1067
HLAVNÍ42522701005185134178232252
TÉMA69222701003981147194
Role4253370100418096131
eozinofilů57233701003474104120157196214232247285
v873337010035
patogenezi,9243370100387399138176212249285317332347
diagnostice12883370100375287125162201231258274305339
a1643337010034
léčbě16933370100155081119155
bronchiálního186433701003862100138169207222256272309325364403
astmatu22833370100346390151186212251
37220622701003466104
|350227010018
VNITŘNÍ4268043010746106127172220280301
LÉKAŘSTVÍ748804301074185130188236280325378400
/11948043010731
Vnitř1270804301074693112140166
Lék.1456804301074083122140
2023;69(6):365-3721615804301074487129173186232274298340363377422465508535576616660
/23208043010731
www.casopisvnitrnilekarstvi.cz442680430107651332012142542953293774274464795215705896176436927117307748128548809159449871007102310631101
23.425553085367287
Leckie528554083316698128145179
MJ,723554083548092
ten831554083225593
Brinke940554083355772110140174
A,11305540834155
Khan12015540833574106144
J,13615540832436
et14135540833356
al.1484554083324760
Effects1560554083335271105138162189
of17655540833757
an18375540833270
interleukin-51922554083155375108130145180218248264302325359
blocking2296554083395593126156172210249
monoclonal25615540835795134172205220258297329344
antibody425654083327091107146185224256
on6966540833876
eosinophils,7876540833473100115153191230269284299325338
airway1141654083314768121154185
hyper‑responsiveness,13416540833768108144165185207241267306345384410425457492530565592618631
and19886540833169108
the2112654083216095
late2222654083154769102
asthmatic2340654083325881119177210231247279
response.2634654083215581120159198224259271
Lancet.4257540833165103135169191204
2000;356:2144-8.6457540833468104140153188221255268303334365402425461475
24.425853085367186
Haldar529854083447692131163184
P,7318540833540
Pavord789854083356799136158196
ID,1003854083156172
Shaw10938540833270102153
DE,1264854083457992
et13748540833456
al.1449854083314760
Cluster1527854083405592119142176197
analysis17428540833270102117149176191217
and19778540833270109
clinical2104854083314762100115147179195
asthma2317854083325881120177210
phenotypes.25458540833977112150188210244284320346360
Am4259540834199
J53995408324
Respir579954083357097136151173
Crit76795408340617699
Care881954083407394128
Med.10249540835590130143
2008;178:218-224.11829540833468104140152182212245257292324355378408443475488
25.4251053085367286
Haldar5241054083447691129161182
P,71910540833539
Brightling7711054083355671110147168184198236274
CE,10581054083407285
Hargadon11561054083437596134166205242280
B,144910540833548
et150910540833456
al.15781054083314659
Mepolizumab165010540835488127166181196225263320352391
and205310540833269108
Exacerbations21741054083326497128162183222254276291328367393
of257910540833756
Refractory2648105408335708811014317519823542511540832155
Eosinophilic4951154083337097112149188227266281296311343
Asthma.8531154083416992131188221234
N1102115408345
Engl116211540833371110125
J1302115408325
Med.134211540835489129142
2009;360:973-984.149911540833569105140153188222258271306339373395430465501514
26.4251253085367187
Nair5281254083457792113
P,65712540833540
Pizzichini7131254083354978110125157195210248263
MMM,992125408355110165178
Kjarsgaard11861254083355184105132171203236257295
M,149712540835468
et158012540833457
al.16531254083314760
Mepolizumab172812540835590129168184199228266324356396
for21391254083195678
Prednisone‑Dependent22331254083355690129167182208247285320344391426465501539578613651672
Asthma4251354083416992130188220
with6601354083506688127
Sputum80113540833371110132170228
Eosinophilia.10441354083327096111149187227265280296311343356
New141513540834479130
England156013540833370109125157195234
Journal180913540832462100121160192208
of203113540833757
Medicine.210213540835590129144176191229264277
2009;360:985-993.239313540833468104140152187222257270306341375397432467500512
27.4251453085367180
Pavord5201454083356799136158196
ID,7311454083156172
Haldar8181454083447692131163184
P,101714540833640
Bradding10721454083365790129168183221260
P,134814540833539
et140314540833456
al.14741454083324760
Mepolizumab155014540835489128167183198227265323356395
in196014540831553
refractory2028145408321557496129161185222244278
eosinophilic232114540833473100114152191230269284299314346
asthma.26821454083325982120178210223
Thorax.42515540833372110132165196210
201065015540833569100132
65:370.7971554083346879114146179192
28.4251653085367288
Ortega5301654083476993127167199
HG,74616540834488102
Liu8651654083314684
MC,96616540835495108
Pavord10911654083356798136157195
ID,13031654083156172
et139116540833457
al.14641654083324861
Mepolizumab154116540835590129168184199228266324356396
Treatment19531654083335084116138196231269291
in226016540831553
Patients23301654083356788104138177198226
with25731654083506688126
Severe271616540833368100134155189
Eosinophilic4251754083337097112149188227266281296311343
Asthma.7831754083416992131188221234
New103217540834580131
England117917540833270109124156194233
Journal142817540832462100122160192208
of165117540833757
Medicine.172317540835590129144176191229264276
2014;201517540833468100131143
71:1198-1207.21731754083346775105133163198220251281315348354
29.4251853085367285
Nair5301854083457792113
P,66318540833540
O‘Byrne7221854083476097129151190225
PM.96618540833589103
Measuring108918540835489121148185206222259298
Eosinophils14071854083337097112149188227266281296322
to174918540832158
Make182718540835487117151
Treatment19981854083325084116137195230269290
Decisions230818540834580113128154169207246272
in259918540831553
Asthma.26721854083416892130188220233
Chest.42519540834078113140163176
2016;150:485-7.61619540833569100132144174204238251286322356378409415
30.4252053085367287
Mukherjee53020540835492122162197218234268304
M,85120540835568
Nair9372054083447792113
P.106820540833540
Blood11252054083365190128168
or131020540833859
sputum138720540832665103126164221
eosinophils16262054083347399114152190230268284299325
to196820540832259
guide20442054083387691130165
asthma22272054083315881119177209
therapy?24542054083226095116149188219243
Lancet271520540833164102135168191
Respir4252154083357097136152173
Med.61321540835590129142
2015;3:824-825.77121540833468100130140175187222255287310346380414426
31.4252253085366981
Kostikas5212254083357299122138168201228
K,76322540833549
Brindicci8262254083365773110150165197228243
C,108322540834053
Patalano11502254083356788121137169207245
F.140922540833239
Blood14622254083355189128167
Eosinophils16432254083337097112150188228266281297323
as198022540833158
Biomarkers20522254083355189147179200231265286314
to238022540832158
Drive24522254083466783116150
Treatment26162254083325084116137195231269290
Choices42523540834078116131163197224
in66423540831553
Asthma7322354083416992130188220
and96823540833270109
COPD.109223540834085121166178
Curr12852354083407697119
Drug142023540834567105144
Targets.15792354083336182120155177205219
2018;19:1882-1896.181323540833468100131143173203216246277313346367397428463498511
32.4252453085367186
Kroegel5252454083355795130170205220
C,75924540834053
Liu8252454083324784
MC,92324540835495108
Hubbard104524540834481121160193214252
WC,131124540835798110
et143524540833456
al.15052454083324760
Blood15782454083365290128168
and176024540833169108
bronchoalveolar18822454083396097136168206244277293325359398414446467
eosinophils23632454083347399114152190230268284299325
in270124540831553
allergic27672454083324863981194252554083385385
subjects52325540832663102117152184208236
after7722554083325075109130
segmental91525540832661100158193231252285300
antigen12282554083327091106145180218
challenge:145825540833269102117132167205243278291
Surface17612554083337091112146178211
phenotype,198525540833977112150188210243283319330
density232825540833873111137152174208
heterogeneity,25492554083377294128149186225260298333425265408315377181
and52126540833270109
prostanoid6452654083396098124147180218256272311
production.9712654083396098137175207231246284323336
J1322265408324
Allergy13622654083415671106127165198
Clin15752654083405570108
Immunol.169826540831573131168206244260273
1994;19872654083346499135147
93:725-734.21492654083346779112146181203234269304317
33.4252753085367186
Prin5262754083355671109
L,65127540833145
Capron71127540834073112133171209
M,93527540835568
Tonnel101827540833367105143178194
AB,12272754083417790
et133227540833456
al.14032754083324861
Heterogeneity147927540834479101135156193233268306341356379412
of190727540833756
human197827540833875133166204
peripheral21972754083397495111150189224245278293
blood25052754083395593132171
eosinophils:269227540833472991141521904252854083397792107133146
Variability5862854083366788104136175191206221243277
in87928540831452
cell947285408331658095
density105828540833873111137152175208
and128228540833270109
cytotoxic14062854083316590127148185216231263
ability16852854083317186101116139173
in187328540831553
relation19412854083215570103124140178216
to217328540832158
the22472854083216095
level23572854083155082116132
and250428540833270109
the26292854083216095
origin27392854083375975113129166
of42529540833757
hypereosinophilia.49729540833768108144165199238264279317355395433448464479511524
Int10362954083155375
Arch11262954083416293131
Allergy12722954083415772107128166198
Immunol.148629540831472130168206244260273
1983;17742954083346499133145
72:336-346.19342954083346981116149184207240275311324
34.4253053085367388
Kuo52630540833572110
HP,6493054083448084
Yu74630540833671
TR,8303054083326983
Yu92630540833570
CT.10093054083407685
Hypodense110730540834476116155194229267293328
eosinophil14483054083347399114152190230268283299
number176030540833775132171207228
relates20013054083215570103124158185
to219930540832158
clinical22703054083324762100115147179195
severity,24783054083266193127148164186220230
airway27213054083324768121154185
hyperresponsiveness42531540833868108144165187221248286325364390405438472510545572598
and104031540833270109
response11653154083215582121159198224259
to144131540832158
inhaled15163154083145290122138173212
corticosteroids17453154083316889114129161198225248282303340356395421
in218231540831553
asthmatic22513154083325982120178210232247279
subjects.254731540832663102118152185209237250
European2814315408332694253254083215897133165203
Respiratory6433254083367197136152173206228265286320
Journal.97932540832462100121160192208221
1994;7:1452-1459.121532540833464100135147180190220251284317337368399432464475
35.4253353085367288
Abdala53333540834182123156173207
Valencia7603354083356885121161194211244
H,102433540834458
Loffredo11023354083327091114138173214254
LF,13763354083316573
Misharin14693354083547199138171194211250
A1739335408341
V,180033540833646
et186633540833458
al.19443354083314863
Phenotypic202733540833573110149189212247289306339
plasticity23863354083395690118142159192209233268
and267433540833171111
targeting280533540832256794253454083387498115154194
of63934540833758
Siglec‑FhighCD11clow7163454083334989106142176196231270287327366408455488517547564603656
eosinophils139134540833474102118158197238278295311339
to174934540832260
the18283454083226298
airway19453454083324971126160192
in215734540831454
a2230345408332
murine228134540835796119136175212
model251234540835797138174191
of272334540833758
asthma.2800345408332608442535540833897130145
Allergy:5883554083415875111134173207221
European8283554083327093131172209243282
Journal112835540832464103126166200216
of136335540833758
Allergy14393554083415874110133172206
and166335540833271112
Clinical17933554083405673112128162196213
Immunology202435540831574133172212251269308349383
2016;71:267-271.242535540833469102135149183217227263298333353385419453464
36.4253653085367491
Matucci53636540835488112151184217233
A,78936540834156
Nencini86536540834581121154171210227
F,111136540833340
Maggiore117136540835488129169186225248283
G,147436540834459
et155236540833458
al.16303654083324863
High171236540834461101141
proportion187236540833962101142182205231248287327
of221936540833758
inflammatory2296365408315547494127187246280303341364400
CD62L271536540834087124159191
low42537540831554107
eosinophils54837540833374102118157197238278294311338
in90237540831454
blood9723754083385595135176
and116437540833271111
nasal12913754083387199134151
polyps14573754083397996130171199
of167237540833758
severe17463754083266296131154189
asthma19513754083326084124183217
patients.21843754083387396112148188211240255
Clinical24553754083405673112128162196213
&2682375408340
Experimental2737375408332661071444253854083213897133173196230247
Allergy.6903854083415874110133172206217
2023;53:78-87.92538540833570104141153190224237272307331368402410
37.4253953085367282
Kanda52339540833570109150183
A,72239540834157
Yun79539540833571111
Y,92239540833544
Bui9823954083367591
D1089395408345
Van,115039540833669108122
et128839540833458
al.13613954083324963
The144039540833373110
multiple156539540835897114137154194212248
functions18293954083185898131157173213253280
and212539540833271112
subpopulations225339540832664105146186227267284317340357396436464
of273339540833758
eosinophils2806395408334754254054083264282121162202219235263
in70940540831554
tissues784405408322396694133169197
under100340540833776117153176
steady‑state12004054083265186119160193217245269304327362
and158340540833272112
pathological17164054083397397136176193233274290324358375
conditions.211240540833170109150166190207246286314329
Allergology24624054083415875111134173213230270310344
International.2827405408315544254154083225779119153176193232272306323337
2021;70:9-18.78041540833470104137147181215230266291324356371
38.4254253085367491
Shah53442540833272105145
K,69742540833450
Ignacio7654254083155595128162179218
A,100142540834056
McCoy107542540835488130169201
KD,12944254083358396
et140742540833458
al.14824254083324963
The156342540833273110
emerging169042540833493130152192209248288
roles19964254083205976113141
of215542540833757
eosinophils223042540833474102118158197238278295311339
in258642540831554
mucosal265842540835796130168196231248
homeostasis.42543540833877137173213242266300328344372387
Mucosal83043540835594127166194228245
Immunol.109343540831574133172212252269283
2020;13:574-583.139443540833470104140154186217230266301333357393428464477
39.4254453085367287
Al‑Shaikhly5284454083415881114153187203234275292325
T,86844540833343
Murphy92744540835493116157197229
RC,11714454083367892
Parker12794454083356890122158180
A,147544540834156
et154744540833457
al.16204454083324863
Location169844540833270104138161178217257
of197144540833758
eosinophils204444540833474102118158197238278294311338
in239844540831453
the24674454083226197
airway25804454083324871125160192
wall278744540835185102118
is42545540831542
critical485455408331547194111145179196
for6984554083185881
specific79645540832667103138154175192225
features10394554083185488111150173208236
of129345540833758
airway13684554083324971126160192
hyperresponsiveness157845540833870111148170194229257298338378406422456491531567595623
and221945540833271112
T2234845540833370
inflammation2435455408315547594128187246280303320359399
in285145540831554
asthma.4254654083326084124183217232
European6754654083327093131172209243282
Respiratory97546540833672100140157180214237276299334
Journal.132746540832564104126166200217231
2022;60:2101865.157646540833470104140154191228243279312345378410447482496
40.4254753085367591
Fukuda53647540833270102141182215
T,77047540833343
Dunnette83247540834585125164200224250285
SL,11364754083326580
Reed123547540833571108149
CE,14034754083407489
et151147540833457
al.15874754083324963
Increased16694754083155488111146179207244285
numbers197347540833776135176213235264
of225647540833758
hypodense233347540833870111151192228268296332
eosinophils2684475408334741021181581974254854083397995112139
in58248540831554
the6554854083216197
blood7704854083395696136177
of96548540833758
patients10414854083397397113149189212241
with13004854083516892131
bronchial144948540833962101141174214230263280
asthma.17474854083326085124183217232
American1997485408341101137160177210244284
Review229948540833572105123159211
of252848540833858
Respiratory26054854083357110014015717921423727542549540832156
Disease.4994954083466290126160188224238
1985;132:981-985.75549540833465102137149181212246260297333366386423459494508
41.4255053085367084
Peters5265054083357094129151180
MS,72450540835489103
Gleich8445054083446198114147187
GJ,10485054083447185
Dunnette115050540834685125164201224250285
SL,14535054083326580
et155050540833458
al.16255054083324963
Ultrastructural17065054083446084107141169194216256290315355377411428
study21525054083265090130164
of233350540833758
eosinophils240950540833474102118157197238278294311338
from27655054083184280140
patients4255154083397396113149188211240
with6825154083516892131
the8305154083226198
hypereosinophilic94451540833870111148171206247275291330370411451467484500534
syndrome:149451540832660101141164202262298312
A1823515408341
morphological188151540835797120161201241258297338355388423439
basis233751540833973101117145
of249951540833758
hypodense257351540833870111152193229268296332
eosinophils.42552540833474102118158197238278295311339354
Blood.7975254083355292132173188
1988;71:780-785.100352540833465102139152186220230265300336362394429465478
42.3047553085367188
Januskevicius3151554083245796135162194229262279312328367394
A,35615540834156
Jurkeviciute3632554083256386117153186203236252291315350
E,39975540833347
Janulaityte4059554083245897135152185202225260286321
I,43955540831529
et44395540833458
al.4512554083324862
Blood4590554083355291131172
Eosinophils4777554083337199115154193234274290306333
Subtypes51265540833271111134169210247275
and54165540833271111
Their30476540833373110126149
Survivability3214654083327194130147181215256273289306330365
in35976540831454
Asthma3669654083417095134193227
Patients.3914654083356992109145184207236251
Cells.4183654083407592109136151
2020;9:1248.43526540833570104140154191205237268301339353
43.3047753085367389
Van31577540833668108
Hulst32867540834483100127152
G,34597540834358
Jorssen3538754083246487116144180219
J,37787540832538
Jacobs3837754083245891130171199
N,40577540834459
et41377540833357
al.4215754083324963
Anti‑IL542997540834181103120144162195232
mepolizumab45527540835894135175192209239279338372412
minimally49857540835874113130189223240256289
influences5295754083155474941331692093047854083326998
residual3170854083225988105147188223241
blood3436854083405899141184
eosinophils36458540833476106123164205248290307325353
in40238540831556
severe41048540832765100137161198
asthma.4327854083336288129191226242
European4594854083337396137179218253294
Respiratory49138540833674104146164187223247287312349
Journal.52878540832466107131172208225241
2022;59:2100935.30479540833470104140154190224238275308341378415449483497
44.30471053085357490
Novosad315210540834483115153180214253
J,342010540832437
Krčmová34721054083345788146185218251
I,373810540831428
Souček378110540833270109141175206
O,400210540834658
et407510540833356
al.41461054083314761
Subsets422210540833270109136172195223
of446010540833656
Eosinophils45311054083327097113151190230269285301327
in487310540831453
Asthma,49401054083416993131189222236
a5191105408331
Challenge523710540833977110126142177216255290
for30471154083185780
Precise31461154083355792126143170207
Treatment.33711154083325186120143202239278301316
Int37051154083155477
J3800115408324
Mol384311540835494111
Sci.3972115408333668397
2023;408711540833570104141153
24:42581154083356881
5716.435811540833468102135150
45.30471253085367389
Freeman31551254083325389126185219258
CM,343212540834096111
Curtis356212540834078100126143171
JL,37511254083245873
Hastie384312540834477105130147183
AT.40441254083417282
Finding41451254083324988129145184225
the43891254083216197
Right45051254083355292132155
Biological:46781254083365292109149190206239274290304
Eosinophil50011254083327199115155194235275292308
Subset532812540833371112140176200
Differences30471354083456283106142165200240273308336
in340213540831554
Asthma34751354083417095134194227
and372113540833271112
COPD.385213540834086124170183
Am4054135408341100
J4173135408324
Respir421613540833572100140157180
Crit44151354083406279103
Care45371354083407496132
Med.468813540835491132146
Epub485313540833373113153
ahead502513540833271108141181
of522513540833858
print53021354083396279118141
13546213540833465
June304714540832463103139
2023.320414540833470104140154
DOI:337614540834696113127
10.1164/RCCM.202305-0811ED.35211454083346781113142175213239277319359415431468504538574610645669707744778807837884897
46.30471553085367592
Cabrera316115540834074115138173196230
López341315540833170111148179
C,361315540834054
Sánchez368915540833266106139179215246
Santos395615540833367107130168196
A,417315540834157
Lemes425115540833267126163191
Castellano446315540834075103127162179196229269308
A,479315540834156
et487115540833457
al.49501554083314863
Eosinophils50341554083327199116155195236275292309336
Sub­539115540833372112137
‑Types30471654083215281123160188
in325816540831554
Asthmatic33351654083417195135194228251268301
and365916540833271112
COPD379416540834087124171
Patients.39881654083356992108145184207236251
Am4262165408341101
J4386165408324
Respir443316540833672100141158180
Crit46361654083406380104
Care47631654083407496132
Med.491816540835591132147
Epub508816540833273112153
ahead526416540833272108141182
of546916540833758
print30471754083396279118141
18320617540833467
April329117540834181104121138
2023.344717540833470104140154
DOI:361917540834695113127
10.1164/rccm.202301-0149OC.37641754083346781113142174212239260292324384398436471506542578611631670703735770820862877
47.30471853085367079
Ijaz3140185408315306292
T,324518540833342
Pazdrak33011854083356796134155188219
K,353318540833550
Kalita3596185408335698499122155
M,376418540835568
et384618540833456
al.39161854083314760
Systems39891854083336390113147205231
biology42341854083385492108146185217
approaches446518540833271111132169202235273308334
to481318540832259
understanding488518540833775115149171198221254292331346384423
Epithelial532218540833271871091471823047195408315306277
Mesenchymal313919540835590117152190222260291349382397
Transition35511954083335083121147162184200238276
(EMT)384219540831952107140162
in401919540831553
mucosal408719540835895127164191224239
remodeling434219540832054112151190225241256293333
and469019540833169109
signaling48141954083264179117150165180218257
in508619540831553
asthma.51541954083325881120177210223
World539219540835894116304720540831554
Allergy31162054083415772106128166198
Organ332920540834769107139177
J.352220540832436
2014;7:13.357420540833468100131143176186215245258
48.30472153085367490
Denton315421540834581119140177216
E,338721540833245
Price34492154083355672104137
DB,36032154083468295
Tran37152154083324982120
TN,38522154083337992
et396121540833456
al.40342154083324760
Cluster41112154083405593119142176197
Analysis432521540834179112127159186201227
of456921540833756
Inflammatory4642215408315537187120177235268289326348382
Biomarker50412154083355189147179200231265286
Expression53442154083336510512716130472254083265368106144
in320922540831452
the32792254083226095
International33922254083145274108129168200222237275313346361
Severe377122540833267100134155189
Asthma39782254083416992130188220
Registry.421622540833570110125151174196230240
Journal447422540832462100121160192208
of469922540833857
Allergy47742254083415671106127165198
and498922540833270109
Clinical51162254083405570108123155188203
Immunology:53372254083157213016830472354083387692130169201215
In327723540831553
Practice33452354083365689121145161193226
2021;9:2680-2688.e7.358723540833468101132141176189224258293329352383417452488501536569575
49.30472453085356981
Chen313924540833975109145
M,329524540835466
Shepard337124540833268102139171191227
K,360924540833447
Yang36672454083356399136
M,381424540835366
et389024540833455
al.39552454083324657
Overlap402324540834678111131145176213
of424724540833654
allergic,4312245408331455992112149162193205
eosinophilic45272454083347196109146182220257271285298329
and486624540833268105
type49822454083215392126
25118245408334
inflammatory5163245408314506683114169225256276312332364
subtypes304725540832662100122154193228254
in331225540831552
moderate‑to‑severe337525540835794133167187219240273295317353375401435466500520553
asthma.39392554083325880117174205218
Clinical41682554083405468105119150182197
and437625540833269107
Experimental449425540833364103137158172229263300321353367
Allergy.48722554083415670104124161193202
2021;51:546-555.50852554083346799130137171201209243277313335368400431442
50.30472653085367186
Corren31452654083407697118151189
J,334526540832536
Du339326540834583
E,348726540833345
Gubbi354426540834381119158173
A,372926540834154
et379526540833455
al.38622654083324658
Variability39322654083366687102133171186201215237270
in421326540831552
Blood42772654083355088126164
Eosinophil44532654083336995109147184223261275290
Counts475426540834077114151172199
in496526540831451
Patients50282654083356687102136173194221
with52612654083506587124
Eosinophilic53972654083336995110304727540833774112149162176190221
Asthma.32782754083416789125181212224
Journal35132754083246197117154185199
of372327540833654
Allergy37882754083405568102122158189
and398827540833167105
Clinical41032754083405467104118148179194
Immunology:430727540831571127163199236251287325356368
In468627540831451
Practice47472754083355486116139153184216
2021;49742754083336697127134
9:511927540833445
1224-1231.e9.51752754083346296126148177205239268276309343352
51.30472853085366981
Kroes31402854083355793128155
JA,33072854083246377
Zielhuis33972854083375286101139176190216
SW,362528540833390100
van373728540833164101
Roon385128540833572111148
EN,40122854083327689
et411328540833456
al.41812854083324759
Prediction42532854083355589127142174197212250288
of455328540833756
response46212854083215481119157195221256
to488928540832158
biological49592854083395491107144183198230262277
treatment52482854083224376108129186221258280
with30472954083516689127
monoclonal318929540835796134173205221259297329345
antibodies35492954083327091107146185224239274301
in386529540831553
severe39332954083266193128149183
asthma.41312954083325982120178210223
Biochem43702954083355088121159194252
Pharmacol.463729540833573105126185217249286302315
2020;179:113978.496729540833569101136148179208241254284312342375408441455
52.30473053085367187
Rogliani314830540833574113128143175213229
P,339130540833540
Calzetta34453054083407388117151173198231
L,369030540833145
Matera374930540835587109143164197
MG,396030540835599113
et408730540833456
al.41583054083324760
Severe423230540833368100134155190
Asthma44363054083416992130188220
and467130540833169108
Biological47943054083355088104143182197229262277
Therapy:508630540833272107128161200231245
When,534530540835896131170182
Which,304731540835796111143181194
and325631540833270109
for33803154083195678
Whom.347331540835897135193206
Pulm36953154083357287145
Ther.385531540833372107128139
2020;6:47-66.400931540833468101135148184196231263281319354367
53.30473253085367389
Eger316032540833373109132
K,331632540833551
Kroes33903254083356099136164
JA,35783254083246681
ten36833254083225797
Brinke38033254083365976116148183
A,401032540834157
et409032540833458
al.41723254083324963
Long‑Term425932540833170110151175207239262322
Therapy460532540833374110133168209242
Response487032540833672101142182222250287
to518032540832261
Anti–IL-5526432540834281105121159178211228264
Biologics30473354083365494112153195213247277
in334933540831555
Severe342933540833371105142166202
Asthma-A36563354083427297138199234259303
Real‑Life398333540833774109126151186204225262
Evaluation.427033540833367103120161195220237278319334
J4628335408325
Allergy46783354083415976114137178213
Clin49153354083415875116
Immunol.505533540831576137178218259277292
Pract53723354083365994129155
2021;9:1194-1200.304734540833470104137146183198229258290327351383415450488502
54.30473553085367388
McDowell315135540835487132171222257272287
PJ,34543554083355567
Diver35373554083456193127149
S,370235540833245
Yang376335540833565103142
F,392135540833238
et397535540833456
al.40473554083324760
The412335540833372107
inflammatory4246355408315527087119177235267289326347381
profile46433554083396198116133148183
of484235540833756
exacerbations49143554083346698130164185225258280295333371398
in532835540831452
patients5396355408339729410930473654083347293121
with31813654083516689127
severe33213654083266193127149183
refractory3517365408320547395128161185222243277
eosinophilic38073654083347399114152190230268283299314345
asthma41653654083325982120178210
receiving43883654083215587121136169184222261
mepolizumab466236540835893132171187201231269327359398
(the50733654083194078113
MEX519936540835487127
study):53393654083265088127158177189
a3047375408332
prospective30943754083396098124163199231256271303338
observational344737540833777104139160195227249265302341373389
study.38513754083264987126158168
Lancet403537540833164102135168191
Respir42413754083357097136152173
Med.442937540835489129142
2021;9:1174-1184.458637540833569102133141177190220247277307330361389420456468
55.30473853085367185
Poznanski315238540833572100139171209235265282
SM,345338540833387100
Mukherjee357338540835492122162197218234268304
M,389638540835568
Zhao398438540833775108146
N,414938540834558
et422638540833457
al.43023854083324760
Asthma43823854083416992130188220
exacerbations46223854083346598130164185224257279295333371397
on503938540833776
benralizumab513438540833974112133166182197226264322354394
are30473954083325387
largely31523954083154768106141157189
non‑eosinophilic.335939540833776114136173212238253291329369407422438453485498
Allergy:38753954083415671106128166198211
European41043954083336991128167203235273
Journal439539540832462100122160193208
of462139540833757
Allergy46963954083415671106127165197
and491139540833270109
Clinical50383954083405570108123155188204
Immunology.52603954083147213016820624430474054083155393125135
2021;76:375-379.319740540833468101132141174206218253285318340372404438449
56.30474153085367389
Nair31574154083457893115
P,329341540833540
O‘Byrne33544154083476198131153192228
PM.360241540833690105
Medical372741540835591131147179212228
algorithms:39764154083324887126148164187226284311324
Approach432041540834282122144182215248286
to462741540832260
adult470741540833372110126149
asthma48764154083336083122180213
exacerbations.511041540833466100132166188228262284299338377404418
Allergy.30474254083415672106128166198208
2021;76:3556-3559.327042540833468101133141174206218253286319353377409442474507518
57.30474353085367281
Menzies‑Gow314943540835590129158174209236257304343395
A,356443540834156
Bafadhel36404354083366988122161200235251
M,391143540835569
Busse400043540833674101127163
WW,4183435408358119129
et433343540833456
al.44104354083324861
An449143540834180
expert459243540833465105141163187
consensus480043540833169107134169208234272298
framework51194354083184174132168219257279310
for54504354083185678
asthma30474454083336185125185218
remission328744540832257117133161189204244284
as359344540833361
a3676445408332
treatment37304454083234581114137197234273296
goal.404844540833979114130144
Journal421444540832464104126167200217
of445344540833858
Allergy45334454083425975111134173207
and476244540833372113
Clinical48974454083415773112128162196212
Immunology.513144540831676136175215254271311352386397
2020;145:75-65.304745540833468101135148178209242253286319341378412424
58.30474653085367187
Menzies‑Gow314646540835488126154170204230251296334385
A,354346540834054
Szefler36104654083326093110127161182
SJ,38044654083325668
Busse38844654083357398124159
WW.4055465408357117126
The419446540833270105
Relationship43114654083356985116137152190227253290305343
of466746540833755
Asthma47354654083406890128185216
Biologics49644654083354987102140179193225252
to522846540832258
Remission529846540833569126141167193207304747540833776
for31374754083185677
Asthma.32284754083416992130188220234
Journal347647540832462100121160192208
of369847540833756
Allergy37684754083415772106128166198
and398047540833270109
Clinical41034754083405570108123155187203
Immunology:432047540831572130168206244260298338370383
In471747540831553
Practice.47844754083355689121145160192226238
2021;9:1090-1098.503647540833468101133141176189219251286322345376408443478491
59.30474853085367185
Maglio315348540835588127143158197
A,337148540834155
Vitale34474854083365376109124160
C,362848540834053
Pelaia37024854083356985118133166
C,388848540834154
et396348540833457
al.40404854083334861
Severe412248540833368101136157192
Asthma43354854083416993132190223
Remissions457948540833571129145171198213252291317
Induced49174854083155493131164198238
by517648540833971
Biologics52674854083365290106145185200233261
Targeting30474954083336182120155177192230269
IL5/IL5r:33324954083144682106122154190210224
Results35714954083357097135150172200
from37864954083194178136
a3938495408331
Multicenter398549540835492107130145177211249270304325
Real‑Life432649540833570102117139173188207242
Study.45834954083325492131163173
Int47714954083155374
J4860495408325
Mol490049540835493109
Sci.5024495408332658093
2023;24:2455.513249540833468101136148182214226262294326359371
60.30475053085367388
Mengelers314850540835489128167201217252273300
HJJ,34615054083446993105
Maikoe357950540835587103133170205
T,379750540833342
Hooibrink385250540834482121136175197213251281
B,414650540833548
et420750540833456
al.42765054083324760
Down434950540834584135173
modulation453650540835795135172188220241257295333
of488250540833757
L‑Selection49525054083314677112128163195220235273311
expression527650540833466105127161188214229304751540833776
on313851540833776
eosinophils32295154083347399114152190230268283299325
recovered35695154083215587124156191212246285
from38705154083184077136
bronchoalveolar40215154083396097136168206244277293325359398414446467
lavage45045154083144778111150185
fluid4704515408317347287126
after48455154083325176109131
allergen4991515408332476297118156191229
provocation.5236515408338609712916719923225426930475254083377689
Clinical31515254083405570108123155188203
and337052540833270109
Experimental349452540833365105140161177235270308329362378
Allergy.38875254083415671106128166198208
1993;23:196-204.411052540833464100133144179214225255285320344375409445458
Pro56862630250122204317
věrné95262630250110213297411517
čtenáře15366263025087169274390499583689
Součástí5686582014356119182234287330368391
Vnitřního9856582014361122146182215279302367430
lékařství1441658201432683132187221265302359383
6/20231850658201435999157212266323
je2199658201432683
navíc23086582014364117168193245
suppelementum25796582014345106170236294318375472529592626689785
Zaznělo5686717014768129183251312343410
na10036717014769129
XXXI.11576717014771144217248277
výročním14596717014760124167234287356386486
sjezdu1970671701475081142195264332
České23266717014771131180241300
kardiologické26516717014761122164233263330361428496526580640699
společnosti.3375671701475011918721727933340146851755958839616722014321
Najdete5686947014377129153217274310365
v9596947014355
něm10406947014364121218
přehledná12846947014366101156219243300365427480
shrnutí17906947014345107141204266302326
několika21426947014364122171232257280329384
zajímavých25526947014348103127150246299351407458521
bloků3099694701436691154204266
z33916947014349
jarního3466694701432678112175198263326
kongresu5687087014351112176240273329373434
České10287087014368123167215271
kardiologické13257087014351106140202226288313376441464516565621
společnosti19727087014345109173198255308371434477514538
v25367087014354
Praze2617708701436093147195251
a28947087014354
Brně.2975708701436094158215233
Věříme,5687227014361116148172269326344
že9387227014349104
pro10697227014366100161
vás12577227014354108151
připomenutí14347227014366100124189253350408470532568592
této2052722701433792128188
významné22667227014355111161225278374437494
internistické2786722701432588122177211274298340377400452501557
akce5687367014354104154209
bude8047367014366129193250
přínosné.10817367014366100124187250293355412430