829
HLAVNÍ42522701005185134178232252
TÉMA69222701003981147194
Current42533701003976100125160198225
trends6663370100255085123161190
in87233701001552
the94033701002664100
diagnosis10563370100375287125163202231246275
of134733701003858
pancreatic142133701003772110141165200234261277307
cancer174433701003065103133168192
36819122701003477119
|325227010043
VNITŘNÍ4268043010746106127172220280301
LÉKAŘSTVÍ748804301074185130188236280325378400
/11688043010757
Vnitř12458043010771118137165191
Lék.1456804301074083122140
2022;68(6):363-3701615804301074487129173188233278301343366380425468511538579619661
/22968043010756
www.casopisvnitrnilekarstvi.cz442680430107651332012142542953293774274464795215705896176436927117307748128548809159449871007102310631101
tion4256230107284795143
of58862301074771
pancreatic67962301074890138179205248288315334374
tumors107362301072775149197224258
across135162301074081107154188221
22159262301074387
studies169862301073362110159178222256
was1973623010764106139
94%213262301074388153
(80).230562301072365109132146
Importantly,247062301071892141191217248290338365384424435
it42576301071947
has49276301074788121
a633763010741
very69376301074184110153
high86676301074867116164
negative104976301074892143183210229270313
predictive138276301074976119169188228259277318362
value176376301074182101149193
(81,197576301072466106117
82).211176301074486109122
This225276301074292110143
is241576301071851
valuable248576301074182101149189239259303
for28077630107247198
clinicians4259030107405977125144184203243291324
as76990301073871
it86090301071644
indicates92490301071664113132172214241283317
that126190301072573114141
EUS142290301073994134
can157690301073779127
also17229030107395890139
exclude188090301074181120139187236280
pancreatic218090301074788137177204247287314333373
cancer.257390301073779127167210236248
In284190301071664
patients425104301075091118137181229256291
with736104301076786114162
PDAC9181043010748105155205
it1142104301072150
is1211104301072154
frequently128510430107265497146194238286313332372
used1677104301075083127177
as1874104301074377
a19701043010744
complementary2033104301074390164213233277350395443470511537580
staging2633104301073665107156175222272
tool425118301072875124143
to588118301073481
evaluate689118301075091132151199240267309
regional1018118301073376126145193242283302
lymph1339118301072666141190239
nodes,15981183010755103153197231247
define1865118301075599123143191235
the2120118301073483127
degree2267118301075599149176219264
of2550118301075579
tumor‑2649118301073482156204231256
-vascular425132301072769111145186235254295322
involvement,767132301072674114162182224268342387436463480
or1267132301075583
secure1370132301074085127175202246
a16361323010748
definitive17041323010756101125145194213241260302346
cytologic2070132301074790122169189238289308349
or2439132301075582
histologic2541132301075675108138185205254305324364
diagnosis425146301074968108157205254287306338
(77,783146301072467111117
83).920146301074487108121
EUS-guided565160301074297138167219268288337382433
fine-needle101916030107224291136166216261307358378422
biopsy1462160301074868117168202244
(preferred1727160301072273100144169213241269313364
over2111160301074687131159
fine-needle229016030107224392137166217262307358378423
aspi‑2733160301073974124144172
ration)42517430107266996116165214236
is682174301071750
the753174301072574119
most8931743010771120154184
favorable1097174301072265105153181223273294338
modality14561743010771120171212232251280323
for180017430107217097
obtaining1918174301074596124166186234254302352
tissue229117430107264579113160205
specimens2517174301073181126168188261306355389
from425188301072453101176
the623188301073585130
pancreas7741883010758101150192220264306340
(Fig.113618830107317493144161
6).131818830107527690
However,14291883010765115181226268312340353
preoperative1803188301075886130181232278306349378398440485
tissue230918830107355690124173218
diagnosis2548188301075777119169219269303323357
may4252023010773114153
not599202301074594122
be741202301074792
needed854202301074590135185230280
in1154202301071765
surgical1240202301073178105153173213255275
candidates1535202301073880128178197246288315358392
with1948202301076282110159
potentially2127202301074797125168216243263304323343383
resectable2530202301072568102147188219261311331375
pancreatic425216301075093142184212256298326346388
lesions834216301072065100120169219253
that1108216301072979121149
are1278216301074270114
highly1413216301074969119169189230
suspected1665216301073482117167213256288332383
of2069216301074974
malignancy.21642163010775117137157207257299348390434447
While26322163010775125145165210
a28632163010742
positive4252303010750101136156186206249294
sample740230301074285161212233279
can1040230301074992142
confirm1203230301074897147172194221298
the1522230301073686132
diagnosis,1675230301075778120171221271306326360378
benign20742303010758105155175226275
findings2371230301073153102154174224275309
don’t27012303010758108158174204
exclude425244301074485126146195246292
the738244301073686132
presence891244301075886131166212262304348
of1260244301075682
malignancy.13632443010782124145164215265307357399443456
Once18402443010769120162206
PDAC20672443010753112164215
is2303244301072761
suspected2385244301074291125176223265297341393
on27992443010756107
initial42525830107196989119140182203
imaging,6502583010727103146197218268319337
the1008258301073787133
next11632583010757103145178
step1362258301074273118170
is1553258301072762
generally16362583010758104155201229273294314356
a20142583010749
staging2085258301074273116168188238290
evaluation2396258301075396139160209252281302352403
to2820258301073785
establish425272301074479109152203224243277327
disease773272301074969103149190225270
extent1065272301074485117161210238
and1324272301074291142
resectability1487272301072771106152195226269320340361380410454
rather196227230107277098148193221
than2204272301072978120170
biopsy.2395272301075070120171206249262
A26782723010753
pre‑2752272301075079123153
operative4252863010748100147175219248268311356
biopsy803286301075879128180216259
may10832863010783125166
be12702863010758105
recommended1397286301073479122171247323369419470516568
if1987286301072652
a20612863010749
diagnosis2131286301075878120171221272307327361
of2514286301075682
chronic2617286301074999127176226246289
or425300301074876
autoimmune522300301074493122170191265340389439484
pancreatitis1027300301075396145187215259301329349379399433
is1481300301072256
suspected1558300301073685119170216259290334385
and1965300301074393143
differential213030030107517197125170198242292320340382402
diagnosis2553300301075272114165214264299318352
yields425314301074060106126177211
difficulties.65731430107507096124146187236257286306351386404
Therapy4253394013861124183230289354416
Radical565356301074586135153192233252
resection83635630107236699142183213231278326
is1182356301071547
the1249356301072472115
only1383356301074593111151
potential1553356301074694121163211237255295314
curative1886356301073684109150177196236279
approach2184356301073786135162208249289337
in2540356301071562
patients2622356301074687113132175222249283
with425370301076787116166
PDAC.6123703010753112164216233
Neoadjuvant8663703010766112162206257277326369412462490
or1376370301075785
adjuvant14813703010749101121170212256305333
chemotherapy/chemoradio‑183537030107489814422027029934939542246651755858862667672179884887691997099010401070
therapy425384301072877122149192242282
may7273843010781123162
improve9103843010725100150178226267310
disease-free1241384301075675108153194228273303327356399445
survival1706384301074189116160180222264284
and2010384301074897147
overall2177384301075596140167210229248
survival2445384301074189116160180222264284
(OS)2749384301073190132156
(84,425398301072468116132
85).578398301075296120134
However,7333983010765115182227270315342355
resection1109398301073478113159202234254303354
with1484398301077393123173
curative1678398301074897125168196216259304
intent2002398301072776104149199227
is2249398301072761
feasible2330398301073277118153172224244290
only26413983010756106126168
in2830398301072675
10%–20%425412301074382148195234276343
of787412301074467
patients.873412301074687113131174221248282298
Unfortunately,1190412301075299122168195225272319359385427445485496
in1705412301071562
these1786412301072472115148191
resected199641230107236598141182211253302
patients,2317412301074687113131174221248282297
positive2633412301074694127144172190230273
resection425426301072770103147189219238286334
margins7794263010773114140189207255288
are1087426301074067110
observed1216426301074898131176202246289339
in1575426301071866
the1661426301072776120
majority18004263010774115133182208228256298
of2118426301074872
cases.2209426301074081115159193209
Thus,2438426301074191139172188
neoad‑2645426301074892141183232260
juvant425440301071967108150198225
chemotherapy670440301074795140214263290338383410451501541
or1231440301075481
chemoradiotherapy1332440301074795140214263290331381400448476524569595637687726
is2078440301072659
the2157440301073483127
standard2304440301074069111159209250276325
of2649440301075478
care2747440301074789115159
in425454301071967
border-line5114543010755105132180224250275295313361406
resectable936454301073275109153194225266316335379
and1335454301074694144
locally1498454301072573114156175193233
advanced1751454301074696137178226267309359
unresectable21304543010753101128171204249290320361411431475
tumors.2624454301073482155204231265281
Chemotherapeutic425468301075199143217266293341385412454503548596624643683
intensive1128468301072573100143191224242283326
regimen1474468301073376126145218262311
with1804468301077291119167
5-fluorouracil,1991468301075178103125173221248295343370411452470489504
oxaliplatin,2515468301075492134153171221240281308327375390
and425482301074189138
irinotecan58348230107164362110158186228269311359
(FOLFIRINOX)962482301072162122163204222267287344405452477
results1459482301072467101148167195230
in1708482301071765
a17924823010739
significantly185048230107325099147165189209249291339366385425
better2295482301074792120150193219
secondary2534482301073175116163212261302328371
resection425496301072770103147189219238286334
rate77949630107276895138
and937496301074089138
OS10954963010760101
(85,1216496301072466109123
86).1359496301074388111124
In565510301071967
resectable652510301073477111155197227269319338383
PDAC,10545103010752110160210226
the1300510301073483127
current1447510301074795122149192241268
standard1735510301074069111159209250276325
of2080510301075479
care2178510301074789116159
is2357510301072558
resection2435510301073376110155196227246294343
fo‑2798510301073078107
llowed42552430107193886151195245
by689524301075796
adjuvant805524301074797116163205246295321
chemotherapy1146524301074795139213262289338382408450500539
or1705524301075582
chemoradiotherapy.1806524301074795140213262289331380399447474523567594635685725737
However,25625243010764112177221262305331343
neoadjuvant425538301074892141183232251299340381430456
therapy901538301072775120146188237277
can1197538301074081129
be1346538301074994
also146053830107405991140
considered1619538301074086135168186235279306349399
in2038538301071866
this212353830107277694127
setting,2270538301073277104135154202251267
especially2556538301074377126171212231271290309349
if425552301071943
risk48755230107335285122
factors629552301072972112142189216250
are899552301074773116
present,1035552301075582125159203251278294
e.g.,1349552301074964113129145
large151355230107256692140184
primary1717552301075582102175216242285
tumors,2022552301073381155203230265281
enlarged2322552301075098117157184232276326
lymph2668552301072565139189238
nodes,425566301074897147191225240
high685566301075170119167
baseline872566301075294127172191209257301
CA11935663010754108
19-91321566301074785114159
levels,1499566301072266107150169202218
significant1737566301073654104152170194214254296344370
weight21275663010768112130179227254
loss,2401566301072270104137153
or2574566301075178
severe2671566301073781122165191234
pain.425580301075091110158174
Chemotherapeutic6195803010753101145219267295343387413455505550597625644684
protocols1323580301075279126153200241288307340
for1683580301072573100
neoadjuvant1803580301075094143185234253300342383431458
and2281580301074391140
adjuvant2441580301074392111158200241289316
tre‑277758030107305699128
atment425594301074168142186234261
are706594301073864107
interchangeable83359430107156390133159198246287335384428468518538582
and1434594301073886136
are1589594301073865107
based1716594301074789122166216
on1952594301074593
FOLFIRINOX2065594301073999139181199244263321381428
regimen2513594301072366116135208253301
or2833594301074572
gemcitabine/nab-paclitaxel425608301074993167207226254295345364412456489535576625655705747788806825853894934977996
combination1441608301074087161210229277318345364412461
(87).1921608301072467108132146
Metastatic5656223010770113141182214243284311329369
disease95362230107466496140180213256
is1229622301071548
an1296622301073785
indication1400622301071663112130170211238256304352
for177162230107216894
palliative1885622301074687106124142182208227267310
chemotherapy.2214622301073785128201249276324368394435484523534
This2768622301073887106138
approach425636301074089139165211252292339
can784636301073677124
prolong927636301074673119138186234282
survival,1229636301073076102145164204245264278
decrease1527636301074588129155197236269313
tumor-related1859636301072471144192218242269311330370397439488
symptoms,2366636301073070144193220266339371387
and2772636301073785133
preserve425650301075077120153197224268311
quality7566503010752100140159178206248
of1024650301075175
life.111965030107234165108123
For1262650301074592119
patients1401650301075395122140184232259294
with1715650301076887115164
a18986503010745
good19626503010753101150200
performance2182650301075398124151199226300341389429472
status,2674650301073766107134182215231
intensive42566430107196794136184217235277320
FOLFIRINOX7646643010742102142184202247267324385431
regimen1215664301072669119138211256304
or1539664301074774
gemcitabine/nab-paclitaxel1633664301074893166207225253295344364411456488534575625654705746787806824852894934976996
combi‑2648664301074087161210230257
nation3047272301074889116135183231
are3298272301073864107
the3425272301072573117
standard3562272301073160101149198239266314
of3895272301074569
care,3984272301073779105148162
whereas41662723010762111155182224265298
gemcitabine4484272301074690163204222251292341361409453
or4956272301074572
5-fluorouracil504827230107416993116163211238285333360401442461479
alone3047286301074160108157201
are3268286301074067110
preferred3397286301075077120144187214241284334
for375128630107237198
unfit3868286301074896120140168
patients4055286301075092119138181229256291
(88).4366286301072466111133146
Currently,3187300301075198125152196244272291332344
target3551300301073274101149194222
therapy3793300301073281126153195245285
is4098300301072356
still417430030107386887106125
limited4319300301072443116135164207257
in4597300301072371
PDAC46883003010750107158208
and4916300301074594144
is5080300301072356
feasible5156300301072872113147165215235280
in5456300301072371
only3047314301074897116157
a32243143010743
minority3287314301077695144192220240268311
of3618314301075175
metastatic37133143010776121149191225254296323343383
patients.4117314301075294121140185233261296313
Olaparib4450314301076383124174216243263313
is4783314301072154
a48573143010743
specific4920314301073686131173192217237277
inhibitor5218314301072169118137186206235282309
of3047328301074872
Poly3140328301074895115155
(ADP-ribose)3315328301072880139185212240259309359393437459
polymerase.37943283010753103123164239283310352386431446
In4260328301072271
patients4351328301075395123142186235262297
with4668328301076988117166
germline4854328301075296123198218236285329
BRCA15207328301074387136187222
or5449328301075178
BRCA23047342301074386133183225
mutations32913423010770117144185212230278325358
who36683423010761109157
didn’t3844342301074564112159174201
progress4065342301074672118168194236269302
on4386342301074492
chemotherapy4498342301073683127199247274321365391432481519
with5037342301076180107155
platinum5211342301074665105132150198244317
derivatives,3047356301075096124145188231260280323368404421
olaparib3489356301075778120172215243264315
results3825356301073580115164185214251
in4097356301072777
a41953563010749
statistically-significant4265356301074273116144165199230250292335356376418446482502553603623648670712755805834
prolonged5120356301075887136157207258309355407
median30473703010774119170189230278
progression-free3346370301075784132182209253287321340389438466491520563609
survival3975370301074188115160180222264283
(89).4279370301073074117140154
An44533703010760109
immune45823703010726100175223271316
checkpoint4919370301074795140182221272322342390418
inhi‑5357370301072674123142170
bitor304738430107507099147175
pembrolizumab32433843010757104179230258306326346383433508550601
is3865384301072660
already394538430107496996140181232273
approved4239384301074999151179227268313364
for4624384301073180108
patients47523843010758101129149193243271307
who50793843010773123173
harbor5273384301075697125176227255
high3047398301074969120170
microsatellite32383983010783103145173222258301330374395415435464509
instability,3768398301072676111142185236257277297326371384
DNA41733983010767127181
mismatch43753983010783103137213256284325375
repair4771398301073579131175195222
deficiency,50143983010758104129150192212258308351395408
or5443398301075685
high3047412301074867117165
tumor3232412301072675149198225
mutational34774123010772120149190218237286335376395
burden3893412301074796123172216265
(90).4178412301072263109132146
NTRK4344412301075599146192
inhibitors4556412301071765114133183202231278305340
lacotrectinib4916412301071859100147174202245287317337385404454
and5390412301073987137
entrectinib3047426301074391118144187228258277325343392
may34594263010770111149
be3628426301074691
considered3739426301073783131164182231275301344394
among41524263010738111159207256
patients4428426301074688115134177225252286
with4734426301076181109157
PDAC4910426301074299149198
harbouring5127426301074586112162211259285304352401
NTRK30474403010757101148194
fusion3261440301072474107126174223
(87).3504440301072568110134148
Conclusion30474654013856118182232266330382415477541
Pancreatic3187482301074585133174200243283311329370
cancer3576482301074082130170213239
remains3835482301072669142183202250283
one4137482301074897141
of4297482301074872
the4389482301072775119
deadliest4528482301074993133182201219263297326
malignancies48744823010773114133151200248289337377396440474
with5367482301076584112160
dismal3047496301074968100174214233
prognosis3300496301075076124174222270304322355
and3674496301074189138
limited3832496301071937111129157200250
options4102496301074797125144192241274
for439549630107247198
effective451349630107436794138179209228269313
therapy.4845496301072876120147188238277289
It5154496301071947
presents5220496301075077120153198246273307
vaguely3047510301074081130176220239278
and3344510301073785133
heterogeneously,3496510301074588116157183230279322370413461509541559599610
and4125510301073784133
the4277510301072572116
grim441251030107457190162
reality4593510301072365105123141169211
is4823510301071547
that4890510301072471111138
most50475103010770118150179
patients5245510301074687113132175222248283
have3047524301074990130173
advanced3240524301074898140182230271314365
or3625524301075482
metastatic37275243010781125153195229258300327347387
disease4134524301075675108153193227272
at4426524301074775
diagnosis.4521524301075675115165214263297315348365
In4906524301072674
regards5000524301073477128169195244277
to5297524301073582
the5399524301073583128
attempts304753830107416898140214263290325
at3392538301073764
early3476538301074080107126166
detection3661538301074690118160201231250298346
of4027538301074468
PDAC4115538301074299149198
without4332538301076281109157205253281
the4633538301072573117
need4769538301074589134184
for497253830107216895
advanced5086538301073887128170217258300350
or5455538301074572
invasive3047552301071967106148181199240283
methods,33505523010774119146195243293326342
a37125523010741
discovery3773552301074968101141188228271298341
of4134552301074872
a42265523010741
cost-effective4287552301074087120149174220244271315356386405446489
biomarker4796552301075069117191232258297340367
with5182552301076685113161
high5363552301074967116164
specificity3047566301073381125165183207226265283310352
and3418566301073784132
sensitivity3569566301073073120153170197216256274302343
has3931566301074584117
currently4067566301073683108135177224250268308
been4394566301074589133180
a45935663010737
goal4649566301074592133151
of4819566301074467
many49055663010770109156194
researchers.511856630107236598141180206244291334360393409
Nonetheless,30475803010757106155199227275319338382416449465
an3532580301074088
effective363958030107436794138179209228269312
screening397158030107327399142187235254302351
tool4342580301072673122142
is4503580301071851
still45735803010733628199118
not4711580301074795122
available.4853580301074080121140158199249268312327
Contrastenhanced52005803010750971451721992402743033047594301074391138178225265306356
CT3422594301074792
using353359430107447694141189
a37415943010738
dual3798594301074591131150
phase3967594301074694134166210
pancreatic4196594301074687134174199242281308326365
protocol4581594301074572118145190231277296
remains4896594301072365138178196243275
the5190594301072572115
main‑53255943010769109127174202
stay3047608301073361102140
method32066083010769112140187234283
for350860830107206793
diagnosing3620608301074563102151198245278295342391
PDAC4030608301074197146194
and4243608301073784133
determining4395608301074588115157182255273320338385433
its484760830107164377
resectability.494360830107236598141181211251300318336354381423434
EUS5396608301073892131
is3047622301071952
an3118622301074189
increasingly3226622301071966107133176217250268316365384424
used3670622301074780124174
adjunctive3864622301074090109156204245275294335378
staging4262622301073362103153171219268
method45506223010773118145194242292
that4862622301072775116143
also502562230107405992140
allows518562230107405978126191225
for542962230107237198
tissue304763630107284779113160204
diagnosis3270636301074968108157205254287306338
when36286363010765113158206
necessary.3853636301074892134176210243285311354366
Additionally,42396363010752101150169197216264312353372391431442
conscious4701636301074086135168209227275323356
indication5077636301071966116134175216243262310359
of5455636301074872
pancreatic3047650301074991138178204247287313332372
imaging3438650301071688129178196244292
using375065030107447795142191
MR39606503010767112
may40916503010771111149
improve4260650301071588137164210250293
diagnostic4572650301074664104153200248282310329369
rates496065030107236491133167
in5146650301071663
selected522865030107317493137178208250299
groups3047664301074975122171220254
of3320664301074872
patients.3412664301075091118137181229256291308
REFERENCES4266880012357112167220281336407470524579
1.42570400853647
​Sung4867041083203773110148
H,64970410834860
Ferlay7237041083366989104135165
J,90270410832940
Siegel9567041083365084122156171
RL,11417041083397183
et123970410833859
al.13127041083365062
Global13897041083476299138170184
Cancer158870410834475112144176196
Statistics17997041083365688109123148170185215242
2020:205570410833972104137149
GLOBOCAN221870410834879123159206246288332
Estimates25647041083376385100156188208241267
of284570410834160
Incidence425714108315528397135168206237269
and70971410833370108
Mortality83171410835794114138170184198219252
Worldwide109771410835995115130168218233271304
for14167141083205677
36150771410833670
Cancers159171410834273110141174194220
in182671410831653
18518937141083366699
Countries.200671410834278115152172193207241267279
CA230071410834183
Cancer239771410834274111142174195
J2606714108326
Clin26467141083425670107
2021;276771410833669101131138
71(3):209-249.4257242083346680112128139173206240263293324356366
doi:8057242083377488100
10.3322/caac.21660.9197242083336375109141173206232260291323354366401431462496531542
2.42573400853651
Arnold4907342083395997134149186
M,69173420835264
Abnet76973420833977114148170
CC,9537342083377486
Neale105473420834276106121155
RE,12237342083336577
et131573420833152
al.13817342083304456
Global14517342083415693132164178
Burden16437342083337090127161198
of185573420833553
51922734208332
Major19687342083528498135155
Types21387342083305695130156
of230873420833453
Gastrointestinal23757342083417398120141177191228249281307329343380412426
Ca‑28157342083376991
ncer.42574420833869101121131
Gastroenterology57074420834374100122142178213250271303323360374412450481
2020;10657442083336698131143
159(1):335-349.e15.12227442083346394112143156167201233265286317351384393427456485496
doi:17327442083377489100
10.1053/j.gastro.2020.02.068.18467442083336375105135168200223239250288319345367387424435470503535568579614645657691726760772
3.42575400853650
Dusek48975420834684109143172
L,67575420833245
Muzik73475420835592120135164
J,91275420832536
Kubasek96275420833672110142168202231
M,120775420835568
et128975420833556
al.13597542083334759
Epidemiology14327542083337186124157214228265280317356387
of183375420833856
Malignant190375420835687101115153190221258279
Tumours219675420833366122160197217243
in245375420831653
the25207542083225993
Czech262875420834070103134171
Re‑28147542083367092
public.42576420833976114129143174186
[online].6257642083185390104118155189205216
2022.8557642083336698132143
[cit.101376420831746608294
2022-2-26].11217642083336698132151181200230263281292
Available142776420834069101115130161199214247
at:16897642083305164
http://www.svod.cz.17677642083365780118130156175225277330339366398434473485516545558
4.304770400853650
Ústav31117042083467193125155
zdravotnickych32817042083306787119150186207244258289318351382419
informaci37147042083175472108129186217248263
a3991704208334
statistiky40397042083295182103117142164179208241
Česke429470420834275101129162
republiky.44717042083235694131169184198227260269
Novotvary475470420834784115152172206238258291
2018505970420833670100130
CR.52047042083427690
[online].53087042083215693107121158192208219
2022.30477142083346799133144
[cit.320571420831847618295
2022-02-26].33147142083336698132151187219238268301319330
Available365871420834069101115129160199214247
at:39207142083305163
https://www.uzis.cz/res/f/008352/novotvary2018.pdf.3998714208336578011814415518120125130335536540243044446948251354256958862164767169071374678181584888091293897310101041107810981132116411841217124712801311134113531392143114491459
5.304772410853649
Siegel31117242083334780119153167
RL,32937242083356779
Miller3386724208355708498132152
KD,35527242083358191
Jemal365772420832559115147161
A.383272420834255
Cancer390172420834172109141173193
statistics,41097242083264880101115140162176207234246
2020.43697242083346799132144
CA452772420834082
Cancer462372420834072109140173193
J4830724208325
Clin48697242083405468105
2020;498872420833568100133145
70(1):7-30.51477242083346685116129140172189221254266
doi:54277242083387690101
10.3322/caac.21590.30477342083346576111142174208233261293324355367402433462493528539
6.304774410853651
Rahib311274420833466103117155
L,328274420833042
Smith333974420833187101123160
BD,35137442083347989
Aizenberg36177442083395482115152190224244282
R,391374420833447
et397474420833354
al.40427442083314557
Projecting41147442083335389104137169192206243281
cancer44097442083306299130163183
incidence4606744208314518296134168205236268
and488974420833067105
deaths500874420833771102123160185
to520774420832157
2030:52787442083336698132144
the54367442083205791
unexpected304775420833774108139177212243266299337
burden33997542083397696133167204
of361775420833856
thyroid,36887542083225988109146160198209
liver,3912754208315296094114123
and404975420833269107
pancreas417075420834071108140160193224249
cancers443375420833264101132165185211
in465875420831552
the47257542083225993
United48327542083448195116149188
States.50347542083335385105138164176
Cancer522575420834072109140173193
Res54327542083367096
2014;30477642083346798128139
74(11):2913-21.32007642083336281112138152162196230261289310340371379
doi:35937642083377489100
10.1158/0008-5472.CAN-14-0155.37077642083336475105131160194218250286321355377410444475508520558600644666695725747783814843875885
Fig.304761101134874127155
6.323061101136087
Endoscopic334562001074086133179209247291338357395
ultrasound-guided37576200107527097123166197242289336383410459505524570609655
fine-needle44296200107294895134162210249289335354393
biopsy483862001075271117164195233
of508862001075174
a5179620010751
mass5247620010778124155186
at545062001075178
the304773001072773112
junction317573001072470117154182201246294
of348573001075174
the357673001073278117
pancreatic371073001075197144182208245291317335373
head409973001075392137183
and429973001075198144
body.445973001075198145182196
Histopathologic467273001076079108135179226272298345390409455502520558
findings52467300107294895141159206252282
confirmed304784001073781127149168194265303349
the341284001072672110
diagnosis353984001074563108154200245275292321
of387784001074568
pancreatic396184001074591137174200236282308326363
ductal434084001074591128156199217
adenocarcinoma457484001074590128175220258302328364382428473544589
(PDAC)518084001072365120167214238