752106164214257275315
syndrome.1314454301073375124173199247321365380
Discussion4254794013872105157207271323375408470534
The565496301074293138
present723496301075885129163209258285
case1028496301074890124169
report1218496301073377128178205237
describes14754963010757102136177205224275321355
a18504963010749
patient,1919496301075799127147191240268284
who22244963010772122171
at2416496301074876
the2512496301073584129
age2661496301074899144
of2825496301075580
four425510301072472121147
years592510301074791131158193
was8055103010772114148
treated973510301073562105146173216267
for1260510301073079106
T‑cell1386510301074972115158177196
non‑Hodgkin16025103010755104154182241290341391429450498
lymphoma2120510301072666142192241290365406
with2546510301077392121169
chemotherapy27355103010748961414255243010774122150198242268310360399
containing844524301074692141168209228276294342391
doxorubicin12555243010755103141189215264313333373391439
at1714524301074774
a18085243010746
cumulative1874524301074694167215234274302320361405
dose22985243010755104137181
of2499524301075478
2302596524301075094138
mg/27535243010770119152
m2.42553830107744995388063265255383010716
Even561538301074989133181
though762538301073584132181231279
this1061538301073584102135
anthracycline1216538301074897124172199241282325365384403451496
dose17325383010755104138183
is1935538301072558
not20135383010755104132
high2165538301075574123172
(the2357538301073057106150
maximum25275383010781122162182256304378
cumulative425552301073986158204222261287305345387
dose831552301074592124167
in1017552301071561
children1097552301073683101119166192233280
is1396552301071547
400mg/1462552301073983128215263294
m2),1775552301076918435528063251868552301072336
it1923552301071542
cannot1984552301073676123170217243
be2246552301074589
considered2354552301073681128160178225268294335384
safe,275755230107297093135149
especially425566301074477127171213231272291309349
given794566301074867108151199
the1013566301072776120
patient’s1152566301075091118137181229256274306
young1477566301073987135183232
age1729566301074090134
and1883566301074088137
stressful204056630107336289132165199224273291
situations235156630107335179127168195214262311344
(such2714566301072456103143191
as425580301074174
respiratory519580301073174108157176203244271318345388
infection)92758030107247195138180210229277325347
during12935803010754102128147195245
the1557580301073381126
years1702580301074588128155189
following191158030107287695114162227246294343
successful2274580301073986126165207241275299348367
cancer2661580301074587135175218244
treatment.42559430107285496136162235279326352368
Already81359430107486793135174223263
in1095594301071563
2010,1177594301074082122161175
the1371594301072572116
patient1506594301074687113132175222249
was17745943010761102135
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with2320594301076179107155
mild2494594301077088106154
diffuse266859430107456387114162194238
hypokinesia425608301074887137186225245293337371389430
with874608301076282110158
LVEF1052608301073778121162
of1233608301074569
50-55%,1322608301074184114157198262279
and1620608301073886136
in1775608301071664
20161859608301074184124163
the2042608301072573117
LVEF2179608301073778121162
was23606083010762104137
54%.2517608301074185150167
In2704608301071664
the2788608301072573117
early425622301074485112132172
1990617622301075190135181
s,818622301073046
first88462230107315178113142
data1046622301075698125167
that1233622301073584125153
long‑term1406622301072675124174203231274301377
survivors1803622301074088115159179221269296331
of2154622301075580
childhood2254622301074796115134184232282331382
cancer2656622301074789138179222249
may3047623010773114152
develop321962301074689130173192240289
irreversible,35286230107164269111152195221255273322342385400
often394762301074569100142190
progressive415762301074673119169195238271305323363406
heart458362301074589129155185
damage478862301074686159200249293
(cardiomyopathy,51006230107215899125173192239313351399304776301075091118167205217
LV328376301074485
dysfunction,338776301075393127152201249290320339387435451
heart385776301075296136163194
failure)40707630107277088107154181224245
and433576301074492142
arrhythmias44967630107457198147185217265338357397431
were4946763010769112139182
published.5147763010753102151171189222270314364380
The304790301074292136
data320290301075090117159
of338090301074973
the347290301072877121
first36129030107244470104133
15376590301074482
patients386790301074991118137181229256291
with417790301076585113161
serious435890301073378104123171220253
late46309030107206087130
clinical47799030107416078126144185226245
cardiotoxicity504490301074082108156175223250297335354394413441484
after304710430107416496138165
therapy3232104301072876121147189238278
of3529104301074973
childhood3622104301074189107126175223271320371
cancer4012104301074183131171214240
were42721043010766109135178
analysed4470104301074290130149189223268318
by4807104301075190
Steinherz4917104301074269111130178226270296335
et5272104301074472
al.536410430107416076
in5460104301071967
1995.3047118301074482126169184
Cardiac3251118301075395121169188228269
failure353911830107266887106153179222
and3781118301074391140
arrhythmias394111830107437097145184215263337356396429
were43901183010767110137180
manifested45901183010775116164183207250284313355406
in5015118301072169
these5104118301073078122156200
series5324118301073680106125169203
of3047132301074872
patients3139132301075798126145189237264299
from3458132301073058106180
636581323010751
to3729132301073481
193830132301075189
years3938132301074790131157192
after4150132301074771103145172
the4342132301073583127
completion4489132301074794169218238282310329378427
of4935132301075579
anthracycline5034132301074896123172198240281323363382401449493
treatment.304714630107285598138165239283331358374
One34411463010765113158
out36181463010752101129
of3766146301075276
153862146301074886
patients3968146301075395122141185233260295
died,4282146301075372116166181
others4483146301075279128172198233
underwent47351463010752100150194220288332380407
successful5161146301073885126164207240274299348367
heart3047160301074791130155185
transplantation325116030107245090137169217236275322348389415433480527
(8).37971603010720618395
In3911160301071662
2015,3992160301074082121157170
Cardinale4181160301074788113160178225264283325
et4525160301074067
al.461116030107375570
prospectively4700160301074571117150198241282311329369411430468
evaluated5187160301074080120138184224250291340
the3047174301072875119
incidence,3186174301071563103121170213261301343357
timing3563174301072443115134181230
of3812174301074569
occurrence,3900174301074485124171197224266314354396410
clinical433017430107365573121139179220238
correlates,4588174301073683109136179197238264306340355
and4963174301073785134
response511617430107246699148197245278321
to5457174301072470
heart3047188301074892133159190
failure325718830107236584102150176219
therapy3496188301072876120146188238277
of3793188301074771
cardiotoxicity3884188301074082108156175223250297335354394413441483
in4387188301071967
26254473188301074486129173
of4665188301074872
anthracycline‑treated4757188301074088115164190231272314354373391439483513541567610651678720770
adult3047202301074088134152178
patients.3244202301074585111129172218244277293
Cardiotoxicity3556202301074787112158176223249294331349388405432473
occurred4048202301074383121167192218260308
in4375202301071561
2264455202301073981122
(9%)4596202301072059125145
of4760202301074366
them.4845202301072470113185200
One50642023010755103145
hundred5228202301074490136184209251299
eighty‑three3047216301074462111159186229256284333359402447
(81%)3513216301072669109170191
patients,3724216301075293120139183231258293309
were40522163010768111138181
in4252216301072169
New43412163010759104169
York4529216301074891117156
Heart47052163010759103143169200
Association4925216301075590123172213231272299318366414
class5359216301074261102135168
I30472303010719
to3086230301072471
II,317723030107163450
and3246230301073886135
433401230301074182
(19%)350223030107216199166188
were37092303010762105132175
in3903230301071664
class398723030107375596129162
III416923030107163553
to4242230301072571
IV.433323030107166273
In4426230301071664
945092303010741
patients,4570230301074688115134177225252287303
cardiotoxicity4893230301073778104152171219246293331350390408436479
was53912303010762104137
manifested30472443010774114163181205249282311354404
as3470244301073972
an3562244301073886
acute3668244301073979127155198
decompensated3885244301074791132179253302347395428470497540590
heart4495244301074690130156187
failure.470224430107216382100148174217232
Six495424430107395796
of5070244301074569
them5159244301072674118192
subsequently53702443010731781283047258301073376125172215263289307346
died.3413258301074563106155170
In3602258301071663
the3684258301072472115
remaining3818258301072365137177195242260307356
2174193258301074079115
patients4327258301074686113131174221247281
developing4628258301074588128170189236285304351399
cardiotoxicity,5046258301073777103150168215242288325344383401428470481
no3047272301074896
hospitalization3163272301074593126175194222263281300336378405423471519
was37022723010762103136
needed.3857272301074589133183227277293
Heart4169272301075397137163194
failure43832723010720628099146172215
therapy4617272301072573116143184233272
was49092723010761103136
initiated506427230107166382109128168195237287
in5370272301071664
all545327230107385775
Tab.425654801135194147174
2.627654801135987
Recommended742655701074483122166238311350397443482529
frequency128865570107285593139186224272310349
of1654655701075175
echocardiographic1745655701074583130176215260286330349395442468512558606624662
examinations2424655701074483128201220267313339358404451481
(according425666701072467104140183209252271317362
Children´s803666701074894112131176201238284309336
Oncology11556667010759106143186205250296333
Group,1504666701075379123169214229
2018)1749666701074282119156179
Dose456680409855101135177
of65068040984571
ANTR738680409851105148194
Dose1282680409855101135177
of147668040984571
RT156468040984589
Frequency210868040984168110158204246293330373
of249768040984572
Echokg258568040984278125171212258
None45669350854686126162
<1282693508542
15133969350853568
Gy142269350854578
or151569350853862
none159269350853978118155
No210869350854686
screening22096935085276083119156196213252292
≥1282705508542
15133970550853568
<1422705508541
35147870550853671
Gy156470550854578
Every210870550853468104128164
52286705508536
years233770550853369103127156
≥1282717508542
35133971750853571
Gy142471750854679
Every210871750853468104128164
22286717508536
years233771750853369103127156
<456729508542
25051372950853572108
mg/m263672950855899124182818730005021
<1282729508542
15133972950853568
Gy142272950854578
or151572950853862
none159272950853978118155
Every210872950853468104128164
52286729508536
years233772950853369103127156
≥1282741508542
15133974150853568
Gy142274150854578
Every210874150853468104128164
22286741508536
years233774150853369103127156
≥456753508542
25051375350853572108
mg/m263675350855899124182818754005021
undecided128275350853978119155188205245281322
Every210875350853468104128164
22286753508536
years233775350853369103127156
Abbreviations:45676470954383124147180215232272295311352394420434
ANTR,90576470954391127167183
anthracycline;110276470954082104146169207241275308325341382417431
RT,15477647095397484
radiotherapy;164676470952361102118159182223257281319360392407
Echokg,206776470953568109149183223237
Echocardiography23187647095366810915018422424728530234338440744545677470954082114
Fig.3048295801134873125152
1.3227295801135479
Chest3333296601074894133164190
X-ray353929660107446995138175
of3730296601074568
October3814296601075897124168214253278
20194108296601074282119155
Fig.3048575601134873125152
2.3227575601135481
Echocardiography3336576501074076122167205249275318336382428453496541588623
image3976576501071889134180218
of4210576501074568
October4294576501075897124168214253278
20194588576501074282119155