690
PŮVODNÍ497922701004395143193242296315
PRÁCE530922701004489137177218
Adverse274533701004280117152176206242
obstetric300333701003876105133168195220236266
and328533701003472110
neonatal341133701003773112150185211247263
outcomes369033701003876103133171231266296
of400233701003858
pregnancy40763370100376196135173207245276313
in440633701001452
high-risk44743370100375290128153177193222256
women474633701005291151186224
with49863370100526894133
heart513533701003772107131160
disease53113370100385381117152181217
|5584227010018
E9564222701004183
/36738043010732
Vnitř3750804301074592111139166
Lék.3935804301074184122140
2024;70(3):E4-E94095804301074487128168182224265290332353368410452481524567
/47078043010732
VNITŘNÍ48058043010745106127171220280301
LÉKAŘSTVÍ5127804301074084130188235280325377399
www.casopisvnitrnilekarstvi.cz42580430107651332012142542953293774274464795215705896176436927117307748128548809159449871007102310631101
Several56562301074286126169195237256
risk8376230107274678116
scores96962301073474120147190224
are120962301074167110
used133562301074881125174
to152662301072874
stratify16176230107336289130157176199243
the187662301072876120
risk20126230107274679116
of214462301074872
cardiac223362301074081107155174214254
complications25036230107408716121022924828832935637542576301074896129
of57076301074871
pregnancy65876301074976119168216256304344386
in106176301071866
women1143763010765112186230278
with143776301076584112160
heart161376301074892132158189
disease.181876301074967100143183216260275
The210976301074291135
mWHO,2260763010774145202263276
CARPREG,2552763010751105150195239281337353
and42590301074189138
ZAHARA583903010749103159211257311
systems91490301073475109137180254287
are122090301074168111
most1350903010774123156185
often155590301074872103146194
reported176990301072669119168195226268318
in210790301071967
the219390301072877121
literature23339030107203866109135177204252278321
(11-13).26749030107246398121160197218231
Balci425104301074689108149168
et620104301074573
al.72010430107416177
prospectively824104301075178126160210256298329349391435454495
validated1346104301074184103122172214242285336
cardiovascular1709104301074183110159178227268311345386435454496523
and2259104301074190140
offspring2426104301074973101137187215234283334
risk278710430107274680118
models4251183010774122172216236268
for71611830107237198
pregnant836118301075077120170218259307334
women11921183010765113187231279
with1494118301076584112160
CHD.16771183010751107165179
They1879118301074191135175
determined2076118301074994121164190265283331375425
the2524118301072876120
outcomes26671183010748961241632094251323010774118152
of597132301074872
213690132301074483121
pregnancies831132301075077120170218259307347366410443
in1295132301071967
2031382132301074487129
women.15321323010764112186231279295
The1848132301074191135
ZAHARA20041323010748103159211257311
I,2336132301071934
CARPREG,23911323010751105151196241283339356
and2767132301074189139
mWHO4251463010774146203264
models7111463010773122172216235268
were10011463010765108135178
evaluated.1200146301074485126145193233260303353369
Offspring1591146301076086113148197224243291341
events1954146301074384127175202237
occurred2213146301074889128175202229272322
during2557146301074996123142190239
772818146301074488
pregnancies425160301075077120170218258306347365409443
in884160301071967
81968160301074484
children1069160301074088106125174200243291
(37.3%).1377160301072466107113158223245258
All165216030107527190
models17591603010773122172216235268
performed2043160301075095121148196223297341391
insufficiently2451160301071967100147171198218258277320369395414454
in425174301071967
predicting511174301075077120170189229259278326375
offspring90617430107487299134183210229277327
events1252174301074485128176203238
(AUC1510174301072376129181
[area171017430107246288131172
under1901174301074896146190216
the2137174301072876120
curve]2277174301074088114158201222
≤25191743010754
0.6)2592174301074460104127
(14).2738174301072464103124138
Limitations425199401385385179211256317362395458522574
A5652163010752
limitation634216301071937110128156197224243291339
of989216301074872
the1077216301072876120
study1213216301073462110159199
is1429216301071851
the1496216301072876120
retrospective163221630107276997124170204252297338368387427470
design2119216301074992126144193240
and2376216301074088137
small25302163010733106146165184
sample2730216301073375148425230301075069113
size.56023030107345289132146
We7282303010774116
did866230301074968117
not1005230301074896124
include1151230301071866107126173222267
patients1439230301075092119138181230256291
with1752230301076585113161
clinically193523030107405977125144184225244263303
insignificant226023030107196699118167215233257277317359407434
heart2716230301074892132159190
disease.304762301074968100145185218262277
Therefore,334762301074191135162205229276303346361
there373062301072876120147190
may3943623010773114153
be411962301074994
a4236623010741
certain429962301074183109140182200248
form45706230107247198172
of476562301074872
selection48606230107337797141182212231279328
bias.521062301075069110143160
Risk53926230107466598135
categorization304776301074082109151201250277296332375402421469517
according358376301074182120167194242261309358
to396076301072874
mWHO4053763010774146203264
classes43367630107405999132166210244
does459976301074897142175
not479376301074897124
allow49367630107416078127191
for51467630107247198
accurately52637630107418212016819423630479030107287090130
classifying319490301074059100133166185209252272319369
all35809030107416079
pregnant367690301075077120170218259307333
women4027903010765113187231279
with432490301076584112160
heart450290301074892132158189
disease.470990301074968100144185218262277
That500390301074292133160
is518090301071952
why5249903010765114152
we5419903010765108
created3047104301074067110150177219269
the3339104301072877121
mWHO34831043010773145203264
<37701043010753
III384610430107193857
class.392610430107405999133166183
Since4132104301074260108148191
these4346104301072776120153198
parturients4567104301074991117148196223242286334361396
did4986104301074967116
not5125104301074997124
exactly5272104301074484125166196215255
meet30471183010774118162190
the3254118301072876120
criteria339111830107406685113156182202242
of3649118301074872
mWHO37381183010774145203263
classes401811830107405999133166210244
III427811830107193857
or4351118301074875
IV,444311830107196575
we45351183010765108
do4660118301074997
not4774118301074896124
assume4914118301074174108155228272
that5203118301072876116144
their5363118301072876120139165
inclusion3047132301071967107126173206225273321
in3388132301071967
group3474132301074976123171221
137141323010744
significantly3778132301073352101149167191211251293341368387427
affected422413230107416592136177207250300
the4544132301072776120
results.4684132301072669103150169197231248
Conclusions30471574013856118182232266330382415477541593
Pregnancy3187174301074673118170221263313356400
in3616174301071969
women37141743010767116193239289
at4033174301074170
high4132174301074969120171
to4332174301072877
extremely4438174301074486118147192268314335377
high4844174301074969120170
maternal50431743010775118147191220271313334
risk540617430107274882122
(mWHO3047188301072497171230292
III-IV)33681883010719395989111159188
was35841883010766109144
burdened37561883010750100128178224273319371
with4155188301076686116166
a43491883010742
high4419188301074969119169
risk461718830107264781120
of4766188301074874
neonatal4868188301074995145196238266309329
and5226188301074191142
obstetric539718830107481003047202301073465109139168188231
complications.3307202301074189166218239259301345374394444495530548
We38842023010775119
found4032202301072474124174226
significantly4287202301073454105155176201223265308359387408450
worse47662023010766116145181227
obstetric50222023010749101136167212241270291333
and5384202301074292143
neonatal3047216301074995145196238266309330
outcomes3405216301074999128169217293339374
in3808216301071968
pregnancies3905216301075079123175225267317359379424460
in4393216301071969
mWHO44912163010774148207270
classes4789216301074161103138173219254
III-IV50722163010719395989111159
than5260216301072878120170
in5459216301071968
mWHO30472303010774146205266
classes3335230301074060101136170215250
<36062303010754
III.36812303010719395976
DECLARATIONS:48526010975395144183236281334371393450506548564
Declaration107325990985597134156197227268297318364410
of150525990984672
originality:15992599098457596143164210252273294323366386
The200826020953782122
manuscript2153260209566102145188218254278296340365
is254126020951747
original26112602095436785129146189225242
and287726020953679124
has302426020954379110
not315726020954386111
been329126020954585125168
published348326020954487132150166196239278323
or383026020954267
submitted392026020953072117183200225253291336
elsewhere.42792602095395786126184228267291330343
Conflict464725990984792139165188209246276
of494525990984672
interest50392599098216796137167209243273
and533425990984187135
financial4852719098264895136183219241282303
disclosures:80527190984667102138160206240286315357391411
None.123227220955195138178191
Funding/Support:144027190984185132179200247294321363409456504551580611630
None.208727220955194138178191
REFERENCES4262960012357112167220281336407470524579
1.42531200853648
Regitz-Zagrosek49131210833570110125147178200236269308329366393428458
V,96731210833544
Roos-Hesselink102931210833573112139160206241267294329345360397428
JW,14743121083248392
Bauersachs158431210833568106140162189222254292319
J,192031210832436
et197431210833456
al.20473121083324760
2018212531210833468100131
ESC227331210833367107
Guidelines23983121083438297136170186201239274301
for27163121083195678
the28113121083226095
management42532210835688125156194228285319356377
of81432210833755
cardiovascular8813221083316384121135172203236261293329344376396
diseases12893221083375277111142168202228
during15293221083387495110147185
pregnancy.17263221083385992130168199236267300309
Eur20473221083336889
Heart214832210834377108129152
J2312322108324
2018;39(34):3165–41.23483221083346798128140174206225257292309320354384415448483519548557
2.42533200853652
Pieper4933321083355084124159180
P.68933210833641
Pregnancy7463321083355690129167200238270303
risk1065332108321376393
assessment.11743321083325885120147173231266304325339
In:15293321083155365
Camm161033210834073131188
AJ,18153321083406880
Lüscher19113321083316894127165200221
TF,21483321083336772
Maurer223733210835487124145179201
G,245433210834357
et252733210833456
al.25993321083324860
The267633210833271106
ESC279933210833266107
Textbook4253422083336395119158197236267
of70834220833757
Cardiovascular7813422083407394132148186218250277309347362395416
Medicine121334220835590129145176192229264
(3149434220831952
edn).156334220833473111129140
Oxford171934220834779100138159197
University19333422083448297129163185212227249283
Press:22323422083365690117144156
Oxford240534220834778100137159197
2018:2851.261934220833468100131143178212246277286
ISBN4253522083154782127
9780198784906.56835220833467100135167197232265299335368404440453
3.42536200853651
Roos-Hesselink49536220833574112139160206241268294329345360398428
J,94236220832436
Baris9983622083356889105131
L,114836220833245
Johnson121236220832563101139166204242
M,147436220835468
et156136220833456
al.16363622083324860
Pregnancy17163622083355590129167199237270303
outcomes20383622083387698129166224259286
in234336220831553
women241536220835188147182220
with26543622083516689127
cardiovascular280036220833164854253722083385391123156183215253268300321
disease:7623722083385379114146173208220
evolving99837220833466104120152168206245
trends12593722083214377115154180
over145537220833769103125
10159537220833566
years16773722083316597118145
in183837220831552
the19063722083226095
ESC201737220833266107
Registry214037220833570109125151174195229
Of238537220834767
Pregnancy24683722083355690130168200238270304
And278737220834179119
Cardiac4253822083407394132147179211
disease6523822083385379114146172207
(ROPAC).87538220831854102138175215235246
Eur11363822083336991
Heart124238220834479111132157
J.141438220832437
2019;40(47):3848-55.146638220833468100130143178214233266298318330365399436472494528561573
4.42539200853651
Jastrow4893921083245683106127165216
N,71839210834457
Meyer78839210835590121155177
P,97839210833539
Khairy103039210833575107122143177
P,122039210833540
et127339210833456
al.13423921083324760
Prediction14153921083355690129145176201216254292
of172039210833857
complications179039210833168126165181196228261283298336374401
in220439210831452
pregnant22693921083396094134172204242264
women254639210835088146181219
with27783921083516789127
cardiac4254021083316485123139171203
diseases6434021083385379114146173208235
referred8934021083215574108129151185225
to113340210832259
a1207402108332
tertiary12544021083225677101117149170204
center.147340210833165103125158180190
Int16784021083155375
J1768402108324
Cardiol.18074021083407394133148186202214
2011;151(2):209-13.203740210833468100128136166196227242276294306341375410434465494507
5.42541200853650
Toprak49541220833367106128161191
B,70541220833648
Govorov77341220834482114152174211243
K,103541220833550
Kurz11044122083357294124
K,124841220833549
et131741220833456
al.13924122083324861
Outcome147241220834785108139176234269
of176141220833756
pregnancy18374122083386094133171204242274307
in216441220831552
a2236412208332
contemporary228741220833268107128162220259298320353374408
cohort271441220833269107145167192
of42542220833757
adults49942220833271109124146174
with6914222083506688127
congenital83542220833268107146181219234256289305
heart115742220833873105126151
disease-13254222083385480115147173208231
a1574422208332
10-year,16234222083356690122156188209219
single-center18604222083264179118133168191224258296318352373
experience.225042220833466105141162178213251283317329
Cardiovasc25964222083407394133148186218251277309
Diagn4254322083456193132170
Ther61043220833372107128
2021;11(6):1344-55.75443220833468101132140171198213246265276306336372409432466498510
6.42544200853652
Fernández-Campos4944422083326688126158197236270300322364397455494533560
BA,10714422083367691
Vargas-Peñafiel11794422083366788126158185206243276314347364381416432
J,162844220832436
Cruz-Dominguez168144220834061100129151198236295310348387424459489
MP,21874422083549095
et229944220833456
al.23734422083324760
Cardiac24504422083407394132147179212
and267944220833270109
obstetric2805442208337774254522083264983105127142174
outcomes6154522083377598128165224259285
in91645220831452
pregnant9844522083386094134172204242263
patients12634522083397293109143181203231
with15094522083516689127
heart165145220833873105126150
disease:18174522083385379114146172207220
a2052452208332
retrospective2100452208320547798135162201236269293309341375
cohort249145220833168106145166191
study.26974522083265088127159169
J2881452208324
Matern42546220835487109142164202
Fetal6434622083326688121137
Neonatal79546220834480118157189211244259
Med.106946220835590129142
2022;35(25):5140-5148.122746220833468101136148183216234268302321333368399430466490524555586622635
7.42547210853645
Suwanrath48347220833270121154192213246268306
Ch,8024722083407891
Thongphanang90647220833272110148187227265297335368406445
P,136447220833540
Pinjaroen14174722083354987102134156193228266
S,169747220833245
et175547220833456
al.18244722083324861
Validation1898472208335678297136168190205243281
of219347220833756
modified226247220835896136151168185220260
World253547220835794115131170
Health271847220834479111127149187
Organization42548220834769107139177192221255277292330368
classification8084822083314679105132147164181213246268283321360
for11824822083185678
pregnant12744822083396094134172204242264
women155248220835189147182220
with17874822083506688126
heart192848220833772104125150
disease20924822083395480115147173208
in231548220831452
a2382482208332
tertiary24284822083225577101117149170204
care26464822083316485120
center2780482208331651034254922083225577
in51749220831552
southern58549220832664102125163198219258
Thailand.85849220833372104119135167205244257
Int11304922083155375
J1220492208324
Womens125949220835894153188226252
Health.152649220834580111127149187201
2018:10:47-53.174249220833468100131143173204218252284303337370382
8.304731200853652
Roos-Hesselink312031210833674113140161208243270297332348363402432
JW,35733121083248393
Ruys368631210833674106133
TPE,384031210833370103116
Stein39773121083325488103141
JI,41393121083244053
et421231210833557
al.42903121083324760
Outcome437131210834786109140177236271
of466331210833757
pregnancy47413121083386095135173206244276310
in507231210831553
patients51453121083397395110145184205233
with53993121083516789128
structural30473221083264971109141165203224257273
or333432210833859
ischaemic34083221083144173111143178236251283
heart370632210833772104125150
disease:38703221083395480115147173208221
results41053221083215582119134157185
of430432210833757
a4375322108332
registry44223221083205494109135158180214
of465132210833756
the47223221083216095
European48313221083336990128167203235273
Society511832210833371104119154176210
of534232210833757
Cardiology.5413322108340739430473322083385391107145185217227
Eur32893322083336990
Heart339533220834479111132157
J.356733220832437
2013;34(9):657-65.361933220833468100130141176212231264282294329363396415452486498
9.304734200853649
Santacesaria310934210833265103124156188222248281302318349
S,347134210833245
Cataldo35293421083397293126141180217
S,375934210833245
Annoni381734210834078116154192207
GA,40373421083438599
et414834210833456
al.42173421083314759
Pregnancy42893421083355589128166198236268301
in460334210831452
women466734210835188146181219
with48983421083506688126
cardiovascular50373421083316384122137175206239265297335350382403
disease54523421083385330473521083266193120155
in321635210831452
the32823521083226095
guidelines33913521083387691130165180195233268295
era:37003521083345588101
an381535210833270
Italian3899352108315377085100132170
single-center40833521083264179118133168191225259297318352373
experience.447035210833466105141162178212251283316329
J4813352108324
Cardiovasc48513521083407394132147185217250277309
Med517435210835490129
(Hagerstown).5317352108319639513416919130473622083264986137176193204
2016;17(10):750-5.326736220833468100131143173202219251282300312346378412436470482
10.30473720085356983
van314337210833164101
Hagen325637210834475114148185
IM,34533721083156982
Roos-Hesselink354737210833573111137157202237263289323338353390420
JW,39793721083248190
Donvito408237210834482120151166188224
V,431837210833644
et437437210833456
al.44423721083314659
Incidence4513372108315528398136170208239272
and479737210833269107
predictors49173721083385992131146177201237258285
of521437210833755
obstetric528237210833675101124157179200215246
and304738210833169107
fetal31663821083185274106121
complications329938210833168125163179193225257278293330368394
in370538210831452
women376938210835087144179216
with39973821083506587125
structural41343821083264969107139162199220252267
heart441438210833771102123147
disease.45733821083385378112144170204216
Heart480138210834478109130154
2017;103(20):1610-18.49673821083346799127137166197230247280314332343372403433463487517547560
11.30473920085366678
Siu31433921083324785
SC,32453921083327386
Sermer33483921083326788147182203
M,356839210835568
Colman36533921083407793150183221
JM,38913921083247992
et400039210833457
al.40743921083314760
Cardiac41513921083407294132147179211
Disease43793921083456187122154180215
in461139210831553
Pregnancy46813921083355690129167200238270303
(CARPREG)500139210831958101137173208242286305
Investigators.5323392108314528411814516818330474022083387092129151178191
Prospective32564022083355693120159194227251267299333
multicenter360740220835795110133148180214252273307328
study39534022083264987126158
of412940220833756
pregnancy42034022083396094134172204242275308
outcomes45294022083377598128165224259285
in483240220831553
women490240220835189147182220
with51404022083506688127
heart528440220833873105126150
disease.54524022083385330474122083266193120155167
Circulation.32294122083405576107145160193214230268306319
2001;104(5):515-21.356441220833468104136144174206242261295313325360391422444474506515
12.30474220085366884
Drenthen314642220834567101139161199234272
W,343342220835767
Boersma351442220833674110131158216248
E,377742220833246
Balci38374222083366884116131
A,398342220834155
et405242220833457
al.41234222083324760
ZAHARA419842220833880125166202245
Investigators.44584222083145284118145168183222254276313335362376
Predictors48484222083355690130145177201238259287
of514942220833757
pregnancy52204222083396195134172205243275308
complications304743220833168126166181196228261283298336375401
in346343220831553
women353143220835189147182220
with37664322083516689127
congenital390843220833268107146181219234256289305
heart422843220833872104126150
disease.43934322083395480115147173208220
Eur46294322083326990
Heart473443220834479111133157
J.490643220832537
2010;31(17):2124-32.495843220833569100132145180211226257287306318353385415447470502535547
13.30474420085366883
Kampman314944220833568126165224256294
MA,346244220835496110
Balci35914422083356883115130
A,374044220834155
van381344220833265103
Veldhuisen39354422083356884122160198213239274312
DJ,42664422083456780
et436444220833456
al.44394422083324760
ZAHARA451744220833881125167202245
II478144220831530
investigators.48294422083155384118145168184223255277314335362376
N-terminal52234422083456890124145204219257289304
pro-B-type30474521083386097120156179201234274309
natriuretic33694521083376991112127164185219241256287
peptide366945210833874112134149188222
predicts39044521083386093133147179203230
cardiovascular41474521083316384122137175206239265297334349381402
complications456245210833167125164179194226258280295332370396
in497145210831552
pregnant50364521083386093132170202240261
women530945210835188146181218
with30474621083516689127
congenital318946210833168107146181219234256289304
heart350946210833772104125150
disease.36744621083385380115146173208220
Eur39094621083337091
Heart.J401546210834479111132157170197
2014;35(11):708-15.422746210833468100131143178211228260288302314347381416439470500511
14.30474720085366984
Balci31504722083356884116131
A,330047220834155
Sollie-Szarynska33744722083327187102117151174206234268289323362388418452
KM,384547220833491105
van396847220833265103
der40904722083387394
Bijl4203472208335516681
AGL,430347220834184116130
et445247220833456
al.45274722083324760
Prospective46064722083355693120159194227251266299333
validation4958472208332648095134166188203241279
and525647220833270109
assessment53844722083325985120304748220832653110145183205
of326648220833756
cardiovascular33364822083316485123138176208241268300338353385407
and375648220833270109
offspring38794822083375776103142164180217256
risk4149482208321366392
models425548220835796135170186212
for44814822083185677
pregnant45724822083396094134172204242264
women484948220835189147182220
with50834822083506688126
congenital522348220833168107146181219234256289304
heart304749220833873104126150
disease.32134922083385379114146172207219
Heart344849220834479111132157
2014;100(17):1373-81.362049220833468100131143173204241260292321341353382412444479501536568578