570
PŮVODNÍ497922701004395143193242296315
PRÁCE530922701004489137177218
Vývoj438833701004380119157172
chronického45773370100296791129167182213247281319358
žilního4951337010031466299115154193
onemocnění516033701003875111171210241278314352367
|5584227010018
E19561722701006695137
/35658043010757
Vnitř36418043010771118137165192
Lék.3852804301074184122140
2023;69(1):E19-E224012804301074487128172186231274298337355369412451489518562607651
/46828043010757
VNITŘNÍ47598043010792152173218266326347
LÉKAŘSTVÍ5126804301074285131189236281326379401
www.casopisvnitrnilekarstvi.cz42580430107651332012142542953293774274464795215705896176436927117307748128548809159449871007102310631101
https://doi.org/10.36290/vnl.2023.01243594480100376493132161177199218457744801004081994675448010015537711513748144480100287389124167204247293316355396414432470516552587605649678714
Vývoj4259870275140269400522587
chronického1083987027510123032344957664274387098511141240
žilního23949870275105171237364431562688
onemocnění31549870275126253372560685786914103311621228
Jiří425137501374575118147
Spáčil,5951375013759125183233263294323
Jaroslava9401375013745103145209256287346402460
Svobodová14221375013760115177243307373437494552
Cévní4251529013364117169230255
ordinace,704152901336096157182242295344397419
Spamed,11461529013354116169260315378400
Praha1569152901335993146207259
Je425203801213789
známo,5362038012144100149233290310
že868203801214495
chronické9852038012146102135191248272318365415
žilní142220380121446893149173
onemocnění16172038012156113164249305351408459515540
se2179203801214092
v22932038012149
průběhu2364203801215892148206258315370
let2756203801212576111
zhoršuje.28892038012144100157190232287312363384
Klinických3296203801215581105161185231278330374430
dat37492038012157106140
je3911203801212576
však4010203801214989139187
málo.42192038012184133158214234
Soubor4252175012454113173235294334
nemocných7802175012459114202261308368420466526
a13272175012454
metody:14022175012486141179238300354382
Z18062178012156
našich18842178012156105145169215271
pacientů,21772178012157107153177228285318374395
kteří2595217801214784134168192
byli28092178012158105130154
vyšetřeni29852178012149100141192227260311368392
klinicky,339921780121477397153177223271322339
duplexní37602178012157113170195247295352376
sonografií4158217801214096153209267300350380407431
a46112178012149
fotopletysmograficky,4682217801213086120175233258309344394435519575633666716746773819425231801214798115
jsme562231801212868152204
vybrali7882318012152103162196245270294
16011042318012154102155
nemocných,12812318012159110195251298354400445501523
kteří1826231801215188138172196
u20442318012159
nás21252318012159108148
byli22952318012160108133157
vyšetřeni24742318012152103144195230263314370394
po28912318012160117
1030302318012155102
a31552318012151
více3228231801215277122172
letech.3423231801212778112163209265287
Ženy37332318012158109165212
tvořily3967231801213688143177201225274
7942632318012155105
%.43902318012183106
Průměrný4518231801215790146230281315372418
věk49592318012151101149
byl51302318012161108133
5452852318012155108
let5415231801212778113
(rozmezí425245801212859115158242294338362
18–82810245801215097150205256
let).1088245801212374109137156
Varixy12662458012155102136160208259
žil154724580121426791
dolních16602458012156112137193217263319
končetin20012458012146101158204253288312368
v23912458012148
rodině2461245801213287145170226277
udávalo27602458012155112161209258283339
4931212458012151101
%32442458012179
nemocných.33452458012155106191247293350396441497519
Sklerotizaci3886245801214996122174208263297321365416461485
žil439424580121426690
prodělalo4506245801215690146204255280329354410
6,34938245801215172127
%,50872458012178101
operaci52102458012155113165199248294318
žil42525980121436892
10,65402598012159107129182
%7442598012188
pacientů.8552598012165115161185237294328384405
Průměrný1283259801216194151236288322379426
index1731259801213289147198247
tělesné2000259801214292117169210266318
hmotnosti23412598012164148205239296352393428452
byl28162598012165113138
27.29772598012159109121
Použili31212598012161116173217242266290
jsme3434259801213273157209
CEAP36662598012166116180234
klasifikaci.3922259801215582131171196226254302352398423444
V43892598012164
klinické4476259801215581105162186232280331
třídě4829259801214175100157209
C150602598012167116
bylo51992598012165113138195
5054162598012160112
pacientů,4252738012157107152176228284318373395
v8422738012153
C29172738012163115
81,10552738012155104120
v11972738012153
C312722738012163116
1514102738012156101
a15342738012152
v16082738012153
C416832738012163113
1418182738012156103
pacientů.19432738012161111157181232289322378399
Regurgitaci23642738012159110168224257314338372422468492
v28782738012153
povrchových29532738012161118166200246302358406458503559
žilách353427380121477296145191247
jsme3803273801212969153204
zjistili402927380121487397137172196220244
u42952738012160
4343772738012156106
%.45052738012184107
Průměrný4634273801215891147231283316373420
čas5076273801214999139
žilního523727380121477296152176234291
návratu4252878012155105152186236269325
po7722878012158115
cvičení909287801214698123168218275299
byl12302878012158105131
24,513832878012152101123177
s.1582287801214062
Výsledky:4253015012464118162191246308363420448
Poslední8953018012153107147171223281337361
vyšetření1279301801214799139191225258309366390
bylo16913018012156104129185
provedeno1898301801215690146194244302354410467
v23873018012147
průměru2456301801215791147231282316372
po28513018012156113
132986301801215196
letech3104301801212374109159206262
(rozmezí3388301801212859114157241293337362
10–283772301801215198153200252
let).4046301801212374109137156
Zhoršení42243018012155111167201242294350374
klinického462030180121477397153177223270320377433
stavu,5075301801213974124171228250
progrese5347301801215690146425315801215689140181232
do6793158012156112
vyšší813315801214798139179203
třídy103831580121326590147196
nastalo12563158012154103143178228253309
u15873158012154
nemocných16633158012154106190247293349396441497
v21823158012147
třídě225131580121326590147198
C124723158012156105
u26003158012153
3626763158012150101
%,28003158012178101
u29233158012154
nemocných29993158012154106190246293349396441497
C235183158012157109
u36503158012154
23,537263158012150102123177
%,39253158012178101
u40483158012154
C341243158012157110
u42563158012154
134332315801215096
%44503158012178
a45503158012147
C446193158012157108
u47493158012154
748253158012150
%.48973158012178101
Neprokázali50213158012164116174208264312362406457482506
jsme425329801212464148200
statisticky647329801214176126159183223258282328375427
významný10963298012149101147203252336393439
vliv155732980121497498148
sledovaných1727329801214165116174231279328384431476532
parametrů22813298012158108141191275326361394451
na27543298012156105
progresi2882329801215891147205238289330353
onemocnění.32583298012156112164248304351407459515539561
Závěr:4253435012458113166218258286
Progrese733343801215587143201234285326377
onemocnění,11323438012156113165249305352408459516540562
u17163438012156
našeho17953438012156105145197254310
souboru2127343801214197153211268302358
nemocných25073438012157109193249296352399443499
sledovaných3029343801214165116175231279328385431476532
1035833438012153100
a37063438012149
více3777343801215075120170
roků3969343801213490138195
v41863438012149
cévní4257343801214696145202226
ambulanci,45053438012150134192248273322378424448469
je4996343801212677
menší50963438012184136192232257
než53753438012157108152
uvádějí4253578012155105154212263288312
populační7593578012158115173229254303348405429
studie.1210357801214075131189213264285
Klíčová425374601235885111155211261312
slova:758374601234268124174225248
chronické10273748012145100132187243266311357406
žilní145437480121436690145168
onemocnění,16433748012155111161245300345401451507530550
progrese.2215374801215689144201233283322373393
Development4254000015078141207268303370439539602671718
of11814000015067115
chronic13334000015053122171239307341395
venous17654000015067128196263331387
disease21894000015069103158221286342405
Introduction:425419501242988125164222283342387426455513572598
Chronic10504198012158113145200256279324
venous13954198012155104160215270309
disease1726419801216386125176224263313
is2061419801213069
known21514198012154111166239295
to2467419801214195
gradually2583419801216395144200255303327350397
worsen30014198012181135168209259315
in3337419801213186
the3444419801214095146
course36114198012152105161193234284
of3916419801216291
years.40294198012154103151184224245
However,42964198012172127200250297346379395
little471341980121305386122145195
clinical492941980121527598154177221270294
data52444198012163111144193
is5458419801213069
available.425433801214895143166190238294318369389
The4254475012455114167
patient6124475012458111148176230289326
group958447501245695153212273
andmethods:12514475012450109170273327364424483543587613
We18864478012182130
used2037447801215392142200
the2258447801213086136
set2415447801213788121
of2557447801215382
our26604478012152108140
patients28214478012155103136159209265297338
with3180447801217195128183
completed3384447801214296179236260311344393451
clinical385644780121426588143166211260283
examination,4161447801214794143226249304352385408463518539
duplex47214478012154109166190240287
sonography5029447801213793148204260293341398454499
and4254618012148103160
photoplethysmography6064618012155111166199253310334385418473519558641697753786834891947992
and16204618012146101158
selected1799461801213888112163208244293350
1602170461801215096148
patients23394618012155104136159210265298338
examined2698461801214996144227251306356413
at3133461801214678
our32334618012153108140
office3395461801215382114141185234
after3651461801214675111161193
103866461801214996
and39834618012146102158
more41624618012182137170220
years.4403461801214594143175215237
Females4661461801214796179227251301341
represented5023461801213181138170220260310366398448505
79%4254758012151101181
in627475801212277
the725475801213287138
group.884475801215587142197254273
The11794758012148104155
mean13554758012182133181236
age16124758012147103153
was17864758012173121160
5419674758012150102
years2090475801214695143176216
(range2327475801212757106161217267
18–822616475801214996148201251
years).2888475801214696144176216241260
Venous31694758012154101157212267306
varices3497475801214695127151196245284
in3802475801212278
lower3901475801212277150199232
limbs4155475801212245128185224
in4400475801212277
the4499475801213186137
family4657475801212877160183207254
were49324758012172122155205
reported5158475801213181138194227263312369
by4254898012157103
49%549489801214999179
patients.7494898012155103136159209265297338359
Venous11294898012154100156211266305
sclerotization1456489801213782105155188243276299341391424447502558
had20354898012153101157
been22144898012154105156212
undergone24474898012152108164215248303358414465
by29334898012154101
6.3%3055489801214970123201
and32774898012146101158
venous3456489801214695150206261300
surgery3777489801213792124180230263314
by41124898012154101
10.6%4234489801214995115167245
patients.45004898012155104136159209265297338359
The48804898012148104154
mean50564898012181131179234
body53124898012154110167215
mass4255038012183132171210
index656503801212176132183230
was9075038012171119158
27.1087503801214897108
We12165038012182129
used1367503801215291142199
CEAP15875038012155103166219
classification.1827503801214265113152191214243270314363396419474529550
The23995038012147103153
clinical257450380121426588143166211259283
class2878503801214265113152191
C130915038012155103
included3215503801212176121144199255306363
503599503801214999
patients,37195038012154103136159209264297337358
C240995038012155107
included4227503801212076121144198255305363
81,4611503801214896111
C347435038012156108
included4872503801212076121144198255305363
155256503801214893
and53705038012146101158
C44255178012158107
included554517801213085130153208264315372
149475178012158103
patients.10725178012163112144167218273306346368
Regurgitation14615178012160111167222255310334367416448471526582
in2064517801213085
superficial21705178012147101158209242274300345368416439
veins26305178012155104128183222
was28735178012180129168
found3062517801213691146201258
in3341517801213085
43%.34485178012158107184206
The36765178012156112163
mean38605178012190140189244
venous41255178012155104159215270309
return4455517801214089123178210266
time4742517801214063146197
after4960517801215584120169202
physical51835178012164120165205228273321345
activity425531801214893128151200223257306
was7535318012173122161
24.59355318012151100120174
s.1130531801213961
Results:4255455012459112157216244281326352
The7985458012147103154
last973545801212169108142
examination1136545801214795143226249304352385408463519
was16765458012171119158
performed18555458012155106139171226259342393450
after2326545801214675111161193
132541545801214893
years2655545801214493141174214
on28905458012153108
average3020545801214591141173222278328
(range3369545801212656104159216266
10–283656545801214995149195246
years).3923545801214493142174214239258
Deterioration42025458012164115148197230254309342390423446501557
of4780545801215281
the4882545801213186136
clinical503954580121426588144167211260284
condition5344545801214296151425559801215680113136191246
and6935598012151106163
progression877559801216093148204237287326365388443499
to1397559801213690
a15095598012151
higher1581559801215982138193243276
class1878559801214871119159198
were20975598012177126159209
observed23275598012158115154205238289338395
in2743559801212782
36%28465598012155105183
patients30515598012160108141164214270302343
in3415559801212682
class3518559801214871119158197
C1,37365598012161109125
in3882559801212782
23.5%39855598012155106126179256
patients42625598012160109142165215271303343
in4627559801212681
C2,47305598012161112133
in4884559801212681
13%4987559801215499176
patients51845598012160109142165215270303343
in425573801212379
C35255738012158110
and6565738012148104160
in837573801212479
7%9375738012152130
patients10895738012157105138161211267299340
in1450573801212379
C4.15505738012158107128
We16995738012185132
did1853573801215679136
not20105738012156111144
demonstrate21755738012156107190245301340374406455487537
any27335738012148104149
statistically2903573801214074123155178217251274319368391414462
significant3386573801214062118174197226252297346401433
effect3841573801215079112162208243
of4106573801215584
the4211573801213388139
followed4371573801212984108131187259309366
parameters47585738012157106139187270321354404436477
on52565738012155111
the5388573801213388139
progression425587801215790144201234283323362385440496
of942587801215584
the1047587801213388139
disease.1207587801215680119169217256307327
Conclusion:4256015012459116175221250308353381439498524
The9706018012149105156
progression1147601801215588143200232282321361383439494
rate1662601801213280113162
of1845601801215483
the1949601801213287138
disease2108601801215579118168216255306
in2435601801212277
our25336018012154109142
patient26966018012156105137160210266298
group3016601801215487141197253
followed3291601801212883107130185258307365
at3677601801214779
the3777601801213288138
vascular3936601801214796135180235258306338
office4296601801215382115141186235
for4552601801212883116
104689601801215097
and48076018012147103159
more49876018012183138171221
years5229601801214695143176216
is5466601801212261
lower425615801212479152201234
compared680615801214599182239288320370427
to1129615801213387
population12376158012157113170225249297329352407463
studies.1721615801214074129185208259298319
Key4256326012358108158
words:6046326012374130166224266290
chronic9156328012145100132187243266311
venous1247632801214897153208263302
disease,1571632801215679118169217256306326
progression.1918632801215790145202234284323362385440496517
Úvod4256754013874137198262
Chronické5656923010752100126173222240281318361
žilní94669230107436180128146
onemocnění11116923010755103148222270312360404452470
(CHŽO)1601692301073080136184241263
dolních18846923010755104123171189229277
končetin2181692301074492140181223251269317
(varixy,2518692301073069110137155195237248
venektázie2786692301074790425706301074892129159199235254297
aj.)7417063010739577294
je854706301071861
časté934706301073979111139181
a11347063010740
diagnóza1192706301074866105154201248283324
se1535706301073276
stanoví1630706301073260101148195235253
poměrně1902706301074897170213239286330
snadno.2250706301073380119168215263277
Vychází2546706301074485123170210247265
se2830706301073275
z30476783010736
anamnézy3102678301074188128200248291327369
a34906783010741
fyzikálního3550678301072366104122159200219265283332380
vyšetření3948678301074183116159186212254301319
(včetně4285678301072462101142169217260
aspekce4564678301074073121165202241282
a48656783010741
palpace4925678301074990108157197237278
končetin5222678301073885132172213240258305
vstoje).3047692301074174102147166209229242
Přesto3307692301074670112145173219
se3545692301073376
údaje3640692301074896136154197
o38566923010748
výskytu3923692301074083116153194225272
v42146923010740
četných4273692301074082109156194233280
různých4571692301072774110158196234282
studiích4871692301073462109158175193232279
značně5169692301073684124164211254
liší54426923010719366885
(od3047706301072469118
131847063010747
do32497063010752100
833368706301074789
%)3475706301077090
(např.3584706301072772112160186196
1,3798706301074757
2,3874706301074761
3,3954706301074760
4).403370630107476880
Výskyt4132706301074989122159201231
je4382706301072265
různý4466706301073077113161198
v46837063010744
různých4746706301072977112160198237284
částech5049706301074383116144185226273
světa5341706301073677119146187
MUDr.425740609562112164189200
Jiří643740609527446885
Spáčil,74674060953781118154171188202
CSc.96574060954684121136
Cévní42575260954684120164181
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