770
HLAVNÍ42522701005185134178232252
TÉMA69222701003981147194
Alarminy4253370100425993118178194231267
–708337010038
nové76233701003776112147
terče9253370100256084115149
biologické10903370100375391107146184200230264299
léčby14053370100145081119155
bronchiálního157633701003762100138169206221256272309324363402
astmatu?19953370100336290150185212250280
35819922701003469111
|350227010018
VNITŘNÍ4268043010746106127172220280301
LÉKAŘSTVÍ748804301074185130188236280325378400
/11948043010731
Vnitř1270804301074693112140166
Lék.1456804301074083122140
2023;69(6):352-3581615804301074487129173186232274298340363377422463505530571612656
/23168043010731
www.casopisvnitrnilekarstvi.cz442680430107651332012142542953293774274464795215705896176436927117307748128548809159449871007102310631101
12.425553085366782
Porsbjerg521554083357192119157172206226264
CM,7985540834094107
Sverrild918554083336396117138153167206
A,11375540834154
Clare1204554083405586107140
M,13575540835568
Lloyd1438554083314683114152
CM,16035540834094107
et17235540833456
al.1792554083324759
Anti‑alarmins1864554083417899114135167181213233291306343368
in22465540831451
asthma:2311554083315780117174206217
targeting2542554083215374111146167182219257
the2812554083226094
airway425654083324768121153184
epithelium628654083357489111149184199213251309
with956654083516688126
next‑generation11026540833872104128147187222260295315348370384422461
biologics.1582654083395492107145185199231259272
Eur1873654083336990
Respir1983654083357097135150171
J.21746540832436
202022296540833569101135
Nov;56(5):1-14.23846540834583115127162196215248266278307325356387399
doi:2802654083397792103
10.1183/13993003.00260-2020.425754083346577107134164197221253283315350382416451484495530565597630665688718752784817829
13.425853085366781
Chan5188540834077108145
R,6758540833548
Stewart735854083325285135167188212
K,9588540833549
Misirovs1018854083546994108129165196222
R,12528540833548
et13118540833456
al.1378854083324759
Targeting1448854083336080117151173187224262
Downstream17228540834583133171196218239272303360
Type2094854083325998133
2223885408334
Cytokines2284854083396690126156172209243269
or25648540833858
Upstream26348540834381107130150183214271
Epithelial425954083326983104141174188202232246
Alarmins682954083405485104161174211235
for928954083185474
Severe1012954083326696129149181
Asthma.1204954083406688124180211222
J143795408324
Allergy1471954083415568102121158188
Clin1670954083395366102
Immunol17839540831570126162198235249
Pract.2043954083345385115138150
10(6),2203954083346482113130140
June2354954083235996129
2022;1497-1505.2494954083336697130141169199230261279308336369401412
14.4251053085366883
Liu5221054083314683
S,61910540833345
Verma6781054083366889146178
M,87010540835568
Michalec95210540835569101138169184218250
L,121710540833144
Liu12761054083314682
W,137310540835766
Sripada14541054083325267106138176208
A,167610540834155
Rollins17451054083367388103117154180
D,193910540834656
et200910540833456
al.20791054083324759
Steroid21531054083325285106143157195
resistance2363105408321548094120142174211243276
of265310540833856
airway27241054083324666119151181
type4251154083225594129
2569115408334
innate6181154083155290121142175
lymphoid80811540831546104143181218233271
cells1094115408332657994119
from12281154083194077134
patients13781154083387092106140177198225
with16191154083506587124
severe17591154083266091125146179
asthma:19531154083325880118175207218
the21861154083225994
role22951154083215772107
of241711540833756
thymic24881154083225989147161193
stromal26961154083264869106163195210
lymphopoietin.42512540831546104142180218257295309343365380417429
J868125408324
Allergy9061254083415670105125163194
Clin11141254083405469106
Immunol.123412540831472129166203240256268
2018;141:257-68.e6.15161254083346798129140170200230238272306339357393428441475510522
15.4251353085366881
Gauvreau52313540834476113145166199230267
GM,80613540834498111
Sehmi93313540833266104161175
R,112413540833649
Ambrose118913540834198137157194220254
CS,14591354083407385
et156013540833456
al.16321354083314658
Thymic170613540833371101159174205
stromal19271354083264869106163195210
lymphopoietin:215213540831546104143181218257295310344366380417429
its25971354083143663
role26761354083215772106
and279813540833269108
potential4251454083397798131168189204235250
as68914540833257
a760145408332
therapeutic8061454083225993114146185220257278293324
target11441454083225474112146168
in132614540831451
asthma.13911454083325880118175207219
Expert162414540833365103138159183
Opin182114540834786101138
Ther197314540833271105126
Targets.21131454083325980117152173200213
2020;24:777-92.234014540833467100133145179211222255289322340374407419
16.4251553085366985
Corren5261554083407798120154192
J,73415540832436
Gil,785155408344597587
GE,8871554083447790
Friffiths992155408333536887105122145183209
MJ,12171554083548092
et132415540833456
al.13961554083314760
Tezepelumab14711554083336393127166202217255313345384
improves187015540831573112134171203237264
patientreported21491554083397293109143182203225259298337358383417456
outcomes26201554083387698129166224259286
in42516540831553
patients4981654083397294109144183204232
with7511654083506689127
severe,8981654083276294129150184196
uncontrolled111516540833775108145183205226264280295330370
asthma15051654083325982120178211
in173716540831452
PATHWAY.181016540833573102147206245276285
Ann211616540834179117
Allergy22541654083415672107128166198
Asthma24731654083416992131189221
Immunol.2715165408315731311684251754083387692105
2021,126,2:187-193.54517540833468101133141172202236249285297327358391409440470503516
17.4251853085366775
Menzies‑Gow51418540835489126155170204230250296334384
A,91218540834154
Corren9801854083407697118151189
J,118218540832436
Bourdin123118540833673111131169183220
A,146518540834154
et153318540833455
al.16021854083314658
Tezepelumab16741854083326291125163198213250307339377
in206518540831451
adults213018540833270107122143170
and231418540833269107
adolescents243518540833170107123157183214247285306333
with27811854083516587125
severe,4251954083266092126146179191
uncontrolled63019540833774106142180200221258273287321360
asthma.10041954083325880118175206219
N1237195408345
Engl129619540833269108122
J1432195408324
Med.147019540835589128140
2021;384:1800-9.162419540833468100131138173206242253282313347383406440450
18.4252053085377188
Menzies‑Gow53620540835692131162178213241263311350403
A,96320540834256
Brightling10432054083365874114153176192207246286
CE,13532054083417588
Ambrose1465205408342102142164202230266
CS,17552054083417689
et186720540833558
al.19492054083334862
Effect20342054083345373108142167
of222420540833959
tezepelumab23062054083225788123163200216254314347388
in271720540831554
oral27952054083386094110
corticosteroid‑dependent4252154083316788112127158194220243276296333348386407447481520555592630665702723
patients11642154083397192107141178199226
with14062154083506587125
severe15472154083266092125146179
asthma:17422154083325880118175207218
results19762154083215480117131153180
from21722154083194077134
the23222154083225994
phase243221540833876108134168
32616215408334
NAVIGATOR26662154083458511813417821942522540833378114
study.5532254083264886124155165
Am73122540834199
J844225408324
Respir8822254083356996134149169
Crit1065225408340607597
Care11762254083407292126
Med.131622540835488127140
2021;203:A1442.14702254083346799130138172205238248290319349386417429
19.4252353085366881
Wechsler51823540835790122159185199233254
M,78423540835567
Gow86323540834482132
AM,100823540834195108
Brightling11282354083365671109147167182196234272
CE,14122354083407284
et150923540833355
al.15762354083324759
Oral164723540834768100115
corticosteroid‑sparing17742354083316888112127158194220243276296333348386407434472504525539577615
effect24012354083345372106138161
of257423540833756
tezepelumab2642235408322558411715519020524242524540835789128
in56624540831552
adults63224540833270107122144171
with8162454083516688125
severe9552454083266092126146179
asthma.11482454083325880118175207219
Am138124540834199
J1493245408325
Respir15322454083356995134148169
Crit1715245408340607597
Care18262454083397292125
Med.196524540835589128140
2021;203:A1197.211924540833568100131138173206238249291320347376408414
20.4252553085357084
Tezspire5202554083326290117154168188221
2107522554083346494
mg85625540835694
injekční961255408314516598127157193207
roztok11792554083205683106142171
v1361255408331
předplněné14032554083385891129167181218251288321
injekční1735255408314516598127157193207
stříkačce.1953255408326486882112144175204237248
Souhrn221225540833268105142161199
údajů242225540833674105119155
o2588255408336
přípravku.26352554083385973111131163193222259271
Available42526540834170102116130162200215248
from:6852654083183975132143
https://www.ema.europa.eu/en/documents/product‑information/tezspire­84026540833758811191451561822022523043563663994564875005345705906276656977097437808058358728979329691001103710941128116511851212123712731294133013691405143614591478149315301548158416051662169317141729176518031828184918821910193819751990201020432065
‑epar‑product‑information_cs.pdf4252754083215795127148167206227264302339371394413429466484521542599631652667704742778810837850890928947
[cit.138627540831948628497
27.14972754083346672
7.158227540833540
2023]163627540833468100134150
21.4252853085366980
Diver5192854083456092126146
S,67928540833244
Khalfaoui73728540833473105119138170208245260
L,101028540833245
Emson106828540833389115153190
C,127228540834052
et133728540833456
al.14062854083324759
Effect14792854083325069103135159
of165128540833756
tezepelumab17202854083225584117156191205242299331370
on210328540833775
airway21912854083324767120152182
inflammatory2386285408315526986117175232263284321341375
cells,2774285408331647994119131
remodelling,42529540832154111149188222237251265303341353
and79429540833269108
hyperresponsiveness91829540833868107142162183217243281319357382397428462499534560586
in152029540831552
patients15882954083397192107141178199226
with18302954083516687125
moderate‑to‑severe197129540835795134168189221242275297319355378404438470504524557
uncontrolled254529540833774106142180200221258273287321360
asthma4253054083325880118175206
(CASCADE):6473054083185799132172214259292311322
a984305408332
double‑blind,103130540833876113152167201224263278292330368380
randomised,14263054083215390129166224238264298337349
placebo‑controlled,17903054083395485117150188227249282318356377398434449464498537549
phase235430540833977108134168
22538305408334
trial.2587305408322425789103115
Lancet271830540833164101133166187
Respir4253154083357096134149169
Med.60831540835589128140
2021;9:1299-312.76231540833468100131138173185214244277312335366397426438
22.4253253085367287
Gauvreau52832540834476113145166199230267
G,81132540834456
Hohlfeld88332540834482120134153187202240
J,113932540832435
Boulet119032540833573110125159181
L‑P,1387325408331458285
et148832540833456
al.15603254083314658
Late16343254083316485118
Breaking17683254083355689121150166203241
Abstract—Efficacy202532540834180106128149181213236304338355373391422454486519
of255932540833856
CSJ11726313254083407397128155184
on283132540833775
allergen‑induced425335408332466195116153187225246262299337374405438477
asthmatic9163354083315780117174206227242273
responses12023354083215480119157194220254281
in149633540831452
mild15613354083577286124
atopic16993354083325389128143174
asthma18863354083325880118175207
patients.21063354083397192106140178199226239
Eur23583354083336889
Respir24603354083367096134149169
J.264333540832436
2020;56269233540833468100133145180213
(Suppl4253454083195086125164179
64):3690.618345408334708698132166199234246
23.3047553085367489
Zoumot31595540833876115174213236
Z,34175540833852
Busaidi34915540833574101135151191207
Al37205540834158
N,38005540834558
Tashkandi3881554083326189127158193232272288
W,41915540835868
et42815540833457
al.4361554083314861
Tezepelumab4444554083336595130171207224262321354394
for4860554083195880
patients4962554083397395112147186209237
with5221554083516891130
severe537355408326629613130476540832157
uncontrolled31276540833879113152192215238278295312349390
asthma:3540654083336186126187221235
a379865408332
systematic3853654083276290115151212246269286320
review4196654083215791109145199
and44186540833373114
meta‑analysis.45556540835996120155179213253287304338367383411426
J500465408325
Asthma5052654083427296137197231
Allergy.5306654083425976113136176210221
2022,15:371-379.30477540833469103138151183214225261294327346379412446458
24.3047853085367187
Préfontaine3149854083355691111149188210244260298334
D,34978540834557
Nadigel35688540834578118134173209225
J,38078540832437
Chouiali38588540834079118156172205221237
F,41098540833239
et41628540833457
al.4234854083314761
Increased4309854083155486108143176203238279
IL-33460285408315476396130
expression47468540833466106128163191218233272311
by50718540833971
epithelial5156854083347490113152188204220252268
cells543985408331653047954083153157
in31219540831553
bronchial3191954083396199138171210225258274
asthma.3482954083325983122180213227
J372695408324
Allergy3767954083415773108130169202
Clin3986954083395571110
Immunol.41129540831574132170209248265278
2010;125:752-4.44079540833469102134147178209244256290323357378416429
25.30471053085367388
Cherry315010540834078114136158193
WB,335710540835794107
Yoon347910540833569109148
J,364110540832437
Bartemes36921054083356991116150209244272
KR,39781054083357287
et407910540833457
al.41501054083324861
A4226105408340
novel428110540833776109143160
IL-14455105408315476394
family456310540831953111127142175
cytokine,47521054083316591128159176215250263
IL-33,5029105408315476396130142
potently518510540833978101135174196212244
activates54441054083316430471154083223871105127161189
human325311540833775134167206
eosinophils.347611540833373100116154193234273289305331346
J3838115408324
Allergy38791154083415773109131169202
Clin40981154083405671110
Immunol.422511540831473132170209248264278
2008;121:1484-90.451911540833569106142155186217249258289320357394418453490503
26.30471253085367289
Wechsler315412540835791125163190206242264
ME,343612540835488102
Ruddy355612540833574113153186
MK,376012540835490106
Pavord388412540833567100138160199
ID,41011254083156173
et419212540833457
al.42671254083314761
Efficacy4346125408333516987119153186220
and458412540833271110
safety47121254083266080115138172
of490212540833858
itepekimab49771254083153873113149180197255288328
in532312540831553
patients5394125408339739511130471354083347395123
with31871354083516790129
moderate‑to‑severe333313540835796136172194228250284308331369393421456489524546581
asthma.39311354083325983122180213227
N4175135408345
Engl423613540833371111127
J4380135408324
Med.442113540835490130144
2021;385:1656-68.458213540833469102134143179214249260291323357392416454491505
27.30471453085367281
Salter31471454083326682105140162
BM,332814540833591105
Oliveria34521454083476479112147169186218
JP,36891454083246166
Nusca377414540834583110143177
G,397014540834358
Smith404614540833391107130169
SG,42341454083327792
Tworek434514540833280118141175206
D,457014540834657
Mitchell46461454083557194125164200216232
PD,48971454083358192
et500814540833457
al.50841454083324861
IL-51641454083154863
25524614540833570
and533514540833271110
IL33546414540831548304715540833468
induce31381554083145394132165200
type33601554083225798135
23517155408334
inflammation3574155408314537289122181240274296313352391
in398815540831453
basophils406315540833973101140181221237253280
from43651554083194280140
subjects452715540832664105121157191216245
with47941554083516791130
allergic49461554083324965101123162178211
asthma.51791554083326084123182216230
Respir54311554083367230471654083266682104
Res.31681654083357198112
2016;17:5.329716540833469102133146177207218254267
28.30471753085367289
Deng315017540834581119159
C,332317540834053
Peng339017540833569107147
N,355117540834458
Tang36231754083326199138
Y,377517540833644
Yu383317540833571
N,391817540834458
et399017540833456
al.40611754083314761
Roles41361754083357390125152
of430217540833857
IL-254373175408315476394130
in451717540831452
type45841754083215596131
24730175408334
inflammation4778175408314527087120178236269291307345384
and517617540833270110
autoimmune53001754083316992130146204304718540835796134170
pathogenesis.32341854083387295133172213248287323350366393407
Front36581854083325290130152
Immunol.382618540831574132171209248265279
2021;12:691559.412118540833469103135144175205219255289322353386419431
29.30471953085367286
Busse314719540833573100127162
WW,3323195408357117128
Holgate34651954083438298137170192226
S,370519540833245
Kerwin37641954083356991144160198
E,397619540833346
et403619540833457
al.41061954083324861
Randomized,418119540833568106146184242258287322361374
double‑blind,456919540833877115154171206229269286301339378392
placebo‑controlled49741954083395588120154193232256290327366388410447463479514554
study30472054083265089128161
of322720540833757
brodalumab,33032054083396199139172188226285318358371
a3692205408332
human374320540833876134167206
anti‑IL-1739682054083327193109132149181197229259
receptor42462054083205589123163186223246
monoclonal451020540835897136175208224263302335351
antibody,48802054083327193109149188229261272
in517020540831554
moderate524320540835796136172194227250284
to304721540832259
severe31232154083266295130152186
asthma.33262154083325983122180213228
Am3570215408341100
J3687215408324
Respir37272154083367299139155177
Crit39212154083396177101
Care40382154083407496130
Med.418521540835590131144
2013;188:1294-302.434621540833469102132144175207243256286317352388412445480514527
30.30472253085367389
Khatri315022540833575108130152169
SB,33332254083326881
Iaccarino34292254083154881112146167184222261
JM,37052254083247993
Barochia38132254083356991128162200216249
A,407622540834156
et414622540833457
al.42182254083314861
Use429422540834370105
of441422540833757
fractional44852254083194175108133149187226259275
exhaled477522540833466105138154190230
nitric5019225408338537699115147
oxide51812254083376884124159
to535522540832159
guide54282254083387730472354083155490
the31512354083226196
treatment32622354083214378111133192228266289
of356523540833757
asthma:36372354083315982121180213226
an387723540833270
official3962235408337567492125141173189
American416623540834199135157173206239278
Thoracic445823540833373112134168201216249
Society472223540833271104120155178213
clinical49492354083314763102117150183200
practice51632354083396195127152168201235
guideline.5413235408338769230472454083387490106144180193
Am325724540834099
J3373245408324
Respir34142454083357198138154176
Crit36072454083406178101
Care37252454083397395130
Med.387124540835591131145
2021;204:e97-109.403224540833569103135144180214251264299335368388419451487499
31.30472553085367083
Shrimanker31452554083327193109168201239270305327
R,348725540833550
Keene355225540833570106145181
O,374825540834758
Hynes382125540834577117152180
G,401625540834358
et408925540833457
al.41612554083324861
Prognostic42372554083355795135174213240264280313
and456525540833170110
predictive46902554083396196136152184209225258293
value49982554083326682120156
of516925540833757
blood52412554083395594133174
eosinophil54302554083347330472654083264280119159199214230
count,329226540833169108146169182
fractional34892654083184175108133149187226259276
exhaled377926540833466105138154190230
nitric4024265408337537698115147
oxide,41862654083376884124160172
and437326540833270110
their44982654083216096112133
combination464626540833169128168184223256278294333372
in503226540831554
severe51002654083266295130152187
asthma:53012654083325983122180213226
a3047275408332
post309627540833878105129
hoc324227540833776110
analysis.336827540833271104120152180196222237
Am3621275408341100
J3738275408324
Respir37792754083357198138154176
Crit39722754083406178101
Care40902754083397395130
Med.423627540835591131145
2019;200:1308-12.439727540833569102133146182217254267298328364400423455485499
32.30472853085367188
Hearn314928540834480112134173
AP,33362854083417783
Kavanagh343328540833569101135173206246284
J,373228540832436
d’Ancona37832854083385290129161199238271
G,406828540834458
et414028540833457
al.42112854083324861
The428728540833272108
relationship44092854083205571104127142181220247285301341
between47642854083397598151186222261
Feno503928540833367106145
and519828540833270110
effectiveness53222854083345473108142166182304729540833266105141168196
of325729540833757
mepolizumab332929540835792132172188204234273331364404
and374729540833271110
benralizumab387229540833875113135169185200230269327360400
in428729540831453
severe43542954083266295130152186
eosinophilic455529540833473100116154193233273288304320352
asthma.49222954083325983121180213227
J5163295408324
Allergy52022954083415772108130169201
Clin54182954083405571110
Immunol304730540831573132170209248264
Pract.33283054083355790123148162
2021;9:2093-6.350730540833469102134143180193229264300333356394408
33.30473153085367287
FitzGerald31543154083324871103149185207241257296
JM,34703154083248094
Bleecker35843154083355287123157187222244
ER,38483154083326983
Menzies‑Gow395131540835590129159175211238260307347398
A,436931540834156
et444531540833457
al.45213154083324862
Predictors46033154083355691131147180205242265292
of491531540833858
enhanced499231540833473112145184216251291
response53033154083205583122162201304732540832662
with31243254083516790129
benralizumab326932540833975114135169185201231270328361401
for36863254083185679
patients37803254083397395111146185207236
with40323254083506689128
severe41763254083266295130152186
asthma:43783254083325983122180213226
pooled462032540833978117134170210
analysis484532540833271104120153180196223
of508332540833757
the51563254083226196
SIROCCO52683254083324884133175214260
and304733540833271110
CALIMA317433540834083116132188230
studies.34213354083265089128144180207221
Lancet365933540833166104137172195
Respir38703354083367199139155177
Med.406333540835591131145
2018;6:51-64.422433540833569102134146183196232264283321358372
ODBORNÝ38876029013353109164218272331378
GARANT:42856029013351105158212270315335
prof.3886616101314471114139158
MUDr.40616161013166116164192209
Michal4287616101316686119164204225
Vrablík,4529616101314672112156177196238260
Ph.D.4806616101314488109158176
III.38866291013122436485
interní398862910131216593132159205225
klinika423062910131396180125145183224
1.4471629101314260
LF4548629101313876
UK4641629101315094
a47526291013141
VFN4810629101314684134
v49616291013139
Praze5017629101314471111146185
POŘADATEL:38876447013350106159214269320361406450476
SOLEN,4380644901314089127165216236
s.4633644901313254
r.4704644901312744
o.4766644901314262
PARTNER3407971012153114172228299353411
POČET4357421019689201295375459
KREDITŮ4357581019693184267376418500606
2109973050541246
Registrace16267410018485162248285346399450525592667
ZDARMA16267593018687191285372499598
TERMÍN25907428019684165256388430538
září25907609013347101137162
202327757609013357112165220
až25907739013353100
srpen2714773901334378141196257
202429957739013356111164216
dostupný25907869013362122165202262324385434
na30477869013361114
online.solen.cz25907995013763128159189253312340390453484543608637687740
On-line3404667050329253166578589911361348
kurz176746670503230466625817
Kardiologie34049780992491900118916531859230625142962342036254033
ONLINE34243480227131262328430486617721
KURZ110243480227116245360472
PŘEDNÁŠKY4486026014555110156214275329377430483
4486222013490
Co589620501454797
je703620501452775
u7956205014554
nových8666205014555105150199235290
tabulek1172620501453888140194219268317
SCORE1506620501454793148202247
opravdu17706205014552104138188233284337
důležité?21246205014553106132181221247283331367
Modelové25076205014577127180228255305350398
situace2921620501453965101154203240289
v5896355014547
ordinaci653635501455286139165219268305331
a10016355014551
jak1068635501452777125
je1210635501452776
řešit1302635501453685122147184
–15036359014160
MUDr.15796359014169118166191205
Jaromír180063590141306791131199216240
Ožana,2056635901415185123165202219
MUDr.22926359014169118165190204
Michal2513635901416986118161198216
Mačák27466359014169106139177213
4486550013490
Speciality589653301454799148186212262287313349397
v10026533014548
léčbě1067653301452775113166215
hypertenze1299653301455599152201236274322376417465
–17816538014160
doc.1857653801414485119138
MUDr.20116538014169118166191205
Ondřej2232653801415194137161198215
Petrák,2464653801414379104130168204223
Ph.D.2703653801414486104152167
4486729013490
Aktuality5896712014555103141194244269295331379
a9856712014550
praktické1052671201455488137186224250287336384
tipy1452671201453863116160
v16296712014547
léčbě1693671201452776113167215
dyslipidemie19256712014554100138163189242267320368449474523
–24656716014160
MUDr.25416716014169118166191205
Eva2762671601414076113
Tůmová,2891671601414080148188224261279
Ph.D.3186671601414486104152167
4486907013490
Co589689001454797
(ne)budeme703689001453180129155208261313362442491
potřebovat12116890014554104140174224276327372421457
od16856890014551104
biochemické1806689001455379129167222270351376414463510
laboratoře2333689001452777129180214263299349383432
pro589704001455488139
stanovení745704001453975125179229274322376401
kardiovaskulárního1163704001455099133186212263307357394443496522572606660686742792
rizika?1972704001453561102128176226261
–22507045014160
prof.2326704501414469109130147
MUDr.24897045014169118166190204
Michal2710704501416986118161198217
Vrablík,2943704501414870108150169185224244
Ph.D.3203704501414486104152167