1003
KAZUISTIKY512322701004696138190209248289309356404
Advanced282133701004280117152190221255293
heart313133701003672107131160
failure3307337010020557086123147182
and350533701003472110
cardiac36313370100306590127142177207
arrhythmia38553370100335883121157186225285300334
in420633701001452
a4274337010034
young432433701003573111149187
adult452733701003472110125152
survivor46953370100286690129145181220244
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childhood5029337010030678298136174213252290
cancer533633701002964102133167191
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/35758043010757
Vnitř36518043010771118137165192
Lék3862804301074184122
2022;68(1):E22-E264004804301074386128172187232277301340358372415459503529572617659
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LÉKAŘSTVÍ5127804301074185131189236280326378400
www.casopisvnitrnilekarstvi.cz42580430107651332012142542953293774274464795215705896176436927117307748128548809159449871007102310631101
patients42562301074990117136179226253287
developing73262301074589129171190238287306354402
cardiotoxicity.115462301073777103151169217244290327346386404432474486
In165962301071663
40174162301074186
(17%18466230107216096162
of202762301074468
patients),211462301074688114133176224250284305318
enalapril245262301074088128146186235262281299
was2771623010761102135
given.42576301074968109152200216
The66176301074190135
remaining81576301072669142183202250268316365
186120076301074382127
patients134676301074991118137180228255290
received165676301072568110152171212255305
enalapril198176301074290131150191240267286305
and230676301074088137
carvedilol246376301073980107151194244262281329349
or283276301074774
bisoprolol.42590301074968100147197223269288336355370
Intravenous8149030107166389115156195237285332379412
diuretics124590301074563110135177205223262296
were1561903010761103129171
required175190301072366115161179205247296
only206790301074491110149
in223590301071562
patients231790301074586113131174221248282
hospitalized26189030107449212517319221926042510430107193774116166
for61110430107206894
acute725104301073878125153196
heart940104301074589129155186
failure.11461043010720628099146172215230
Oral1395104301075885126145
diuretics1559104301074665112138181208227267302
were18801043010762105131174
added2074104301073786136179229
to2323104301072471
the2413104301072573117
therapy2550104301072472116143184233272
in2842104301071663
43425118301074484
(20%529118301072163106173
of722118301074468
cases).810118301073678111155188209222
One10521183010757105149
hundred1221118301074592140189215258307
eighty‑five1548118301074059107155182224251275295336379
(82%1946118301072163105171
of2136118301074569
patients)2224118301074788115134177225251286307
recovered2551118301072366107153193236262305354
from42513230107235198171
cardiotoxicity,616132301073778104152171218246292330349389407435477489
of1124132301074569
those1212132301072573121154198
251430132301074184
(11%153413230107216094155
of1708132301074569
patients)1796132301074788115134177225252286307
achieved2123132301073878126144187228271321
full246313230107216988106
recovery,2589132301072366107153193236262305317
and425146301074189138
160583146301074483128
(71%731146301072367108169
of920146301074771
patients)1011146301075091119137181229256291312
achieved1343146301074181129148192232275326
partial1688146301075092118149168208227
recovery1935146301072669110157197240267310
(11).226514630107246398115129
Regarding565160301074793146189218268289339391
cardiotoxicity,978160301074993122172193243273322363384426447477522535
there1535160301073687134163208
is1765160301072762
no18481603010758109
safe1978160301074387113159
cumulative21581603010749100176227247290320340384429
dose26091603010758109145192
of2822160301075783
anthracycline.425174301074190118167194236278321362381401450495510
According956174301075293133180208257276325376
to1352174301072875
renowned1448174301072670119168234284329380
experts1848174301074484135181209240276
in2145174301071867
the2233174301072776122
field237517430107234489109159
of2555174301074772
cardio­2648174301074082109158178227257
‑oncology425188301072778128169217237286337378
lifelong82418830107254469114134183232283
follow‑up112718830107307899118167233262312362
of1510188301075378
childhood1609188301074695114134184233282332383
cancer2013188301074688137179222249
survivors2283188301073987115159180222270298333
treated2637188301073361105146174217268
with425202301076484112160
anthracyclines605202301073886113162188230270313353372390438482516
is1141202301071749
recommended.1210202301072467109155229302346395444488538554
The1784202301073989133
most19372023010771119153182
widely2139202301076282131175194234
known2393202301073685134198247
are2660202301073865108
the2788202301072573117
recommendations425216301072770113160235309355404454496524543592642676
of1121216301075075
the1217216301073079124
Children’s13622163010753102121141191218262311327359
Oncology17422163010762112153201221271321363
Group2125216301075987135184234
(drawing2380216301072673101143208228277328
from2728216301072654102177
evidence‑based425230301074485106156201251292336366417460494540591
medicine)10372303010781126177197238258307352375
for1432230301073280108
the1561230301073585130
long‑term1712230301072676125176204233277305380
follow‑up2113230301073180100120169235264314365
of2498230301075681
patients26002303010757100128148192242270305
treated42524430107285599140168212263
in708244301071867
childhood796244301073988107127177226275325376
and1193244301073988139
under1352244301074796146191219
the1591244301072776121
age1733244301074090135
of1889244301074772
251981244301074388
(5).209024430107226689103
According2214244301075292132179207256276325375
to2610244301072674
these2705244301072675121155200
recommendations,425258301072669110157231304348396445486513532580629662678
the1123258301072573118
patient1261258301074688115134178226253
should1534258301073178127175194243
be1797258301074792
clinically190925830107375675122141181223242261301
examined2230258301074180122195214261306356
annually2606258301073785133181221241259299
after42527230107416598141169
the614272301073382128
completion762272301074693168219239284313332381431
of1214272301075378
anthracycline1312272301074796123172200242284327367387406455500
treatment.1833272301073361105146174249294343371388
At2241272301075886
the2347272301073483128
same2495272301073982157202
time,2717272301073453127173188
his425286301074969104
blood550286301075980130182234
pressure805286301075988133168204253281326
should1152286301074292143193214265
be14392863010758105
monitored15662863010782133184204234283312357409
annually19962863010750100150200243263284326
and23432863010749100151
he25162863010757103
should2640286301074292143193214265
also42530030107426297147
be5933003010759106
monitored7203003010783134184204234283312357409
by11503003010759100
echocardiography1271300301075396146196240283311362382432484512556608658699
(or1991300301073280109
using2121300301075691111161213
other2355300301075685136182210
imaging25873003010727102145197217267319
methods)4253143010774119148197246297331353
regularly,798314301072569120168188229257277318330
according1149314301073980120167195244264313363
to1532314301072674
the1626314301072675120
dose1767314301074796130175
of1963314301074671
doxorubicin2054314301074796135183211260311331372391440
(or251531430107226896
equivalent2632314301074192140160202244425328301071964113141
dose586328301075099133178
of785328301074873
other879328301074876125170198
anthracycline),1097328301074291118167195237279322362382402450495518532
age1650328301074191136
at1807328301074169
time1897328301072848122167
of2085328301074873
diagnosis2178328301075069111161210259294313346
and2545328301074190140
chest2706328301074089134169199
radiotherapy425342301072769119139188216265310338380431471
as917342301074377
shown1014342301073685134200250
in1284342301072170
Table1375342301074480130151196
2.1591342301074663
ECG1674342301074496150
also184534230107436396146
focusing2011342301072674117165199218267317
on23493423010750100
QTc24693423010763104140
interval263034230107217097141168213256275
should425356301073482132181200251
be6963563010756102
performed8193563010755101129156205233308353404
after1244356301074771104147174
the1439356301073483128
completion1588356301074694169219240285313333382431
of2040356301075479
potential21403563010756106134177226254274315335
cardiotoxic2495356301074789116166185234262310349369410
treatment42537030107285599140168243288337365
and811370301074089140
later97137030107196089132159
as1151370301074175
needed.1246370301074893139190235286303
At1570370301075279
the1670370301072777122
same1812370301073476151196
time,2028370301072848122167183
the2231370301072877122
patient2374370301074991119139184233261
should2655370301073482132181200251
be425384301075097
instructed543384301072676110141169219261293337389
on9533843010756106
healthy10803843010756102144164193243283
lifestyle138438430107274772117152183227248294
and1699384301074998149
aggressive18693843010749100151179224259294313356400
management22913843010782124174216267313388434484512
of2824384301075681
cardiovascular425398301074082110159178227268311345387435455497524
risk96939830107264679118
factors.1108398301072265106137185213248266
Any13943983010752101140
cancer1555398301073881130171215242
patient1818398301074890118138183232260
under2098398301074796146191218
age2337398301073990135
of2492398301074772
525843983010743
years2647398301073983124151186
is2854398301071751
considered425412301074086135168187236280306349399
to844412301072572
be936412301074792
at1048412301073865
risk113341230107244476114
of1267412301074569
cardiotoxicity1356412301073879106154173221248295333353393412440483
when18594123010762110154202
starting2081412301073160102128160179227276
chemotherapy2377412301073785129203251279327371398439489528
included425426301071967108127175224268319
anthracyclines.764426301073886114162189231272314354373392440485519536
Our13204263010758107133
patient1474426301074788116135179228255
in1749426301071665
the1834426301072574118
present1972426301074774118152196245272
article226442630107386596116156175220
underwent2504426301074593143187214282326374401
cardiological425440301074082110159178227248297348368409451471
examination916440301074788130204224273314342362411460
in1397440301072271
2010,1488440301074791132172188
before1697440301075298123171199243
the1961440301073079125
onset21064403010751101134180208
of2335440301075176
cardiological2431440301074386113162182231251300351371412454474
symptoms,425454301073478155207237286363398416
with863454301077495125176
the1060454301073788134
finding1216454301073253104156176226278
of1516454301075783
diffuse1620454301075879104134185220267
hypokinesis1909454301075798151202243265316362398418453
and23834543010750101153
a25574543010750
slightly262845430107436383135185214235277
reduced425468301072771122171213257308
LV754468301074890
ejection864468301075272117159191211260310
fraction1195468301073160103145176196245295
of1511468301075681
50%.1613468301075196165183
Twenty‑seven18174683010749110155204232276305340386428472522
years2359468301074892134161197
after2576468301074974106150178
the2775468301073585130
completion425482301074087161211231275304323371420
of866482301074570
chemotherapy,956482301073786130204253281329374401443493533545
the1521482301072574118
patient1660482301074789116136180228256
develops1936482301074691132175195244294328
manifestations22854823010770112160179204247282311353380400448497531
of2836482301074570
heart425496301074893134162193
failure63949630107256888107156183227
and886496301074392142
is1049496301072054
diagnosed1123496301075170111162211260294340390
with1534496301076787116165
sinus1719496301073655104152186
tachycardia1925496301073072113162202242285312361381422
and2367496301074392142
numerous2530496301074998172217245293342376
ventricular425510301074287138167195217259309330373401
extrasystoles.848510301075294127156200235279315346395416463499517
There13875103010750103149178223
is1631510301072862
no17155103010757108
relevant1845510301073580101148191234285314
evidence2180510301075396117169215266309354
for2555510301073282111
acute2688510301074992143173218
viral42552430107416188131151
myocarditis.5965243010774113162204246274323342371391425442
This1059524301074292112145
patient1225524301075092120140185234262
should1507524301073482132181201251
have1778524301074990131175
been1974524301074995141190
monitored21855243010773123172192221268296340391
annually2596524301074190139188229249269309
or425538301074876
every522538301075193138165209
other752538301075684134179207
year.980538301074791133160174
With11745383010782103132182
regard1376538301073579130172199249
to1646538301073583
the1750538301073585130
type1901538301073579131177
of2099538301075581
anticancer2200538301074998126146187230279321365392
therapy2613538301073685130158201252292
and425552301074190140
the586552301072978124
development730552301075196137182202251302377422471499
of1249552301075075
dilated134555230107507090131159202253
cardiomyopathy,1619552301074284112161180229304344392443486514563602615
late225455230107216391134
anthracycline2409552301074291119168195238279323363383402451496
toxicity425566301072875114134176195224268
is713566301072054
considered788566301074189138172191241286314357408
to1217566301072977
be1314566301075297
the1432566301072978124
aetiology1576566301074287116136185205254305347
of1943566301075075
myocardial20385663010775115163205248275324344385405
dysfunction2463566301075192127153202251293324344393442
in425580301071967
our512580301074694121
patient.654580301074789117136181229257274
Endomyocardial948580301073988137186261300348390432458507526567587
biopsy1555580301074767116166200242
was18175803010763104138
not1976580301074594122
indicated.2119580301071664114134174216244287338354
The2494580301073989134
patient2648580301074790117137181230257
responded425594301072770105155205255305350401
auspiciously847594301074089123173193234254302352385405446
to1314594301072775
routine1410594301072674123152172221266
treatment1696594301072856100141169244289338366
of2082594301074873
heart2176594301074893134161193
failure239059430107236686105154181225
and2635594301074190141
we27965943010765110
assumed425608301074176111160235281333
that779608301073686129157
it957608301072756
would10356083010773122172193244
not13006083010756106135
provide1456608301075887135177198249295
information1772608301072776101150179255298326347396447
that2240608301073686128157
would24186083010773123173193244
affect2683608301074974103148191223
further425622301072476105138189236265
treatment712622301073665111154183261308359388
procedure.1122622301075988138182227280331359405422
He15666223010766113
is1701622301072762
currently17856223010749100129158204255284305348
stabilized,2155622301074273117170191212232272317370388
but25656223010759110140
with2727622301077596127178
a4256363010741
low487636301072777144
LV652636301074991
ejection764636301075272117160192212262312
fraction1098636301073160103146177198247298
of1417636301075681
30%1520636301075297166
(based1707636301073284127162208260
on19886363010756106
echocardiography2115636301075295145195238281309359379429480508551603653693
in2829636301072777
October4256503010760102132180230275302
2019).748650301074185125163186200
After968650301075075107150177
assessing1165650301073872106151185219237286336
the1521650301072574119
prognostic1660650301074775122173221270304333353394
markers20746503010771112139178222249283
(good2378650301072170119168219
exercise2617650301074181125152191210244288
tolerance,42566430107287596141168211260301344360
NYHA8056643010757103161214
class1040664301073959100134169
II,122966430107183854
improvement1304664301071792142170218259303378423472500
of1824664301074772
LV1916664301073981
ejection2017664301074363107149181200249299
fraction,233666430107235194135166186235285301
almost2658664301073959133183217247
normal425678301074898125201242262
level708678301072368110154174
of902678301075377
NT‑proBNP),10006783010762106129181209257304362408431446
the1466678301073282127
short‑term1613678301073887136164196221250293321396
prognosis2030678301075481129180229279313332366
is2416678301072357
considered2494678301074492141175194244289316360411
good,425692301074999150202218
and664692301074999150
so835692301074292
the948692301073585131
conservative1100692301074896147181227255300343372392435479
treatment1600692301073664109150179255301350379
procedure2000692301075786134177221273322350394
is2415692301072761
continued.2497692301074896147175195245294339391408
The425706301074293138
patient5847063010757100128148193242270
met8757063010781127156
the1051706301073685130
criteria120270630107487596125168196216258
for1480706301073280108
primary1609706301075785106180222250294
prevention1923706301075886130172216265293313362412
of2356706301075580
sudden2457706301074189140190236285
cardiac2763706301074790117425720301074969110151
death597720301075196137165214
and831720301074392142
was9947203010767109143
implanted1158720301072095145166207256284327378
with1557720301076687116165
the1742720301073079124
ICD.1887720301072173132146
Due20547203010760109154
to2229720301072977
the2327720301072978123
narrow2471720301075092119147195261
QRS27527203010763109153
complex425734301074086160210230274313
on758734301074594
the872734301072573118
ECG,1010734301073990142159
cardiac1189734301073879106154173213254
resynchronization1463734301072467101142191232280306353402421457500527546594643
therapy2126734301072573118144186235275
(CRT)2421734301072171116158186
was26277343010762104137
not2784734301074594121
indicated.425748301071968118137179221249292343360
Heart8067483010758103144171203
transplantation103074830107295799148182232253294343371413441461510559
is1610748301072054
not1684748301075099127
excluded1832748301074585126145194244289340
to2192748301072977
be2290748301075196
considered2407748301074189138172191242286314358409
in2836748301072069
the425762301072876120
future.56576230107217098146173216231
However,8167623010754103167211252295322334
the1170762301072573117
presence1308762301074673117150195243284326
of1654762301074569
CADASIL17437623010749103161211254272313
syndrome2076762301073172121170197244318362
may24587623010771112151
prevent2629762301074674117157201249276
the425776301072878124
transplantation570776301073664108158192243264307356385428457477527577
(12,1168776301073273113129
13).1318776301075292114129
CADASIL14687763010759116176228272292333
syndrome1823776301074184135186214263339385
is2229776301072761
associated2311776301075084119170213233275303347399
with2731776301077495124174
possible304762301075099134168187237257302
serious337062301073176103123172221255
neurological364562301074691139167214235284335354395437457
and412262301073988138
psychiatric428062301074882124164213232273301329349390
dysfunction469062301074788123148198247288319339388437
at514762301073967
a5234623010739
young529362301073886135184234
age.304776301074190134150
Authors321776301075097125174223250285
Lesnik352276301073781115163182220
Oberstein3762763010758108154180215244287306354
et413776301074169
al.42267630107385874
published432076301074796145166184217265310360
a4700763010739
study475976301073160108158199
on497876301074594
the509276301072574118
possible523076301074797131164183233253297
association304790301074073106154195213253280299346394
between346190301074690118184227271319
CADASIL3800903010747101158208250268308
and412790301073885134
myocardial4280903010770108155196237263311329369388
infarction46889030107156386128154192222241289337
in504490301071663
2013.512790301074083122159175
In532190301071664
this54049030107257391123
study,3047104301073463112162203216
NOTCH332831043010755117158208265309
mutation36121043010772120149191219239288337
was39691043010763105139
confirmed4129104301073885135159179207282327377
in4527104301071765
414613104301074180
individuals.4714104301071665115135176197247295336356389407
Thirty‑two5141104301074091110137169212241270338386
of3047118301074872
the3139118301072574118
413278118301074179
mutation33771183010771119148189217236285334
carriers3731118301073779106133153197224259
had4010118301074687136
neurological4167118301074590138164212232280331350390432452
symptoms,4639118301073172147197225272346379396
ranging5055118301072466114164183231281
from535611830107214997171
130471323010744
transient311113230107265496145179198243292319
ischemic345113230107175092141186260280321
attack379213230107396799141182221
to4033132301072674
multiple41271323010772120140169188239259304
strokes445213230107316189137176220254
and4727132301073988138
cognitive4885132301073986137186205234254296340
decline.5245132301074792134154173222267283
The3047146301074292138
evidence3205146301074688108158203252294337
of3563146301075075
myocardial36591463010776115164206248276325344385405
infarction408514630107217094137165205236255304354
was44601463010767109144
found4624146301072675124173223
in4868146301072170
104958146301074787
of5066146301075075
415162146301074685
(24.4%)5268146301072670111127171237259
mutation30471603010774122151194222241290340
carriers,3407160301074183111139159204231266283
337111603010744
had3776160301074990140
a39371603010742
history3999160301074968102132179207251
of4271160301074873
acute4365160301074183132161204
myocardial45901603010774113162204246274323342384403
infarction501416030107196892136163203234254303352
and5387160301074190140
current3047174301074089116144188237265
Q/QS3332174301076096156198
ECG3550174301074193147
abnormalities,3717174301074091140190218293334354374403422467502518
242561743010743
had4320174301074788139
a44791743010740
history4540174301074767100130178205249
of4810174301074772
acute4902174301074082130159203
myocardial51251743010773113161203246273322342383403
infarction304718830107196892135162202233253302352
but34191883010753102131
no35711883010751100
current3692188301074392119147191240268
Q/QS39801883010764100159201
abnormalities,4202188301074494144193221296338358377406426470505522
and4745188301074392143
549081883010747
had4976188301075193143
current5139188301074492119148191240268
Q/5428188301076399
QS30472023010761104
abnormalities31722023010749100150200229305347368387417437482517
without3710202301077494124174224274303
a40342023010749
history4104202301075776111141189218262
of4387202301075682
acute4490202301074991140170214
myocardial47252023010782122171214257285335355396417
infarction5163202301072676101144172213244265314365
(silent30472163010724577696140189217
myocardial32852163010774114162205247274323343384404
infarction)370921630107206993136164203235254303353375
(14).4105216301072565105127142
In3187230301071968
addition,3275230301073989139158187206255304321
the3616230301072674119
aetiology3756230301073883112131180200249300341
of4117230301074671
restrictive4208230301072468102132159179220251271313356
ventilation4585230301073882131159178198239267286335384
disorder499023030107466699148176224269296
needs5307230301074691136187220
to3047244301072875
be3143244301075197
dealt3261244301075196137156185
with.3467244301076787116165182
It3670244301072049
may37402443010775117157
involve3917244301072170110158179221265
paresis4202244301075294122166200219253
of4475244301075075
the4571244301072978124
left471524430107216691123
diaphragm,4859244301075070111161211238281331406422
which53022443010766116135177225
was30472583010765106140
noted3207258301074695123166216
by3444258301074786
auscultation3551258301073886119161209228257298326345394443
findings401425830107214290140159207257290
on4325258301074594
admission4439258301073989162182215249267316365
and4824258301073887137
the4981258301072574119
chest5120258301073886131165194
X‑ray.533525830107467098141180192
Symptoms3047272301074179153203231277351384
of3451272301074570
late354127230107165784127
anthracycline3688272301073886113161188230270313353372391439483
toxicity4191272301072572110129170189217260
may44712723010770111150
also464127230107385890139
include4800272301071664105124171221265
arrhythmias.508527230107386492141179211259332351392425442
(2)304728630107246891
In3158286301072776
case3254286301074890124169
of3444286301075580
our35452863010755104132
patient36972863010757100128148192241269
we39872863010772116
found4124286301073180129178228
frequent4373286301073159103154202247296324
premature4718286301075785129203245273322349393
ventricular5132286301074892141169196217258306326368395
contractions3047300301074191142171200244288320341392443479
(PVCs).3548300301073280129182219243258
PVCs38273003010755104157195
may40433003010784127169
contribute4234300301074998150179208229281332363408
to4664300301073686
LV4772300301074992
dysfunction48863003010758101138165216267310343364415466
and53743003010750101153
manifestation30473143010773115163183207251286315357385405453502
of3570314301074570
heart3661314301074590131158190
failure.387131430107216483103151178221237
Interventional412831430107176693136163208252301328348396445487506
radiofrequency4655314301072466116136184209237281331379424473514557
ablation5232314301073989109151178198246296
therapy3047328301072877122149192242283
is3350328301072660
currently3430328301074896124152196245272292333
available3784328301074889131151170212262283328
and4132328301074897148
can4300328301074890139
affect4459328301074973101146188219
the4699328301073584129
ventricular4848328301074892142169197217258307327368395
ectopy5264328301075193124172223263
substrate3047342301073482134169199227270299343
and3411342301074998149
eliminate358134230107527292167187237279307351
or3953342301075685
significantly4059342301074161111161181206227269312362390410452
reduce4532342301073479130179221265
PVCs.48183423010754101153190208
As5047342301076097
the5165342301073686131
number531734230107571061813047356301075096124
of3191356301075681
ventricular3293356301074893142170198218260309329371398
extrasystoles3712356301075192124152195229271307337385405451485
decreased42183563010757102145172216258292338389
and4628356301074898148
LVEF4797356301074890134176
improved,49943563010726101152180228270314366382
the5397356301073585130
intervention304737030107196997141169215260310338358408459
was35273703010773116151
indicated.3700370301072676127147189232261305357375
The40963703010750101147
present4264370301075887132167213263291
case4576370301074992127173
is4770370301072661
similar4852370301074161137157177219247
to5120370301073684
another5225370301074999150178228274302
4-year3047384301074474115159201228
old3296384301075576126
patient34433843010757100128148193242270
(published3733384301073283132183204223257306351402
by4156384301075797
us4274384301075690
in4384384301072776
2010)4480384301075296137177201
who47023843010773122172
was48943843010773116150
treated5065384301073563107148176220271
with5357384301077292121171
standard3047398301073464107156207249276326
doses33943983010756106141186221
of3636398301075681
chemotherapy3738398301074897143218268296346391419462513553
containing4312398301074896146174217236286305354405
cardiotoxic4738398301074891118168188237265313353373415
daunorubicin51733983010757991481972472753253047412301075070111131180
(at324741230107317199
a33664123010749
cumulative3435412301074897171220240281309329371415
dose38714123010756105140185
of4077412301075580
3754178412301075192135
mg/m2),4333412301077112115522845614128063264587412301072438
mitoxantrone,46464123010781101130177216259308335363411461506521
and5188412301074897148
with5356412301077393122171
an3047426301074190
allogeneic315742630107496988137188233282327347388
bone35664263010757107157202
marrow37884263010781123150179227292
transplantation.4101426301073563105154188238259301350377420448467516566583
Twelve47054263010749109154174216260
years4985426301074792133160195
after5201426301074873105148176
the5397426301073685130
diagnosis3047440301074867108157205254288306339
of3406440301074570
acute3496440301073878126155197
myeloid37134403010771110153173221240290
leukemia,4023440301071660108146189263282322338
and4382440301073886135
following453744030107216989108156221240288338
a48954403010738
viral495344030107385884126145
infection511844030107176488132173204223271320
of5458440301074569
an3047454301074190
unknown3157454301074897136187236302352
cause,3529454301074183131165210226
he3775454301074994
developed3889454301075094136180200249300346397
symptoms4307454301073475151201230277352386
of4714454301074873
heart4808454301074893134161193
failure.502245430107246786106154181225241
Severe5284454301074287128172200244
dilated304746830107496887129156199250
cardiomyopathy;3317468301073880107156175223298337385436478506554593610
and3948468301073887137
severe,4105468301073176117161188231247
left437246830107176185118
ventricular4510468301073882131158185205246294314355382
dysfunction4912468301074788122148197246287318337386435
with5367468301076382111160
ejection3047482301074362105146176195243291
fraction335848230107204889129160179226274
of3652482301074569
12%3740482301074178143
were39034823010761105131174
found4096482301072168116163212
on4328482301074593
echocardiography.4441482301074081128176217258285332351399448475516565613652664
The5124482301073988132
patient5276482301074687114133177224251
required3047496301072770121170189216260311
a33794963010746
heart3445496301075499140167199
transplant3664496301073361103152186236257298347375
194060496301074987
years4168496301074489130157192
after4381496301074570102146173
the4575496301073282127
diagnosis4722496301075474115165214264298317351
of5093496301075378
leukemia5192496301072469117156200274294335
at3047510301074169
the3136510301072978123
age3280510301074292137
of3438510301074873
233532510301074590
(15).3642510301072566104128142
Conclusion30475354013856118182232266330382415477541
Late3187552301074080106148
cardiac3353552301073676101148166205244
consequences3616552301073681128160202251297339386425466499
after413355230107376090131156
anthracycline4308552301073783109156181221260301340357375421464
therapy4791552301072470113138179227265
may50745523010769109146
become5239552301074588128173246288
a30475663010741
complicated3108566301074288162212232250290332359401451
therapeutic3579566301073078122149190240285333361380420
problem4019566301075178125175195239313
even4351566301074687130178
many45495663010775116164203
years4771566301074285125152186
after497756630107436698140167
successful5163566301073683123162205238272297346364
anticancer3047580301074189116135175216264305347374
therapy.3441580301072776120146188237277289
Although3187594301075372100148196245294342
the3549594301072674119
treatment368759430107275497137164238282330357
of4064594301074771
heart4154594301074792132158189
damage4363594301074888162203252296
is4679594301071750
constantly4749594301073985134167196237285312331371
improving,5140594301071891140167214255274322371387
long‑term3047608301072069119170199228272300376
follow‑up3444608301073180101120170236266316367
of3832608301075681
high‑risk3933608301075776127176205234254288327
cancer4280608301074891141183227254
survivors4555608301074190117162183225274302338
should4913608301074191141190210261
focus5194608301073281123173207
on54216083010756106
subclinical3047622301073481131173192211259278318360379
cardiotoxicity3446622301074789116164183232259306345364405424452495
before39616223010757102126174201245
the4226622301073483128
onset43746223010754103137181210
of4604622301075479
such4703622301074087128177
complications,4900622301074794168218238257298339367386434483517533
in5453622301072674
particular3047636301074989114144162201248266305330
on3396636301074491
possible3506636301074593125157175223241284
progressive3809636301074571117165191232265297314354396
left422463630107155880111
ventricular4354636301073678125151176195234280298337363
dysfunction,4735636301074584117141188235274303321368415430
by5184636301074583
regular5286636301072264113159177216241
monitoring30476503010773122170188216262289308356405
of3471650301074569
levels3559650301071660101143163195
of3773650301074569
serum3861650301073175101149222
cardiac4103650301073778104152170210251
biomarkers4373650301074766113187228254292335361395
and4787650301073886135
using494165030107457896143192
of5153650301074568
modern52416503010770119168212238287
imaging3047664301071992133182201249298
methods.33656643010780124152200248298331348
If3733664301072548
the3801664301073482126
cardiac3947664301074687114162181221261
dysfunction4228664301075595129154203251292322341389437
has4685664301075495128
already483366430107476592135175224264
progressed5117664301075683130180206249283316360410
into304767830107196794141
a32076783010748
heart3275678301075599139166197
failure,349267830107307291110157184227241
no37536783010755104
treatment3876678301073562105145172246291339366
guarantees42626783010755103144170212260287330375409
a46916783010747
complete4758678301074793168217237281309352
restoration5130678301073376110139186213254282301349398
of3047692301074872
the3139692301072775119
heart3278692301074892132159190
function.3487692301072473121161191210258307323
In3830692301071866
order3916692301074875123167193
to4129692301072874
better4223692301074994122152195222
understand4464692301074896145189216250279320368418
the4901692301072876120
pathogenesis5041692301074991118166215265309357401435453486
and3047706301074191141
dynamics3208706301075798148190264284325360
of3589706301075580
late368970630107266895139
cardiovascular3848706301074890117166185234276318352394442462503530
complications4399706301074795170221241260301343371391440489523
after4942706301074973105149176
anticancer5138706301074897125144185228277318362389
treatment304772030107275496135161234277325351
and3417720301073784133
the3569720301072471115
possibilities3703720301074594126159177225244262280307325368401
of4123720301074468
its421072030107154377
primary430672030107467290163203228270
and4596720301073784132
secondary4747720301073074114160207256296321364
prevention,5130720301074572114154196243269288335382397
further304773430107247399130178222249
randomized3315734301072769117166214289307344387437
studies3771734301073463111160179223257
are4047734301074167110
necessary.4177734301074893134176210243285312355367
This3187748301074292110143
publication3350748301074896146165184224265292311359408
was37787483010763104138
supported3935748301073279129179228255286329379
in4333748301071866
part4418748301074890116147
by4585748301074888
a46927483010740
grant4751748301074874116164191
from496174830107225097171
Ministry5152748301076988135154187216242286
of5457748301074771
Education,3047762301074290138178220247266314362378
Science,3445762301074485104147196236279293
Research3758762301074893126170211237276324
and4102762301074492141
Sport4263762301074594143170201
of4483762301075175
the4578762301073179123
Slovak4721762301074564112152194232
Republic,4972762301074993143191241260279319335
VEGA5327762301074892147200
01/0738/213047776301074484111154195238281313357397
(administrative3463776301072462112185204252270303332359401428446488531
financial401377630107244492132180221240280299
support).4332776301073380130180229256287310323