871
52619722701003471113
|350227010019
VNITŘNÍ4268043010746106127172220280301
LÉKAŘSTVÍ748804301074185130188236280325378400
/11948043010731
Vnitř1270804301074693112140166
Lék.1456804301074083122140
2023;69(8):525-5321615804301074487129173186232274298341363378422464508536578620661
/23218043010731
www.casopisvnitrnilekarstvi.cz442680430107651332012142542953293774274464795215705896176436927117307748128548809159449871007102310631101
DOPORUČENÝ42522701004899143195240292333374427474
POSTUP91422701004495135175228272
Doporučený42533701004585123162187225256290328364
postup80533701003776106133172210
diagnostiky10313370100375287125163202231259275309347
a1394337010034
léčby14443370100155082120156
chronické16163370100296791130167183213247282
hepatitidy191433701003672110145172188215231269305
D.223633701004559
Datum231133701004580106145205
vydání253233701003573111146184199
doporučení:274733701003776114154178217247282319335350
2023311333701003375109142
Diagnosis425567015078113178246315382437471527
and990567015063132201
therapy1229567015046115178228291360427
of1695567015065113
chronic1847567015052121170237305340393
hepatitis2279567015066129198263311345393428483
D:2801567015078114
Czech2953567015061116178232301
national3292567015067132179214281349414448
guidelines.3779567015067135170238302336371439502558595
The4412567015067134198
date4648567015067132179242
of4928567015066114
release:5081567015047110145209273329392428
2023425707015072143213282
For425905012148102135
the57790501213388138
first7339050121295487127160
time,91190501213355138188208
this113690501213388111150
is130390501212462
a1383905012148
separate144990501213989146194226274307355
Czech1822905012158102152197252
recommended209190501213382128181264347397452508558615
practice272490501215689137181216239284332
that307490501213387135167
focuses325990501212984129183222272311
only3588905012154110133180
on3786905012154110
HDV3913905012165131185
infection.411690501212378107157202237260314370390
Until4524905012164119151174197
now,4738905012156110183199
HDV4955905012165131185
infection515890501212378107157202237260314370
has4251045012155104143
been5921045012157108159215
mentioned8321045012183134189222245300355406463
only13201045012155111134181
in1526104501212479
the1630104501213388138
guidelines17931045012156111134191241265288343393433
on22511045012155110
hepatitis23861045012156106163212244267301324363
B27731045012155
virus2852104501214972105160199
(HBV)3076104501212993147202233
infection,3334104501212379108158203239262317373393
in3752104501212479
the3856104501213388138
HBV/HDV40191045012165120175204270337391
co-infection4435104501214598132156211240291336372395450505
chapters.49651045012145100148205238287320360382
The53711045012150106157
European4251185012149103135190247298346401
Association8501185012162102141197242265313346369424479
for1353118501212984117
the1494118501213389139
Study1657118501214981135192240
of1921118501215584
the2029118501213388138
Liver2191118501214771119168201
(EASL)2416118501212876139189235263
clinical270311850121446891146169214262286
practice3013118501215789138183218241286335
guidelines33721185012156110134190240264287343393433
from3828118501213063118201
July4053118501213792116163
202342401185012151102150201
were44651185012174123156206
the4695118501213388138
basis48571185012157106145168207
for5088118501212984117
writing52291185012174107130164187242298
this425132501213388111150
guideline.5971325012156110133190240264287343393413
HDV4251465012165132187
can640146501214594150
co-infect818146501214599132157212241292337373
a12191465012148
susceptible1296146501213994133179228285318341398422473
host17971465012156111150185
with2010146501217497131186
HBV22241465012166120175
(co-infection)2428146501212870124157182237266317362398421476532557
or3014146501215588
superinfect3130146501214094151203236259315344394440475
a36341465012148
person37101465012157109142182237293
chronically40321465012145100132187243266311360383407454
infected4515146501212378107158204239289346
with4889146501217498131186
HBV.51041465012165120175190
HBV/53221465012166120175205
HDV4251605012165132187
coinfection630160501214599122177206256302337360415471
usually1120160501215594149197220243291
leads1429160501212474122179218
to1666160501213387
acute1771160501214993148181231
hepatitis20201605012156106163212245268301324363
with2401160501217498131186
a26061605012148
wide2672160501217498154205
clinical289516050121456891146169214263286
spectrum3200160501213996147193228261316399
ranging3618160501213281136192216271327
from3963160501213063118201
an41831605012148103
asymptomatic4305160501214887135220276309363447495528551595
course,4919160501214599154186227277297
to5235160501213387
mild53401605012184107130187
hepatitis,4251745012155106163212244267300323362384
to837174501213387
acute952174501214893148181230
liver121017450121244795144177
failure.1415174501212978101125179212262282
However,17251745012165121194243291340373389
only21421745012155110134181
a23511745012148
small24281745012139122170194217
proportion2673174501215790144201257290326349404460
of3161174501215584
cases3273174501214594133183223
(around3524174501212873106160216271328
238801745012151
%)39591745012179105
progress4092174501215790144201233283323362
to4482174501213387
chronicity.45971745012145100132187243266311334367416433
In5058174501212479
contrast,5165174501214599155187219268307341362
superinfection425188501214094151202235258313342393438474497552607
with1059188501217498131186
HDV12721885012165132186
on14851885012155111
chronic16231885012145100132187243266310
HBV19601885012166120175
infection2162188501212379107158203239262317373
very2562188501214897130180
often2769188501215584120170225
leads3021188501212474122179218
to3266188501213387
severe3380188501214090138187220270
acute3677188501214893148181230
hepatitis,39341885012156106163212244267300323363384
which43451885012173129152197252
progresses4624188501215790144201234283323362412452
to5103188501213387
chronic52171885012145100132187243266310
hepatitis4252025012155106163212244267300323362
D8072025012166
(CHD)893202501212884148215241
in1153202501212479
up12512025012155112
to1382202501213488
9014892025012151104
%16122025012179
of1710202501215584
cases1814202501214493132183222
and20562025012148103160
is2235202501212362
associated2317202501214887126181227250298330380437
with2773202501217498131186
more29782025012183139172221
severe3219202501213990137186219269
chronic35072025012145100133187243266311
outcomes38372025012155110144187241325375415
than4271202501213388136191
HBV44822025012165119174
monoinfection.46752025012184139195250273328357408453489512567622643
CHD53382025012158122189
has4252165012155104143
been5892165012157108159214
shown825216501213994149222278
to1125216501213387
progress1233216501215790144201233283323362
more16162165012183139172221
frequently1859216501212962112169224274330362386433
and23132165012148104160
more24952165012183138171221
rapidly2737216501213381138162218242289
to3047216501213387
liver315521650121244795144177
cirrhosis3354216501214467100133188244283306345
than3720216501213388136191
HBV39332165012165119174
monoinfection.41282165012184139195250273328357408453489512567622643
Globally,425230501216590146205254278302350367
an8212305012149105
estimate955230501215191125149233282315366
of1350230501215585
4.5–131464230501215273128180226272
%17652305012180
of1874230501215585
HBsAg-positive19882305012166122161223279312371428467491525548597647
persons26642305012158110144185241298337
are3030230501214982133
infected3192230501212480110161207243293352
with3573230501217499132188
HDV,37902305012166134190205
representing4024230501213384142176226267318375408431487544
12–724597230501215297146193244
million48712305012184108132155179235291
persons51912305012158110144185241298337
infected425244501212379108158203239288345
with797244501217497131186
HDV10092445012166133187
in1223244501212378
absolute13282445012148105144200224278311361
numbers.17162445012155110193250301334374395
HDV21382445012165132187
infection2351244501212479108158204239262317373
is2751244501212362
still284024450121407396120143
rare3010244501213281113163
in3200244501212379
the3305244501213389139
Czech34712445012158103153198253
Republic,37512445012154104161217274298321365387
with4164244501217498131186
a43772445012148
maximum44522445012183131179202285340423
of4902244501215584
a50132445012148
few5088244501212980153
dozen52682445012156111153203259
patients,4252585012157105137159209264296336357
almost799258501214871153208247280
exclusively1097258501214996139162216255277325373397444
foreigners1558258501212984116166189244299349381421
coming1996258501214598181204258314
from2327258501212962116199
endemic25432585012150105161211294317361
areas,2921258501214880129177216236
mainly31752585012183130153207230277
from3470258501212962116199
Mongolia36862585012180135190245300324346394
and40972585012148103159
other4273258501215587141191224
Asian45142585012161101124171226
countries.4757258501214598153207239271294344383404
With51782585012185108141195
the5391258501213387137
increasing425272501212379124156206254293316371427
migration8712725012184107163195244276299354410
of1300272501215584
people14032725012157108164221245295
from1717272501213063118201
endemic19372725012150106163213296320364
areas,2320272501214981131179218239
the2578272501213388139
incidence2736272501212378123146203253309354403
and31582725012148103160
prevalence3337272501215790140187236259310365410459
of3815272501215584
hepatitis39182725012156106163212244268301324363
D43002725012166
in4385272501212479
our44832725012155110143
country4645272501214498153209241274324
may49882725012183131177
increase5184272501212379124156206254293344
rapidly.425286501213381138162218241289305
Experts751286501215098155207239275316
estimate1088286501215090124147230278310360
that1469286501213388136168
the1659286501213388138
prevalence1819286501215689139187235259309365410459
of2299286501215584
HDV24042865012165132187
among26122865012148131186242298
HBsAg29312865012166120159220275
positive32272865012157113152175208231279328
patients35772865012156105138161211267299340
in3938286501212378
the4038286501213388138
Czech41972865012158103153199254
Republic44722865012154104161217274298321365
is4859286501212362
around4942286501214881136191246303
152662865012151
%.53382865012180102
Until4253005012165119152175198
2020,6413005012151101150200220
interferon879300501212378110159192224274307362417
(IFN)α-based1314300501212951100164191246277335384423473530
therapy1862300501213389139172220277323
was22033005012173122161
the2382300501213388138
only25383005012155110134181
treatment2737300501213365115163196279329385417
option31723005012155112145168222278
for3468300501212984117
CHD.36033005012158122189207
Gradually,3827300501216598147203258306329352399415
pegylated42603005012157108165212237284317366423
interferon4701300501212479111160193225275308362418
(PEG-IFN)5137300501212881128192226251300364391
α4253145012155
treatment498314501213366116164196279330386418
proved934314501215790144191241298
to1250314501213387
be13553145012157108
more14813145012183138171221
effective1720314501215080113163209244267315364
than2102314501213389137192
treatment2312314501213365115163196279330385418
with2748314501217397130185
conventional2951314501214599154201250306338361416472520543
(standard)3512314501212966100149204261309341397426
IFNα3956314501212372136192
–41703145012150
2542383145012151102
vs.4358314501214888109
174485314501215195
%45983145012179
virological4695314501214872104159183238295318363411435
response5148314501213282122178234290329379
at425328501214881
the524328501213388138
end6803285012150106162
of860328501215584
489623285012152104
weeks10843285012174123174221264
of1366328501215584
treatment.1468328501213365115163196279329385417439
Subsequently,19253285012149103160199250307362412467500523570586
however,25293285012156111184233281330363378
more29253285012184139172222
than3165328501213388136191
half33743285012155103127156
of3548328501215584
the3650328501213388139
patients38073285012157105138161211267299340
successfully4165328501213993138182231270310340395419442489
treated4672328501213366116164196245303
so4993328501213994
far5105328501213079111
experienced52343285012150971542062382624253425012150105150198255
virological697342501214872104158182236293315360408431
relapse1146342501213282105153209248298
after1461342501214877113162194
treatment.1673342501213365114162194277327382414435
Extending2126342501214896132181236292315370425
the2569342501213387137
duration27243425012156110142191223245300355
of3097342501215483
PEG-IFNα31983425012153100163197222270334390
treatment3605342501213365115162194277327382414
to4037342501213386
241413425012151
years4209342501214796144176216
did4442342501215679135
not45953425012155110142
increase4755342501212377122154204251290340
treatment5112342501213365115163195277327383415
success425356501214094139183232271310
according756356501214993137191224280303358414
to1192356501213387
the1300356501213388139
results1460356501213282122176200233273
of1754356501215584
most18603565012183138177211
clinical209235650121456891147170214263287
trials.240035650121336589137160199221
Bulevirtide4253705012154109133183231255287323346402453
(BLV)901370501212982129179210
is1135370501212362
a12213705012148
synthetic1292370501214088145177232282316339384
lipopeptide1699370501212447103159216267324358381437488
consisting2210370501214599154193216255289312367423
of2657370501215584
472764370501215299
amino28873705012148131154209264
acids3175370501214893116172212
from3410370501212963117201
the3635370501213388138
preS13797370501215790139188234
domain40543705012157112196244267322
of4400370501215484
the4507370501213388139
large4669370501212472104160210
HBsAg49033705012165119158219274
protein,5201370501215689144177226250305326
which4253845012173129152196251
binds694384501215780135192231
to942384501213387
NTCP,10473845012165116171223232
thereby1297384501213388138171220277323
preventing1638384501215790139186235291323346401457
HDV21123845012165132186
from2316384501212962117200
entering25343845012150105137186219242297353
the2905384501213388138
hepatocyte.30613845012155105162210243296342391427476496
Clinical3575384501215881103158181226274298
trials389038450121336689137160199
have41073845012155103149198
tested4323384501213382121155204261
the4601384501213388139
efficacy4757384501215080112138183231276325
and51003845012148103159
safety5277384501214088117167200250
of425398501215584
BLV5313985012154101151
treatment703398501213366116164196280330386418
at1143398501214880
doses12453985012156111151201240
of1507398501215584
2,1612398501215272
517053985012152
and17783985012148104160
101960398501215198
mg20793985012184140
once22403985012155111156205
daily24673985012156104127150198
subcutaneously,2686398501214094151197251285333389439495550589613660676
alone3384398501214871126182233
or3638398501215588
in3747398501212479
combination3848398501214498182238262317365398421476532
with4401398501217497130186
PEG-IFNα.46083985012153101165199225273337393415
As50453985012161102
the5168398501213388139
optimal532839850121551121451684254125012183132155
duration6034125012156111143192224247302358
of984412501215584
BLV10914125012154101151
treatment1265412501213365115163196279330385418
has17054125012156104143
not18714125012155110143
yet2037412501214796130
been21904125012157108159214
established,2427412501215090123172229253276315370421478499
it2949412501212356
has30284125012156104143
not31944125012155110143
yet3360412501214796130
been35124125012157108159215
possible37504125012157113152191214270294345
to4118412501213387
assess4228412501214887126176216255
the4506412501213388139
sustained4667412501214094134168216239295345402
virological5092412501214872105159183238295318363412435
response,425426501213383122178234290329380399
as843426501214887
BLV9494265012154101151
treatment1118426501213366116164196279330386418
was15544265012174122161
not17344265012155110143
discontinued1896426501215679118163217273305328383438488546
in2460426501212479
the2557426501213388139
studies.2714426501214074129185208259298319
According30524265012161105148202235291314370426
to3496426501213387
the3602426501213388138
results3759426501213282122176200233273
of4051426501215484
clinical415342650121456891146169214263286
trials,445742650121346690138161200221
a46964265012149
higher4763426501215679134190240273
dose50544265012157112151202
of5274426501215584
BLV53774265012154101151
(10425440501212875121
mg)5684405012183139166
provides755440501215790145192216272322362
no11384405012156111
benefit12704405012157108163214244270303
compared1594440501214599182239288320370427
to2042440501213488
a21514405012148
dose22204405012157112151201
of2443440501215584
225484405012151
mg26204405012184140
once27814405012155111156205
daily.30074405012156104128151198215
In425454501212479
July522454501213792115163
2020,7034545012151101149199219
BLV9404545012154102151
received1109454501213383128177200249298355
conditional1482454501214498154210233266289344400447471
marketing19714545012183131163210259292315370426
authorisation24154545012148103136191246279302341390423445500556
from2989454501212962117200
the3207454501213388139
European33644545012149102135189246297345400
Medicines37824545012180131188211256279334384423
Agency42234545012161116166222267316
(EMA)4557454501212876156218245
for4820454501212984117
the4955454501213388138
treatment5111454501213366115163196279329385417
of425468501215583
CHD5264685012158121188
and7314685012148103159
compensated908468501214497180237287342381430462511567
liver149346850121234694143175
disease,1686468501215679117167215254304323
with2027468501217396129184
a22284685012148
recommendation2294468501213282127180263346396451507555587610664720
to3031468501213387
continue3135468501214598153185208263317367
BLV35194685012154101150
treatment3687468501213365114162194277327382414
at4118468501214880
a42164685012148
dose42814685012156111150200
of4499468501215483
245994685012151
mg46684685012183139
daily48244685012156104127150197
until50384685012155110142165187
clinical524346850121456790145168212260283
benefit4254825012157108164214244270303
is749482501212463
seen.833482501213990141197218
The10724825012150106156
conditional1250482501214498154210234267290345401449472
marketing17434825012184132164211260294317372428
authorisation21924825012148103136191246279303342391423446501557
was27704825012174122161
switched29534825012139114137170214269320377
to3351482501213387
a34594825012149
standard3529482501213973122177234282314371
marketing39214825012183131164211260293316371428
authorisation43704825012148103136191246279302342391423446501557
in4948482501212379
July5048482501213792115163
2023.52324825012151101150201221
Key4254993012358108158
words:6044993012374130166224266290
Czech9154995012158103153198253
national11904995012155103136159214269317341
guidelines,15524995012156111134190241265288343393433454
chronic20274995012145100132187243266310
hepatitis23594995012155106163212244267300323362
D,2742499501216785
bulevirtide28484995012157112136186234257290326349405456
(BLV),3325499501212882129179210228
pegylated35754995012157108164212236284317366424
interferon4020499501212378111160193225275308363419
alfa.4460499501214871101150171
Preambule4255494013867113172233326390454487546
Níže565566301075981121168
uvedená764566301075094141195243295340
doporučení11355663010751103157210240293337383435456
pro1623566301075181132
diagnostiku1787566301075072116169221274311343365406458
a22775663010742
terapii2351566301072875104150203225247
infekce262956630107207298145187230276
virem42558030107416290135210
hepatitidy663580301074894145189218238268289340382
D10725803010758
(HDV)1158580301072381141188218
byla1403580301075091112155
vytvořena1585580301074186119164214242287337379
členy1991580301074161107157197
pracovních2216580301074978121164212254305325367417
skupin2660580301073473123175196245
pro425594301075078127
virové57359430107416290139181226
hepatitidy820594301074894145189218238268289340382
České1222594301075296132171216
hepatologické1459594301074894145189218266287337389410452491536
společnosti2016594301073485136157203246296346381412432
(ČHS)2469594301072474132175200
České2690594301075196131171215
lékařské425608301071963101144171206244287
společnosti731608301073282131152196237285334368398417
Jana1167608301073071119160
Evangelisty1346608301074181123171221265285305338367410
Purkyně1775608301074491118157200250294
(ČLS2088608301072372112156
JEP)2262608301073173118141
a24216083010740
Společnosti2480608301074190139160204245294342376406425
infekčního42562230107197096142183225276297350401
lékařství857622301071966107152181218249296318
(SIL)120562230107256788131157
ČLS1393622301075294141
JEP.1564622301073277124132
Poprvé1727622301074695148177224270
se2028622301073481
jedná2140622301072066119170214
o23846223010749
samostatný2464622301073479156207243275319349400441
doporučený425636301074999150201230280322365415455
postup,9006363010750101136166216267283
který1203636301073870115143187
se1410636301073480
věnuje1510636301074085134184204249
pouze17806363010749100150188233
infekci203363630107186893138178219239
HDV.22926363010757116163176
Dosud24886363010758108144192243
byla2751636301075091112154
infekce42565030107196894139179220264
HDV7156503010757117164
zmiňována9046503010736113133182233275318368410
jen1340650301071965115
v14806503010741
doporučených1546650301074999151202231281323367417458499549
postupech21216503010749100136166216267314357407
týkajících2554650301072772112156177198239260302351
se425664301073379
infekce52366430107196893138177218261
virem80466430107406189133208
hepatitidy1031664301074893144187216236265285336377
B14286643010745
(HBV),1493664301072381127174203218
v17306643010741
kapitolách1790664301073882132153182230251293335384
HBV/HDV21946643010756103149178237296342
koinfekce2556664301073886107156181225265305349
(1,42567830107246678
2).53367830107446883
Základem645678301074992132155197248294370
pro1045678301074978127
napsání1202678301074891142177221271291
tohoto1523678301072877127177207255
doporučeného1808678301074999151202231281323367417463514564
postupu24026783010749100136167217268318
byla2750678301075091113155
doporučení425692301074999151202231281323367417437
Evropské892692301074284113162214249288333
asociace1255692301074176126169190232274318
pro1603692301075078127
studium1760692301073364114165186235310
jater210069230107196190134163
(EASL)2292692301072467123168209234
z25566923010736
července2622692301074084112158203253425706301074084
2023528706301074488131176
(3).72470630107246790105
Maximální8487063010770112153174248290311360380
možné12477063010774123160210256
dodržování1523706301074898149177216265306349398418
odborných1961706301074899150200228278318359408
doporučení2389706301074998150200228278320363413433
je2841706301072065
podmínkou4257203010750101153228248298338387437
dosažení883720301074999134178217261311332
efektivní1235720301074470115155187208251302322
péče1578720301075096139183
o17827203010748
nemocné1851720301074894170220263313359
s22317203010734
virovou228572030107416291139181231281
hepatitidou2587720301074894145189218238268289425734301074999149
D5967343010758
v6767343010741
celostátním739734301074084105155191222265294344364440
měřítku.12017343010773119147167197237287305
Předkládaný1528734301074573117169209231274325367417458
dokument2008734301074899139189264310360389
je2419734301071965
oporou25067343010748100151179228278
při280673430107507999
jednání425748301071965117167209259279
obou7307483010748100151201
odborných9577483010748100151202231282322364413
společností1397748301073384135157202245295345381411432
se1855748301073480
státními1961748301073464108136187207282303
orgány2290748301074877127169219259
a25757483010741
s26427483010734
plátci2702748301075071114143183203
zdravotní425762301073686115158200249278328348
péče.797762301074996139183200
Úvod30475494013874137198262
Virus318756630107466693141174
hepatitidy3382566301074993143184211230258277326366
D37705663010758
(HDV)3850566301072480138183211
se4082566301073478
v41825663010740
angličtině4244566301074189138157175216246265312356
často4622566301074081115144190
označuje4834566301074883132173213261280323
jako517956630107196098145
delta5346566301074993112140181
virus,304758030107416086135168184
i32495803010719
když3287580301073886127165
taxonomicky3471580301072869109156205253327346386424467
správné3956580301073483110152192241285
je4259580301072063
označení4341580301074883132173213256304322
HDV.46825803010757115160171
Považuje4872580301074591131173210258277321
se5212580301073377
za5308580301073678
defektní54055803010749933047594301072467105136184203
virus,326759430107406086134167183
jehož3467594301071963112160196
životní367959430107375697144171220238
cyklus3934594301074083121142189222
je4173594301071963
závislý4253594301073678118138170189229
na4499594301074889
viru460459430107416087135
hepatitidy4756594301074892142184211229258276325366
B51385943010746
(HBV),5201594301072380125171198212
od5429594301074898
něhož3047608301074892140189225
„využívá“3292608301072664107156192211252294319
všechny3631608301074175119160208256294
tři394660830107275473
(malý,4039608301072495136155195207
střední426660830107336289132182230248
a45346083010741
velký)4595608301074184104141184208
povrchové4823608301075099139167206254302342385
proteiny5229608301074976123151193212260298
(HBsAg),3047622301072480125158210259282295
které3359622301073869112138181
slouží3557622301073453101149186205
jak377962230107196098
ke3894622301073881
vstupu3992622301074174103151201249
do4258622301074998
hepatocytů,4373622301074892142183210257298341372420435
tak4825622301072869107
k49496223010738
jejich500562230107196381100140188
opuštění5210622301074898147179208251299317
(3).304763630107246687101
Podle3170636301074592142161205
jiných339763630107203886125164212
odborníků3632636301074898147197224272291331379
je4033636301072064
přesnější4119636301075077119153201245264296314
označení4456636301074883132173213256304322
HDV48016363010757115160
jako498463630107195997145
satelitního5151636301073476103145165183211260278328376
viru,304765030107416187136152
který3226650301073870113139183
využívá3436650301074185134171190232274
pro3737650301075077125
svůj3889650301073376125144
životní406065030107365697145173222241
cyklus4327650301074184123144192225
HBV45796503010757103149
jako475565030107196099146
hostitelský4928650301074998132161180209252271304342386
virus.534165030107416087136169186
Taxonomické3047664301074277118165214263338356397435479
zařazení3552664301073779106148185229277296
HDV38756643010757115161
se4062664301073479
stále4167664301073463105124169
vyvíjí.4362664301074185129149169188204
Podle4592664301074693143162207
poslední48256643010750100134153197247296315
klasifikace5166664301073859100134152176197235277318361
patří3047678301075092119146165
HDV32396783010757115161
do3426678301074998
rodu3550678301072775125173
Deltavirus37496783010759104123151193233253279328361
čeledi4137678301074082102146196215
Kolmioviridae,4379678301074593112186205253294313340359409450494509
která4914678301073970112139181
je5122678301071963
částí5211678301074182116145164
říše540267830107264681125
Ribozyviria3047692301074565114163199242286305332351391
(4).345569230107246687100
Jedná3572692301073176126174214
se3804692301073377
o38986923010748
RNA39636923010746104156
virus.413669230107416087135168185
Nukleová43386923010757105143163207256297338
kyselina4693692301073881115159179197245286
viru499669230107406086135
(HDV5148692301072480138183
RNA)53486923010746104156179
kóduje3047706301073886136183202246
jediný3320706301071963113132180219
strukturální356570630107346390138176207255282324343391409
protein4000706301075077125152195213261
–42887063010745
antigen4359706301074189116135185229277
viru466270630107416187136
hepatitidy4824706301074893143184212230259278327367
D52187063010758
(HDV),5302706301072481139184212226
exprimovaný3047720301074484135163182256306347389437476
ve3550720301074185
dvou3662720301074991139188
izoformách.3877720301071956104128177204279321362410427
Zatímco4331720301074991119138212254301
malý46597203010774115135175
protein4861720301075078125153196215264
(S‑HDV)515272030107246493152211257285
je5463720301072064
nutný3047734301074894122169207
pro3270734301074975121
replikaci3407734301072769117136154191233273291
viru,371373430107415985133148
větší3876734301074183110144162
(L‑HDAg)405473430107236280137194244291314
se4383734301073477
podílí4476734301074997146164185202
na4694734301074888
tvorbě4798734301072770116143192236
obalu5050734301074796137155202
zralého5268734301073562103121164212259
virionu.304774830107416086106154202250266
Oba33337483010760111152
proteiny3506748301074976123151193212260298
HDAg38247483010757115165214
se4058748301073478
váží4156748301074182119138
na4314748301074989
HDV44247483010756114160
RNA46047483010745103156
a47807483010741
vytváří4841748301074084115158200226245
ribonukleoprotein,5106748301072746961451932412792993433923047762301075077124151194212260276
který3341762301073869111138181
je3540762301071963
následně3621762301074889122141185235283327
obalen3966762301074898140159203251
všemi4235762301074074118192210
třemi446476230107275497170189
izoformami4671762301071955103127174201275316390408
HBsAg.50977623010757103135187236252
Díky5367762301075877117160