1103
PŘEHLEDOVÉ479422701004388130181216258306358404446
ČLÁNKY525622701003973122176223272
Farmakologická29483370100376892153187222260275314353368398433468
léčba34323370100155182120155
osteoporózy36033370100386795130169208247271310340378
a3997337010034
prevence40473370100376196132167205236270
zlomenin:43333370100304685145180218233271286
doporučení463533701003877115154179217248282320335
pro498633701003762100
klinickou51033370100335065102118148182220258
praxi53773370100376297134150
|5584227010018
E23564222701004179114
/36318043010732
Vnitř3708804301074592111139166
Lék.3893804301074184122140
2024;70(2):E7-E234053804301074487128168182224265290333355369411455478521566610
/47088043010731
VNITŘNÍ48058043010746106127172220280301
LÉKAŘSTVÍ5128804301074084130188235279324377399
www.casopisvnitrnilekarstvi.cz42580430107651332012142542953293774274464795215705896176436927117307748128548809159449871007102310631101
84.425553085367489
Kendler5305540833569107146162196218
DL,764554083457791
Marin8715540835487108123161
F,10485540833339
Zerbini1102554083387293133148186201
CAF,13195540834083116122
et14565540833457
al.1529554083314760
Effects1605554083325170105137161189
of18105540833757
teriparatide188255408322567793132165186219241256295330
and22285540833169108
risedronate235255408321376398137158196234266288322
on26905540833776
new27825540833772123
fractures425654083184174107131169191225252
in6986540831453
post-menopausal7716540833978105129148208243281320360393431458491507
women12986540835189148183222
with1540654083516790128
severe1689654083266194128150184
osteoporosis1894654083376488122161201240262299326341367
(VERO):2282654083195892128176194206
a250965408332
multicentre,25616540835896111134150182216254276298332344
double-blind,4257540833876114154169204227267283298336375388
double-dummy,8287540833876115154170204228268306363421452462
randomised1305754083215492131169227242268303343
controlled16637540833268107128150187203218253292
trial.197175408321435990106119
Lancet.21057540833165103135169191204
2018;391:230–240.23257540833468100131143178211243252287322356394426458494506
85.425853085367286
Saag528854083326598137
KG,681854083357891
Petersen789854083356991125146173208246
J,10528540832436
Brandi1105854083355790128167182
ML,13038540835587101
et14208540833456
al.1493854083324760
Romosozumab15708540833574132170197235263302359392431
or20188540833758
alendronate2093854083324782120159180218256288310344
for2454854083185677
fracture2548854083184073105130168189223
prevention27878540833961954259540833266104126141179217
in6589540831452
women7259540835189147182220
with960954083516789127
osteoporosis.1103954083376487120159199238259296323338364378
N149695408345
Engl15569540833370109125
J169695408324
Med.17359540835590130143
2017;377:1417–1427.18939540833468100129139174206241251281312342371404435466498531538
86.4251053085367389
Lindsay,5321054083314785124150183214224
R.,7741054083355062
Cosman,85410540834077104161194232245
F.,11171054083323851
Zhou,118610540833876114152165
H.,13691054083445770
et145710540833456
al.15311054083324760
(2006).16091054083195387123158177188
A1814105408341
novel187310540833876108142158
tetracycline2049105408322557899132164198229245260298332
labeling23991054083154887122138153191230
schedule26471054083265896131171208224258
for4251154083185678
longitudinal5241154083155392131147169208247262301333349
evaluation89311540833567100116154186208224262301
of121411540833857
the12921154083226096
short-term140811540832665103125150170192226248307
effects17351154083355474108141166193
of194911540833857
anabolic202711540833270103142181197213245
therapy22921154083226196117151190222
with25341154083516790128
a2683115408332
single27351154083274280119135170
iliac425125408315304577109
crest5531254083325387114137
bone70912540833978116151
biopsy:8801254083385492132158191204
Early11041254083326587102134
actions12581254083316388103141179206
of148312540833757
teriparatide.1559125408322567792131164186219240256294329342
Journal192012540832462101122160193208
of214712540833857
Bone222312540833674113148
and239012540833270109
Mineral251812540835570108143164197213
Research,275012540833671971324251354083325384122135
21(3),5751354083346681114131143
366–373.73313540833469104142174206241253
87.4251453085367180
Díez-Pérez5241454083456196125147184217238272302
A,84414540834155
Marin91814540835486108123161
F,109714540833339
Eriksen1154145408332536999128163201
EF,13731454083336571
et146214540833457
al..1537145408332476073
Effects16281454083335271105138162189
of183614540833756
teriparatide1910145408322567793132165186219241256295330
on225814540833776
hip23521454083375291
and246214540833169108
upper258914540833776116151172
limb27801454083142987126
fractures4251554083194175108132171193227255
in70115540831453
patients7751554083397395111146185207235
with10311554083516790129
osteoporosis:11811554083386589123163203242265302330345372384
a1586155408333
systematic16401554083265987111145204237259275307
review19681554083215689105140192
and218115540833271111
meta-analysis.231315540835894117150173206245277293326353368395409
Bone.274315540833675114150162
2019;120(3):1–8.42516540833468100130143173203237257290307319349382418432
88.4251753085367389
Simpson53217540833247105144171209248
EL,7981754083326477
Martyn-St89317540835587108133167206228259280
James119117540832557115150176
M,138517540835568
Hamilton147117540834477135150165187224263
J1752175408324
(2020)17941754083185286119153172
Clinical19841754083405570108123155188203
effectiveness22051754083345372107139164179211246284319346372
of259517540833757
denosumab,26701754083387311114917621342518540835790129141
raloxifene,5791854083205369107137152172206244279291
romosozumab,88318540832058116154181219247285343375414426
and132218540833270109
teriparatide1444185408322557792131164185218240255294329
for17861854083185677
the18761854083226095
prevention19841854083386094126160198220235273311
of230818540833857
osteoporotic23781854083376487121159199238259296318333365
fragility27561854083194174113128425195408315305286
fractures:5261954083194174106130168189223250263
a804195408332
systematic8511954083265986109143200233255270302
review11681954083215587103138189
and137219540833270109
network14961954083387395148186207238
meta-analysis.174919540835893115148170203241273288320347362388402
Bone216619540833574112147
130:11508123291954083346498111141169199233268300
89.4252053085367184
Orwoll52120540834768120157173187
ES,7192054083336678
Scheele80820540833364101136170185219
WH,1039205408357101113
Paul116420540833566103117
S,129320540833244
et134920540833455
al.14162054083314658
(2003)14862054083185184120152168
The166620540833271105
effect17832054083335271105137160
of195420540833856
teriparatide2022205408321547589128160180212233248286320
[human23532054083195794151182219
parathyroid25842054083387191123144181211232269284322
hormone4252154083377394150187223257
(1–34)]6922154083194980111144160176
therapy8782154083225892111143180210
on109821540833774
bone118221540833875112146
density133821540833871107132145166199
in154721540831551
men160821540835790126
with17452154083506485121
osteoporosis.18772154083376284116153191228248283309322347359
J2246215408324
Bone228121540833571108141
Miner243321540835468104137157
Res26012154083346893
18:9–1727052154083336374107143172200
90.4252253085367388
Saag5292254083326598137
KG,6812254083357891
Zanchetta78822540833770108141179214236260293
JR,10962254083246175
Devogelaer118622540834581113150190225240273308329
JP,15302254083246065
et161022540833456
al.16822254083324760
(2009)17572254083195387123158176
Effects19482254083335271105138162190
of215322540833857
teriparatide2225225408322567792132165186219240256295329
versus25702254083316687114151178
alendronate276322540833247821204252354083385895132164185218
for6552354083185576
treating7432354083224376107128143180218
glucocorticoid-induced9742354083375289120156188224245269284315351366404426442479517554585618657
osteoporosis:16432354083376385118156195233254290317331356368
thirty-six-month2024235408321587393117150172198212243263320358396417454
results24902354083215480116131153180
of268223540833756
a2750235408331
randomized,2794235408320528942524540833876134150179213252265
doubleblind,70524540833877115154170205244260275313352364
controlled108524540833168106128149186202217252292
trial.1392245408322435991106119
Arthritis15262454083416387126147162185200226
Rheum176724540833674109147205
60:3346–335519872454083347083118151186222260293326359391
91.4252553085367082
Kaufman,52425540833568106125184217255267
J.80825540832437
M.,8612554083556981
Orwoll,95925540834769122160176191203
E.,11792554083334659
Goemaere,125425540834483118176208243265299311
S.158125540833346
et164425540833456
al.17172554083314760
(2005).17932554083195387123157176187
Teriparatide19962554083336385100139172194227248264302337
effects23502554083345473107140164191
on255825540833776
vertebral26512554083316587111145184206239254
fractures4252654083184073106130168189223250
and69426540833270109
bone82326540833877116151
mineral99326540835873111146167200215
density122826540833873111137152175208
in145626540831552
men152826540835792131
with16782654083516689127
osteoporosis:18242654083386488121160200238260297324339365377
Treatment22212654083335084116138196231269290
and253126540833270109
discontinuation2659265408338548011214918720922442527540833875107129144182221
of66127540833757
therapy.7332754083226095116149188220230
Osteoporosis9782754083477497131169209248270307333348374
International,13682754083155274108129168200222237275313346361373
16(5),17572754083346584118136147
510–516.19202754083346596134168199230244
92.4252853085367187
Lindsay,5262854083314785124150183214224
R.,7642854083365063
Scheele,84128540833365103138174189224236
W.109128540835868
H.,11732854083455871
Neer,125828540834580115137146
R.,14192854083355063
et149628540833456
al.15672854083324760
(2004).16422854083185286122158176187
Sustained18432854083337096120152168205240280
vertebral21382854083316587111145184206239254
fracture24072854083184073105130168189223
risk2644285408321376393
reduction275128540832155941324252954083315571109147
after5882954083325076109130
withdrawal7342954083516689127166187220271304319
of106929540833756
teriparatide1141295408322557792131164185218240255294329
in148629540831452
postmenopausal155429540833978104127186221259297337370407433467482
women205229540835088146181219
with22872954083516689127
osteoporosis.24292954083386488121160200238260297324339365379
Archives2823295408341624253054083316984117151178
of61830540833857
Internal6903054083155374108129168200216
Medicine,92130540835590129144176191229264276
164(18),121230540833566102122153184203214
2024–2030.144130540833468101133170202236269304316
93.4253153085367186
Leder,52931540833166105140161171
B.71731540833649
Z.,7833154083385164
Tsai,8643154083335588103115
J.99731540832436
N.,10513154083445870
Uihlein,11393154083435896111146161199212
A.136831540834156
V.,14413154083364558
et151631540833456
al.15903154083314760
(2014).16673154083195287118149167178
Two186231540833380117
years19973154083306597118145
of215931540833857
denosumab223331540833873111149176213271304343
and259331540833270109
teriparatide2719315408322567792132165425325408321547591130164
administration60632540833271129144182197223246268301323338376414
in103732540831553
postmenopausal110732540833877104127185220258297336369407433466482
women160632540835088146181219
with18423254083516689127
osteoporosis19863254083376487121159199238259297323338364
(The23673254083195594129
DATA251332540834585114151
Extension2681325408333658912316118820242533540833776
Study):5173354083335492131163181193
A727335408341
randomized7843354083215492131169227243272306345
controlled114633540833168106128149187203218253292
trial.1455335408321435890106119
The159033540833372107
Journal171433540832462100122160192208
of193933540833756
Clinical20123354083405570108123155188203
Endocrinology223233540833270109147180201217255293309347387419
and266733540833270109
Metabolism,2793335408354894253454083225494132148163189247260
99(5),7003454083347089122141152
1694–1700.8673454083346699135173203233266302315
94.4253553085367389
Atkins,5293554083416292109147173186
G.73035540834357
J.,8023554083243749
&866355408339
Findlay,9203554083324785124140172203212
D.114735540834557
M.121835540835569
(2012).13013554083195387119149167177
Osteocyte14933554083477497131170202236261295
regulation18023554083215594132147180201217255293
of211035540833756
bone218135540833978116151
mineral:234735540835772110145166199215227
A2588355408341
little264435540831530527792127
give27863554083385386120
and42536540833270109
take.5493654083225585119131
Osteoporosis6953654083477498131170210248270307334349375
International,10853654083155375108130168200222238276314346362374
23(8),14743654083346987121139150
2067–2079164036540833468104136169200235267301
95.4253753085367185
Ominsky,525375408347105119156182211244253
M.79337540835568
S.,8753754083334557
Niu,9473754083455996108
Q.106937540834758
T.,11423754083324153
Li,12103754083314658
C.128237540834053
et134937540833456
al.14193754083324759
(2014).14933754083185185116146163173
Tissue-level16813754083324874100136171193209243274308323
mechanisms201837540835892124161193230245270327353
responsible23853754083215480119157195220234273288322
for27223754083185576
the28123754083225994
increase4253854083155283104137168194229
in66938540831552
bone73638540833977115149
formation9013854083185576134165186201238276
and119238540833269108
bone131538540833977115149
volume14803854083316883120177212
by170738540833969
sclerostin17923854083265772106127163189212226263
antibody.20713854083326990104143181220251260
Journal23473854083246299119157189204
of256638540833756
Bone263738540833674111146
and279838540833269108
Mineral42539540835469106141161193208
Research,6473954083357096130161182212249261
29(6),9223954083356886119136147
1424–1430.10833954083346496127164194224256290302
96.4254053085367389
McCLung,53140540835487128160197235274286
M.83440540835569
R.,9194054083365063
Grauer,9994054083446598136171192202
A.,12174054083415669
Boonen,130340540833573112151186224236
S.155640540833346
et161940540833456
al.16924054083314760
Bone,176940540833573112147159
H.194540540834457
G.201940540834357
(2014).20934054083195387119150167178
Romosozumab228840540833573132170197235263301359392431
in273640540831452
postmenopausal28054054083397742541540832649107141179217257289327353386401
women83941540835087145180218
with10704154083506588126
low120841540831553104
bone132441540833977116150
mineral148741540835772110144165198213
density.171341540833873111137151174207217
N1943415408344
Engl200041540833270109124
J2136415408324
Med217341540835489129
2014,231441540833468100130142
370(5),24694154083346699118151170181
412–420.26624154083346594128165197231243
97.4254253085367079
Cosman52142540834076102159191228
F,76642540833238
Crittenden821425408339607596120153190229263300
DB,11384254083468193
Adachi124842540834179110142179193
JD145842540832570
et154542540833455
al161742540833247
(2016)16814254083185185116146164
Romosozumab186242540833573130168194231259296354385424
treatment23034254083214275107128185219257278
in259842540831451
postmenopausal26664254083397710312618321742543540833875114146183209241256
women69543540835087145179217
with9264354083506587124
osteoporosis.10644354083376386119157196234255291317332357370
N1448435408344
Engl150643540833370108123
J1643435408324
Med168143540835589128
375(16):1532–154318234354083346597114145176193204233263295327360391420454486
98.4254453085367287
Saag5244454083326596134
KG,6704454083347689
Petersen7714454083356789122142169203240
J,102344540832435
Brandi10694454083365688126164178
ML,12594454083548598
et136944540833355
al.14354454083324759
Romosozumab150544540833673130168194231259296353385423
or193944540833858
Alendronate20094454083415589127165185222259291312345
for23654454083195576
Fracture24534454083325183114138175195228
Prevention269344540833555881201531904254554083223674111
in55045540831552
Women61645540835793151185222
with8524554083516688125
Osteoporosis.9914554083477396129167206244265301327341367380
N1385455408344
Engl144345540833370108123
J1580455408324
Med161845540835489127
2017;17594554083356899128137
377:1417.19104554083346599108138168198226232
99.4254653085367285
Lewiecki,52646540833165115130164196226241253
E.79546540833345
M.,8564654083546880
Blicharski,952465408335506496133164185211241256268
T.,12364654083334153
Goemaere,130546540834482117174206240260294305
S.162646540833245
et168746540833455
al.17584654083324759
(2018).18334654083195285116147164174
A2023465408341
phase208046540833977108134168
III22644654083153044
randomized23244654083215390129166224238267300339
placebo26794654083385485117150188226
controlled42547540833167105126147183199213247286
trial725475408322435789103
to84347540832158
evaluate9154754083346598112149181202235
efficacy1164475408334527087119151182215
and139347540833270108
safety15154754083265977111132165
of169547540833756
romosozumab176547540832057115152178216243281338370408
in218747540831552
men225347540835892130
with23974754083506587124
osteoporosis.25364754083376385119157195234254291317331357369
The42548540833371105
Journal5444854083246299120158189204
of76248540833756
Clinical8324854083405468106120151183198
Endocrinology104448540833370108146178198213250288303340379411
and146948540833169107
Metabolism,159048540835489110143181219234249274331343
103(9),19474854083346597115147164174
3183–3193.21354854083346595128164195226255287299
100.42549530853668105120
McClung55649540835486126140176213251
MR,81949540835489102
Brown9324954083365692142180
JP,11234954083245963
Diez-Perez11974954083456093122143178211231264293
A1501495408341
et155349540833455
al.16204954083314658
(2018)16894954083195185115145163
Effects18634954083325069103134157184
of205849540833856
24212549540833465
months220149540835795132153190215
of242849540833755
treatment24944954083224275106127184218255276
with27814954083506587124
romosozumab42550540832157115152178216243281338370408
followed848505408319567185123173207246
by110950540833869
12119350540833463
months127150540835795133154191217
of150350540833756
denosumab157450540833872109147173209266298337
or192650540833758
placebo19995054083385485117150188226
in224050540831552
postmenopausal230750540833977103125183217254292331363400426458473
women27955054083508742551540835792129
with5715154083506587124
low71251540831552102
bone83151540833977114149
mineral99651540835872109144164196211
density:122451540833872109135149171204217
a1457515408332
randomized,15055154083215391129166224238267300339351
double-blind,187351540833875113151166200223262277292329367379
phase226951540833876108134168
2,245351540833446
parallel25165154083387191123138153187202
group27345154083385995133171
study.4255254083264986124155165
J604525408324
Bone64252540833573111145
Miner80152540835469106140161
Res9765254083357096
33(8):1397–140610865254083346683116134145174203236268300330360396431
101.30475530853669102114
Cosman31735540834076102159191228
F,34135540833237
Crittenden346255408340607597121154191229264301
DB,3775554083458193
Ferrari3879554083336687108140160175
S406655408333
et41105540833456
al41785540833146
(2018)4236554083185285116146164
Romosozumab44125540833573130168194231259296353385424
FRAME48475540833367109164197
Study:5056554083325290128159172
a524055408332
post52835540833977103126
hoc54205540833876107
analysis30476540833269101115146173187212
of32736540833756
the3342654083225993
role3449654083205772106
of35696540833755
regional3638654083205493107144182214228
background38806540833871102132169189226263301339
fracture4232654083194072104127165185218
risk446465408320356190
on45676540833875
nonvertebral46566540833775113143177197221254293314346361
fracture5030654083184072104127164185218
outcome.5261654083387597127163221255267
J304775408324
Bone30857540833573111145
Miner32447540835569107141161
Res3419754083367096
33(8):1407–14163529754083346684117134145174205240272304334364394424
102.30478530853668102117
Langdahl31758540833163100138176207244259
BL,3445854083356678
Libanati3535854083314583115152183204218
C,37648540834052
Crittenden382785408340597496119151188226260297
DB,4135854083458092
et42388540833455
al.4304854083324658
Romosozumab43738540833572129166192229256293350381419
(sclerostin480385408319437489122143179204227241278
monoclonal50928540835794131168200214251288320334
antibody)543785408332693047954083213674112150181198
versus3256954083326585111148173
teriparatide344095408322547489127159179211232246284318
in37699540831551
postmenopausal38329540833876101124180214251289327359395421453467
women43109540835187144178215
with4537954083506486123
osteoporosis4671954083376385118155194231252288314328353
transitioning5035954083224274111136150171186223260274311349
from5395954083183976133
oral30471054083375890104
bisphosphonate31621054083395379116154191217255292330367398419452
therapy:36251054083225993113145183213226
a3862105408332
randomised,39051054083215390128165222236261295334345
open-label,426210540833775110147168184215253288302314
phase458710540833876107133167
34765105408334
trial.4810105408322425788102114
Lancet493610540833163100131164185
2017;51331054083346797126135
390:1585.527910540833466101113142171204237248
103.304711530853669104118
Leslie31771154083316591105120153
WD,3342115408357103113
Lix34671154083314676
LM,35551154083318699
Johansson366511540832562100131169194220258295
H,397211540834456
et404011540833455
al.41071154083324658
(2012)41771154083185285116145162
Does435111540834583118144
osteoporosis45071154083376385118156195233254290316330356
therapy48741154083226094114146185215
invalidate51011154083155282115129143182213234267
FRAX538011540833266108148
for30471254083185576
fracture31371254083184072104127164185218
prediction?33691254083396093132146178201216253291314
J3697125408325
Bone373512540833674111146
Mineral389512540835469106140161193208
Research41171254083356995130161181212249
27:1243–125143801254083346676105134165197233263292326357
104.304713530853669106121
Fink31801354083324784113
HA,33051354083458598
MacDonald341613540835486117162200238270284323
R,375113540833548
Forte38121354083326990114147
ML397113540835486
et406913540833455
al413713540833146
(2019)41951354083195286117146163
Long-term437113540833168105144165187220241298
drug46821354083385896134
therapy48281354083225994114146185216
and505613540833269107
drug51751354083395997135
discontinuations5322135408338537811014618430471454083223673110142163178215253278
and334214540833269107
holidays34661454083377590105143174204231
for37131454083195677
osteoporosis38061454083376386119157196234255291317332357
fracture41801454083183972103127164184218
prevention:44141454083396093125158196217231268306318
a4748145408332
systematic47971454083265884107140197228249264295
review.51091454083215486101135185195
Ann532114540834178116
Intern54531454083155230471554083225575113
Med317415540835589128
171:37–5033161554083346394102137168200233266
105.304716530853669104118
Dennison317716540834580117154169194232269
EM,345816540833387100
Cooper356916540834077115153188209
C,378916540834052
Kanis385316540833568105119145
JA,40091654083256477
et409816540833455
al.41651654083324659
(2019)42351654083195285116146163
Fracture44101654083325183115138175196229
risk4651165408320356190
following4752165408319567185123173188225263
intermission50271654083145272105126184198223249263301338
of537716540833756
osteoporosis54441654083386430471754083225593132170191227253267293
therapy.33541754083215993114146184215224
Osteoporos35921754083477396129167206244265301327
Int39331754083155273
30:1733–174340201754083346881110138172204240270298328360
106.304718530853669105120
Black31791854083355081113142
DM,333218540834599112
Schwartz345518540833364101151183203227256
AV,37231854083417381
Ensrud38161854083326994114152190
KE401718540833568
et409718540833455
al416318540833247
(2006)42211854083195285120155172
Efects44041854083335084116139166
of458118540833756
continuing464818540833167105125140177213228265303
or496218540833758
stopping50311854083264985123162177214252
alendronate5294185408332468011715517621230471954083386990123
after31851954083325074107128
53327195408335
years33761954083316596116143
of353319540833856
treatment:36041954083224276107128185220257278291
the39091954083225994
Fracture40171954083335284115139176197230
Intervention42621954083145272105126160194231252266304341
Trial4618195408333496495110
Long-term474319540833168105144165187220241298
Extension50561954083336488121159184198236273
(FLEX):53441954083195081113153172184
a3047205408332
randomized30932054083205390128166223238266300338
trial.3445205408322435889104116
JAMA357520540832463118159
296:2927–2938374820540833468102114149182215247279309343375409
107.304721530853669103111
Ravn31732154083356798136
P,332421540833539
Christensen33772154083407797112138160193231256291328
JO,37192154083257282
Baumann381621540833567104161193230267
M,409821540835467
et417921540833456
al.42492154083324759
(1998)43222154083195079114148166
Changes450221540834077109146184218245
in476121540831552
biochemical48272154083395491123160194252266297329344
markers518521540835889110140173194220
and542021540833169107
bone304722540833977115149
mass321322540835789115141
after33712254083325074108128
withdrawal35162254083516688125163184216266298313
of384622540833756
ibandronate39192254083155386123161182218256288309342
treatment:42782254083224276107128185220257278291
prediction45862254083396093132146178201216253291
of489422540833756
bone496722540833977115149
mass513322540835789115141
changes529122540833169100138176210236
during30472354083387595110148186
treatment.32472354083214275107128185219257278290
Bone355123540833673111145
22:559–564.37102354083346980115147178215248282318330
108.304724530853669106121
Watts318324540835788109133160
NB,33582454083448091
Chines34642454083407792129163189
A,366824540834155
Olszynski37382454083476287116149188213242258
WP,40112454083579397
et412324540833455
al.41932454083324759
(2008)42672454083185285120155173
Fracture44542454083335284116139176197230
risk4699245408321366190
remains480424540832154111143157195220
reduced50392454083215493130161194233
one528724540833775109
year54112454083316596116
after30472554083325074107128
discontinuation31892554083385278109146183204219256293324345360397435
of363825540833756
risedronate.3708255408320356195134154191229260281314326
Osteoporos40482554083477395129167205244264301327
Int43892554083155273
19:365–37244762554083346376110144177213244276309
109.304726530853669105118
Black31782654083355082113143
DM,3334265408345100112
Reid34602654083356984122
IR,35952654083155063
Boonen367126540833674112149184221
S3905265408333
et395126540833456
al402026540833246
(2012)40792654083195286117146163
The425526540833371106
efect43742654083345286118141
of452926540833756
34598265408334
versus46452654083326586112149175
64833265408334
years48802654083316596116143
of503626540833756
zoledronic51052654083286580114153173210248262293
acid54122654083316377115
treatment30472754083224276107128185220257278
of334227540833755
osteoporosis:34142754083376386119157196234255291317331357369
a3799275408332
randomized38472754083215391129167224239267300339
extension42032754083346588121159184198236273
to449327540832258
the45672754083226094
HORIZON-Pivotal467727540834592127143180224269291327341373410431463478
Fracture51712754083335284115139176197230
Trial5417275408333506496110
(PFT).30472854083195385119141151
J3212285408324
Bone325028540833573111145
Miner340928540835469106141161
Res35842854083357096
27:243–25436942854083346676110141173209240274308
110.30472953085366598113
Cosman317229540834076102159191228
F,341229540833237
Cauley346129540834072109123158188
JA,36612954083246377
Eastell37502954083326490113146161175
R,393729540833548
et399729540833455
al.40642954083324659
(2014)41342954083195285117147164
Reassessment430929540833670101127153187213239296330368389
of470929540833756
fracture47772954083183972103127164184218
risk5006295408321366190
in510829540831552
women517129540835188146180217
after54002954083325074107128
33047305408334
years30963054083316596116143
of325430540833755
treatment33243054083224376107128186220258278
with36173054083516688125
zoledronic37573054083286580114153173210248262293
acid:40653054083326478116128
when420830540835088122160
is438330540831440
it443830540831436
reasonable44893054083215485111149186218256272306
to481030540832158
discontinue48833054083385278109145183204218256293327
treatment?52253054083214275107128185219257278303
J3047315408324
Clin30853154083405469106
Endocrinol320531540833270108145177198213250288303
Metab352231540835489110142181
99:4546–455437173154083346881115147181216254290322354388
111.30473253085366594105
Diez-Perez31633254083456093122142178210230263292
A,346632540834154
Adachi353132540834178109140177191
JD,37333254083246979
Agnusdei382332540834178115151176214248262
D,409632540834555
et416232540833455
al.42283254083324658
Treatment42973254083334982113133190224261281
failure4590325408318506478115135168
in476932540831551
osteoporosis48313254083376385118155194231252288314328353
IOF51953254083146193
CSA529932540834073113
Inadequate54233254083145182304733540833872111148180201234
Responders32953354083356995134172209248282303329
Working363833540835793114144160197235
Group.388733540834465101139177189
Osteoporos40903354083477396129167206244265301327
Int.4431335408315527386
201245303354083356899128
Dec;23(12):2769-74.467233540834680112124159193210241270288299333366397430453483513525
112.30473453085366596111
Miller,3170345408354698398132152161
P.334334540833539
D.,33943454083455567
Pannacciulli,347334540833566103140171203233247284298313327339
N.,38233454083455769
Brown,39043454083355592142180192
J.410734540832436
Pet41543454083356889
al.42553454083324658
(2016).43253454083185185116146163173
Denosumab451034540834580117154180217274305343
or486534540833758
zoledronic49343454083286580114153173209247261293
acid52383454083326377115
in536534540831451
postmenopausal542834540833876304735540832648105139176213251283320345377391
women344935540835187144178215
with36753554083506586123
osteoporosis38093554083376385118155194231252288314328353
previously41733554083385992123138174211237251281
treated44663554083214174105126158197
with46743554083506586123
oral48083554083375890104
bisphosphonates.49233554083395378116153191216254291328366397418450476489
The542335540833270104
Journal30473654083246299120158189204
of326536540833756
Clinical33353654083395468105120151183198
Endocrinology354736540833269108145177198213250287303340379410
and397136540833269108
Metabolism,409336540835488110142181219234248274331343
101(8),44503654083346596110143160171
3163–3170.46353654083346495128163195225254286298
113.30473753085366597111
Cosman,317537540834076102159191228240
F.,34323754083323850
Nieves,34983754083455993125158185197
J.371137540832536
W.,37643754083576779
&3859375408339
Dempster,391537540834580137175202224257278287
D.421837540834656
W.429137540835766
(2017).43743754083185285116145164174
Treatment45643754083334983114135192227264285
sequence48663754083266099136170207239272
matters:515437540835889110134167187214226
Anabolic53963754083417911030473854083397792106138
and320438540833169107
antiresorptive33303854083326990104125158184222243282303318350383
therapy37323854083225994114147185216
for39673854083185576
osteoporosis.40623854083376385118156195234254291317331357369
Journal445038540832562100120158190204
of467338540833756
Bone474838540833573111145
and491238540833269108
Mineral503938540835469106140161193208
Research,52663854083356995130161181212249261
32(2),30473954083346683116133144
198–202.32053954083346397134165198230242
114.30474053085356598114
Geusens,317540540834378116142177215241255
P.,34434054083354053
Marin,351040540835486107123161174
F.,36984054083323952
Kendler,376340540833569107145161196217227
D.400440540834556
L.,40744054083314558
et414640540833355
al.42154054083314760
(2018).42894054083185286118149167178
Effects44814054083325170104137161189
of468440540833656
teriparatide4753405408322557793131164186219240256295329
compared509640540833168125164197218252292
with54024054083496588126
risedronate3047415408320376399139160198237270292326
on338841540833775
the34784154083216095
risk3588415408320366393
of369641540833757
fractures37674154083184174107132170192226254
in403541540831453
subgroups410241540832664103143165203241281308
of442441540833757
postmenopausal449641540833877104128186222260299339373411437471487
women499741540835089147183221
with52324154083506790128
severe53754154083266194128304742540832156
osteoporosis:31204254083376589124164204244267305333349376390
The352742540833273109
VERO365342540833671107156
trial.3826425408322446194111125
Journal396842540832463102125164198214
of419942540833858
Bone427442540833575114150
and444242540833171111
Mineral457042540835471110146168202219
Research,48064254083357199135168190222261275
33(5),50984254083346888122142154
783–794.526942540833469104141174208245259
115.30474353085366698113
Leder,317743540833166105140161171
B.336543540833649
Z.,34314354083385164
Tsai,35124354083335488103115
J.364443540832537
N.,36984354083455871
Uihlein,37864354083445997112147162200213
A.401643540834156
V.,40894354083364557
et416443540833456
al.42374354083324760
(2015).43154354083185286118148166177
Denosumab450943540834681119158184221279312351
and487743540833270109
teriparatide5003435408322567792132165186219240256295329
transitions5350435408321437611414015530474454083223775113140
in320244540831452
postmenopausal326944540833977104127185220259297336369407433466482
osteoporosis37664454083376487120159199238259296323338364
(the41454454083194078113
DATA-Switch427344540834585114151172204253269291322360
study):46484454083264987126158176188
Extension48514454083336590123161188203241279
of514544540833756
a5216445408332
randomised52634454083215492131169227242304745540832661101
controlled316345540833168107128150187203218253292
trial.3470455408322445991107119
Lancet,360545540833165103135168191204
386(9999),382445540833469104123156191226262280291
1147–1155.41304554083346293125158188216246279291
116.304746530853667101117
Cosman318546540834078105164197235
F,344146540833339
Kendler350146540833671109149165200222
DL,37444654083467993
Langdahl385846540833165104144184216255271
BL,41504654083366882
et425346540833558
al.43314654083334862
Romosozumab441446540833574134173200239267306365398438
and487346540833271111
antiresorptive50054654083327092108130164192231253293316331364399
treatment:54254654083224479304747540833253111146183205218
the32784754083215994
importance338547540831471110149170195227265297330
of372847540833756
treatment37974754083214376108129187222260281
sequence.409147540832660100137172209241275287
Osteoporos43904754083477497130169208247268305331
Int.4734475408315527487
2022483447540833467100135
Jun;33(6):1243-1256.498147540832462100111146179197230247259289318350382404435464499533546
117.30474853085366698106
Hui31704854083448297
RL,32844854083356781
Adams338248540834179111169196
AL,35944854083417387
Niu36974854083456098
F3811485408333
et386048540833456
al393348540833247
(2017)39974854083195287118148167
Predicting41814854083355690129144176201216254293
adherence449048540833271109144166200238270304
and481048540833270109
persistence49364854083387495122137163186220258290324
with52774854083506688127
oral54204854083385992107
bisphosphonate30474954083395480119157196222261300338376408430464
therapy35244954083215994115148187219
in375649540831452
an382149540833270
integrated39044954083145274107147168201222256296
health421349540833772104119141179
care44054954083326485119
delivery45374954083387389104136170192226
system.47764954083265885108142200213
J5002495408324
Manag503949540835487125157196
Care52484954083407294127
Spec538849540833372107140
Pharm304750540833573105126184
23(4):503–51232475054083346987120137149184218252288322353383
118.30475153085366699115
Ross317551540833573100126
S,331451540833245
Samuels337251540833265122160194210235
E,362051540833346
Gairy36795154083437590111145
K,383751540833549
et389951540833456
al.39685154083314759
A4040515408341
meta-analysis409451540835792114146169201238270286317344359385
of449151540833757
osteoporotic45605154083376487120159198237258295317332364
fracture49375154083184073104128166187221
risk5171515408320366291
with52755154083506688126
medication54145154083579230475254083385385118140155193232
nonadherence.329452540833776114146185224259280314352384418430
Value37395254083366782120155
Health.390952540834479111127149187200
2011;14:571–581.412552540833468100127136166197209244278310343377411443452