1583
PŘEHLEDOVÉ42522701004388130181216258306358404446
ČLÁNKY88722701003973122176223272
Farmakologická4253370100376892153187222260275314353368398433468
léčba9093370100155182120155
osteoporózy10803370100386795130169208247271310340378
a1474337010034
prevence15243370100376196132167205236270
zlomenin:18103370100304685145180218233271286
doporučení211233701003877115154179217248282320335
pro246333701003762100
klinickou25803370100335065102118148182220258
praxi28543370100376297134150
E2219422701004179116
|350227010018
VNITŘNÍ4268043010746106127172220280301
LÉKAŘSTVÍ748804301074185130188236280325378400
/11948043010731
Vnitř1270804301074693112140166
Lék.1456804301074083122140
2024;70(2):E7-E231615804301074487129169183224266291333355370412455478522567611
/22718043010731
www.casopisvnitrnilekarstvi.cz442680430107651332012142542953293774274464795215705896176436927117307748128548809159449871007102310631101
32.425553085367187
Rozenberg5325540833574102136174213249270309
S,8615540833345
Al-Daghri927554083415679126158197235256272
N,12195540834558
Aubertin-Leheudre12975540834179118153175199215253275308342381416454493514548
M186555408355
et19405540833457
al20175540833247
(2020)2085554083185287119154172
Is22775540831541
there2339554083226095116150
a251055408331
role2562554083215874109
for2691554083195678
menopausal278955408358934256540833876115148186212245261
hormone705654083387698156194233268
therapy992654083226095117149189220
in12316540831553
the1304654083215994
management14186540835790128160199234292327365386
of18246540833756
postmenopausal19006540833977104127185221259297337369407433467482
osteoporosis?2401654083386488121160200238260297324339365390
Osteoporos28106540834774425754083225594134173194231258
Int698754083155375
31:2271–2286788754083346574109144177209242273308342377
33.425853085367185
Gartlehner523854083437697121137171209247281302
G,8388540834357
Patel907854083356788122137
SV,1057854083326978
Feltner1147854083336682104142177198
C,13578540834053
et14228540833456
al.1491854083324759
(2017)1563854083195286118147166
Hormone17428540834482103161199237272
therapy2026854083226095116148187218
for2257854083185577
the2346854083226095
primary2453854083396075133165186219
prevention2685854083396094126160197425954083223775113
of5569540833857
chronic631954083316990128166181213
conditions8629540833168107146161183199237275301
in11819540831553
postmenopausal12529540833978104127186221259297337370407433467482
women:17529540835188147182220232
evidence2002954083346682121156194226260
report2280954083205494132154179
and24779540833170109
systematic2604954083265885108142200232254269301
review4251054083215587103137189
for6291054083185678
the7221054083216095
US83210540834476
Preventive9231054083355690122156194216231264298
Services12361054083336889124140172205232
Task14831054083336187117
Force.16161054083326991122156168
JAMA179910540832464120162
318:2234–224919761054083346596109144179213249286318352384417
34.4251153085367388
Eastell5281154083336692115149165180
R,72211540833650
Rosen78611540833574100135174
CJ,9741154083406779
Black10671154083365184116146
DM,1227115408346101114
et135611540833456
al.14271154083314760
(2019)15011154083195387119149167
Pharmacological168211540833573105126185217249286302340380395427460475
management217211540835789127160199234292327365386
of257311540833756
osteoporosis26441154083376487121159199238425125408321588599126
in56712540831553
postmenopausal63612540833978104127186221259297337370407433467482
women:113512540835088146181219231
an138312540833270
Endocrine146912540833371110148180202217255290
Society177612540833271103118153175209
clinical2002125408331466199114146179194
practice22131254083386093125149165197230
guideline.24601254083387591129164180195233268280
J2756125408325
Clin27971254083405570108
Endocrinol42513540833370109148180202217255293309
Metab75013540835489111144183
104(5):1595–162294913540833465102121155173185215245277311347378409443478
35.4251453085367186
Ettinger527145408333547893131170205226
B,77014540833548
Black8341454083365184116146
DM,996145408346101114
Mitlak11271454083546992107140170
BH131314540833680
et141014540833456
al148314540833147
(1999)15461454083195081116151169
Reduction173214540833570109147179203219257295
of204414540833756
vertebral21171454083316587111145184206239254
fracture23881454083184073105129167189223
risk2627145408321366292
in273614540831452
postmenopausal28051454083387742515540832649108143181220259293330357390406
women85115540835189147182221
with10921554083516789128
osteoporosis12401554083386488122160200239261298325340366
treated16271554083224377109131165205
with18521554083516789128
raloxifene:20001554083215470108138154173208246281294
results23151554083205481119134157185
from25201554083194178137
a2677155408332
3-year27301554083345688122154176
randomized4251654083215492131169227242271305345
clinical7871654083324762100115147180195
trial.999165408322445991107119
Multiple113616540835492108130145184200235
Outcomes138816540834786108139176234269296
of170216540833756
Raloxifene17761654083356883121152167186221259294
Evaluation20871654083336598113151183205220258296
(MORE)240116540831872120156190210
Investigators.262816540831553841181451681842232554251754083225980107121
JAMA56117540832464120162
282:637–64573817540833468102114150183216248285322355
36.4251853085367288
Barrett-Connor5331854083356889111145168192212254291330368406428
E,98118540833245
Mosca104618540835593120152185
L,125118540833145
Collins13161854083407793108123161187
P,152318540833540
et158318540833356
al.16591854083324760
(2006)17391854083185286122158176
Effects19351854083335271105138162190
of214518540833756
raloxifene22211854083215469107138153172207245280
on252118540833776
cardiovascular261618540833265861241391772092422684251954083316984117138
events57819540833466100139160188
and78119540833270109
breast9051954083396195127153176
cancer109719540833164102134167189
in130119540831553
postmenopausal136919540833977104127185220259297336369407433466482
women.186619540835188147182220233
N2114195408345
Engl217419540833371110125
J2314195408325
Med235419540835489129
355:125–137249819540833467100111141171205242273303335
37.4252053085367079
Barrett-Connor5202054083356889111145168192212254291330368406428
E,96320540833346
Cox102520540834077107
DA,11482054083458599
Song126320540833270109148
J,142620540832537
et147820540833457
al.15502054083324760
(2009)16262054083195387123158176
Raloxifene18182054083356883121151167186221259294
and212720540833270109
risk2252205408321366292
for23602054083185678
stroke24532054083264971108139173
based26422054083387198133172
on283020540833776
the4252154083226095
framingham5352154083184174131147184223261294352
stroke9022154083264971108139173
risk1090215408321366292
score.11982154083265895116150163
Am137621540834199
J1490215408324
Med153021540835489129
122:754–76116742154083346499111145178213250282314344
38.4252253085367288
Black5312254083355183115146
DM,694225408345100114
Cummings82522540834076134192207245284310
SR,11522254083336882
Karpf12512254083356889129148
DB141722540834581
et151522540833457
al158922540833147
(1996)16532254083195080116151169
Randomised183922540833668106146184242257283318358
trial2214225408322435991106
of233722540833757
effect24112254083345372107139163
of259222540833756
alendronate266522540833248821201591812184252354083387092125
on56523540833775
risk654235408321376393
of76123540833756
fracture8322354083184073105129167189223
in106923540831452
women113623540835088146181219
with13692354083516789127
existing15102354083346681108131146184223
vertebral17472354083326687112146185206239255
fractures.20162354083184174106130168189223250263
Lancet229423540833164102135168191
348:1535–1541249923540833469105118147177210243280311341376406
39.4252453085367185
Cummings52424540834076134192207245284310
SR,8492454083326781
Black9452454083355183115145
DM,1104245408346101114
Thompson123324540833271110168207234272311
DE,15582454083457992
et166424540833457
al.17352454083324760
Effect18092454083335271105138162
of198624540833756
alendronate20562454083324882121160181218256289311344
on241524540833775
risk2505245408320366292
of261124540833857
fracture26822454083194174106130168189223
in42525540831552
women49025540835188146181219
with7222554083506688126
low86125540831553104
bone97825540833877115150
density114125540833873111137152174208
but13622554083387699
without14732554083516689127165203225
vertebral17112554083326687112145184206239254
fractures:19782554083184073105129167188222249261
results22522554083205481118134156183
from24482554083194178136
the25972554083215994
Fracture2704255408332528511714117942526540832155
Intervention4952654083155374108129164198236258273311350
Trial.860265408333506597113126
JAMA.100126540832464120162176
1998;280(24):2077–2082.11932654083346499134146181215250270304336353365400434467501534565600635669681
40.4252753085367489
Orwoll52727540834769122160176191
E,73127540833346
Ettinger791275408332537893131170205226
M,103127540835468
Weiss111227540835891106132159
S1284275408333
et133027540833456
al140027540833247
(2000)14612754083185286122159177
Alendronate16522754083415691129168189226265297319353
for20182754083195678
the21092754083226095
treatment22182754083214377109131189224262283
of251527540833757
osteoporosis258527540833764871211601992382602974252854083264167
in50728540831553
men.57528540835893131144
N734285408345
Engl79428540833371110125
J934285408324
Med97428540835489129
343:604–610111828540833470102114149185221258295326357
41.4252953085366981
Saag5262954083326598137
KG,6832954083357791
Emkey79429540833290120154186
R,100029540833549
Schnitzer106929540833265103141156178209243264
TJ135329540833354
et142729540833456
al150329540833247
(1998)15702954083195081116151169
Alendronate17592954083415691129168190227265298319353
for21322954083185678
the22292954083226095
prevention23442954083396095127161199221236274312
and267629540833270109
treatment2805295408322437742530540833254112147186207
of65330540833756
glucocorticoid-induced7303054083385491124161193231252277292324362377416438455493532570602636675
osteoporosis.14263054083376487121160200239261298325340366380
Glucocorticoid-Induced18263054083446098130167200237259284299331368384423445462500539577609643683
Osteoporosis25293054083477498132170210249271308335350376
Intervention4253154083155374108129164198236258273311350
Study7903154083325491131162
Group.96831540834365102140180192
N1175315408345
Engl123531540833371110125
J1375315408325
Med141531540835489129
339:292–299155931540833467101114149183216250282316351
42.4253253085367085
Harris5233254083447696118133159
ST,6943254083336775
Watts78232540835788109133160
NB,9553254083447992
Genant105932540834479116148186207
HK127832540834479
et137032540833355
al143832540833146
(1999)14973254083185079114149167
Effects16763254083335170104136160187
of187632540833756
risedronate1944325408321366296135156193231263284317
treatment22743254083214276107129186221259280
on256632540833775
vertebral26543254083316586110143182203236251
and42533540833270109
nonvertebral54733540833876114146180201226259299320353369
fractures9293354083184073105130168189223250
in119233540831452
women125733540835189147182220
with14903354083516689127
postmenopausal163033540833978104128186221259297337370407434467482
osteoporosis:21253354083386487121160199238260297324339365377
a2515335408332
randomized25603354083215492131169228243272306345
controlled42534540833168107128150187203218253292
trial.737345408321435890106119
Vertebral8753454083366890114148187209242257
Efficacy1152345408332506886118151183216
With13883454083577396134
Risedronate15413454083365177112152173210249281303337
Therapy189734540833372107128161200232
(VERT)21483454083195791127161183
Study23503454083325491131162
Group.253234540834465102141180192
JAMA274434540832464119161
282:1344–135242535540833468101114144174209246283314344377410
43.4253653085367186
Reginster52536540833570110125163189212246267
J,80636540832436
Minne85536540835570108146181
HW,1049365408344102112
Sorensen11743654083337193127165191226264
OH145236540834792
et155736540833456
al162736540833147
(2000)16873654083195387123159177
Randomized187836540833568106145183241256286320359
trial2250365408322435991106
of237036540833756
the24403654083215994
effects25483654083345372107139163191
of275236540833857
risedronate282236540832137634253754083347293129167198220253
on69037540833774
vertebral7763754083326586110143181202235249
fractures10383754083183972103126164184218244
in129437540831451
women135837540835086144178215
with15853754083506587125
established17223754083336082114153168182208245279318
postmenopausal205237540833876102125182216253291330362399424457472
osteoporosis.25363754083376385118156195233254290316331356369
Vertebral4253854083366889114148187208241257
Efficacy695385408332506886118150182216
with9243854083506688126
Risedronate10633854083365177112152173210248281302336
Therapy141238540833272106128161200231
(VERT)16563854083185791126160182
Study18513854083325391130162
Group.202638540834465102140180192
Osteoporos22313854083477497131169209248269306333
Int25773854083155374
11:83–9126643854083346270105139175210242
44.4253953085367490
Barrionuevo5323954083356889111127165203241276308346
PM,89539540833589102
Kapoor101439540833569108147186207
E,123939540833245
Asi13023954083406883
N,140239540834558
et147739540833457
al.15513954083324760
Efficacy1628395408333516886118151183217
of186239540833757
pharmacological193639540833977109131189221254291306345384399431464479
therapies24333954083216095116149188203238265
for27153954083195678
the28103954083226095
prevention4254054083396094127161199220236274312
of75540540833857
fractures8304054083184174106130168189223250
in109840540831553
postmenopausal116940540833877104127185220258297336369407433466482
women:166940540835088146181219232
a1919405408332
network19694054083377295148185207238
meta-analysis.222540540835792114147170202240272288319346361387401
J2644405408324
Clin26864054083405570108
Endocrinol28124054083337142541540833876109130146184222238
Metab.67841540835590112145184197
2019;104(5):1623–1630.89041540833468100130143173204241260294312324354385418453489520551585620632
45.4254253085367388
McClung53442540835588130146184223263
MR,81842540835592107
Geusens94642540834480119146182221248
P,121542540833540
Miller12764254083557187103138160
PD145742540833682
et156042540833457
al163842540833248
(2001)17074254083195489126158173
Effect19014254083335372107141165
of208742540833858
risedronate21664254083213764100140162200239272294329
on251642540833877
the26144254083226197
risk2732425408321376494
of284742540833858
hip4254354083385493
fracture5404354083184175107132171193227
in78843540831554
elderly8634354083345090126148164196
women.108043540835290149185224238
Hip133943540834560100
Intervention14604354083155476110132168203242264279318357
Program18384354083365795136157191250
Study21094354083335593133166
Group.229643540834466104143183196
N2513435408345
Engl257943540833472112128
J2728435408324
Med277343540835591132
344:333–34042544540833470107119154187220256288324360
46.4254553085367489
Boonen52745540833574112151186224
S,76445540833245
Orwoll82245540834768122159175190
ES,10254554083336679
Wenderoth111745540835790128167202223261282320
D,145045540834657
et151945540833457
al.15894554083314759
(2009)16614554083195387123158176
Once-weekly185045540834785117151174226260295326342374
risedronate2237455408320366297136157195233265287321
in257145540831452
men263645540835792130
with27794554083516688127
osteoporosis:4254654083376487121160199238260297324338364377
results8224654083205481118134156184
of102646540833756
a1102465408332
2-year,11534654083355587121153174184
placebo-controlled,13574654083385486119152192230254287324363384406443459474509548561
double-blind,193846540833876114153169204227267283298336375388
multicenter234546540835895111133148180214252274307329
study.26934654083265088127159169
J2881465408324
Bone42547540833574112147
Miner58847540835469107142164
Res7674754083357097
24:719–7258794754083356679112144175212244278313
47.4254853085367078
Wallach51648540835788103118150182220
S,74848540833345
Cohen80648540834076114149187
S,100648540833244
Reid10634854083357085123
DM1199485408345100
et131148540833456
al138048540833247
(2000)14394854083195386122158176
Effects16284854083325170104136160188
of182848540833756
risedronate1897485408321366297136157194232264285319
treatment22284854083224377108130188222260281
on252248540833775
bone261048540833877115150
density277248540833873111425495408326406295
and53249540833269107
vertebral6524954083316485109142181202234249
fracture9134954083184072104127165185219
in114449540831452
patients12084954083387092106140178199226
on144649540833775
corticosteroid15334954083316788112127158194220243276297333348386
therapy.19324954083215893113146184215224
Calcif21694954083397186118132151
Tissue23324954083324974100137171
Int25154954083155273
67:277–28526004954083346676111143177208239272306
48.4255053085367490
Reid5335054083357085124
DM,675505408345101114
Hughes80750540834482121159194220
RA,10455054083367893
Laan11555054083326597136
RF130850540833669
et139550540833456
al.14695054083324760
(2000)15475054083185286122159177
Efficacy1742505408332506886118151183216
and197650540833270109
safety21035054083265978112135168
of228950540833857
daily23645054083387085100132
risedronate2514505408321366297137158195234266288321
in285350540831553
the4255154083226095
treatment5415154083214377109131189224262284
of84551540833857
corticosteroid9235154083316889114130162199225249283304341357396
induced13395154083155392130162196235
osteoporosis15955154083376487121160199238260297324339365
in198151540831452
men205451540835792131
and220551540833270109
women:233551540835088147182220232
a2588515408331
randomized2640515408321549213116922824342552540832963103
trial.549525408322446092108121
European6915254083337092130170206238277
Corticosteroid-Induced98952540834078100125140173210238261295317355371410433450488528566599633673
Osteoporosis16835254083477599133172212252274312339354381
Treatment20845254083335185118140199235273295
Study.24005254083335493133165175
J2596525408325
Bone264252540833574113149
Miner2812525408355714255354083387394
Res5345354083357097
15:1006–10136475354083346475104136172208246277308340370
49.4255453085367285
Delmas5275454083458196154186213
PD,7575454083358091
Recker86454540833671103134168189
RR,10705454083357185
Chesnut117254540834078113140178215238
CH142754540833984
3rd,15285454083345492105
et165054540833456
al.17235454083324760
(2004)18005454083185286123159176
Daily19935454083457893108140
and214954540833270109
intermittent22755454083155374108129188203225249283321343
oral26355454083375891107
ibandronate275954540831453861244255554083385996135167189223
normalize6635554083377697156188203218247281
bone95955540833978116151
turnover11255554083226081120158190224245
and138555540833270109
provide15095554083396098130145184219
significant17435554083264180118133151168200233271292
reduction20505554083215594132164188204242280
in234555540831553
vertebral24125554083326688112146185207240255
fracture26825554083184174106130168189223
risk:425565408321366292107
results5475654083215582119134157184
from7475654083184077136
the8985654083226095
BONE100856540833683129162
study.11865654083264987126158168
Osteoporos13695654083477497131170209248270307334
Int17185654083155374
15:792–79818085654083346475108141175209241274309
50.4255753085367287
Chesnut52857540834078113140177215238
CH78257540833984
3rd,8825754083345593105
Skag10035754083336396135
A,115457540834155
Christiansen12255754083407899115141164180211250276311349
C1590575408340
et164657540833456
al171857540833247
(2004)17815754083195387123159177
Effects19745754083325170105137161189
of217957540833757
oral22525754083375992107
ibandronate23755754083155487125164185222261293315348
administered2739575408332711291444255854083385379102136157191230
daily6735854083387086101133
or82358540833759
intermittently9005854083145274107129187202225249283321342358390
on130758540833876
fracture14015854083184073105129167189223
risk1641585408321376393
in175158540831553
postmenopausal182158540833978105128186221259297337370407434467482
osteoporosis.23215854083376487121159199238259297323338364378
J2717585408324
Bone275858540833674113148
Miner42559540835470108143164
Res6045954083367198
19:1241–12497175954083346477107137169199232263293325358
51.4256053085367082
Reginster52460540833570110125163189212246267
JY,8086054083246069
Adami89360540834180112170185
S,109560540833245
Lakatos11576054083316595128150187214
P1387605408336
et143960540833457
al151260540833248
(2006)15766054083195387123159177
Efficacy1770605408332506886118151183216
and200360540833270109
tolerability21296054083215874109130163202218233248271304
of245060540833757
once-monthly25236054083387610814216522426230132236042561540831547
oral4866154083375992107
ibandronate6076154083155487125164185222261293315349
in97061540831452
postmenopausal103761540833877104127185220258297336369407433466481
osteoporosis:15336154083376487121159199238259297323338364377
21924615408334
year19726154083316597118
results21056154083205481118134156184
from23036154083184078136
the24536154083226095
MOBILE2562615408355103139154186220
study.279661540832649874256254083387080
Ann52062540834180117
Rheum65362540833574109146204
Dis8726254083466187
65:654–6619756254083346879114148183220258293323
52.4256353085367187
Eisman5256354083334774131163201
JA,7396354083256579
Civitelli8316354083405587103126159175190205
R,104963540833549
Adami111163540834179112169185
S1309635408332
et135463540833456
al142363540833247
(2008)14836354083195387123158177
Efficacy1673635408332506886118150183216
and190263540833270109
tolerability20246354083225874109130163203218233248271304
of234163540833857
intravenous2411635408314527495128160194232270308335
ibandronate275963540831453861244256454083385996135167189223
injections6656454083155368103135159175213251278
in96064540831553
postmenopausal103064540833978104128186221259297337370407434467482
osteoporosis:15306454083376487121159199238259297323338364377
2-year19246454083345587121153174
results21156454083215582119135157185
from23176454083194178136
the24716454083216095
DIVA25836454083456198136
study.27376454083264987126158168
J425655408324
Rheumatol46465540833674109147205237259296312
35:488–4977916554083346778113149184221258291324
53.4256653085367186
Barrionuevo5296654083356889111127165203241276308346
PM,89266540833589102
Kapoor101266540833568108146185207
E,123666540833346
Asi13006654083416883
N,140166540834557
et147666540833456
al.15506654083324760
Efficacy1627665408333516986119151184217
of186266540833756
pharmacological193666540833877109130189221253290306344384399431464479
therapies24336654083216095116149188204238265
for27166654083185677
the28116654083216095
prevention4256754083396094127161199220236274312
of75567540833857
fractures8306754083184174106130168189223250
in109867540831553
postmenopausal116967540833877104127185220258297336369407433466482
women:166967540835088146181219232
a1919675408332
network19696754083377295148185207238
meta-analysis.222567540835792114147170202240272288319346361387401
J2644675408324
Clin26866754083405570108
Endocrinol28126754083337142568540833876109130146184222238
Metab.67868540835590112145184197
2019;104(5):1623–1630.89068540833468100130143173204241260294312324354385418453489520551585620632
54.4256953085367388
Black5296954083355183115146
DM,690695408345100114
Delmas8196954083458196154186213
PD,10476954083368191
Eastell11546954083326592115149164180
R1349695408335
et140069540833456
al147169540833247
(2007)15346954083185286123155175
Once-yearly172469540834786118152175207241273294310341
zoledronic20816954083286581116156177214252268300
acid23966954083326479118
for25296954083195678
treatment26226954083224377109131189224262284
of42570540833757
postmenopausal49770540833977104127185220259297336369407433466482
osteoporosis.9947054083376487121160199238260297324338365378
N1388705408344
Engl144870540833270109124
J1588705408324
Med162770540835490129
356:1809–1822177170540833568102114144175210246283314345379413
55.4257153085367185
Reid5277154083357085124
IR,6687154083155165
Horne74971540834483104143178
AM,94471540834096109
Mihov107071540835570108146178
B,126571540833548
et133071540833456
al.14027154083324861
Fracture14797154083335285117142180201235
prevention17307154083396195127161199221236274313
with20597154083516689127
zoledronate22037154083286581116155177214252285306340
in256071540831452
older26297154083375392127148
women27947154083508842572540835792130
with5717254083506688127
osteopenia.7137254083376487121159199235273288320333
N1061725408345
Engl112172540833371110125
J1261725408325
Med.130172540835489129142
2018;379(25):2407–2416.145872540833569100132144179211244263297332350362398429465498530562594624655669
56.4257353085367288
Boonen52773540833574113151186224
S,76573540833346
Reginster82573540833570110125163189212246267
JY,11067354083246169
Kaufman118973540833569106125184217255
JM145873540832479
et155173540833456
al162273540833147
(2012)16837354083195287118148166
Fracture18637354083335285118142180201235
risk2112735408321366292
and221973540833169108
zoledronic23427354083286581116155177214252267299
acid26557354083326480118
therapy278873540832159944257454083215493124
in56474540831553
men63274540835893131
with7787454083516689127
osteoporosis.9207454083376487121160199238260297324339365378
N1314745408344
Engl137474540833270109124
J1514745408324
Med155374540835590129
367:1714–1723169774540833569102112142171204235272303332367401
57.4257553085367180
Reid5267554083357186125
DM,671755408346101114
Devogelaer80675540834581113151190225241273308330
JP,11567554083246065
Saag12417554083336698137
K1399755408335
et145475540833457
al153175540833247
(2009)15997554083185287123158176
Zoledronic17967554083377490125165186224262277309
acid21267554083326479118
and226575540833170109
risedronate2394755408321366398137159196235267289323
in273775540831553
the28107554083226095
prevention4257654083396094127161199220236274312
and75776540833270109
treatment8867654083214377109130188223262283
of118976540833756
glucocorticoid-induced12657654083385491123160193230251276291323360375414437453491530567599633673
osteoporosis19577654083386487121160199238260297324339365
(HORIZON):234276540831862110147162200245291310322
a2684765408331
multicentre,27357654083579511013314842577540833165103124146180192
double-blind,63077540833876114153169204227267283298336375388
double-dummy,103177540833876114153169204227267305363420451461
randomised15057754083215391131169227242268303343
controlled186177540833168106128149186202217252292
trial.2166775408321435890106119
Lancet229877540833164102135168190
373:1253–1263250177540833567101112142172207240276307337370404
58.3047553085367389
Lyles3157554083326077112139
KW,33175540833597107
Colon-Emeric3444554083417894133172195230288323345361393
CS,3858554083417588
Magaziner39675540835588127160190206244280301
JS42895540832557
et43675540833457
al.4445554083324761
(2007)4526554083195488125158178
Zoledronic4725554083387591127167188226265280313
acid5059554083326480119
and51995540833270110
clinical5330554083314762101116148182197
fractures3047654083184073106130168189223250
and33126540833270109
mortality34366540835896118142175190205228262
after3713654083325176109131
hip3859654083375292
fracture.3966654083184073106130168189223235
N421665408345
Engl42766540833371110125
J441665408325
Med44566540835489129
357:1799–180946006540833467101111141170203239276307338373409
59.3047753085356982
Reid3141754083356984122
IR,3275754083144963
Horne33507540834381102139174
AM,35367540834095107
Mihov36567540835368105143174
B,38427540833547
et39017540833455
al.3968754083324759
(2020)4039754083185185117150168
Effects4219754083325169103135158185
of44167540833756
zoledronate4484754083286479113152173209246278299332
on48287540833774
cancer,49157540833062100131164184194
cardiac5121754083316383121135166198
events,5331754083336598135156183196
and30478540833270109
mortality31718540835896117142175190205228261
in34488540831452
osteopenic3516854083376487120159199234272287319
older3851854083375392127148
women.40148540835189147182220233
J426285408325
Bone43028540833574112147
Miner44658540835469107142164
Res4644854083357097
35:20–274756854083356878114148186217250
60.3047953085367489
Cummings31579540834077136194209248287314
SR,3491954083336983
San35959540833266104
Martin37209540835588109134150188
J,39299540832436
McClung39869540835588129145183221261
MR42679540835592
et43809540833456
al.4457954083324861
(2009)4539954083195387124159178
Denosumab47379540834682120159186224282315355
for5112954083195779
prevention5212954083396095128162201223238277315
of304710540833757
fractures31191054083184073106130168189223250
in338410540831553
postmenopausal345210540833877104127185220258297336369407433466482
women394910540835188147182220
with41841054083516689127
osteoporosis.43261054083376487121160199238260297324339365378
N4720105408344
Engl478010540833270109124
J4920105408324
Med495910540835590129
361:756–76551041054083346898107140173207245277309342
61.30471153085366981
Bone314211540833574112147
HG,330211540834589102
Wagman341811540835788127185218256
RB,36871154083357284
Brandi37841154083365790128167182
ML397911540835587
et407911540833456
al414911540833147
(2017)42091154083185286118148167
10438911540833466
years44681154083316597118145
of462711540833756
deno469611540833873111150
sumab485911540832663121153193
treatment50651154083214377109130189224262283
in536111540831553
postmenopausal542711540833978304712540832649107141179217256289326352385400
women346012540835088146180218
with36911254083506588126
osteoporosis:38291254083376487120158198236258295321336361374
results42151254083215581118133155183
from44111254083184077134
the45581254083226094
phase466512540833877109135170
34847125408334
randomised48941254083205391129167225240266301340
FREEDOM524712540833266100132177225280
trial3047135408322435991106
and316813540833270109
open329313540833776112150
label34581354083154787122138
extension.36111354083346690124162188203241279293
Lancet391913540833165103135169191
Diabetes41251354083466193132168190224251
Endocrinol439113540833370109148180202217255293309
5:513–52347161354083344580111141177211244279
62.30471453085367187
Langdahl,315414540833165103142181213251267279
B.345214540833649
L.,35211454083314557
Teglbjaerg,359814540833263103118157172204239260299311
C.392914540834053
S.,40021454083324558
Ho,40791454083448395
P.419314540833541
R.,42531454083355063
et433514540833456
al.44111454083324760
(2015).44901454083195387119149167178
A4687145408341
24-month47481454083346689148186224246284
study50521454083264987126158
evaluating52291454083346699115152185206222260299
the30471554083226095
efficacy3160155408334527088120153185218
and339615540833270109
safety35231554083265978113135169
of371015540833756
denosumab378415540833873111149176213271304343
for41451554083185677
the42401554083226095
treatment43531554083214377109131189224262283
of465415540833857
men472915540835792130
with48771554083516689127
low502215540831553104
bone514415540833877116151
mineral531315540835772110145166199215
density:304716540833873111137152175208222
Results32861654083367198135150172200
from35041654083184077136
the36571654083226095
ADAMO376916540834187127182230
trial.4017165408321435890106119
The415316540833372107
Journal427716540832463101122161193208
of450316540833756
Clinical45771654083405570108123155187203
Endocrinology479716540833371110148181202217255294310348387419
and523416540833170109
Metabolism,53601654083549011214530471754083397793108134192205
100(4),326717540833466102121154172183
1335–1342.34651754083356497130167198228263296308
63.30471853085367287
Saag,31481854083326598137150
K.331118540833550
G.,33751854083445870
Pannacciulli,345918540833567105143175208238254291306321336349
N.,38221854083445870
Geusens,390618540834479117143178216243256
P.,41751854083364153
et424218540833456
al.43121854083324760
(2019).43861854083185286118148166177
Denosumab457718540834581119157184221279311350
vs494118540833259
risedronate5013185408321376398137159196234267288322
in534918540831452
glucocorticoid-induced54151854083385391304719540833168100137158183198230266282320342358396435472504538577
osteoporosis:36371954083376386120158198236258295321336362374
Final40241954083324785117132
results41691954083215481118133156183
of436519540833756
a4434195408332
24-month44781954083346689147185224245283
randomized,47741954083205391130168226241270303343355
double-blind,514219540833876114153169203226266282297334373386
double-dummy304720540833876114154169204227268305363421452
trial.3514205408322435991106119
Arthritis36482054083416387125147162185200226
&3889205408340
Rhematology,394420540833574109167199221258274312351383393
71(7),43522054083356782117136147
1174–1184.45152054083346291121159190217248285297
64.30472153085367489
Smith,315421540833290105128166178
M.335021540835569
R.,34372154083355062
Egerdie,351721540833371106127165180215227
B.,37622154083354961
Hernandez,384121540834479101139171209249283313327
T.418621540833242
N.424521540834559
et432121540833457
al.43962154083314760
(2009).44742154083185286122157175186
Denosumab467821540834681119157184221279311351
in504721540831452
men511721540835792131
receiving52652154083215588122137169185223262
androgen304722540833270109130167207242280
deprivation334422540833873112134149182215237252290328
therapy36902254083216095116149188219
for39272254083185577
prostate40212254083396198125148181202236
cancer.427422540833264102135168189200
The449122540833372107
New461522540834580131
England476322540833371110125157195234
Journal501522540832462100121160192208
of524022540833757
Medicine,53142254083548912914417619130472354083387384
361(8),31472354083346899114147165177
745–75533392354083346597134165198231
65.30472453085367286
Cummings315024540834076134192207245284310
SR,34762454083336882
Ferrari35742454083326688109142163179
S,376924540833345
Eastell38312454083326592115149164179
R4026245408336
et407824540833456
al415024540833247
(2018)42132454083195387119150168
Vertebral43972454083366890114148187209242257
fractures46702454083194174106130168189223250
after49362454083325176110131
discontinuation50832454083385379112148187208224262299331353368406445
of304725540833757
denosumab:311725540833873111149176213271303342355
a3485255408331
post352925540833978105128
hoc367025540833776108
analysis379125540833270102118150177191218
of402225540833756
the40912554083226095
randomized41992554083215492131169227242271305345
placebo-controlled45572554083395587119153192231254288325363385406443459474509549
FREEDOM511925540833267101133179227282
Trial5414255408333506698113
and304726540833270109
its31712654083153765
exten32512654083346690124162
sion.34282654083264179118131
J3574265408324
Bone361426540833573112147
Miner377626540835570108143164
Res39562654083357097
33:190–19840682654083346779108139174212243273308
66.30472753085367389
Dennison315427540834581119157172198236275
EM,344627540833388101
Cooper356527540833976115155190212
C,379427540834053
Kanis386427540833569107122148
JA,40292754083246478
et412527540833456
al.41982754083324860
(2019)42762754083185286118148166
Fracture44602754083325285117141179200234
risk4712275408320366292
following4821275408319567287125176192230269
intermission51072754083155374108129188203229255270308347
of547127540833757
osteoporosis30472854083376487121160199238260297324338364
therapy.34272854083216095116149188219229
Osteoporos36722854083477497131169209248269306333
Int40212854083145274
30:1733–174341102854083346982112141175208245275305335368
67.30472953085367179
Jähn-Rickert31432954083245694132155192207239269304325349
K,350929540833549
Wölfel357529540835793109128163179
EM,377029540833288101
Jobke388729540832463102133167
B,407029540833648
et413529540833356
al.42072954083324760
Elevated42832954083334883115148170204243
Bone454229540833674113148
Hardness47062954083447697136174209235262
Under498429540834482121156177
Denosumab517729540834581119157184221279311351
Treatment,30473054083335084116137196231269290303
With33693054083587496134
Persisting35223054083356990117132158181197235274
Lower381430540833269120155176
Osteocyte40093054083467497130169202235260294
Viability43223054083355284123138154169191225
During456630540834583104120158197
Discontinuation.47823054083456187119156194216231269306339361376414452465
Front52663054083335290128150
Endocrinol543430540833371304731540833876109130146184222238
(Lausanne).33003154083195084121148181219257292309320
2020363631540833468101135
May378631540835587118
15;11:250.39193154083346475105133141177212246258
68.30473253085367388
Tsourdi31483254083325492130150188203
E,336432540833245
Langdahl342232540833164102140179211249264
B,369832540833548
Cohen-Solal375932540833976114149186208240277293325340
M,411232540835467
et419232540833355
al.42603254083324760
Discontinuation43323254083456086118155193214229267304336357372410448
of479332540833756
Denosumab486132540834580118156182219276308347
therapy52213254083215994115147186217
for54513254083185577
osteoporosis:30473354083366284117155193230251287313327352364
A3423335408340
systematic34753354083255783105138194225246260291
review3778335408320538499133183
and397233540833268106
position409033540833875101115137151188225
statement43273354083264880100133189223260281
by462033540833768
ECTS.469933540833271106138151
Bone.486233540833472109143154
201750283354083336697125
Dec;105:11-17.516533540834579110123152182215225254281299328357362
69.30473453085367285
Watts315034540835789110135162
NB,33293454083458194
Roux344034540833573112143
C,360034540834053
Modlin367034540835493132147162200
JF388734540832458
et396234540833356
al403534540833247
(2012)40993454083195287118148166
Infections42823454083155372106139163178216255281
in458034540831553
postmen465034540833877104127185220258
opausal492534540833877110148174207222
women516534540835088146181219
with54013454083516689127
osteoporosis30473554083376488122160200239261299325340367
treated34343554083224478110132166205
with36603554083516789128
denosumab380835540833873112150177215273305345
or417335540833859
pla42533554083395587
cebo:436135540833165105144156
coincidence45383554083316884122154169208243282314348
or490735540833759
causal498635540833265103129162178
association?51843554083325986124157172205226242280319344
Osteoporos30473654083477497131170209248270307334
Int33963654083155374
23(1):34863654083346887118133145
327–337364636540833467100132164197229
70.30473753085367186
Choi315437540834078116131
NK,33063754083448094
Solomon34213754083327186125183221260
DH,370137540834590103
Tsacogianis38243754083335588120157196212244282297323
TN,41673754083337992
et427937540833456
al.43553754083324861
(2017)44363754083185286118147167
Comparative462337540834077135175208229262283299331366
safety50093754083265978112135169
and519837540833270109
effectiveness53273754083345372107139164179304738540833266104139166192
of325438540833756
denosumab332538540833873111149176213271303343
versus36823854083326687114152178
zoledronic38743854083296682117156177215253268300
acid41893854083316479118
in432138540831553
patients43883854083397293109143181203231
with46333854083516689127
osteoporosis:47743854083386488121160200238260297324339365377
a5166385408332
cohort521238540833168107145167191
study.5418385408326498730473954083387080
J3142395408325
Bone318239540833574112147
Miner334439540835570108143164
Res35243954083357097
32(3):611–61736363954083346784118135147182213240273310341370
71.30474053085367183
Black31454054083355183115146
DM,3305405408346101114
Abrahamsen343440540834181102135173206263290325363
B,381240540833548
Bouxsein387540540833574112143171206221259
ML,414940540835486100
et426440540833456
al.43354054083324760
Atypical44104054083416296136151183216232
femur465740540831852110148169
fractures48414054083184073106130168189223250
-5106405408321
review51414054083215587103138189
of534540540833757
epidemiology,54164054083347489304741540833873131146184200238278310319
relationship33844154083215570103124140178216242280295334
to373641540832259
bisphosphonates,38124154083395581120158196223262301339377410431465492505
prevention.43354154083386094126161199220235273312325
and467841540833270109
clinical48044154083324762100115147180195
management.501741540835789127160199234292327365386400
Endocr543441540833371304742540833876109130
Rev.319342540833570102112
2019;40(2):333–368.332042540833569100131143178214234268286297333366399435467502537551
72.30474353085367389
Starr31574354083335487109131
J,330843540832437
Tay33654354083336192
YKD,347843540833672119130
Shane362943540833371104142177
E.382743540833346
Current38944354083407798120154193215
understanding412943540833876116151172200223256295334349388427
of457743540833757
epidemiology,46544354083347490129164223238276292331371403413
pathophysiology,5088435408339729413217121125028130832336137841630474454083387080
and314244540833270109
management326644540835890128160199234292327365387
of366844540833857
atypical37404454083325487127143175208223
femur397844540831953111149170
fractures.41634454083194174106130168189223250264
Curr44424454083407698119
Osteoporos45774454083477497131169209248269306333
Rep.492644540833570109122
2018;16:519–529.506344540833468100131143173204217252283313351385418452463
73.30474553085367287
Khosla315145540833574112139154187
S,335445540833346
Burr34174554083357394116
D,355045540834556
Cauley362345540834072110125160192
J3832455408324
et387345540833456
al.39464554083314760
Bisphosphonate-associated40234554083355076115154192219258296335373405427461484516543569608640655687709743782
osteonecrosis48224554083386487121160198233266287325351366392
of523145540833757
the53044554083226095
jaw:54164554083154798111
report30474654083215594133154179
of324246540833756
a3314465408331
task33614654083225481111
force34874654083195678109143
of364546540833757
the37174654083226095
American382846540834199134155171202235273
Society411746540833271103118153175209
for43424654083185677
Bone443546540833574112147
and459846540833169108
Mineral472246540835470108143164197212
Research.49504654083357097132164185216254267
J5233465408324
Bone527346540833573112147
Miner54354654083557030474754083387394
Res.31564754083357097111
2007328247540833468105137
Oct;22(10):1479-91.343547540834679103116151186204235267285297327358390423447482514523
74.30474853085366884
Khan315148540833574106145
AA,33154854083418499
Morrison343348540835593115137152178216255
A,370848540834155
Hanley378348540834476114130164196
DA,39994854083458599
et411848540833456
al.41944854083314760
Diagnosis42744854083456092131169208234249275
and456948540833270109
management469848540835790128160199234292327365386
of510448540833757
osteonecrosis5181485408337648712015919823326528732430474954083264167
of313449540833756
the32104954083215994
jaw:33244954083154798111
a3454495408332
systematic35064954083265885109142200233254270302
review38274954083215587103138189
and403549540833270109
international41644954083145274107129167200221237275313345361
consensus.454449540833168107133168206233270296310
J4873495408324
Bone491749540833574112147
Miner508349540835570108143164
Res.52674954083357097111
2015539749540833468100130
Jan;30(1):3-23.30475054083245694106141176195227241253288310341376389
75.30475153085367389
Yarom31605154083366790129190
N,337451540834560
Shapiro345751540833373108149166189228
CL,37095154083417490
Peterson38225154083367196131155184224265
DE,41105154083468297
et423051540833559
al.43135154083324964
Medication-Related440151540835592134151184219243260300341365404441459493516552594
Osteonecrosis501951540834776101137178218255290313353381398426
of546951540833758
the304752540832262100
Jaw:317152540832459112127
MASCC/ISOO/ASCO3322525408356100136179220249267301351402428468504547595
Clinical39415254083405874115132166201218
Practice41835254083365994128155172206242
Guideline.444952540834485102143180198215255292306
J4779525408325
Clin48285254083405774115
Oncol.496752540834788123162180195
2019518652540833471105137
Sep534752540833370112
1;548352540833545
37(25):2270-2290.30475354083346885121157177190227263297332357389425461498512
76.30475453085366985
Black31455454083355183114144
DM,3302545408345100113
Geiger34275454083447994132167188
EJ,36285454083325870
Eastell37115454083326591114148163178
R,390154540833649
et396354540833456
al.40315454083324760
Atypical41045454083406195134150181214229
Femur434654540833265123160181
Fracture45405454083325184116140177198232
Risk47855454083355076106
versus49035454083326687114150176
Fragility50925454083325284123138153168190223
Fracture53285454083325284116140178304755540832155
Prevention31175554083355690122156195216231269308
with34405554083516689127
Bisphosphonates.35825554083365177116154193219258297335374406428461488502
N4099555408345
Engl415955540833371110125
J4299555408324
Med.433955540835489129142
2020449655540833468101135
Aug464755540834178117
20;383(8):743-753.47795554083346881116151185203236254266300330363384416449482494
77.30475653085367281
Amgen314156540834199137172210
(2020)33645654083185286119152171
(ClinicalTrials.gov3548565408318577287125140171204219253270286318333359372411449480
Identifier:40415654083155489126148163181197232253267
NCT00523341)432156540834485120154190224257292324359390404
https://clinicaltrials.gov/ct2/47385654083375883122148161187208236252266304319351383399421442458489505531544583621652676704728763790
show/study/NCT00523341304757540832664102153177201225262302333357403444479513549584617652684720750
78.30475853085367187
Shane315158540833270103141176
E,334358540833245
Burr34045854083367495116
D,353758540834556
Abrahamsen360958540834180102135173205263289324362
B,398758540833648
et405158540833457
al.41245854083314760
Atypical42005854083416296136151183216231
subtrochanteric444758540832764103125146184216254287325346380401417449
and491258540833270109
diaphyseal50375854083385385124163193220255287302
femoral53555854083195311115030475954083215469
fractures:31325954083184174106130168189223250262
second34105954083266194131169209
report36355954083205493132154179
of383059540833756
a3902595408332
task39505954083215481111
force40775954083185677108142
of423559540833757
the43085954083215994
American441859540834199134156171203236274
Society470859540833371103119153176209
for49335954083195678
Bone502759540833574112147
and519059540833270109
Mineral531559540835470108143164197212
Research.30476054083357097132164185216254267
J3330605408324
Bone336960540833674113148
Miner353260540835470108143164
Res.37116054083367197111
2014383760540833469100131
Jan;29(1):1-23.39846054083245694106141175194226240252282301332366379
79.30476153085367285
McKenna315361540835587122157195233266
MJ,34396154083558193
McKiernan355361540835487122139174195234266304
FE,38786154083326578
McGowan397761540835487132171222255293
B4291615408335
et434761540833456
al.44246154083324760
Identifying45056154083155489127149164184218234272311
Incomplete48376154083155385122181220236271293327
Atypical51856154083416296136152184217233
Femoral543861540833367304762540835796117150166
Fractures32266254083325285117141179200234261
With35006254083587496135
Single-Energy36486254083324785124139174197232269304326364396
Absorptiometry:405762540834180107145167207229244282340375398419453467
Declining453762540834581113129144181196234273
Prevalence.48246254083355589122155170205243275309321
J5158625408324
Endocr519662540833270109147180201
Soc.541062540833371104117
2017304763540833468100129
Feb319263540833266105
13;1(3):211-22033136354083346475105120154171183218250277296327362396
80.30476453085367388
Adler31516454083417995129151
RA,33176454083357892
El-Hajj34256454083324770115148163180
Fuleihan36206454083326884119134172204242
G,387764540834457
Bauer395064540833568106140162
DC412764540834587
et422964540833456
al430064540833248
(2016)43636454083185286118149167
Managing454664540835487125157196211249288
osteoporosis48496454083386487121160199238260297324339365
in522964540831553
patients52976454083387193109143181203231
on304765540833776
long-term31386554083155391130152175209230288
bisphosphonate34416554083395481119158196223262300339377410431465
treatment:39216554083224377109131189224262284297
report42336554083215594133154179
of442765540833757
a4498655408332
Task45456554083336187117
Force46776554083337091123156
of484865540833757
the49206554083216095
American502965540834199134156171203236274
Society531865540833371104119153176209
for30476654083185678
Bone314066540833574112147
and330266540833270109
Mineral342766540835470107142164197212
Research.36546654083367198133164186217255268
J3937665408324
Bone397766540833573112147
Miner413966540835570108143164
Research43196654083357097132164185216254
31:16–3545886654083346574104135173205238
81.30476753085377286
Greenspan315567540834568103140180207248282322
SL,34996754083336680
Vujevich36016754083377591127161178211251
K,387367540833652
Britton3947675408336587599124163203
C,417167540834155
et424867540833558
al.43286754083334963
Teriparatide44136754083336588104145179202236259275315352
for47876754083185880
treatment48896754083224580114137197233273296
of520767540833858
patients52876754083407497113149189212241
with30476854083516790129
bisphosphonate-associated31976854083405682122161200228268307346385418441475499532559586625659674707729764804
atypical40226854083325589130146178212228
fracture42716854083194175108133171193228
of452068540833857
the45986854083226197
femur.471668540831954113151173184
Osteoporos49216854083487599133173213253275313340
Int.5283685408314537589
2018539368540833570102134
Feb;29(2):501-506.304769540833266106118153187206240258270305339371390424458494507
82.30477053085367390
van316170540833266105
de329070540833874
Laarschot338770540833166100123151185224264287
DM,3697705408346102117
McKenna383770540835588125161200240273
MJ,41337054083558296
Abrahamsen425270540834181104139178212271299335375
B4650705408336
et470970540833457
al.47907054083314862
Medical487670540835490131148181216232
Management513270540835488127161201238297334373396
of304771540833758
Patients31267154083366992109145184207236
After33847154083416187123145
Atypical35517154083416398140157190224241
Femur381471540833267127166188
Fractures:40247154083325388121147186209244272286
a4332715408331
Systematic43857154083326492117152211245268285318
Review472571540833571105122158211
and495771540833271112
Recommendations50907154083367210614420426330033938041430477254083223878118145
From32107254083335492152
the33807254083226198
European34967254083327093131172209243282
Calcified37967254083407491124141161179215256
Tissue40707254083325178106145181
Society.426972540833372106123159183218229
J4516725408324
Clin45587254083405773112
Endocrinol468872540833372113152186209226265305322
Metab.502872540835591115149190204
2020525072540833469103139
May540772540835488121
1;105(5):1682-99.30477354083344475108144163198217231262295331366388424461473
83.30477453085367287
Samelson314874540833265123158174200238277
EJ,34397454083335971
Broe35257454083355694129
KE,36687454083357083
Xu376574540833874
H,385374540834557
Yang392574540833564102141
L,408174540833145
Boyd414074540833674105144
S,429874540833245
Biver43587454083355083117138
E,451174540833245
et457174540833456
al.46417454083324760
Cortical47167454083407798123138170203218
and494974540833169109
trabecular50727454083224376115151183221237269290
bone537674540833978116151
microarchitecture304775540835772104126163196217248286301324357390414452473507
as357175540833258
an364675540833270
independent37327554083155392127166202240279314352373
predictor41227554083396094134149181205242264
of440275540833857
incident44757554083155385100139174212234
fracture47257554083194174106130168189223
risk4965755408321366292
in507475540831452
older51437554083375392127148
women530875540835088146181220
and304776540833270109
men317076540835792130
in331476540831452
the33807654083226095
Bone348976540833573112147
Microarchitecture365076540835469101123160193214245283298321354387411449470504
International41687654083155374108129168200222237275314346361
Consortium454376540834077115142180202226242279337
(BoMIC):48947654083185492148163204225236
a5144765408332
prospective51907654083386097124163198231255270303337
study.30477754083264987126158168
Lancet323177540833164102135168191
Diabetes34377754083456193132167190224250
Endocrinol.370377540833270109147180201217255293309322
2019;7(1):34-43.404077540833468100130143176192224239250286321344381413426