759
5512227010015
Antitrombotická415233701004281108124151176214274312352378394424458494
léčba46623370100155082120155
a4833337010034
digestivní48833370100375391126156183199236274289
endoskopie518933701003472110149178212250288304339
|5584227010018
539561722701005994136
/35498043010757
Vnitř36258043010771118137165192
Lék.3836804301074184122140
2022;68(8):538-5423996804301074487128172187232277301343365380425466510538581625666
/46828043010757
VNITŘNÍ47598043010791152172217266326346
LÉKAŘSTVÍ5126804301074185131189236281326378400
www.casopisvnitrnilekarstvi.cz42580430107651332012142542953293774274464795215705896176436927117307748128548809159449871007102310631101
VE512622701004689
ZKRATCE523022701003986132180216256297
warfarinu425547012174123156190240273298354409
večer857547012155105152202236
v1115547012156
den1193547012164115172
výkonu1387547012156107156211267323
udržovací1732547012163121154200255303353399423
(nikoliv217754701213689113161216241265314
saturační)251354701214797131187220270316372396429
dávkou,2965547012163113160208263319341
v3329547012155
případě340654701216599123181230288339
DOAC3768547012174144204261
za4051547012150101
2–34174547012159108159
dny4355547012164120167
po4544547012164121
výkonu4687547012156108156211268323
a5033547012155
v5111547012155
případě518854701216599123181231288340
LMWH425687012147129214280
v727687012153
terapeutické80268701213788122171229281337371395441488538
dávce1363687012160109157202252
481637687012155109
hodin1768687012160116174199255
po2045687012161118
výkonu.2185687012153104153207264320342
Dříve2549687012171105129178228
lze280068701212771122
zvážit294468701214799149193217252
podání3218687012161118176225281306
nižší354668701216084127169194
než3762687012160111155
terapeutické393968701213888122171229281337372396441489539
dávky4500687012161110157206257
LMWH4779687012152133218285
(2×508668701213383143
denně5252687012160112168224276
dle42582701215681132
hmotnosti):579827012153137193227283339379414438466486
profylaktickou108782701215588144174226251300347384408453501555611
(jednou172082701212756107165221277333
denně)2075827012154106162218269296
nebo2393827012153104162219
vyšší263482701214697138177201
profylaktickou285882701215488143173225250299346383407453500555611
dávku3491827012154103150198255
(jednou376882701212655106164220276332
denně4123827012154105161217269
dle441482701215478129
hmotnosti).4565827012153137193227283339379414438466486
Obecně5073827012166125176223279330
by5425827012155102
terapeutické42596701213383117167224277333367391437484534
úrovně98196701215690145194251302
antikoagulace1305967012150106139163211265315372428452501547597
nemělo1924967012157108193244269325
být2271967012158106143
dosaženo2436967012158114154204248299356412
dříve287096701215891116165215
než3107967012157108152
za328296701214394
cca339896701214691140
483561967012152106
hodin3689967012156112171195251
od3962967012156114
výkonu4099967012149100149204260316
(Tab.443796701213083126183204
6).46639670121537999
Pacient4251107012153102148172224281315
by7621107012165113
měl8971107012192144169
být10891107012165113151
o12621107012163
podávání13481107012165122181230278328385409
antitrombotik17791107012157114147172206240296381439496530555603
před2404110701216599150209
a26361107012156
po27151107012165122
endoskopickém28601107012158115173230270318373432457503551601686
výkonu35681107012157109158213270326
řádně3917110701214190148205257
poučen41961107012166123180226276333
včetně45521107012156101151186243294
písemné4869110701216590130182267324376
formy5267110701213894128214261
(kalendář425124701212876126151202259316365399
ke846124701214898
stažení966124701214175125170221277301
on‑line12901247012155112145171195251303
–16151247012151
https://www.cgs-cls.cz/antitromboticka-terapie-a-endoskopicky-vykon/).168812470121579012718422524628231138646354155960566070073278080484486791295899610431099113211561190122412791364142214781512153615821630168017131747179718311881193819632014204920982131218422412299235523952442249725552580262626732724275728062858290629613017305330863105
Klíčová425141501235886111156213263314
slova:760141501234975132182233256
antitrombotická10371417012156111144167200233288372429485518541586633683
terapie,1741141701214090123172229253303323
antikoagulační20851417012156112144167214268317373429452500545601624
terapie,2730141701214190123172229253303324
protidestičková3075141701216497152185208265316356390413458504558606655
léčba,3751141701213181127184233254
digestivní4026141701216488144194234268291340396420
endoskopie,44671417012157113170226265312366424447498518
přímá5006141701216498121205253
orální5281141701216295144167223246
antikoagulancia,4251557012148103136159205259308364419442490545590613661682
povýkonové11281557012157113160211258312368423470519
krvácení.1668155701214781133181226275331354374
Antithrombotic4251808015077146193228275344394461561630697745780833
therapy12951808015048117180229293361429
and17611808015064133202
digestive20001808015068103171234290336371438499
endoscopy25371808015063131200267322376442510578
Antithrombotic4252007012161114145166198251282334416471525556577620
therapy1065200701212882130162208263308
comprises1392200701214092174228260282319368406
anticoagulation1817200701214497128149192244291345398420466497518572626
and2462200701214397152
antiplatelet2633200701214497128149204226273303351373422454
treatment.3107200701212859107153184265314368398418
The3545200701214499148
number37122007012151104185240289320
of4052200701215077
patients4149200701215299129151199253284323
treatedwith4492200701212859107153184231287375397429482
various4994200701214389120142195249286
forms5300200701212578109191228
of425214701215583
antithrombotic528214701214599130152184239270324406462517549571614
therapy1163214701212983132164212268313
is1496214701212058
growing.1574214701215284137209232286341361
Procedures1955214701215080134179227283337368417455
of2431214701215179
digestive2530214701215375130179218251273320368
endoscopy29182147012147101157211249293346402448
are3386214701214476125
very3531214701214492124174
frequently3725214701212558107163217266321352374421
indicated4166214701211974129151195243274323379
by4565214701215399
general46842147012152101156206237285307
practitioners5012214701215385132176210232264286340395445476516
and4252287012148101156
doctors6012287012152105149183235266305
of926228701215078
various1023228701214490121144197250288
specialisations.1331228701213589139183204251273294332379410431485539576596
Interdisciplinary1947228701211973104151183237259296340361416439460514560591640
cooperation2606228701214092146202251283329360382435489
andmutual3115228701214397152250303335388434456
understanding35912287012150104159207239277310357411465487541595
are4206228701214374122
required4348228701212876132185206237285341
in4709228701211872
order4801228701215081136184216
for5036228701212578110
digestive5165228701215274128176214247268315362
endoscopy4252427012150105160214253297350406451
to896242701213386
be10022427012157107
effective1129242701214978110159204238260307356
and15052427012148102157
safe.1683242701213987115164183
Hence,18862427012165115170214262281
we21872427012173122
present2329242701215688137175225280311
an26602427012148102
overview27822427012155101149181231254303376
based31782427012156104142192248
on34462427012155109
recent3575242701213382126174229260
European,38562427012148101132186242292339394413
British4290242701215385108140162200254
(1),456424270121287494111
and46962427012147102157
North48732427012166120152187241
American51352427012160142192224247290338392
guidelines4252567012156110132187237260282336385424
(2)869256701212776101
for990256701212882114
endoscopic11242567012149104160214252296349405428471
procedures,1616256701215587141185233290343375424462482
with2119256701217295127181
respect2320256701213281119175225270304
to2644256701213285
guidelines27492567012155109131187236259281335385423
for3192256701212983114
perioperative33272567012156106138160214270320352400431453501549
care3896256701214491123172
in4088256701212277
general41852567012155104159208240287310
(3).4515256701212776100117
Antithrombotic4252707012161115147169201255286340423478533565587631
therapy1076270701213084133165213268314
management14102707012180127181228283332415464519550
in1981270701212074
patients20752707012153101133155204258290329
undergoing24252707012151106161210242297351374428483
digestive2928270701215375130179218251273320368
endoscopy33162707012147102157211249294346402448
procedures3784270701215385139183231288341373422460
is4264270701212058
based43432707012153101139188245
on46082707012151106
individual4734270701212074130152199222278331379401
consideration5155270701214194149187209264314346425284701214880102156210
of656284701215180
postprocedural7562847012154108147180235267321365413470523555602625
bleeding1401284701215477126176232255309364
(particularly1785284701212581129160195217261315337384416438485
a22902847012145
delayed23552847012153103126173217266322
one)26972847012152107156181
on28982847012151106
one30242847012152107156
hand,3201284701215299153209229
and3450284701214599155
thromboembolic3625284701213084116169252308362412495550605628650694
risk433928470121305290136
on44952847012152107
the4622284701213084133
other4776284701215183137187219
hand,5015284701215299153209229
ideally5264284701212076125172195217263
in425298701212378
cooperation523298701214396150206257288336367389444498
with1041298701217295127181
the1243298701213185135
physician13982987012155110155193215259281328382
prescribing1800298701215587136175219250273328351405460
antithrombotic22812987012146100132154186240271325408463518550572616
therapy.2917298701213186135167214270315331
Despite32682987012165115153209231263312
all360029870121476991
efforts,3711298701214978109163195230270290
patients40212987012155103135157206260292331
taking4373298701213179125148203258
antithrombotic46512987012146101132154186240272325408464518550572616
medication52872987012182132188210425312701214592124146200255
are700312701214475124
at844312701214476
a9403127012144
higher1004312701215173128183232264
risk128831270121285189135
of1443312701215179
postprocedural15423127012153107146178234266320364412468522554601624
bleeding2186312701215275125175231253307362
in2569312701211973
comparisonwith2662312701214193176232279311333371426480570593625679
those3361312701212983137175225
without3606312701216992124178232286318
this3945312701212983105143
risk;410831270121295189135157
this4285312701212983105143
fact4448312701212573117151
should4619312701213690144198221276
be49163127012152102
accepted5038312701214488131179235267315371
by5429312701215398
attending425326701214880114162217273295349404
physicians8493267012156111156194216260282329383421
and12903267012148102157
patients14683267012156103135157206261292332
should1820326701213993147201224279
be21193267012156106
informed2246326701212276104158190273322379
of2645326701215482
it.274732670121235575
Postprocedural28423267012153105143176232264317362410466520551599621
bleeding3483326701215679129179235257311367
is3870326701212260
mostly39513267012182136174207230276
manageable42473267012183130184231286335382438461510
with4778326701217295127181
a49793267012148
subsequent5047326701213992148186236292346395450481
endoscopic4253407012150105160214253297350406428472
procedure.917340701215789143187235292345377426445
By13823407012154101
contrast,1503340701214598152184215263301334354
cerebral1877340701214593125174230262309332
and22293407012148103158
cardiovascular2407340701214593124180202256302349387432485508555586
thromboembolic3013340701213488119173255311366416498554609632654698
complications3731340701214597180236259281324372404426480534572
are4324340701214879128
often4472340701215584119167222
life-threatening471434070121244674123156188242274322369401449504526580635
and53703407012148102158
not4253547012155110141
uncommonly5873547012159113157210293375429484506553
disabling.1160354701216083121169224247269324379399
One15793547012173128178
should1777354701214498152206229284
always2081354701215375148195240278
consider23803547012149101156194216272321353
postponing27533547012161116154187243298353375429484
an32573547012153107
elective3384354701215578127172206228275323
procedure3728354701216193146191239295349380429
in4177354701212882
a42793547012153
patient43523547012161109141163212267298
with46703547012178101133187
temporary4877354701213786168224279311358390439
antithrombotic53363547012153107138160425368701213387119172255311365397419463
therapy908368701213286136168215271316
(after1244368701212872100135183215
pulmonary14793687012156111133215269324371403452
embolism19513687012149132188242265287325407
or2379368701215385
after2485368701214775110158190
coronary2696368701214396128182236283315364
stent3080368701213972120175206
insertion).3306368701212377115164196231253307362386404
Basic4253827012154102140162206
principles651382701215890112167211233288311361399
of1070382701215684
administration11753827012149104187209263285323356388435467489543598
of1793382701215684
antithrombotic18973827012149104135157189243275328411467521553575619
therapy2536382701213488138170217273318
in2874382701212579
the2973382701213589138
context3131382701214699154185233280314
of3466382701215684
an35703827012149104
endoscopic36943827012151106161215254298350407429473
procedure4187382701215890144188236292346378427
are4634382701214981129
described47843827012157106145189220243299348405
in5209382701212479
Table5308382701215191147170219
1.425396701215267
Digestive512396701217396152201240273296343392
endoscopy9243967012157112168223261306359415461
procedures1406396701216395149194243299354385435473
can1900396701215199154
be20743967012164114
categorized2209396701215199131179236290322345387437494
according2723396701215599142195227283305360415
to3159396701213993
postprocedural32723967012164119157191247279333378427483537569617640
bleeding3932396701216487137187244266321377
risk4329396701213962100146
(Table4496396701213486127183207256
2).4773396701215883101
Postprocedural48943967012160112151184240273327372420477531563611633
bleeding425410701215780129179236258312367
risk81241070121345795141
can973410701214694148
be11414107012158108
specifically1269410701214197147191213242267311358381403449
reduced1739410701213482139192236284341
in2100410701212579
some2199410701214195178227
procedures2447410701215890143188236292346377426465
(ERCP2932410701213077129186237
with3189410701217598130184
papillary33934107012158106162184207229276307357
balloon37704107012158106128150204259314
dilation4104410701215880102149181203257311
instead4436410701212479117149198245300
of4757410701215684
sphincterotomy,4861410701214197152174228272306354386440472525607652667
mechanical4254247012183133178232279333355399447469
securing914424701213988133187218241295350
of1284424701215482
polypectomy13864247012156111134181237288332366420502547
base,19534247012156104142191210
etc.).2183424701214982125145171188
Acetylsalicylic4254387012161103151183231254292339362383427475498519563
acid1008438701214387108163
administered1191438701214499181202256278316348396428476532
as1743438701214381
secondary1844438701213584128180235290337368417
prevention2280438701215384133179226281312333387441
(primary2741438701212479111133214261292341
preventive3102438701215284132178226280311333380428
indications3550438701211872127149193240271293346400438
are4008438701214475123
very4151438701214391123172
narrownowadays)4342438701215198129161214285356409481528583629674712735
should5097438701213589143197219274
not53914387012150104136
be4254527012157106
discontinued551452701215273111155207261292314367421469525
perioperatively10964527012152102133156209265314346393424446493540563609
(discontinuation172545270121247697135179231285316338392445491522544598652
is2397452701211956
associatedwith2473452701214481119173217239285316364420508531562616
an3109452701214397
approximately3226452701214499154186239283305387433464512535581
threefold3827452701212882113161211239293315370
increase4217452701211973116147196242280329
in4566452701211972
thrombotic4658452701212982113166248304358389411454
complications!).5132452701214093175230252274317365425466701213354107160198218244261
The706466701214498147
riskiest87246670121285087132155203240272
procedures1164466701215183135179226281333364412449
are1633466701214373121
the1774466701212881129
only19234667012149103125170
exception2113466701214490131178233264286338392
inwhich2525466701211871159212234277329
discontinuation2874466701215173110153204258288310363415461492513566620
is3513466701211956
explicitly3589466701214490145167188231252284305350
requested3959466701212875130183231269301348403
by4382466701215196
the4497466701212881130
digestive4646466701215173127175212244266312359
endoscopist.5025466701214498152205243286337392414451483503
Reduction4254807012154103160213257292314368422
of868480701216088
dual9764807012161115162184
antiplatelet11814807012153107138160216239286318366389438471
therapy1672480701213892142173221277322
is2014480701212967
better21014807012162112144178227259
abandoned23804807012153109156211266320375425481
in2881480701212983
high-risk2984480701216083137192223256278316362
patients33664807012162110141163213267299338
–37244807012155
particularly37994807012162110142177199242296319365397420466
those4285480701213893147185234
with45404807012178101133187
recently4747480701213887131179234265288334
implanted51014807012129111166190236291322370427
coronary425494701214598129183238285316366
stents811494701213871119174206245
(Table1076494701212879120175198248
3)1344494701215074
–14394947012149
and15084947012147101157
postponement16854947012156111149182238293347397479529584615
of2320494701215482
an24224947012148102
elective2544494701214972121166200222270318
procedure2882494701215688141186234290344376424
should3327494701213892147201223279
always3626494701214770142190234273
be39194947012156106
considered.4045494701214496151189211267316348397453473
Bridging425508701215486108163218240294349
of794508701215078
warfarinwith8925087012170117148179227258280334423446478532
low-molecular-weight1444508701211973144175258312335384428482504551582609682730752807861892
heparin23565087012151100156204235257311
(LMWH)2687508701212469149231295321
is3028508701211957
not31055087012151105137
indicated3262508701211973128150194241273321377
routinely3659508701212881135167189243292315361
(in4040508701212446100
some4160508701213589171220
cases,4400508701214188126175214234
this4654508701212882104142
practice4816508701215384132175209231275322
increases5158508701211973117148197244282331369
the425522701213387137
bleeding582522701215982132182238260314369
risk).97252270121355795141169187
Bridging1179522701215688111166221244298353
with1552522701217699131185
LMWH17575227012150130212277
is2054522701212664
appropriate21385227012151106162194248304336359405437485
in2643522701212680
patients27445227012159107138160209264295335
with3099522701217699131185
high3304522701215880135190
(or3514522701213181113
moderate)36475227012186140197246278325357405429
thromboembolic4097522701213589121174257313367417500556610633655699
risk481652270121355896142
(Table4978522701213182123178201251
5).524952270121547997
Furthermore,53665227012151103134425536701213387137169251305337386405
LMWH8505367012145125208272
therapy1143536701213085134166213269314
carries1478536701214290121153176225264
specific1762536701213793143188209238263307
risks,208953670121305391137178198
particularly23075367012155103134169191235289311358390412459
in2786536701212175
patients28825367012154102134156205259291330
with3233536701217194126180
renal3433536701213179134181204
function3657536701212782136180214236290345
impairment40225367012121103159207229260343393447479
(Table4521536701212677118174197246
4).478753670121507592
In4899536701212276
patients49965367012154102134156205259291330
with5347536701217194126180
a4255507012148
high493550701215982136191
thromboembolic704550701213691122176258314369419501557612635657700
risk,142555070121365896142164
a16105507012151
statement1681550701214476124156204287336391422
of2123550701215987
the2230550701213791140
physician23905507012161116160199221265287333388
indicating2798550701212781137159203250282304358413
anticoagulation32315507012152106137160203256304359412435482513535589644
is3895550701212765
always3980550701215275147194239278
appropriate42785507012152107163195249305337360406438486
before47845507012161111139193225274
an50785507012152106
elective5205550701215376126170204227274322
procedure425564701215789142187235291345377425
(Table871564701212778119175198247
6).113856470121517693
Direct425578701216789120169214248
oral693578701215183130153
anticoagulants866578701214498129151195248295350404426473527558598
(DOACs)1484578701212489158215270309333
should1837578701213690144198220276
not21335787012151105137
be22905787012153103
administered2413578701214499181204258280318351399431479536
on29695787012150105
the3094578701212983133
day3247578701215299143
of3411578701215078
the3510578701212882132
procedure,3662578701215385138183231287340372421439
not41225787012151105137
even4279578701214692140195
in4494578701211973
one45875787012151106155
with4762578701217092124178
a49605787012144
low5025578701211973145
risk519057870121285189135
(e.g.,534557870121247089143163183
biopsy);425592701215780134190228275301318
a7635927012149
longer832592701212478133188237269
withdrawal1121592701217497129183238270318389436459
is1600592701212462
recommended1682592701213382126179262344393448504553609
in2311592701212478
high-risk2409592701215678133187219251274312358
procedures2787592701215789142187235291345377425464
(this3271592701212958113135173
cessation3464592701214593131170218249271325380
should3864592701214094148202225280
not41655927012155109141
be43275927012157107
bridged4454592701215789111167222271328
with4802592701217496129183
LMWH50055927012147127210274
given5299592701215779126174229
the425606701213387137
rapid582606701213279135157213
onset8156067012154109147196229
and10646067012147101157
elimination124160670121497294176199253300331353407462
half-time)17236067012155102124153181213235317367391
(Table2134606701212879120175198248
7).240260670121507895
Recommencement4256207012154104150204287371421477522571654705761793
of1239620701215887
antithrombotic13486207012151106139162195250282337421477533566589634
therapy2003620701213691142175223280326
after2350620701215281117167200
a25716207012151
high-risk2643620701215982138193226259283322369
endoscopic30336207012153109166221260305359416439484
procedure3538620701216194148194243300355387437
should3996620701214398153209232289
always4306620701215175148197242282
be46096207012160111
determined47426207012159110143192225309332387438495
by52586207012160107
the5386620701213692142
endoscopist4256347012150105161216255299352409432471505
and9506347012145100156
the1127634701212984134
recommended1282634701212978123177260342392447504553610
intervals1913634701212075107155188239287310348
should2282634701213691146200223279
be25826347012154104
considered2707634701214194149188211267317349398455
minimal:31836347012180103157180262310333353
1–23557634701214793139
days37176347012153101146185
after3923634701214473109158190
the4134634701213084134
procedure4289634701215386140185234291345377426
in4736634701212075
the4832634701212984134
case4987634701214189128178
of5186634701215180
P2Y125286634701215099150197241
inhibitors;425648701212379134157214237270324357398417
2–38636487012156103153
days10376487012161109154194
after1252648701215281118167200
the1473648701213792142
procedure1637648701216093148194243300355387437
in2095648701212783
the2199648701213792142
case2363648701214897136187
of2571648701215988
DOACs;26806487012170140199254295314
in3015648701212883
the3119648701213792143
evening32836487012154101151206229285341
of3645648701215988
the3754648701213792143
day39186487012160108154
of4093648701215988
the4202648701213792143
procedure4366648701216194148194243300355387437
for4824648701213388121
warfarin49676487012177125158190239272295350
with53386487012178102135190
a4256627012148
maintenance4946627012190138161216249298353401457502551
(not1066662701213487142175
saturation)1262662701214695127182215263295319374429455
dose;17386627012162117157207227
and19866627012154109166
4821736627012157110
hours23046627012162117172205245
after2570662701215483120169202
the2793662701213994145
procedure2959662701216396150196245302357390439
in3420662701212984
the3525662701213995145
case36916627012151100139189
of3902662701216090
LMWH40136627012153134218283
at4317662701215487
a44256627012154
therapeutic4501662701213994144177226282333389422445489
dose.50126627012162117156207227
Earlier52606627012155104137160183234267
administration4256767012148105188211266290329363395444476499554610
of1056676701215988
a11656767012152
lower-than-therapeutic1239676701212782155205237265298354402457489522577628661709766817872905928973
dose22336767012161116155205
of2460676701215888
LMWH25696767012151132215281
(twice2871676701213263139163208257
a31496767012152
day32226767012160108154
per33976767012161112145
weight)35636767012178127151207262294321
can3905676701214998153
be40796767012161112
considered42126767012149103158197220277327360410467
in4700676701212883
this4804676701213792115154
context:49806767012148102158190239287323344
prophylactic53456767012161941484256907012157113158183231275311334378
(once825690701213183138183232
a10796907012151
day)11516907012159107153179
or1352690701215790
higher1463690701215982138193244276
prophylactic1761690701215992147204260305330378422458481525
(once2308690701213183138183232
a25626907012151
day26346907012159107153
per28086907012160111144
weight)29736907012176126149205260293320
doses.33146907012159115154204244265
In3600690701212782
general,37046907012158109164215248296320340
a40656907012151
full4138690701213287111134
anticoagulation42936907012151106139162207260309365420443491524547602657
effect4972690701215382115165211246
should5239690701214398153208232288
not4257047012155111143
be5907047012157107
achieved719704701214893148171221269318375
earlier1115704701215098131155178228261
than1397704701213388136191
approximately16107047012148104162195249294318401449482531555603
4822347047012151104
hours23597047012155110166198239
after2619704701214877114163196
the2836704701213388139
procedure.2996704701215790144190239296351383433453
The4257187012149105156
patient6027187012153101134156206262294
should917718701213691145200223280
be12187187012153104
properly1343718701215386140197247280303351
informed1715718701212074103158190274324381
of2117718701215180
the2218718701213084135
course2374718701214194149181221272
of2667718701215180
antithrombotic2768718701214599132154187242274328411468523556578623
therapy3412718701213084134167215271317
before37507187012154104134189221271
and4042718701214499156
after4219718701214473109158191
the4431718701212984134
endoscopic45867187012147102158213252297350407430475
procedure,5082718701215386140185234291345377427447
including425732701212379124147201258281336393
a8397327012148
written9087327012174107131164199248304
form1233732701212984117201
(a1455732701212974
calendar1550732701214593117167223279327360
can1931732701214594149
be21017327012157108
downloaded22307327012157112184240264319368424475532
online27837327012155111134157212263
for3067732701212984117
this3205732701213489112151
purpose).33777327012157112145202258297348373392
Key4257495012358108158
words:6047495012377132168227268292
antithrombotic9177497012151106138161194249282336420477533565588633
therapy,1571749701213691141174223279326342
anticoagulation19347497012150106138161206259308364419442490523546601656
therapy,2612749701213590141173222279325341
antiplatelet29747497012151106138161218242290322372396446479
therapy,3475749701213590140173222278325341
digestive3837749701215982138188227261284333382
endoscopy,42407497012152108165220259304358415461477
direct4738749701215982115164210245
oral5005749701215790138162
anticoagulants,518874970121501051381612062593084257637012156111134182237270310331
postprocedural7787637012156112152185242275330375424482536569617641
bleeding.1440763701215781131182240263318374395