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tepen10093300100266199134172
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kritéria42512400275121215280370487580645766
a126812400275116
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možnosti284412400275181307410539665768856923
Debora4251630013777135201265307365
Karetová,8121630013768126168226267331388445475
Agáta13091630013772135194234293
Jeníšová16241630013745103169199248312369427
II.42517800133265276
interní524178001332686121175210271296
klinika844178001335178103163188239293
kardiologie11601780013352105141202227287313373435460515
a16981780013353
angiologie17751780013353113174199260285346408433487
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LF23831780013352104
UK25101780013372131
a26641780013353
VFN,27411780013361115185208
Praha2972178001335993146207259
Vaskulitidy4252290012155102141189244269292326350407455
velkých899229001214898122169220265320
tepen1239229001213282140191248
(LVV,1506229001212875125185201
large1726229001212472106162212
vessel1958229001214897137177228253
vasculitis)2230229001214897137182238262285319343382408
postihují26572290012157113153188211267322347370
aortu30472290012148103137173228
a32952290012148
velké,3362229001214898122169219239
z36212290012142
ní3683229001215579
odstupující37812290012155113152187242300355380404449472
tepny.4273229001213383140196242259
Řadíme45522290012153102159183267318
sem4889229001214091175
především5083229001215790140198249297337361444
24252430012151
nemoci,4962430012155106190246292316337
a8522430012148
sice920243001213963108158
obrovskobuněčnou10982430012154112146201249289336390448504560611657712768824
arteritidu1941243001214882118168202226260283341396
(GCA,2356243001212992150213237
Giant2612243001216589138194227
cell2858243001214595119143
arteritis)3021243001214881117167201225259283322348
a33892430012148
Takayasu3456243001215092139189235285324379
arteriitis3855243001214881118168201225249283307347
(TAK).4221243001212881137191222241
Obě44822430012169127178
nemoci46802430012155106190246292316
jsou5015243001212464120176
vzácné,5211243001214793143189245296316
také425257001213383131181
proto636257001215791147181236
jejich903257001212475100125171227
časná1160257001214595135191240
diagnostika1430257001215781130187244300340375400447498
často1958257001214595135170225
selhává.2213257001214092117173222270319342
GCA25852570012165124187
(dříve2803257001212883117141191241
nazývaná30742570012156105149201253303359409
Hortonovou35132570012165122156193248305361410465521
temporální4064257001213484169227284318367392448472
arteritis)4567257001214881118169203228262286326352
je4949257001212576
idiopatické5055257001212482106162220270304328374421471
zánětlivé425271001214393149201235259283332382
onemocnění8262710012155112163247303350406457513537
probíhající1383271001215790146204228286335360384429453
zejména1856271001214293118202253310358
ve2234271001214898
stěně2352271001213974124180232
medie26032710012183135193217268
a28912710012148
adventicie.29592710012148105154204261294318363387438459
Pojí34382710012153107132156
se3613271001214091
často3724271001214594134169224
i39672710012124
s40112710012139
extravaskulárním4070271001215098135168217265314354401457482531564621644728
zánětem,4818271001214394150201235285369391
nejčastěji52292710012155107131177226266425285001213383108132
ve583285001214898
formě706285001212986119204256
polymyalgia9872850012157114139187272319369393450474523
revmatica.1536285001213283132217266299324369419441
V20032850012155
současné2084285001213996152198247288344395
době25042850012157113171223
je2752285001212576
zřejmé,2853285001214377128152237288309
že3187285001214394
tato3307285001213382116171
arteriitida3503285001214982119169203228252286310368417
zahrnuje3945285001214394150183240296321372
širokou434228500121406497153201256312
škálu4680285001213987137162217
fenotypového4923285001212980137193227278336393441491548604
vyjádření:4252990012148100125174232265316373397417
rozlišujeme866299001213388131156180220275300351436487
GCA13772990012165124187
velkých1588299001214898123171222267323
cév1935299001214595143
(LV-GCA)2102299001212875126157226285348377
a25022990012149
kraniální2574299001214782132188212261286342366
formu2964299001212985119203259
GCA32472990012165124187
(C-GCA).3458299001212885111180239303331351
Takayasu3832299001215093140191237287327382
arteritis4238299001214882119169203228262286326
je4588299001212475
charakteristická46872990012145101150183233281317368402426466501525571618669
postižením5379299001215711442531300121397498141192248272356
tepen800313001213383141193249
odstupujících10693130012154112152187242300356380404449473518574
z16633130012142
aorty,17253130012148104137174224241
zejména1986313001214293118201253309358
subklaviálních,2363313001214095152200226274322346395419475498544599621
kde30043130012146102153
granulomatózní3177313001215689138194249274329413462495550593649673
zánět3869313001214393149200234
vede4123313001214898156207
ke4349313001214797
vzniku4465313001214894150174221277
stenóz4762313001213974124180236278
až5060313001214892
uzávěrů.5172313001215598149196246279335356
Postižena4253270012153107148182207250301358407
je855327001212476
nejen9543270012155107132183240
medie12173270012183135193217268
a15093270012148
adventicie,15803270012148106155205262295319365389440461
ale2064327001214973124
i22123270012123
intima.2258327001212480113137221270293
Diagnostika425341001216791140197253309350385409456506
se955341001214091
opírá10703410012155113138172221
o13153410012155
zobrazovací1394341001214398157191240284340388438484507
metody,19253410012184135170225283332349
zejména2298341001214293118202254311360
PET/CT26813410012154102155184241294
(s2999341001212967
průkazem3090341001215791147195245289340425
zvýšené3539341001214395146187238295346
metabolické39093410012183135169219277334359383428476526
tepen4459341001213383141193250
aktivity4733341001214896133157206231265316
ve5073341001214898
stěnách5195341001213974124181230276332
tepen),425355001213383141194250277296
k7513550012147
přesnému828355001215791142182238290374430
zobrazení1288355001214399157191241285336393417
tepen1735355001213383141194250
slouží2015355001214064120177221245
CT22903550012158112
nebo24323550012156107165222
MR26843550012180136
angiografie.28503550012148104161186242299333382412440491512
Iniciálním3392355001212480105150174223248304328412
vyšetřením38343550012148100141192226260311367391476
je4340355001212475
duplexní44463550012156112170195246294351375
ultrasonografie.4851355001215580114147197237293350406464497547577604655676
Laboratorním425369001214798155212246296329384418475499583
vyšetřením10303690012148100140192226260310367391475
zjišťujeme152736900121436892132168223248299384435
známky1984369001214399148233280332
zánětu2337369001214394150202236292
(zvýšení2651369001212871123175215267323348
CRP30203690012158112167
a32093690012148
sedimentace3279369001213991149173257309366399449495545
erytrocytů),3845369001215184136173207262309359397453479499
chybí43653690012145101148206231
specifický4618369001213997149195219250277323370421
marker50613690012184133166214264298
pro5381369001215791146
monitoraci4253830012183140196220255310344393439463
aktivity911383001214896133157206231265316
nemoci.12503830012156107192248294318340
Výsledky4253970012156105146170221279327379
léčby826397001212475122179226
u10753970012155
LVV1152397001214898159
jsou1334397001212464120177
obecně15333970012155113165212268319
lepší1875397001212475133173197
než20953970012155107151
u22683970012155
většiny2346397001214898132174198254301
systémových2669397001214089129164215299355404455500556
zánětlivých3248397001214293150201235260283333384429485
onemocnění37563970012155111163247304350407458514538
a43173970012148
stavů4388397001213974124172228
s46393970012139
postižením47013970012157114154189213256307364388472
cév5196397001214595143
malého53623970012183132425411001212475132188
kalibru.633411001214797122146203237294316
LVV969411001214798159
však1148411001214889139186
není13554110012155107163188
benigním15634110012157109166190246303327411
onemocněním.19954110012155111163247303350406458514538623645
V26604110012156
dlouhodobém2736411001215781137194250306364420479530615
horizontu33724110012155111145170213269326359415
je3807411001212576
nutno39034110012156112146202258
vést4182411001214898138173
nemocné43764110012155107191247294350402
do47984110012157113
remise4931411001213384168192233284
léčbou5235411001212475122179236292
založenou425425001214394118174217268325381437
na8834250012155104
imunosupresi,10084250012123107163219276316371429463514554578599
včetně1628425001214893143177233285
nových19334250012156112160212256312
biologických2266425001215782138163219276301346394445490546
přípravků,2833425001215790115173206256303352408430
a32834250012149
následně33524250012156105145169220279335386
sledovat3759425001213964115173230278327361
a41404250012148
léčit4209425001212375121145179
potenciální44094250012157114147198254300324373398454478
vznik4907425001214894151175223
ischemie5150425001212464110166217302326377
různých425439001213389133190236281337
cílových78543900121456995151199251296352
orgánů.1160439001215589146195251307328
I15114390012124
tak1558439001213383131
jsou1712439001212465121177
relapsy1912439001213384109158216256305
časté2240439001214595135170220
a24834390012148
chronické25544390012145101135190247271317364414
vaskulární2991439001214998138186242267316349406430
komplikace34444390012147102186244269293341391437487
jsou3954439001212464121177
zdrojem41544390012143100134189214266350
významné45274390012148100146203252336392444
morbidity.49944390012183139173231256314338372423440
Klíčová425456001235885111155211261312
slova:755456001234167124174225248
arteritis1021456001214881117166199222255278317
velkých1356456001214998122168218262317
tepen,1691456001213383140191246267
velkobuněčná1976456001214898121168222279334389440485540588
arteritis,2582456001214881117166199223256279318339
Takayasu2939456001214991138187233281320375
arteritis,3332456001214880116166198222255278317338
diagnostická3688456001215780128184239294333367390435481530
kritéria4236456001214781105138187220244292
202245464560012151101150200
(ACR-EULAR),4764456001212989145197229280343390453507534553
imunosupresivní533545600121231061614254700012155111150204261294344383406454511534
terapie,980470001213382115164220244294314
revaskularizace.1315470001213383130179218265320343391424447490540585634654
Large4254950015058124173241304
vessel7684950015066127182237300335
vasculitis11414950015066130185239307341376423458514
–16774950015068
new17834950015067130222
classification2043495001505388153208263297346381435500547582649717
criteria27984950015052102136183246295329393
and32304950015063132200
new34694950015067130222
treatment3729495001504696159224271373436504552
options43194950015066134182217284352408
Large425515001214796128183232
vessel675515001214796135173223247
vasculitis939515001214895134178233256278311333372
(LVV)1328515001212874122182212
affects1558515001214776108158203238278
the1853515001213387137
aorta20075150012148102135170218
and22435150012147102158
the2418515001213387137
large2572515001212471103158208
arteries2797515001214880115164196219269308
branching3122515001215689137191236290313367423
from3562515001212962116198
it.377851500121235576
There38715150012150105155188237
are4125515001214880129
242715150012151
diseases4339515001215679117167215253303342
in4698515001212378
particular,47935150012157105137172195239293316363395411
namely52215150012155102185235258305
Giant425529001216589136192224
cell670529001214594118141
arteritis832529001214981117166199223256279318
(GCA)1171529001212891149211239
and14315290012148103160
Takayasu1612529001215092138188233282321375
arteritis2009529001214880116165198222255278317
(TAK).2347529001212981136189220238
Both26075290012154109142197
diseases2825529001215780119170218257307347
are3193529001214881130
rare,3345529001213281113163183
which35495290012174130153197252
is3823529001212362
why39065290012174130175
early4102529001215199131155202
diagnosis4325529001215780128184239294333356395
often4742529001215584120169225
fails.4988529001212978101125164185
GCA4255430012165123185
(formerly631543001212855110143227277310334381
called1033543001214594117140190248
Horton‘s13015430012166121154190244300320357
temporal1678543001213383166223279312360384
arteritis)2082543001214981117166199223256279318343
is2445543001212463
an25295430012148103
idiopathic2653543001212380103158215264296351374419
inflammatory3093543001212378107134182265348396429483515566
disease3679543001215780119170218257307
taking4007543001213382128153208265
place4292543001215781129174223
mainly45355430012184132155210234281
in4837543001212378
the4936543001213388139
wall50955430012174122146169
of5284543001215584
the5389543001213388139
media4255570012184134192215263
and7165570012148104161
adventitia.9055570012148105153203259291314347370418440
It1373557001212457
is1458557001212463
often1549557001215584121170226
associated1803557001214888127182228251299332381438
with2270557001217397130186
extravascular2484557001215097133166215261310349394449473521553
inflammation,3066557001212378107134182265349397430453508564585
most36795570012183139178212
commonly3919557001214599183266321377401448
in4396557001212378
the4503557001213388139
form4670557001212984117201
of4900557001215584
polymyalgia50125570012157113137185269315364387443467515
rheumatica.425571001213388139194277325358381426474496
It943571001212457
is1022571001212362
now11075710012155110183
clear1312571001214568118167199
that1533571001213388136169
this1724571001213388111151
arteritis1897571001214880116166198222255278317
includes2236571001212479124147202259309348
a26075710012148
wide2677571001217497154204
range2903571001213382137193243
of3168571001215584
phenotypic32755710012157113163219274307356414438482
expression:3780571001215097154187237277316339394449469
a42715710012148
distinction4342571001215679118152175230275311334389444
is4809571001212362
made48935710012184132189239
between51545710012157108141217267318373
large425585001212472104160211
vessel664585001214998138177228252
GCA9445850012165123186
(LV-GCA)1158585001212975125155223281344372
and15585850012148104161
the1747585001213389139
cranial1915585001214577126182205253276
form2220585001212984118202
of2450585001215584
GCA25635850012165123186
(C-GCA).2777585001212884110178236299327345
Takayasu3151585001215091138188234282322376
arteritis3556585001214881117166199223256280319
is3903585001212463
characterized39945850012145101149181230275311360393417460510568
by45905850012157104
involvement4722585001212479126180204252302386436492525
of5275585001215584
the5388585001213388139
arteries425599001214881117166199222273312
arising760599001214881104144166222278
from1061599001212963117201
the1285599001213388139
aorta,14475990012148103136172221242
especially1712599001215089146197243266314337360408
the2143599001213388138
subclavian2305599001213994150196219267314337385441
arteries,2769599001214880116166199222272312333
where31255990012174129180213263
granulomatous3411599001215688137192247270325409457489544599638
inflammation4072599001212479108134182265348397429452507563
leads4658599001212474122179218
to4899599001213387
stenosis5010599001213973122178233272295334
and53675990012149104161
occlusion.4256130012155100144167222261284339395416
Not8626130012166121154
only10376130012155111135182
the1240613001213388139
media14006130012183134191214262
and16846130012148103160
adventitia18656130012148105153202258290313346369417
are2303613001214981131
affected,2455613001214877110160206241291348369
but28456130012157112145
also3012613001214871110165
the3199613001213388138
intima.3358613001212479111134218266287
Diagnostics425627001216790138194249304344378401445486
is939627001212362
based10296270012157105145195252
on13096270012155110
imaging14476270012124107155211234289345
methods,18206270012183134167222277334374395
especially2242627001215190146198243266314337361408
PET/CT26786270012153101152180236289
(with29946270012129100123156212
evidence3233627001215098122178229284329378
of3639627001215584
increased3751627001212378123156205253293343400
metabolic41796270012183134167216273329353376420
activity4627627001214893128151200223257306
in4961627001212379
the5067627001213388139
arterial5233627001214981117166199223271294
walls),4256410012174122145169208232251
CT6976410012158111
or829641001215487
MR9376410012181135
angiography10936410012148104160183238294327376432488534
is1648641001212362
used1731641001215595145202
for1954641001213085118
accurate2093641001214893136191224272305354
imaging24686410012123106154210234289345
of2834641001215584
the2939641001213388139
arteries.3099641001214880116166198222272312333
The34536410012150106157
initial3631641001212378101134157205229
examination3881641001215097145229252307355387411466521
is4423641001212463
duplex45076410012156111168192242289
ultrasonography.4817641001215579112144193232287343398455487536592648694710
Laboratory425655001214797153209242291323377410460
examination907655001215097145228252307355387410465521
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used1533655001215594145202
to1756655001213387
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signs2156655001214063119174213
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inflammation2495655001212479108134182265349397429452507563
(elevated3079655001212976100150197246278328385
CRP34856550012158111165
and36716550012148104160
erythrocyte3852655001215083134170225258312358407444493
sedimentation4366655001214090147171254304360392441474497552607
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marker8946690012183132164211260293
to1208669001213387
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disease1675669001215780119169217256307
activity.2003669001214893128151200224257307323
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in1331683001212379
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CSc.137174000954584120135
II.4257520095173449
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Cit.43787400095466388103
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Vnitř462374000954183100125149
Lék.479074000953674109125
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