571
PŘEHLEDOVÉ479422701004388130181216258306358404446
ČLÁNKY525622701003973122176223272
Duální389133701004583118134171186
GIP409433701004360100
a4211337010033
GLP-1426133701004375117142163
agonisté444133701003372111148164192220255
a4712337010034
změny476233701003091126164200
lipidového4978337010015306883122161196231269308
spektra530233701002866102136165190225
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39564222701003477
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Vnitř3760804301074592111139166
Lék.3945804301074184122140
2024;70(1):35-394105804301074487128168182224265290330347362406448475516558
/47088043010731
VNITŘNÍ48058043010746106127172220280301
LÉKAŘSTVÍ5128804301074084130188235279324377399
www.casopisvnitrnilekarstvi.cz42580430107651332012142542953293774274464795215705896176436927117307748128548809159449871007102310631101
12.425553085366884
Berberich528554083357192131167188204236274
AJ,821554083416880
Hegele9215540834479118153169204
RA.1144554083357893
Lipid1257554083314685101140
effects1416554083345473107140164192
of16275540833757
glucagon-like1703554083385491123156195233272294311326356390
peptide21125540833974114136151190225
1235655408334
receptor2410554083205587121160182219241
analogs.26705540833270102118156195222235
Curr425654083407698119
Opin5606540834786102140
Lipidol.715654083324786102140179195207
2021;32:191-199.9386540833468101132141176208221250281313331362392428439
13.425753085366883
Dahl5267540834578116131
K,6757540833549
Brooks742754083365794133163192
A,9527540834155
Almazedi10257540834157114147176210250265
F,13087540833238
et13647540833456
al.1438754083324760
Oral15167540834769102117
semaglutide16517540832661119151190206243266281320355
improves20247540831472111133170202236263
postprandial23057540833977104127167188221259298313345361
glucose2684754083385391123160186221
and4258540833270109
lipid54785408315306985123
metabolism,6848540835792114147186225241256282340353
and10508540833270109
delays1172854083387389121152179
gastric1364854083387097120142157189
emptying,15668540833492131154187203241280293
in18728540831553
subjects19388540832663102118153185209237
with2188854083516789127
type2329854083215595130
2247385408334
diabetes.2520854083385385125160182216243257
Diabetes2790854083456193425954083397496130157
Obes5979540834787123150
Metab.7629540835489112144184196
2021;23:1594-1603.9749540833468101132140175210221251281314349372403434470503515
14.4251053085366984
Novodvorský52610540834583115153192225262284311341375
P,91710540833640
Haluzík9741054083447691129158174205
M.119610540835468
The128110540833272107
Effect14041054083335271105138162
of158210540833857
GLP-1165510540834476112133164
Receptor183510540833671103137176198235257
Agonists210810540834180118156171197221248
on237310540833775
Postprandial24651054083357299122161183216254293308340355
Lipaemia.28371054083314742511540833972107164180212225
Curr6651154083407798120
Atheroscler80011540834162100135156194220253268303324
Rep.113911540833671110122
2022;24:13-21.127711540833468101136148183215227257287309339371380
15.4251253085366883
Mulvihill52412540835492108140156194209224239
EE.7791254083336579
Regulation87412540833570110147162195216232270308
of119812540833757
intestinal12711254083145274108134158173211243258
lipid1545125408315306985124
and168512540833270109
lipoprotein18101254083152969107147169206228261277315
metabolism214112540835792114147186225241256282340
by249712540833870
the25831254083215994
proglucagon-derived2693125408339619813815319042513540833164103141180202243277299314347381421
peptides86113540833874113135150189224251
glucagon11271354083385391123156195233271
like1413135408315306094
peptide152213540833974114136151190225
11762135408334
and181113540833169108
glucagon19341354083385491123156195233272
like2221135408315306094
peptide233013540833874113135150189224
2.256913540833447
Curr26311354083407697119
Opin276513540834787102140
Lipidol.4251454083314786101140178194207
2018;29:95-103.64814540833468100131143178212225260294316347379412424
16.4251553085367086
Nauck53215540834578116148179
MA,73215540835597111
D’Alessio8641554083465997113148175202217256
DA.114015540834686101
Tirzepatide,12621554083335071102137176210232247287322334
a1617155408332
dual167015540833876109125
GIP/GLP-118151554083446096117161193229251282
receptor21181554083215588122162184222244
co-agonist23821554083326993126165204243258284308
for27111554083185678
the28101554083226096
treatment4251654083224377109131189224262284
of72216540833756
type7911654083225696131
2935165408334
diabetes9831654083385385124160182216242
with12391654083506688126
unmatched137816540833876133166188218256291331
effectiveness17221654083345372107140164179211246284319346372
regrading21071654083215595116149188203241280
glycaemic24001654083385385117150184242257289
control270316540833168106128149186202
and42517540833270109
body54917540833978117149
weight71417540835085100138176198
reduction.9271754083215595132164188204242280293
Cardiovasc12361754083407294132147185217250276309
Diabetol.15601754083456193132167190227243256
2022;21:169.183117540833468101136148183215223253284318329
17.4251853085366876
Moura52118540835493131152185
FA,7251854083337185
Scirica8291854083336580101117149182
BM,103018540833590104
Ruff11531854083367393112
CT.12851854083397584
Tirzepatide13891854083324970101135174207229244283318
for17261854083195678
diabetes:18231854083385486125160183216243256
on209818540833776
track21931854083224376108139
to235118540832258
SURPASS242918540833276112148185219251
current27001854083316990112146184205
therapy.4251954083226095116149188219229
Nat6701954083447799
Med.78419540835489129142
2022;28:450-451.94119540833569102136149184217230264297331355391424455465
18.4252053085366985
https://clinicaltrials.gov/ct2/show/NCT04255433.5262054083385983123150162189209238253268306321353386401424445461493508534548587625657680709733769795820857896947970101610571093112711631196123112631298133113641376
19.4252153085366982
Sattar5262154083326587111144165
N,71021540834558
McGuire78621540835587132170185206241
DK,10452154083468196
Pavo11602154083356798136
I,131421540831528
et136121540833456
al.14362154083314760
Tirzepatide15142154083335071101136175208229245284319
cardiovascular18512154083316485124139177209242268300338354386407
event227721540833366100138160
risk2455215408321376393
assessment:25662154083325985120147174231266304326339
a425225408332
pre-specified4722254083396094118144183219252267284301336376
meta-analysis.86322540835792115148170202240273288320347362388401
Nat12802254083447798
Med.139422540835489129142
2022;28:591-598.155122540833469101136149184217230265297329348382414449463
20.4252353085367287
Wilson5302354083577489115153191
JM,7392354083247992
Nikooienejad8492354083446090127166181216254289304336375
A,124223540834155
Robins131423540833674114129167193
DA,15252354083458599
et164123540833457
al.17152354083324760
The179323540833271106
dual191723540833875108123
glucose-dependent20582354083385390123160186221244285320359394433472506545566
insulinotropic264223540831452781161311461842222444252454083215897113145
peptide58724540833974114136151190225
and82924540833270109
glucagon-like9552454083385491123156195233272294311326356390
peptide-1136224540833974113136151190225248279
receptor16582454083205587121160182219241
agonist,191624540833271109147163189212225
tirzepatide,2158245408322375889123162195217232271306318
improves249324540831573112133171203237264
lipoprotein277424540831530691084252554083396097119153168206
biomarkers6492554083385492150182204234268290317
associated9832554083325985123156171203225259298
with12992554083506688126
insulin14432554083155279116131146184
resistance1645255408320548196122145178216248282
and194425540833270109
cardiovascular20712554083316485123138176208241268300338353385406
risk2495255408321366292
in260525540831452
patients26752554083387193108143181203230
with4252654083516689127
type5672654083225595131
2713265408334
diabetes.7632654083385385124160182216243256
Diabetes10352654083456092132167189223250
Obes130026540834787123149
Metab.146526540835489112144184196
2020;22:2451-2459.167626540833569102136149184218231266298331362380411443476508519
21.3047553085366980
Várkonyi3143554083366687116153191221236
TT,3394554083336977
Pósa3487554083357197129
A,36325540834154
Pávó3701554083356797134
N,38505540834557
et39235540833455
al.3993554083324759
Perspectives4067554083356889115154188220244258290324350
on44325540833775
weight4522554083518599137175195
control47335540833167105126146183198
in49465540831552
diabetes5014554083385283122157178211238
-526755408321
Tirzepatide.5303554083324969991321712033047654083223674109120
Diabetes3181654083456091130165186219246
Res3440654083367096
Clin3550654083405569106
Pract.3670654083355587119142155
2023;202:110770.3839654083346799134144179212244256285312343375408441453
22.3047753085367287
Nauck31517540834576113145174
MA,33427540835596109
Quast34697540834784116142164
DR,3650754083458194
Wefers37627540835789108142162189
J,39687540832435
et40217540833455
al.4093754083324759
The41697540833371106
evolving42927540833465102117149164201240
story4549754083264985106139
of47057540833756
incretins4778754083155284104137159174211236
(GIP5032754083186075110
and51597540833269108
GLP-1)52847540834475110131161174
in54767540831451
metabolic30478540835892114146185223239253284
and33518540833169108
cardiovascular3478854083316384122136174205238264295333347379400
disease:3897854083385378113144170204216
A413385408341
pathophysiological4193854083397192130168207245275301316353369406445460491524538
update.47518540833776115146168201212
Diabetes4983854083456092130165187220247
Obes52498540834786121148
Metab.541685408354893047954083225492104
2021;23(Suppl31659540833468100130138172206224255291330369384
3):5-29.356395408334506296118148181192
23.30471053085367286
Wilson31531054083587388113151189
JM,33611054083247891
Lin34711054083324784
Y,357410540833643
Luo363610540833268106
MJ,37611054083558091
et387210540833455
al.39461054083324759
The402510540833271105
dual414910540833976107122
glucose-dependent42901054083395390122158184219241281315354389427465499537558
insulinotropic48671054083155278115129144181219240261297337351383
polypeptide5269105408339779212416319823730471154083223776111
and317811540833270110
glucagon-like33071154083395492124157196234273295312326356391
peptide-1371711540834075115137152191226249280
receptor40161154083215688122162184221242
agonist427811540833271110148163189212
tirzepatide4510115408322375889123162195217232271306
improves483611540831573112134171203238264
cardiovascular51201154083326586124139177209242269301339354386408
risk3047125408321366190
biomarkers31561254083395391148180200230264284311
in348512540831552
patients35561254083397192107141178199226
with38001254083516688125
type39441254083215494129
24091125408334
diabetes:41441254083385384122157179212238250
A4413125408340
post447212540833977103125
hoc461612540833875107
analysis.474212540833269101115146173187212225
Diabetes49861254083456091130165186219245
Obes525012540834786121147
Metab.54161254083548930471354083225492104
2022;24:148-153.316513540833468100134145180211222251282317339369398431443
24.30471453085367084
Tschöp31491454083335384121158197
M,336414540835467
Nogueiras344814540834582121157191205225257282
R,374814540833548
Ahrén38141454083417898131168
B.399914540833648
Gut406514540834481102
hormone-based41851454083377595152189227261283321353379412451
pharmacology:465414540833876107127184215246282297334372403415
novel508714540833875106139153
formulations5258145408318557513316918321423524930471554083377499
and315915540833268106
future32771554083195677114133166
possibilities345615540833876101126140177191205219240254287313
for37811554083185575
metabolic386815540835891112144181219233247278
disease41581554083385277110141166199
therapy.43701554083225892112143181211220
Diabetologia.46021554083456090128162183219233270308322352364
2023;66:1796-1808.49791554083346798132142176210221250278309344366395425459493505
25.30471653085367083
Tan31401654083325894
TM.32441654083328597
Co-agonist33511654083397495126163199235248273294
therapeutics36541654083225891110141178212247268282312337
come400116540833166121155
of416516540833754
age422916540833168101
for43401654083185373
obesity.442316540833674108132145166198206
Nat46381654083457595
Rev47421654083356899
Endocrinol.485016540833268105141172191205241277291302
2023;19:66-67.51621654083346697129139167195207240274295330361366
26.30471753085367185
Rosenstock31441754083357399133170196218254286315
J,347117540832435
Frias3518175408332516697123
J,365217540832436
Jastreboff36991754083245681104124158196234253272
AM,398217540834196109
et410217540833456
al.41691754083324659
Retatrutide,42391754083357091123144165202224238277311322
a4572175408332
GIP,4615175408344599497
GLP-1472417540834475110130160
and489617540833169107
glucagon50141754083385390121153191229266
receptor52921754083205485118157178214235
agonist,304718540833270108145160185208220
for32811854083185576
people337118540833873111150165199
with35841854083516587125
type37221854083225594129
23865185408334
diabetes:39131854083385283122157178211237249
a4176185408332
randomised,42211854083215391129166224238264298337349
double-blind,458418540833875113151166200223262277292329367379
placebo49771854083385485117150188226
and521718540833269107
active-53381854083326387101133167189
-controlled,30471954083215490128149169206221235270308320
parallel-group,33811954083397192124139153187202224264284321358396407
phase380219540833977108134169
23985195408334
trial4033195408321425788103
conducted415019540833167105143180212235268307
in447119540831552
the45371954083215993
USA.464419540834475115129
Lancet.478719540833164102133166188200
2023;402:529-544.500119540833468100134145179214246258292325358381414449485497
27.30472053085367078
Jastreboff31422054083245681104125158197235254273
AM,343120540834196109
Kaplan355620540833568106121153190
LM,376220540833287100
Frías3878205408332516697123
JP,40182054083245963
et409720540833456
al.41692054083324659
Retatrutide42442054083356991123144165203224239277311
Phase457220540833571103129163
24752205408334
Obesity480220540834786121147161183216
Trial5034205408333496496110
Investigators.51612054083145282116142164179217249270306327353366
Triple-Hormone-Receptor30472154083334964102118152174219257278336373411445468504538570603642663700720
Agonist378521540834178116154168193216
Retatrutide40182154083367092124145165203225239278312
for43472154083195676
Obesity444121540834786121147161183216
-4674215408321
A4713215408341
Phase477121540833572104129164
24952215408334
Trial.5004215408332496495110122
N5143215408345
Engl520621540833269108122
J5346215408324
Med.538721540835589128140
2023;389:514-526.304722540833468100134145179213246259293323354376409442475487
28.30472353085367187
Abdelmalek314723540834180119153168225256271305335
MF,34952354083548792
Suzuki36002354083336998135165181
A,379423540834154
Sanchez386123540833365102134171205234
W,410923540835766
et418823540833456
al.42572354083324659
A4329235408341
phase438323540833976108134168
2,456423540833546
adaptive462423540833170101140161176208241
randomized,48782354083215391129167224239267300339351
double-blind,52422354083387611315216720122426330472454083152966105117
placebo-controlled,31812454083395486117150189227250283319357377398435450464498537549
multicenter,374824540835794109131145176209247268301321330
52-week40962454083346786138171206236
study43492454083274986125156
of452324540833756
HM15211459624540834599129159191222249
in486324540831451
patients49322454083397192107141178199226
with51762454083506587125
biopsy-53182454083395491130156188209
-confirmed30472554083215490128145162182240274313
non-alcoholic337325540833775113135166181212248286324339353385
steatohepatitis37712554083264881113134170208242280313334348370385410
-4194255408321
Study42282554083335391129160
design44012554083397399113151188
and460325540833169107
rationale4723255408321537489126164196210244
of498125540833755
HM-TRIA-201505025540834498120149186201241262292325357
study.5420255408326488630472654083386979
Contemp314026540833976114134167225263
Clin34172654083405469106
Trials.3537265408332496495110135148
2023;369926540833467100134144
doi:38572654083387691102
10.1016/j.cct.2023.107176.39732654083346577107138169199223239251282313336349384417450484495525556588620649680692
ODBORNÝ38876029013353109164218272331378
GARANT:42856029013351105158212270315335
prof.3886616101314471114139158
MUDr.40616161013166116164192209
Michal4287616101316686119164204225
Vrablík,4529616101314672112156177196238260
Ph.D.4806616101314488109158176
III.38866291013122436485
interní398862910131216593132159205225
klinika423062910131396180125145183224
1.4471629101314260
LF4548629101313876
UK4641629101315094
a47526291013141
VFN4810629101314684134
v49616291013139
Praze5017629101314471111146185
POŘADATEL:38876447013350106159214269320361406450476
SOLEN,4380644901314089127165216236
s.4633644901313254
r.4704644901312744
o.4766644901314262
PARTNER3407971012153114172228299353411
POČET4357421019689201295375459
KREDITŮ4357581019693184267376418500606
2109973050541246
Registrace16267410018485162248285346399450525592667
ZDARMA16267593018687191285372499598
TERMÍN25907428019684165256388430538
září25907609013347101137162
202327757609013357112165220
až25907739013353100
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dostupný25907869013362122165202262324385434
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online.solen.cz25907995013763128159189253312340390453484543608637687740
On-line3404667050329253166578589911361348
kurz176746670503230466625817
Kardiologie34049780992491900118916531859230625142962342036254033
ONLINE34243480227131262328430486617721
KURZ110243480227116245360472
PŘEDNÁŠKY4486026014555110156214275329377430483
4486222013490
Co589620501454797
je703620501452775
u7956205014554
nových8666205014555105150199235290
tabulek1172620501453888140194219268317
SCORE1506620501454793148202247
opravdu17706205014552104138188233284337
důležité?21246205014553106132181221247283331367
Modelové25076205014577127180228255305350398
situace2921620501453965101154203240289
v5896355014547
ordinaci653635501455286139165219268305331
a10016355014551
jak1068635501452777125
je1210635501452776
řešit1302635501453685122147184
–15036359014160
MUDr.15796359014169118166191205
Jaromír180063590141306791131199216240
Ožana,2056635901415185123165202219
MUDr.22926359014169118165190204
Michal2513635901416986118161198216
Mačák27466359014169106139177213
4486550013490
Speciality589653301454799148186212262287313349397
v10026533014548
léčbě1067653301452775113166215
hypertenze1299653301455599152201236274322376417465
–17816538014160
doc.1857653801414485119138
MUDr.20116538014169118166191205
Ondřej2232653801415194137161198215
Petrák,2464653801414379105130168204223
Ph.D.2703653801414486104152167
4486729013490
Aktuality5896712014555103141194244269295331379
a9856712014550
praktické1052671201455488137186224250287336384
tipy1452671201453863116160
v16296712014547
léčbě1693671201452776113167215
dyslipidemie19256712014554100138163189242267320368449474523
–24656716014160
MUDr.25416716014169118166191205
Eva2762671601414076113
Tůmová,2891671601414080148188224261279
Ph.D.3186671601414486104152167
4486907013490
Co589689001454797
(ne)budeme703689001453180129155208261313362442491
potřebovat12116890014554104140174224276327372421457
od16856890014551104
biochemické1806689001455379129167222270351376414463510
laboratoře2333689001452777129180214263299349383432
pro589704001455488139
stanovení745704001453975125179229274322376401
kardiovaskulárního1163704001455099133186212263307357394443496522572606660686742792
rizika?1972704001453561102128176226261
–22507045014160
prof.2326704501414469109130147
MUDr.24897045014169118166190204
Michal2710704501416986118161198217
Vrablík,2943704501414870108150169185224244
Ph.D.3203704501414486104152167