1348
50018522001003480125
|350220010019
www.casopisvnitrnilekarstvi.cz442680400107651332012142542953293774274464795215705896176436927117307748128548809159449871007102310631101
VNITŘNÍ4268040010746106127172220280301
LÉKAŘSTVÍ748804001074185130188236280325378400
PŘEHLEDOVÉ42522001004388130181216258306358404446
ČLÁNKY88722001003973122176223272
Diagnostika4253300100456195134171210240267283317353
a794330010034
léčba8443300100155082120155
hyperurikemie101533001003773112148172210234251285319379394429
v1461330010035
kardiovaskulární15123300100336993131146185220256285319357372407431470485
prevenci20133300100376297133168205236251
na228033001003772
základě236833001003166100117152190226
patofyziologického26103300100377299137157196229244283299338376391422456490528567
mechanismu319333001005995126163198236251280340377
jejího3586330010015506580119158
vzniku376033001003568106122156194
Body425590013867129194258
k720590013860
zapamatování802590013850111175236329390435497558618682715
Kolektiv56576001074594114159198230249291
českých88376001074184118157201241290
a1200760010742
slovenských126976001073453102143188237271309353393442
odborníků1738760010749100151201228278297338387
připravil21527600107517898148176218259279298
v2477760010742
roce254676001072775117160
2024273376001074589131172
expertní42590001074483133178205236284303
konsenzus74990001073886134167212260297345378
pro114990001074976123
diagnostiku129490001074968108157205254287316335373421
a1737900010741
léčbu179990001072063105154202
zvýšené202390001073680123157201249293
hladiny233890001074867108157176224262
kyseliny262290001073881115159178197245283
močové4251040010774122163210250293
u7411040010748
pacientů811104001075092132151195243270317
se1151104001073478
zvýšeným1252104001073680123157201249287362
kardiovaskulárním1637104001073880106155173221262303336374422441482508557575649
rizikem,230910400107264582101139182256271
který2603104001073869111138181
lze280710400107195598
shrnout425118001073481108157205253281
v7261180010741
následujících786118001074989123141185235283302320360379419467
bodech:1273118001074999149193234282297
„425133008960
Hyperurikemie565132001075798149195222272299319358402476496540
představuje1127132001075077121172206236278319368388433
KV1581132001074596
rizikový169813200107274784104143191232277
faktor.1996132001072467106137185213226
„425147008960
U5651460010756
pacientů638146001074991131150193241268316
s9711460010734
hypertenzí,1022146001074886136181208239281329366386401
diabetem,1441146001074867107156201229272345361
dyslipidemií,1819146001074889123142160209229278322395414432448
CKD,2284146001075195154168
kumulací2469146001073886159206225266306325
KV2811146001074594
rizikových56516000107274784104143191232277317366
faktorů954160001072467106137185213262
či1239160001074060
KV1322160001074495
onemocněním1440160001074898143217267309358403452471545
je2009160001071964
třeba209616000107285599149192
stanovit2311160001073363106155204245265294
hladinu2628160001074969110160180229277
KM5651740010745118
a7041740010741
při76717400107497797
zjištěné88617400107365676109139182231276
hyperurikemii1184174001074887139185212261289309348392466486505
také1711174001072770109152
index1885174001071968118163203
sKM/sCR.2110174001073479152186218269315334
„425189008960
V5651880010746
prevenci634188001075078122163207256298317
KV975188001074595
rizika109418800107264684104143186
je1303188001072064
třeba139118800107285599149192
zahájit1606188001073780129171190210239
intervenci186818800107196896139166211255304346365
při225718800107507797
hodnotách2378188001074897148197247275317359407
indexu2809188001071968565202001074994135184
sKMµmol/l/sCrµmol/l772202001073379152201276325346379400433464516543593667717737770791
≥15872020010753
3,6.1663202001074460106123
Ten1809202001074281130
identifikuje1962202001071969114163191211236256295344364409
pacienty2394202001074992133153198247274318
s27352020010733
HU27922020010756113
v5652160010741
důsledku628216001074997131150195246285334
zvýšené984216001073781126160205254299
produkce1306216001074977125176224263304347
KM,16752160010745118135
která1833216001073869113140183
je2038216001071964
spojena2124216001073484134154199248289
se2436216001073378
zvýšeným2537216001073681125159204253293368
KV565230001074595
rizikem.68223000107264784104143187261279
„304763008960
Pacienty318762001074586126145189237264307
je352162001071963
třeba36106200107285598148189
edukovat382662001074494142180227268309337
o4189620010748
rizicích42636200107274683103143162202250
spojených454062001073383132151195244282322370
s4937620010733
HU4997620010757113
a5136620010741
o5204620010748
úpravě527862001074898125167207250
životního31877600107375799147175225244295345
stylu355976001073464107128176
(omezení376276001072571147192230274324343
konzumace413276001073987137175224299341383426
fruktózy458576001072453102141173221257301
(slazené49137600107245777118156200250295
nápoje),523576001074991141192211256278293
vnitřností,318790001074192111140168218268302332352368
mořských3582900010775125153188227271312361
plodů,397190001075071120172220237
alkoholu,423590001074261100149199248269318334
udržování4596900010749100127167215256299349368
zdravé499190001073787114157198242
tělesné52619000107287292137172221266
hmotnosti31871040010748122170198246294328357376
a35821040010741
dostatečné3643104001074997131160201228271312360404
hydratace).4067104001074887135161203230272312355376389
„3047119008960
Léčba3187118001074185127177219
je3433118001072065
vedena3525118001074185136181230272
k38241180010738
cílovým388911800107416081130172216292
hladinám4208118001074868109160179228269344
KM45791180010745119
<47251180010754
3604806118001074589135
µmol/l49681180010749124173193226247
u52421180010748
mužů53181180010774123160209
a31871320010741
<32551320010754
3003336132001074589136
µmol/l34981320010749124173193226247
u37721320010748
žen.3847132001073780129146
Poklesy4020132001074592132153197232274
koncentrace4320132001073987136178221270297324367408451
KM47981320010745119
pod49441320010750100151
2505122132001074489133
umol/l52811320010749123173193226246
nejsou3187146001074892111144192241
pravděpodobně3447146001075077119158207251300349399448498546590
spojeny4057146001073483132151195243282
s43581460010734
benefitem.4412146001074994142187210230258301374391
„3047161008960
Terapií3187160001074178103143191209226
1.3427160001074453
volby3495160001074086104151189
je3698160001071961
inhibitor3774160001071864111128176193220265290
XO40791600010748104
alopurinol,4197160001074158105153200225243289336354368
který4579160001073767108133174
se4767160001073376
podává4857160001074997145184222262
v51331600010741
postupně5188160001074996128156202250297339
titrovaných31871740010728467399145184225272310348396
dávkách3602174001074989128165207247294
obvykle3915174001074897137179217237280
v42141740010741
rozmezí4275174001072672107180224260278
od4573174001074897
1004689174001074483128
do4836174001074997
3004952174001074487132
mg/den.50981740010773122154198241288303
Do54211740010758106
dosažení3187188001074996129170206248295313
cílové351818800107405877125164206
hladiny3742188001074967106155173220257
KM40171880010745116
jsou415118800107195199146
vhodné4315188001074188136185232276
kontroly4609188001073884132158184230248288
po4915188001074997
4–65030188001074491137
týdnech.5185188001072869117164208248295310
„3047203008960
Léčba3187202001074083124174215
má34192020010774115
pokračovat3550202001075099138166207248294334376403
i39702020010719
po4005202001075099
dosažení4121202001074997131173210252301319
cílové445720200107405979127168211
hladiny4685202001074867107157175223262
KM49642020010744117
při509720200107507796
pravidelném52102020010749761181581772262702893187216001074892166
monitorování33732160010773122171189217264291338378420468486
2×3879216001074498
ročně.3996216001072774115163207222
„3047231008960
Léčba3187230001074083125174215
hyperurikemie3422230001074887137182209257284303341384457476520
vyžaduje3961230001074184123165215262281325
mezioborový43052300010774118156175223273322349396436480
přístup.480423000107507796129158206255270
LITERATURA426253001234978134189250318368438498567
1.42527000853648
Rees49127000833570106133
F,64227000833238
Hui6982700083448297
M,81327000835468
Doherty89827000834684123158179204237
M.115327000835569
Optimizing124027000834786109124182197226241279318
current15762700083316990112146184206
treatment18002700083214377109131189224262283
of210127000833857
gout.217627000833876114137150
Nat23442700083457799
Rev246127000833570102
Rheumatol.258127000833674109147204237259296311324
201442528000833468100131
May;10(5):271-283.57128000835587118131162193213246264276311344377396427460494507
2.42529000853651
Du48929000834583
L,58529000833145
Zong64329000833874113151
Y,80729000833543
Li86329000833247
H923290008344
et98029000833356
al.10482900083324760
Hyperuricemia112129000834476116151172210231247279312370385417
and155029000833270109
its16722900083143764
related17492900083215570102124157197
diseases:19592900083385379113145172206233246
mechanisms221729000835893125163195233248274331357
and258729000833270109
advances2709290008331701031361734253000083326693
in53930000831553
therapy.6133000083226196118151191223233
Signal8673000083334887126159174
Transduct10623000083335184123149189227260284
Target13673000083336283122157180
Ther.156830000833373108130140
2024;9(1):212.172930000833569103135147183203235250262297329360373
Available212230000834273106122137170210226261
from:24043000083194179138151
<http://doi:257530000834380102126166179206227263302318330
10.1038/s41392-024-01916-y>.4253100083346678109140174208233258294324354387420441478511543566603635665697728751783826834
3.42532000853651
Leung48932000833165103141179
N,68132000834558
Yip7513200083355190
K,85432000833549
Pillinger91632000833550658094132171206227
MH,115632000835498111
Toprover128032000833266106127164196230251
M.154432000835468
Lowering162532000833168119153174190228266
and190432000833270109
Raising20253200083366883109124161200
Serum22383200083336788126184
Urate24353200083446497119152
Levels:26003200083316597131147173185
Off-27983200083476886108
-Label4253300083215487127162178
Effects6183300083335271105138162190
of82333000833756
Commonly89533000834077135193231270285317
Used122733000834470105144
Medications.138633000835590129145177209231246284323349363
Mayo176433000835587118156
Clin19353300083405570108
Proc.20583300083355693126139
2022221233000833569102136
Jul;97(7):1345-1362.2364330008324627789124157173208228239269299335367389420450485518531
4.42534000853651
Borghi4893400083357495133171186
C,68834000834053
Tykarski7543400083336091124145173203219
A,98634000834155
Widecka105434000835773112147180210243
K,131034000833550
et137334000833356
al.14423400083314760
Expert151534000833265104140161186
consensus171434000833168106132167205232269295
for20223400083185677
the21123400083226095
diagnosis22203400083385385124162200227242268
and250134000833270109
treatment26233400083214377108130188223261283
of42535000833757
patient4973500083397293109143181203
with7153500083516689127
hyperuricemia85735000833868108144165203225240272306364379411
and128335000833270109
high14073500083385392130
cardiovascular15523500083316485124139177209242268300338353386407
risk.1974350008321366292107
Cardiol20963500083407394132148186201
J.231335000832436
2018;25(5):545-563.236535000833468100131143178213230264282294330365398420454488522534
5.42536000853651
Borghi4963600083357496134172187
C,70336000834053
Domienik-Karłowicz77736000834584142157192230246276296333366388403442493508540571
J,136936000832436
Tykarski14253600083336192125146174204220
A,166536000834256
et174136000833456
al.18183600083324760
Expert189936000833265104140161186
consensus210636000833168106133168206232270296
for24233600083185677
the25213600083216095
diagnosis26363600083385486125163201228243269
and42537000833270109
treatment5523700083224478109131189224263284
of85537000833756
patients9303700083387193109143181203231
with11793700083516689127
hyperuricemia132537000833768108143164203224239271305363378410
and175437000833270109
high18813700083385392130
cardiovascular20293700083316485124139177209242268300338354386407
risk.2455370008320366292106
2023258037000833468101136
update.2735370008337761151484253800083225568
Cardiol5083800083407394132147185201
J.72438000832437
202377638000833468101136
Dec92738000834681114
29.10563800083346879
6.42539000853652
Bieber4943900083355185125160181
JD,6923900083257181
Terkeltaub7913900083326384115149164187220257296
RA.11043900083367993
Gout:121439000834483121144157
on138839000833776
the14813900083216095
brink15933900083386076113144
of175439000833756
novel182739000833876108142158
therapeutic20023900083226095116149188224262284299331
options23503900083387799115153191217
for25843900083195678
an267939000833270
ancient2766390008332701021174254000083347294
disease.5344000083385379114146173208220
Arthritis7694000083416287125146162184200226
Rheum.101040000833674109147204218
2004124340000833468104141
Aug;50(8):2400-2414.139940000834178117129164198218252270281317349384421444475507538569581
7.42541000853645
Zhu48441000833876113
Y,61241000833543
Pandya66941000833667105145176209
BJ,8934100083356072
Choi97941000834078116132
HK.11254100083448095
Comorbidities123441000834077136174195235251289305327342377404
of165241000833857
gout172341000833877115137
and187541000833270109
hyperuricemia199841000833868108144165203224240272306364379411
in242341000831553
the24904100083226095
US259941000834476
general268941000833873111146168201216
population:42542000833977117155171203225240278316328
NHANES76942000834489130175209243
2007-2008.102742000833468104137155186220257292305
Am134842000834199
J1462420008324
Med.150242000835489129142
2012165942000833468100130
Jul;125(7):679-687.1804420008324627889119149184202237256268303336370393430466499505
8.42543000853652
Gaffo4974300083447696115153
AL,6694300083417387
Jacobs7764300083245688125165191
DR98743000834582
Jr,10884300083254656
Sijtsma1163430008333486385113171203
F,138643000833238
et144443000833456
al.15204300083324760
Serum16004300083326789127185
urate18044300083385992114147
association19714300083325885123156171203225240278317
with23074300083516689127
hypertension245443000833768108144165189223261288302340379
in285343000831452
young42544000833168107145184
adults:62644000833271109124147174187
analysis83144000833169102117149176191217
from10664400083184077136
the12194400083226095
Coronary13324400083407799136174207228262
Artery16124400083416286120141176
Risk18054400083365177107
Development193044000834581113147163201241299334372394
in234144000831553
Young241244000833569107145184
Adults261444000834179117132154182
cohort.2814440008331684254500083387697122135
Ann57645000834179117
Rheum70845000833574109147204
Dis.9284500083456187100
2013104445000833468100130
Aug;72(8):1321-137.118945000834178117129162196214247265277307337369401420450480512519
9.42546000853649
Zoccali48946000833875107138171186201
C,70446000834053
Maio77146000835587103141
R,92646000833549
Mallamaci98946000835587103118150208240272287
F,129046000833339
Sesti13434600083326794117133
G,149046000834357
Perticone15614600083356990115130162199237272
F.184746000833339
Uric19004600083446581112
acid20274600083316479118
and215946000833169109
endothelial228246000833472111149171209244260275307322
dysfunction2618460008338709711715619422625026542547000833776
in51647000831553
essential5844700083346187122160182197229245
hypertension.84447000833768108144165189223261288302340379392
J1251470008325
Am129147000834199
Soc140547000833371104
Nephrol.152447000834580119157179216232245
2006178447000833468104140
May;17(5):1466-1471.193947000835587118131161191207241259271301332368404427458489521553563
10.4254800085356983
Kuo52148000833471108
CF,6424800083397176
Yu73148000833569
KH,8124800083358092
Luo91648000833168105
SF,10334800083336469
et111548000833355
al.11824800083324759
Role12544800083347287122
of138848000833755
uric14564800083365772104
acid15724800083316377116
in170048000831451
the17644800083215993
link1869480008315296696
between19774800083387395147181216253
arterial22424800083325276110130145177192
stiffness2446480008326486382101139174200226
and268448000833269107
cardiac280348000833163844254900083375283114
hypertrophy:55149000833767106140161185205242280318347360
a923490008331
cross-sectional9664900083315288114140160186220252275290327364395410
study.13884900083264885123154164
Rheumatology156449000833472106142199230251287303340378409
(Oxford).19854900083196494115151172209228239
201022364900083336697128
Jun;49(6):1189-1196.23764900083236097109142174193225243254283310340373396426453482516529
11.4255000085366678
Kang52250000833568107146
DH,68650000834691103
Park8085000083356788119
SK,9465000083326782
Lee104650000833266101
IK,11665000083155065
Johnson125050000832462101139165203242
RJ.15115000083356274
Uric16045000083446580112
acid-induced17355000083326479118140156194233271303337376
C-reactive21305000083405476110142174198213246280
protein24295000083386097119153168206
expression:2654500008334651051261601872142294255100083377688
implication52951000831572111127142174207229244282321
on86651000833775
cell957510008332658196
proliferation10695100083396098114129148182203236258274311350
and143551000833270109
nitric1560510008338537596112144
oxide17205100083376883122157
production18935100083396098137175207231246284323
of223251000833756
human230451000833875133166204
vascular25245100083316491123161176208230
cells.2770510008331658095121135
J425520008324
Am46452000834199
Soc57952000833271103
Nephrol.69852000834479118157178215231244
200595852000833468104138
Dec;16(12):3553-3362.111152000834681114127157188207239269286298334367399432454486519554587600
12.4255300085366884
Rao52853000833568106
GN,65453000834489102
Corson7755300083407799126164203
MA,99753000835597111
Berk11275300083367192123
BC.12695300083367690
Uric13785300083446580112
acid15105300083326479118
stimulates16475300083265065123160176208229263290
vascular19575300083316491123161176208229
smooth220653000832684122161183221
muscle244653000835895122154169204
cell2670530008331648095
proliferation27855300083386097425540008315304984105138159175213251
by69554000833970
increasing7845400083145284106140172198213251290
platelet-derived10935400083385487108142158192215234275310331347379413453
growth15655400083385996147172210
factor17945400083185284108145166
A-chain19795400083416396134167182220
expression.221754000833466106127161188215229267306319
J2555540008324
Biol25985400083355188104
Chem.272154000834078113171184
199142555000833464100132
May57255000835487118
5;266(13):8604-8608.7055500083344580114149168200230247259294329364401424460495530566579
13.4255600085366883
Moshkovits52256000835493120157187225257273295323
Y,85956000833543
Tiosano9165600083334987114147185224
S,115356000833346
Kaplan121356000833468107123155193
A,142056000834155
et148956000833456
al.15595600083324860
Serum16335600083336889127185
uric18325600083375874106
acid19525600083326479118
significantly20845600083264179117133150167199232270292307339
improves243756000831472111133170202236263
the27145600083226095
accuracy2823560008332644255700083316990123155189
of62957000833757
cardiovascular7015700083316485123139177208241268300338353386407
risk1123570008321366292
score12315700083265895116151
models.139757000835796135170186212225
Eur16385700083326990
J1743570008324
Prev17835700083355589122
Cardiol.19205700083407394132147185201214
2023214957000833569102136
May230157000835487117
9;30(7):524-532.24345700083344782116136170190202237270302325359392425437
14.4255800085367085
Feig5315800083336783122
DI,6745800083466275
Soletsky7705800083337288123146174204239
B,103058000833649
Johnson109958000832564103141168207246
RJ.13665800083366376
Effect14635800083335271106139164
of164858000833757
allopurinol17265800083324863102142181202218257296312
on205958000833877
blood21565800083405695134174
pressure23515800083396196123150188209244
of261658000833757
adolescents26945800083327211012716218942559000833165103125152
with5925900083516689127
newly73459000833772123139171
diagnosed9205900083385385124162200227262302
essential12375900083346087122160182197229244
hypertension:149659000833868108144165190223261288303341379391
a1902590008332
randomized19495900083205391130169227242271305345
trial.2309590008321435890106119
JAMA.244259000832565120162177
2008263459000833468104139
Aug278859000834178117
27;300(8):924-32.4256000083346777112146183202236254266301334366389421454466
15.4256100085367085
Agarwal53361000834181114137191225242
V,79761000833646
Hans86561000834578117145
N,103261000834559
Messerli111361000835591119147183206222238
FH.13746100083327792
Effect14886100083335372108141167
of167761000833858
allopurinol17576100083324965104145184207223262302319
on209861000833877
blood21976100083405696136177
pressure:23966100083396197125152191213248262
a2680610008332
systematic2734610008327608911314842562000835790113129161
review6036200083215689105140192
and81262000833271110
meta-analysis.93962000835793116150173206244277294326354369396410
J1366620008324
Clin14076200083405671110
Hypertens153462000834476117153175201235274301
(Greenwich).18526200083186284119155193245261294332350362
2013223162000833469101132
Jun;15(6):435-442.238062000832462101114144175193227246259294327361384421459492505
16.4256300085367086
Badve52563000833569108141176
SV,7156300083327079
Pascoe8086300083356794127164200
EM,102263000833388102
Tiku11386300083335080119
A,127163000834155
et134163000833356
al;14116300083324860
CKD-FIX148563000834075122147181196235
Study17346300083325492132164
Investigators.19126300083155385120147170186225258280318340368382
Effects23086300083325271105138163191
of251363000833757
Allopurinol25846300083415773111151190211227266304321
on42564000833776
the5176400083226196
Progression6296400083355795135157191219246262300340
of98464000833858
Chronic105764000834079101139178193226
Kidney12996400083355291130166198
Disease.15136400083456188124156184219232
N1761640008345
Engl182164000833371111127
J1964640008324
Med.200464000835490130144
2020216464000833469102137
Jun231764000832463101
25;382(26):25042513.2434640008334708111715218620423927329230534037641144842565000833470101132145
17.4256600085377181
Doria53266000834788111129163
A,72166000834258
Galecki8046600083458097135170202220
AT,10506600083427384
Spino11596600083337592133173
C,135866000834156
et143966000833559
al;15246600083325063
PERL161366000833670108143
Study17816600083345797139173
Group.198066000834568108149190205
Serum22106600083337194135196
Urate243166000834568104127163
Lowering262066000833272126163186203244285
with4256700083526993133
Allopurinol5816700083425975115157197220237277317334
and93867000833373114
Kidney10746700083365495135172205
Function130267000833371111145171188228268
in159367000831555
Type167167000833362104142
11836670008335
Diabetes.18946700083466397138175199235263278
N2195670008346
Engl226467000833373114131
J2417670008325
Med.246567000835693134149
2020263767000833571105141
Jun280167000832565105
25;382(26):2493-2503.4256800083347081117152186204239273292305340373407440463495530565599612
18.4256900085356884
Mackenzie52169000835486117147180218246261295
IS,8296900083144658
Hawkey90069000834375125155188219
CJ,11316900083406678
Ford12216900083326990127
I,136069000831527
et140069000833355
al;14676900083324758
ALL-HEART153769000834172103118163195237273306
Study18556900083325390128160
Group.202769000834364101138177189
Allopurinol22286900083415670108147184205220257295310
versus25506900083326586113149175
usKMl27376900083376397153168
care4257000083316485119
in55770000831553
UK62370000834479
patients7157000083397294109144182203231
with9597000083516689127
ischaemic10997000083154173111144178236251283
heart139670000833772104125150
disease15597000083385379114146173208
(ALL-HEART):17807000083186091123139184218260296330352364
a2157700008332
multicentre,220270000835795110133148180214252273295329341
prospective,25567000083386097124163198231255271303337349
randomised,4257100083215391130168226241267302341354
open-label,79271000833776112150172188220260295310323
blinded-endpoint11287100083385469106145180219242278316355394432448485507
trial.1648710008321435890105118
Lancet.177971000833164102134168190203
2022199571000833468101135
Oct214371000834780104
8;400(10359):1195-1205.22597100083344781117153172204235268301333351363392420450484506537566600634646
19.4257200085367083
Neogi52972000834581120160176
Tuhina.72672000833367105121159192206
Chapter95372000834078111151174208230
19120372000833566
-1290720008321
Asymptomatic133272000834169102162202224262321354376392424
Hyperuricemia:177772000834577118154175214236252284319377393425438
Cardiovascular22367200083407395134149188220254281314352368401422
and267972000833271111
Renal2810720008336724257300083387086
Implications.53273000831573113129144176210232247286324351365
In:9187300083155365
Terkeltaub10047300083336485116151167189223261300
Robert.132573000833674114150172197210
Gout155673000834483122145
&1713730008340
Other176573000834771110145167
Crystal19537300083406195123146179195
Arthropathies.21697300083416388126148185225259281319335370397411
W.B.260073000835869106119
Saunders,2740730008333661041434257400083387394121134
2012,57574000833468100130142
s733740008326
226-238.77474000833469102126157192226240
20.4257500085367287
Williams5257500083577389104118150208234
B,77275000833648
Mancia83375000835487125157172204
G,105075000834357
Spiering11207500083327186121142158195234
W,136775000835767
et144775000833456
al.15167500083324760
[201815897500083185387118149
ESC/ESH175175000833367107134168201245
Guidelines20097500083448297135170186201238273300
for23227500083185677
the24127500083226095
management252075000835789127159198233291326364385
of42576000833757
arterial4977600083325377111132148180195
hypertension].70876000833768108143165189223261287302340379396408
Kardiol11317600083356990128143181197
Pol.13437600083367288101
2019;77(2):71-159.145976000833569100131143176211227261279291324357375406436469480
21.30472700085367082
Mancia314627000835487125157172204
G,336827000834357
Kreutz34422700083355791129152182
R,364227000833549
Brunströ37082700083365795133160183204223223
m3950270008358
M,402527000835568
et411027000833456
al.41842700083324760
2023426127000833468101136
ESH441427000833367111
Guidelines45422700083448297136171186201239274301
for48602700083185678
the49552700083226095
management506727000835790128160199234292327365387
of547127000833756
arterial30472800083325378111133148180196
hypertension325828000833768108144165189223261288302340379
The365228000833372107
Task37752800083326087116
Force39072800083327091122156
for40782800083195678
the41712800083226095
management428128000835890128161200234292327365387
of468328000833857
arterial47552800083325378112133149181196
hypertension496628000833868108144165190224262288303341379
of536128000833756
the54332800083215994
European30472900083326889126165200232269
Society332929000833270102117151173206
of354829000833655
Hypertension:361629000834475114150170195228266291306343381393
Endorsed402229000833269108146167194228267
by430229000833869
the43832900083226094
International44902900083145273106127165197218233271309341356
Society485829000833370103117152174207
of507729000833756
Hypertension514629000834375114149170194228265291306343381
(ISH)30473000083183364107125
and318430000833168106
the33023000083225993
European34073000083326888125163198229266
Renal368530000833569106137152
Association38493000083416893131162177208229244281318
(ERA):41793000083195185127145157
Erratum.43483000083325273105126163220233
J4593300008323
Hypertens.462830000834475114148169193226263288301
2024;41(12):1874-2071.49413000083346799130141175205219250279296308337367399429451481514546577586
22.30473100085367288
Bletsa31513100083355186108136169
E,333631000833346
Paschou33983100083356794126164202240
SA,36543100083337488
Tsigkou37583100083325469108138175214
V,398831000833544
et404831000833456
al.41213100083314760
The419731000833272107
effect43203100083345372107139163
of449931000833857
allopurinol45723100083324762100140178199215253291307
on489531000833776
cardiovascular49873100083316485123139177209241268300338353386407
outcomes54103100083377598304732000833168126161188
in325632000831452
patients33293200083387193108143181203230
with35803200083506688126
type37273200083215595131
23878320008334
diabetes:39333200083385385124160182216243255
a4208320008332
systematic42613200083265885108142200232254270301
review.45833200083205587103137188199
Hormones480332000834482104162200239274301
(Athens).51243200083196081119154192219236247
2022539132000833468101136
Dec;21(4):599-610.304733000834581113126161193208241258270305338373397434464495508
23.30473400085367287
Rahimi-Sakak314934000833568106121179194216248281311344374
F,353834000833238
Maroofi359134000835487108145184202219
M,382434000835568
Rahmani390734000833568106164196234249
J,417134000832436
et422134000833457
al.42923400083324760
Serum43673400083326789127185
uric45663400083375974106
acid46873400083326479118
and481934000833270109
risk4943340008320366292
of504934000833857
cardiovascular51213400083316485123138176208241267300337353385406
mortality:304735000835795117141174189204227260274
a3334350008331
systematic33783500083265985109142200232254269301
review36923500083205486102137188
and389235000833270109
dose-response401435000833876102137160182216243282320359385420
meta-analysis444735000835792114147169201239271287318345360386
of484635000833756
cohort491535000833168106144166190
studies51183500083264987126141176203
of533335000833857
over540335000833769103124
a3047360008332
million30943600083577388103118156194
participants.33043600083387192117132164179218251289311339352
BMC367236000833590131
Cardiovasc38183600083407394132147185217250277309
Disord.41423600083456187125147185198
2019435636000833468100130
Oct450136000834780104
15;19(1):218.46203600083346475105135155186201213248279310324
24.30473700085356984
Virdis31433700083355171108123148
A,330337000834154
Masi336937000835485111125
S,350637000833244
Casiglia35633700083397197111149163178209
E,378437000833244
et384037000833455
al.39073700083324659
Identification39783700083145286123144159176193224256277292329366
of435637000833755
the44233700083225993
uric45283700083375772103
acid46433700083316377115
thresholds47703700083215979112138175212227265291
predicting50733700083385992131145176199214251289
an537437000833168
increased54543700083155230473800083315285116143177216
total32753800083225879112127
and341438000833169107
cardiovascular35343800083316384121136173205237263295332347378399
mortality394538000835795116140172187202224257
over421438000833769102123
20435038000833367
years.44293800083316496116143156
Hypertension.459838000834475114149170194227265290305342380393
2020;75(2):302-308.500338000833468100133146178210228261278290325358391411442476511524
25.30473900085367287
Bos314839000833574100
MJ,32623900083548092
Koudstaal336839000833472110149175199231264279
PJ,36603900083365567
Hofman374039000834483102161193231
A,398539000834155
et405339000833456
al.41233900083314760
Uric41963900083446580112
acid43223900083326479118
is445339000831541
a4507390008332
risk4552390008321376393
factor46583900083185284108145166
for48383900083185677
myocardial492939000835788125158191212250265297313
infarction52553900083155372105126157181197235273
and304740000833270109
stroke:31714000083264971108139173185
the33724000083216095
Rotterdam34824000083357395120153175213245303
study.38004000083265087127158168
Stroke.39844000083325375112143177189
2006418840000833569105140
Jun;37(6):1503-1507.434440000832462100112147179195228247258288318352385407438468502535541
26.30474100085367187
Tian31504100083334981119
X,328541000833851
Wang335241000835788126165
P,353341000833539
Chen358841000834077112151
S,375441000833245
et381441000833457
al.38864100083324760
Association39614100083416996134167182214236251289327
of430441000833756
Normal437641000834483104163195210
Serum46024100083326788127184
Uric48024100083446580112
Acid49294100083417388127
Level50714100083316698132148
and523441000833270109
Cardiovascular53584100083407394132147304742000833769102129161199214246267
Disease33304200083456187122154180215
in356142000831552
People362942000833569107147163198
Without38424200083587496135173211233
Risk40914200083355177107
Factors42144200083326194118155176203
for44334200083185678
Cardiac45264200083407394132147179212
Diseases47534200083466187122154181216242
in501142000831553
China.50794200083407893131163176
J5271420008324
Am531142000834199
Heart54254200083458030474300083325378
Assoc.31404300083416995134166180
2023333543000833468101136
May348643000835587118
16;12(10):e029633.36194300083346678108138155187218237249283319352386421455488500
27.30474400085367180
Tian31404400083334981119
X,327344000833851
Wang333844000835788126165
A,351744000834155
Wu358544000835794
S,369244000833346
et375144000833456
al.38204400083324860
Cumulative389444000834076134172187219241256289323
Serum42304400083336889127185
Uric44284400083446581113
Acid45544400083417287126
and469444000833169108
Its48164400083153765
Time489444000833249107142
Course504944000834077115136164199
Are52614400083416296
Associated5371440008340689513330474500083314678100134173
With32354500083577396134
Risk33834500083365177107
of350545000833756
Myocardial357645000835486123156189210248263295311
Infarction39014500083155372105126157181197235273
and418845000833270109
All-Cause4312450008341567193136169207233268
Mortality.459445000835593115140172188203225259269
J4877450008324
Am491645000834199
Heart502945000834479111132157
Assoc.52004500083416996134167180
2021539445000833569102133
Jul30474600083246277
6;10(13):e020180.31404600083344676108127159189206218252288321355387418453466
28.30474700085367288
Tian31504700083334981119
X,328447000833852
Chen335047000834078113151
S,351647000833345
Xu357647000833874
Q,366547000834761
et374047000833457
al.38114700083324760
Cumulative388647000834077134172187220241257289323
Serum42244700083336889127185
Uric44244700083446480112
Acid45514700083417287126
Exposure469247000833365105143170207229263
and496947000833270109
Its50934700083153765
Time517347000833249107142
Course532947000834077116137164199
With30474800083577496134
the31964800083226095
Risk33074800083355177107
of342948000833756
Incident35014800083145285100139173212233
Stroke.37494800083335475113143177190
Stroke.39544800083325475112143177189
2023415848000833569102136
Aug;54(8):2077-2086.431048000834178117129164199219252270282317351384419437468502538573586
29.30474900085367387
Lv315549000833261
Q,323749000834862
Meng331949000835591130169
XF,35094900083397278
He360849000834480
FF,37084900083336672
et380149000833456
al.38784900083324861
High39604900083456099138
serum41194900083266283122181
uric43204900083386075108
acid44494900083326480119
and458949000833271110
increased47204900083155386108142174201237277
risk5018490008321376393
of513249000833857
type52104900083225697133
25364490008334
diabetes:5419490008339548630475000083397598133160173
a3241500008332
systemic32945000083276088111146205220253
review35685000083215689105140192
and378150000833371111
meta-analysis391350000835894117150173206245278294326354369396
of433050000833858
prospective44095000083396199126166202236260276309344
cohort477450000833270109148170195
studies.49905000083275089129145180207221
PLoS523250000833668106139
One.539250000834787122135
2013;8(2):e56864.304751000833468100130141177196230247259294328363398433470482
30.30475200085357185
Han314452000834375112
T,326852000833240
Lan332052000833164101
L,343352000833144
Qu348952000834683
R,358452000833548
et364552000833354
al.37125200083314658
Temporal378252000833262118157194215247262
Relationship40565200083356984115136151188225251288302340
Between44085200083356991143176211248
Hyperuricemia466852000834374113148168206226241272305361376407
and508752000833168106
Insulin52055200083155277114128143180
Resistance5397520008334699510930475300083264880118149182
and324153000833169107
Its33605300083143663
Impact343553000831572110142174197
on364453000833775
Future37315300083326789126147180
Risk39235300083355076105
of404053000833755
Hypertension.410853000834374113148169193226263288303340378390
Hypertension.451053000834475114149169193226264289304341378391
201749135300083346798127
Oct;70(4):703-711.505253000834778102115147179198230247258291323356377408439466475
31.30475400085366981
Li314354000833147
B,320454000833548
Chen326654000834078113151
L,343154000833246
Hu349154000834482
X,358754000833851
et365354000833456
al.37235400083324760
Association37985400083416895133166181213235250288326
of413954000833756
Serum42105400083326788127184
Uric44095400083446480112
Acid45355400083417388127
With46765400083577396134
All-Cause4824540008341577294137170207234269
and510754000833270109
Cardiovascular5230540008340739413214718521725027730475500083316984117138
Mortality320055000835493114139172187202225258
in347455000831452
Diabetes.35425500083456092132167189223250264
Diabetes38215500083456193132168190224250
Care.40875500083407294128140
2023424255000833468101136
Feb439355000833367106
1;46(2):425-43345145500083354377114133166184196231263298320357389422
32.30475600085367288
Adamstein315656000834180113172199223257273311
NH,348856000834591104
MacFadyen361356000835588121154185224257292331
J,396556000832436
Weber402256000835992132169190
BN,42335600083368295
et434956000833558
al.44285600083324861
Abstract451056000834181109132154188221245
12593:477656000833565101134167179
Associations49765600083417097136169185217239255294333360
of535756000833757
Serum543556000833369304757000832159117
Uric31825700083446581113
Acid33135700083417287126
and345857000833270109
Cardiovascular35855700083407394132147185217250277309347362394415
Events40195700083336499137158186
in422357000831553
a4294570008332
Clinical43455700083405570108123155187203
Trial4566570008333506698113
of469857000833756
IL-1β4773570008314466192127
Blockade.49185700083365189122152186225260272
Circulation.52085700083405577108145161193215230268306320
2023;148:A12593.304758000833468101136147177208244257299329359394426459471
33.30475900085367186
Mancia315059000835487125157172204
G,337159000834457
Kreutz34455900083355892130152183
R,364559000833549
Brunström37115900083365795133160183204241300
M,402859000835467
et411259000833457
al.41865900083324760
2023426359000833468101136
ESH441659000833266110
Guidelines45435900083448297136171186201239274301
for48615900083185678
the49565900083215994
management506759000835890128160199234292327365387
of547159000833756
arterial30476000083325378111133148180196
hypertension325860000833768108144165189223261288302340379
The365260000833372107
Task37756000083326087116
Force39076000083327091122156
for40786000083195678
the41716000083226095
management428160000835890128161200234292327365387
of468360000833857
arterial47556000083325378112133149181196
hypertension496660000833868108144165190224262288303341379
of536160000833756
the54336000083215994
European30476100083326889126165200232269
Society332961000833270102117151173206
of354861000833655
Hypertension:361661000834475114150170195228266291306343381393
Endorsed402261000833269108146167194228267
by430261000833869
the43836100083226094
International44906100083145273106127165197218233271309341356
Society485861000833370103117152174207
of507761000833756
Hypertension514661000834375114149170194228265291306343381
(ISH)30476200083193466110128
and318962000833270109
the33126200083215994
European34206200083336990128167203235273
Renal370662000833671109141156
Association38766200083416995134166181213235251289327
(ERA).42176200083185186129148159
J4390620008324
Hypertens.442862000834476116151172197231269295309
2023475062000833569102136
Dec490062000834581113
1;41(12):1874-2071.50276200083344277107122154184202214244275308338361392426459491501
34.30476300085367388
Williams31516300083577489104119151209235
B,340163000833548
Mancia346463000835587125157173205
G,368463000834357
Spiering37566300083327187121143158196235
W,400663000835867
et408963000833456
al.41606300083324760
2018423563000833468100131
Practice43816300083355689121145161193226
Guidelines46226300083448297136171187202240275301
for49396300083185677
the50316300083226095
management514163000835890128160199234292327365387
of304764000833757
arterial31206400083325378112133149181196
hypertension333364000833768108143165189223261288302340379
of372964000833756
the38026400083226095
European39146400083326990127167202234272
Society420364000833371104119153176209
of442964000833857
Hypertension450364000834476116151172197231269295310348386
and490664000833270109
the50326400083226095
European51446400083326990127167202234272
Society54336400083337130476500083314681103137
of320165000833757
Cardiology:32746500083407394132148186202240279311325
ESH/ESC361665000833266110136170203244
Task38776500083326087117
Force40116500083326991122156
for41846500083185677
the42786500083226095
Management439065000835487125157196231289324362384
of479165000833756
Arterial48646500083416387121142158190205
Hypertension.508665000834476116151173197231269295310348387400
J5503650008324
Hypertens.304766000834476116151173197231269295309
2018337166000833569100131
Dec;351866000834580113126
36(12):2284-2309.36596600083356988120150168179215249283319342373408443478489
35.30476700085367186
Unger315167000834482121155177
T,334667000833341
Borghi34066700083357395133171186
C,361067000834053
Charchar368267000834077110131162200232253
F,395467000833238
Khan401067000833574107145
NA,417367000834586100
Poulter429167000833572110125148182203
NR,45126700083458195
Prabhakaran46256700083355689128166199229262284317355
D,499867000834556
et507267000833457
al.51476700083324760
2020522567000833468101135
International5379670008314527410812930476800083387092108146185217233
society33006800083266598113148171205
of352568000833857
hypertension360368000833768108144166190224263289304343381
global40056800083385492132165181
hypertension420668000833869109145166191225263290305343382
practice46086800083396194127151166199232
guidelines.48616800083387692131166182197235270297311
Hypertension.51926800083457711715317419923327129831330476900083377689
2020;75((6)):1334-57.315169000833468101135148181214232249282300317329359388421457480514547553
36.30477000085367288
Unger315470000834482121155177
T,334970000833341
Borghi34097000083357495133171186
C,361470000834053
Charchar368570000834078110131162200232254
F,395770000833238
et401470000833456
al.40887000083324760
EULAR416770000833276107151186
recommendations43727000083205587124182240275313352385406422460498525
for49157000083185677
cardiovascular50117000083316485123138176208241268300338353385406
risk5436700008320366292
management304771000835993132166207243303339379402
in347071000831555
rheumatic35477100083216197137197230253269303
and387171000833373113
musculoskeletal400671000835998126159199215254282314349366402425460476
diseases,45037100083405683119153180217245259
including47847100083155488104143183199239279
systemic50857100083276189113149209225258
lupus53657100083155495134162
erythematosus30477200083345589114152187245277299336363400426
and348772000833170109
antiphospholipid36097200083327091106146184222249288327365381396435450489
syndrome.41127200083265897136157194253288300
Ann442572000834179117
Rheum455672000833573108146204
Dis.47737200083466187101
2022488772000833468101136
Jun503672000832462100
81(6):768-779.51507200083346681114132144177209245267299333366377
37.30477300085367079
Sato31457300083326587124
Y,328873000833543
Feig33507300083326682120
DI,34897300083456174
Stack35827300083325386118148
AG,37497300083418497
et386573000833456
al.39407300083324760
The401973000833272107
case41447300083326591126
for42897300083185677
uric43857300083375974106
acid-lowering45107300083326479118140156195246280301317355394
treatment49237300083214377109130188223262283
in522573000831452
patients52967300083397294109144182203231
with30477400083516689127
hyperuricaemia318974000833868108144165203224240272305340398413445
and364974000833270109
CKD.377374000834075122133
Nat39227400083447799
Rev403674000833570102
Nephrol.415474000834480119157178216232244
2019441474000833468100130
Dec;15(12):767-775.455974000834681114127157187204236266284296329361394413444478511523
Další45987520011061108131169193
literatura480975200110244779125158204236287320366
u51947520011051
autorů5264752001104597129179212264
a41207620011046
na4184762001105298
www.casopisvnitrnilekarstvi.cz430176200110671372082272673143524034574805185656186416737057587818048528989459781016104910971121114311841226