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ČLÁNKY88722001003973122176223272
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astmatu11263300100346390151186212251
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přímo186962001075079100176227
stimuluje21266200107346586162212233283304350
mastocyty2506620010774117153184233276321354399
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také181576001072871111156
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interakci23617600107196897141170213253294314
bronchiálního26987600107497812717742590001074090111153174223244295346
epitelu80190001074395116146190212261
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tohoto425118001072876127177206255
proteinu701118001075079128157201221271320
se1043118001073480
ukázala1144118001074888132171215236278
jako1444118001071961101150
vysoce1616118001074085121171214259
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cesta2240118001074084119150193
léčba2455118001071965108159202
těžkého2679118001072872111151196425132001074898
refrakterního55313200107267197126170209242286315365386437488
astmatu1070132001074176107182225254304
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lékařem768160001071965105149177222297
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účinků2669174001074887105152189236
zahrnuje425188001073679127153202249268312
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respirační2041188001072669103152171198239280328346
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infekce,263718800107196790134172211254268
pruritus425202001075077125151171199247280
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vzácně785202001074179122162210255
také1059202001072869107150
anafylaktické1229202001074189130153197217257295326345385423466
reakce1715202001072669109147187229
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Interleukin-3356521600107196591133158177220266303323369396436476
(IL-33)10572160010723418098137178198
je1270216001071962
produkován1347216001074975121170216253299338379425
zejména178821600107367795167210257297
fibroblasty210021600107234291117162211230270302330371
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plic,144223000107506987127142
jeho1600230001071962110158
produkce1774230001074976122172218256295336
je2126230001072063
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také2757230001072768106148
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traktu.162324400107285596134165213229
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pro2348244001074976123
interleukin-249724400107196794136163182226274312332380408
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který636258001073868111137180
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imunity2420258001071992140188206234277
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Th22771258001074292135
lymfocytech.425272001071960135159207248291322365407455472
Monoklonální9232720010771120169218257278326375416436484502
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blokující1872272001075070119158206225244285303
IL-33220227200107196078119161
je2390272001071963
itepekimab.248027200107194790140185224244318360410425
Jeho425286001073175124172
účinnost624286001074788106154203251285314
je964286001071963
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v14312860010740
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studiích1993286001073362110160179197237285
fáze2305286001072365103146
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a25472860010741
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výsledků882300001074184118136180231268316
je1223300001072063
léčivo1311300001071963104123164211
vhodné1547300001074190138188236280
pro1852300001075077124
pacienty2001300001075091132150194242269312
s23383000010733
eozinofily2396300001074493128147195244268287306346
nad2767300001074889138
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mikrolitru,713314001077392130158205225243271298346362
pacienti1098314001075091132151194242269288
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počtem1720314001075099140170213286
eozinofilů2030314001074392128147195243267287306353
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jeho2466314001071963111160
podání2649314001075099149190238256
neprofitovali425328001074892142169216240260288335375416435454
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Interleukin-2531876200107196692134160178222268305325372400438481
se368462001073376
jeví377662001071962102121
jako39126200107195996143
další407062001074989107139156
možný4242620010773121156203241
terapeutický44996200107276995136184228275303321360397439
cíl49546200107405878
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léčbě510462001071962102150194
těžkého531462001072869105143185304776001074795
refrakterního31577600107266891118158195225266292339357406453
astmatu.362576001074073101173213239286301
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cytokin415476001073980111156193213259
aktivuje442976001074077107125165212230273
Th2471776001074290132
buňky,486476001074996143180221232
bazofily,511276001074989125171194213231270281
eozinofily540876001074391304790001073655102150173193211250
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mastocyty.3370900010773113146174220261303333375387
Pravděpodobně377390001074570111150198241290338388435485533576
se436590001073477
také445890001072868106148
podílí462290001075098147166186204
na484290001074888
neoangiogenezi494690001074891140181228277295342392435483526563581
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remodelaci3110104001072669143191241285305345386404
dýchacích3536104001074990129177218258277317365
cest.3923104001074082116145161
Humanizovaná41061040010757105178219267286322369409451499540
monoklonální46681040010773122170219257278326375415434482501
protilátka5191104001074976123151169188229256294336
brodalumab3047118001074976123172213231278351391440
(již35041180010723446298
schválená3619118001073373121160201220263311351
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která5069118001073868110136178
blokuje5263118001074969116155202221264
jeho3047132001071962109156
účinek3219132001074786104150194231
je3465132001071962
nyní3543132001074784132150
předmětem3709132001074975116165237280307348420
klinického414513200107385775122139179216257305352
zkoumání,4512132001073674120167239278325343358
studie4885132001073362108157175217
fáze5118132001072364100142
252761320010743
zatím5335132001073576103121193
nepřinesly3047146001074892142169188236280314332372
pozitivní3439146001075099134154182200242291309
zprávy3768146001073686113155195238
o40261460010747
jeho4093146001071963112160
účinností4273146001074788106154202251284313332
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případě468514600107507696145187236280
astmatu4985146001074174103177218245293
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Závěr30471710013862123184242288
Cílem318718800107516989132204
léčby3407188001071962102151189
astmatu3612188001074173102174214241288
je3916188001071962
plná3994188001074968115155
kontrola4164188001073885132158185231250290
symptomů4470188001073373146195222268341387
a48731880010740
prevence4929188001074976118158200247287329
exacerbací.52731880010744831231632042303047202001074990129147162
Pro3225202001074570116
adekvátní3357202001074088131169211252278326344
léčbu3716202001071962102151198
je3930202001071962
potřebná4007202001074997124150192240288328
precizní4350202001074976118158176212259277
diagnostika4643202001074866106154201248281309328364406
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vyloučením5113202001074183102149196236277324342414
jiných304721600107193886124164212
nemocí,3285216001074892166215256274290
které3601216001073869111138181
mohou38082160010774122171219267
astma4101216001074175104178218
bronchiale4345216001075077124173213261280320339383
připomínat,475421600107507796145194268287335376403419
případně519921600107507796145187236284328
diagnostika3047230001074866105153200247279307325362403
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léčby3521230001071961101149187
komorbidit,3724230001073783155203228277296343361388404
které4143230001073767109134176
kompenzaci4334230001073884156204248294330371411428
astmatu4778230001074072100172212238285
dále5078230001074888106148
zhoršují.5242230001073583130156189235253270285
U30472440010757
části3130244001074082116145164
pacientů3320244001075092133152196244272320
se3666244001073478
nedaří3771244001074893143184211230
dosáhnout4028244001074997131173222270319367396
plné4450244001075070118163
kontroly4639244001073986135162189237257297
nad4962244001074990140
nemocí5128244001074993167216258276
při543124400107507796
použití30472580010750100149186206235254
konvenčních3328258001073886136176220269310358377418467
léčebných3822258001071964105148199248287328376
postupů.42252580010750100134164213263312327
V45792580010746
takovém4652258001072870109157198242316
případě499525800107507897148190240285
je5306258001072064
potřebné53972580010751100304727200107285496145194237
včasné3301272001074079120153200244
odeslání3561272001074897141174193233280299
pacienta3876272001074990131149192240266307
do4200272001074896
centra4312272001074082130156183224
pro4552272001075076123
obtížně4691272001074897125143179228271
léčitelné4978272001071963104122149192211258302
astma,5296272001074173102175216231
kde3047286001073887132
je3206286001071963
možné32962860010775124160209254
indikovat3576286001071968118137175223264306333
cílenou393628600107405980125174223271
léčbu.4234286001071964106155204221
Většina4481286001074789118153171220261
dostupných4769286001074998132161210260309348388437
biologik5233286001075069118138187237256294
cílí30473000010740597998
na3170300001074989
eozinofilní3285300001074493128147195244268287306354372
zánět3683300001073679127171198
dýchacích3907300001074989129177218258277317365
cest,4298300001074082116145161
pro4485300001074976123
pacienty4634300001075091132150194242269312
s49713000010734
méně50313000010773118166210
častým5267300001074081114143186260
neeozinofilním3047314001074993138188223243291340365385404452471545
astmatem3618314001074175104179220247290365
může40093140010774122159202
být4238314001075090121
zváženo4386314001073681122160203252301
podání47133140010750100150191240259
tezepelumabu4998314001072871109152202248267315389430480529
(v3047328001072463
programu3130328001074976123173200241315362
časného3512328001074082115163207255304
přístupu).383532800107507796129158206255303325338
PROHLÁŠENÍ48535800974387144199239292335376430452
AUTORŮ:954358009749101143200245299316
Prohlášení128635700984573119166187229263305352373
o1674357009845
původnosti:173535700984693134179227274320354383404423
Publikace217435800954082127144161195233269308
byla24983580095447997133
zpracována264735800953378102139176218254291334371
s3034358009529
využitím307935800953775119152169195212277
uvedené337235800954380119163203246286
literatury3674358009517335997121158183226249288
a3978358009536
nebyla403035800954383127163181217
publikována426335800954487132150166200243279316359396
ani46753580095367996
zaslána478735800953270100117153197233
k5036358009534
recenznímu50863580095236299137180213257274340382
řízení4853700095244174112156172
do67537000954387
jiného7793700095173477117160203
média.1000370009565105150167203218
Střet12353690098426998141170
zájmů:142136900983679100169215234
Žádný.167237000954380125168202214
Financování:190336900984161108149195232277318359406427446
Ne.236637000955191104
Poděkování:248736900984590137180221266307348395416435
Ne.293937000955191104
Registrace306136900984688135156190219248290326368
v3445369009841
databázích:350336900984687116158205247284306342389408
N/A.392737000955180122139
Projednání408336900984573119141183231278319365387
etickou44863690098417192128170214261
komisí:476336900984186155176210231250
N/A.503037000955180122139
LITERATURA426393001234978134189250318368438498567
1.42541000853648
Global4864100083435997136169184
strategy6834100083264970103125158198229
for9254100083185677
Asthma10154100083416891129187219
Management124741000835486124156195229287322360381
and164141000833169108
Prevention,17624100083355589121155193214229267305318
GINA209341000834359103144
Main225041000835487102139
Report240241000833570109148169193
2024.260841000833468101132145
Available2765410008341721041194254200083154786102137
from5774200083194178136
https://ginasthma.org/2024-report/72942000833759831221491621892092452602983303573804184765085215595816196456807147477798028248588979369589821010
(cit.1754420008319496486100
25.18694200083346981
8.196542000833448
2024).202842000833468101133151162
2.42543000853652
Mortimer49643000835493114139154212247268
K,78343000833550
Lesosky8524300083316592130157187221
M,109143000835568
García-Marcos11784300083447798129144176198254287308339376403
L,160043000833145
et166343000833457
al.17384300083324861
Global18174300083446098138171186
Asthma20224300083416992130188220
Network226143000834580102155193214245
Phase252543000833572105131166
I2710430008315
Study27444300083325391130162
Group.42544000834465103141180192
The63144000833272107
burden7514400083397798137171210
of97444000833757
asthma,10444400083325982120178210223
hay128144000833770100
fever13954400083185385119141
and154944000833270109
eczema16724400083346697131189221
in190744000831553
adults197344000833271109124146174
in216144000831452
17222744000833463
countries:230444000833168106144166187203238264277
GAN259544000834385130
Phase273944000833572105131166
I425450008315
study.4554500083264987126158168
Eur6394500083326990
Respir7444500083367197136152173
J.93245000832537
202298445000833469101136
Sep113645000833267106
15;60(3):210286512584500083346475110146165199216228263295326359393428462
3.42546000853651
Asher49346000834169107142163
MI,6734600083546982
Rutter7724600083357395120154175
CE,9634600083407386
Bissell10664600083355177103138154169
K,125246000833449
et131846000833456
al.13914600083314760
Global14674600083446098138171186
Asthma16704600083416992130188220
Network190746000834479102155193214245
Phase216846000833673105132167
I2351460008315
Study23834600083325391130162
Group.256246000834465103141180192
Worldwide27714600083579411542547000831554105121159194
trends6394700083214377115154180
in83947000831452
the9104700083226095
burden10244700083397798137171210
of125347000833756
asthma13294700083325881119177210
symptoms155847000832658117156178215274300
in187747000831553
school-aged19494700083265896135173189212244283318357
children:2326470008331698499138159193231243
Global25894700083435998137170186
Asthma2794470008341699242548000833895128
Network56848000834580102155193214245
Phase82848000833573105132167
I1010480008315
cross-sectional10404800083315390117143164191226259283298336375407422
study.14784800083264987126158168
Lancet.166148000833265103135169191205
2021188148000833468101132
Oct202948000834779103
30;398(10311):1569-1580.21484800083346881116150185204235267300331358373385415445479513536567597631667679
4.42549000853651
Stern4884900083325386107145
J,64549000832436
Pier6934900083354984104
J,81049000832435
Litonjua8584900083314668104142157194226
AA.10964900083418398
Asthma12064900083416891128185217
epidemiology14364900083337287125160217232269285322361393
and184149000833269107
risk1961490008320366191
factors.20644900083185183106143164191204
Semin228049000833367124139176
Immunopathol.246949000831471128166203241280312333371409424437
202042550000833468101135
Feb;42(1):5-15.57650000833266105117152185202234248260295317348378390
5.42551000853651
Molnár49751000835593109147180201
D,71951000834556
Gálffy7965100083447792112131166
G,98251000834458
Horváth106051000834583105140173195233
A,131451000834155
et139051000833456
al.14675100083324861
Prevalence15485100083355691123156172207245277311
of188051000833757
Asthma19575100083427093131189222
and220051000833270109
Its23305100083143765
Associating24155100083427096135168183215237253291330
Environmental2766510008332701021184255200083215896154189227249282297
Factors7375200083336294118155177204
among95652000833290128167206
6-12-Year-Old11775200083345889118139171203234256275325341380
Schoolchildren157252000833365103141180196228266281296335356391429
in201652000831552
a2084520008331
Metropolitan213152000835489111133170210249264279302335373
Environment-251952000833370102117139176214272307345367386
-A42553000832162
Cross-Sectional,5035300083406198125151172204239271295311349387419435447
Questionnaire-Based96653000834785120147170185223261299332347368402425462495522557596
Study.15785300083325391130162172
Int17665300083155374
J1856530008324
Environ189653000833270101117138175214
Res21255300083367198
Public223853000833573112128143174
Health.242853000834479111126149187200
2021264453000833468101132
Dec279253000834581113
20;18(24):13403.4255400083346881111142161195227244256286316352387421433
6.42555000853651
Papadopoulos49055000833567106139178216256294332348386412
NG,91555000834590103
Miligkos10315500083547085100139169206233
M,127755000835467
Xepapadaki135755000833972111144183216255287317333
P.170355000833641
A1757550008341
Current18115500083397697119153191212
Perspective20365500083356990117156192224248263296330
of237955000833757
Allergic24495500083415671106127165180212
Asthma:26745500083416992130188220232
From4255600083325289148
Mechanisms58856000835489122160192230245272329356
to95956000832258
Management.103356000835487125157196231289324362384397
Handb144556000834477115154193
Exp165356000833365105
Pharmacol.177356000833573105126185217249286302315
2022;268:69-93.210356000833569101136149184217253265300334358393426438
7.42557000853645
Oppenheimer48757000834787126162200238273288346381402
J,90757000832436
Hoyte96057000834483114139172
FCL,115057000833272104117
Phipatanakul12855700083357287126159181214252284314353368
W,167057000835867
et175557000833456
al.18285700083324861
Allergic19065700083415671106127166181213
and213657000833270109
eosinophilic226257000833473100114152191230269284299314346
asthma26255700083325982120178210
in285257000831553
the4255800083226096
era5415800083345689
of65158000833757
biomarkers7295800083385493151184205236271292320
and106958000833271110
biologics:12005800083395493109147187203235263275
similarities,149658000832641100115130163184200223238273300314
differences1830580008339547493128149184222254288316
and216658000833271110
misconceptions.22975800083577399132169208240274314336352390429455469
Ann278758000834179118
Allergy4255900083415672106128166198
Asthma6385900083416992130188220
Immunol.87459000831572130168206244260273
2022116259000833468101136
Aug;129(2):169-180.131359000834178117129160190224243277295307336367401425456487522535
8.42560000853652
Peri4926000083356990105
F,61260000833238
Amaddeo66560000834199131170209244283
A,96260000834155
Badina103260000833568107123160193
L,123960000833245
et129960000833456
al.13706000083314760
T2-Low14446000083336889122159210
Asthma:16696000083416992130188220232
A1916600008341
Discussed19716000083466187120157184210245285
but227060000833977100
Still238460000833354698499
Orphan249860000834769108147179217
Disease.273060000834561871221544256100083266173
Biomedicines.5146100083355088147182221236268283321356383397
202392661000833468101136
Apr107761000834180102
20;11(4):1226.11946100083356981112139154187205217246276311345358
9.42562000853649
Janežič4896200083245694129159174206
A,71062000834155
Locatelli78062000833168101134156190205220235
I,103062000831528
Kos10726200083357399
M.118662000835569
Inhalation12706200083145290123138170192207245284
technique15696200083215588126164179217255290
and187462000833270109
asthma19976200083325982120178210
outcomes22226200083377598129166224259286
with25236200083506688126
different2664620008338537392127148182220241
corticosteroid-containing4256300083316890114130162199225248282303341356395417451488526548581596634649686726
inhaler11666300083145290123138173194
devices.137563000833973106121153187214228
J1618630008324
Asthma.16576300083416992131188221234
2020190663000833469101135
Jun;57(6):654-662.205763000832462100112147180197230248260295329364387424460493506
10.4256400085367085
Cote5236400083407799132
C,66964000833952
Pearle73464000833669101122138173
JL,9206400083245669
Sharafkhaneh100264000833371103124157176209248280318353392
A,140764000834155
et147564000833456
al.15446400083324760
Faster16176400083326288112145166
onset179664000833876102137160
of196964000833756
action20386400083326488104142180
of223164000833757
formoterol23016400083185677136174196230251288304
versus26186400083326687114151178
salmeterol2809640008326597442565000835792115148170207223
in66265000831552
patients7296500083387193108143181203230
with9736500083516689127
chronic11146500083316991128166181213
obstructive134165000833877104127148187219243258291325
pulmonary16806500083397792150188227259280314
disease:20086500083395480115147173208221
a2243650008332
multicenter,228965000835795110132148180213251273307328338
randomized2641650008320539213116922724242566000832862102
study.5426600083264987126158168
Pulmonary7266600083357287145183222254275309
pharmacology105166000833877109130189221253290306344384416
&1479660008339
therapeutics.15306600083226095116149189224262284300332359373
2009191866000833468105140
Feb207366000833266106
1;22(1):44-9.21946600083344277112130161176188222259282317328
11.4256700085366678
Nwaru51667000834596128150188
BI,7176700083355163
Ekström7936700083336392115136173231
M,103767000835568
Hasvold111867000834477103136174190228
P,135967000833540
et141267000833456
al.14816700083324760
Overuse155467000834780115136174200235
of180267000833757
short-acting187267000832664102123148167200232256271309348
β2-agonists22336700083387192124163201239254280303331
in257767000831553
asthma26436700083315881119177209
is286567000831541
associated4256800083325885123156171203225258298
with7396800083506688127
increased8826800083145284105140171198233272
risk1170680008321376393
of127968000833756
exacerbation13516800083346598130164185225258280295333371
and173868000833270109
mortality:186368000835796117142175190205227261275
a2154680008331
nationwide22016800083387092107145184234250288323
cohort254068000833168107145167191
study27476800083265088127158
of42569000833757
the4976900083226095
global6076900083385392131164179
SABINA80269000833273109125170211
programme.10286900083396198137158191249307342354
Eur13986900083326990
Respir15036900083367198136152173
J.169169000832537
2020174369000833569102136
Apr189469000834180102
16;55(4):1901872.20116900083346578113145163196213225255285321353384417451464
12.4257000085366884
Domingo52470000834584142157195234272
C,81270000834053
Rello8807000083367186101139
J,103570000832436
Sogo108770000833270110148
A.125170000834055
As-needed13227000083416889128163199238273313
ICS-LABA16507000083155690112145189224265
in193170000831452
mild19997000083577287126
asthma:21417000083325881119177210222
what237870000835189122143
does253770000833876112138
the26917000083226095
evidence2801700008334668242571000833873111143177
say?.6177100083265990114123
Drugs.75671000834567105144170184
201995571000833468100130
Nov;79(16):1729-37.110171000834483115128161194213245276294306336365399434457490522528
13.30474100085366984
Cusack315341000834078104138171202
RP,33764100083357277
Satia34744100083336689104137
I,363241000831528
O‘Byrne36814100083486198131153193228
PM.393041000833691105
Asthma40564100083417093132191224
maintenance430141000835891106145167201240273312345379
and470141000833271110
reliever4832410008321567287123156190212
therapy:50654100083226197118152192224237
Should532341000833372111150165205
this30474200083226075101
be316342000833974
the32534200083216095
standard33634200083264982120159191212250
of362942000833756
care?37014200083316485119144
Ann386042000834179117
Allergy39924200083415772107128166198
Asthma42054200083416992131188221
Immunol.444142000831573130168206244260273
2020472942000833569102136
Aug;125(2):150-155.488042000834178117129159189224241275293305335365399423454484516528
doi:54244200083387691103
10.1016/j.anai.2020.30474300083346678109140172203228245258292330362377390426460493527540
04.36024300083347083
009.370043000833470106117
Epub383243000833371110149
2020399643000833468101135
Apr414743000834180102
24.42644300083346678
PMID:435843000833589104150163
32339657.453643000833467102135168203237270277
14.30474400085366984
Papi314544000833567106122
A,328044000834155
Chipps33494400083407893132172198
BE,35614400083356982
Beasley365644000833671103129145179211
R,388144000833549
et394444000833456
al.40134400083324861
Albuterol-budesonide40874400083415796134156190211249264287327365404439466504542557596631
fixed-dose4732440008317346599138161201239266301
combination504744000833168126165181219251273288326364
rescue54254400083215582304745000833169104
inhaler31674500083145290123138173194
for33774500083185677
asthma:34704500083325982120178210222
a3708450008332
plain37564500083385486102139
language39114500083154785124162194233268
summary419545000832663121179211233267
of447745000833857
the45504500083216095
MANDALA466045000835597142188228259303
study.49784500083275088127159169
Ther516345000833271106128
Adv530645000834180112
Respir54344500083367030474600083266581102
Dis.31644600083456187101
2024328046000833468101133
Jan-Dec;18:17534666241232264.34284600083245795117164199232245275306319348378410443479515551586620651682712746779814847884896
15.30474700085366883
Kistemaker31454700083355177101134192225255289310
LE,34704700083326578
Oenema356347000834783121156214246
TA,38244700083337084
Meurs392347000835590128149176
H,411447000834557
et418747000833456
al.42584700083324760
Regulation433347000833671110148163196217233271309
of465747000833857
airway47294700083324768121154185
inflammation4929470008315537087119177235267289305343381
and532547000833270109
remodeling544947000832155304748000835896136171187202240279
by334748000833970
muscarinic343848000835795121154187208224262277309
receptors:37684800083215588122161184221242270282
perspectives40714800083397596123163198231256271304338365
on445748000833776
anticholinergic45534800083327192108140178217233248286321342381396428
therapy50024800083216095116150189220
in524348000831553
asthma53164800083325982121179211
and304749000833270109
COPD.317149000834085122167178
Life33644900083324766101
Sci.3480490008332658093
2012358849000833468100130
Nov373349000834583115
27;91(21-22):1126-33.38644900083346777112144159193225243274309327339369396426460483516549561
16.30475000085356882
Cazzola31405000083397199129165180211
M,336150000835467
Calzetta34395000083397085112145166189221
L,367150000833143
Rogliani372550000833572110124138168205219
P3955500008335
et400150000833354
al.40665000083314657
Interaction41345000083155272104124156187210224260297
between44425000083387394145178212249
corticosteroids47025000083316686110124155190216237270290326340377402
and511550000833268106
muscarinic523250000835693118149180200214251265296
antagonists30475100083326990122160198236250275298325
in338451000831552
human344851000833875132163201
airways.36615100083324667119152182208221
Pulmonary38945100083357286143181219250271304
pharmacology421051000833977109129187218250286301339378409
&4630510008339
therapeutics.46805100083215993114146184219256278293324351364
201650565100083346899129
Feb519851000833265104
1;36:1-9.53145100083344276110122151169203213
17.30475200085366876
Agache313752000834179112144182217
I,336752000831528
Beltran34085200083367186109130163201
J,362352000832436
Akdis367352000834171109124150
C,383752000834053
et390352000833457
al.39735200083324760
Efficacy4047520008333506886118151183217
and427752000833270109
safety44005200083265978112135168
of458252000833756
treatment46525200083224377109131189224262284
with49495200083516689127
biologicals50905200083385492108146185200232265281307
(benralizumab,5410520008319589430475300083385992107122151189247279319331
dupilumab,339753000833875114130145183240273312324
mepolizumab,374053000835792131170186201230269326359398410
omalizumab416953000833795128143158187225283315355
and454353000833169108
reslizumab)4670530008321558297112141179237269309326
for50155300083185678
severe51115300083276294128149183
eosinophilic53135300083347310011415219130475400083397792107122154
asthma.32195400083325881119177210223
A3459540008341
systematic35185400083265885109142200233254270302
review38375400083215587103137189
for40435400083185678
the41385400083226095
EAACI425054000833376119158173
Guidelines44405400083448297136171187201239274301
-4759540008320
recommendations47975400083215587124183240275314353385407422460498525
on533954000833776
the54325400083226095
use30475500083376398
of316155000833756
biologicals32335500083385492108146185201233265281307
in355555000831553
severe36235500083266193128149183
asthma.38215500083325982120178210223
Allergy.40605500083415671106127165198208
2020428355000833468101135
May;75(5):1023-1042.443355000835587118131164197215248267278308340373407429460491528560573
18.30475600085366985
Li315056000833147
T,321456000833241
Yin32735600083355189
J,337956000832436
Yang343256000833565103142
Y,359156000833543
et365256000833456
al.37255600083324760
Dupilumab380256000834684123139154191249281321
in414056000831452
chronic42105600083316990127166181213
rhinosinusitis44405600083205974112150177192230267293308331346372
with48295600083516689127
nasal49735600083387097130145
polyposis:51355600083397894125165204231246272284
current54365600083326930475700083214378117139
status,32075700083275184106145172186
challenges,341457000833170103119135170209249285312326
and376157000833271111
future38935700083185881120142176
perspectives.40915700083397597125165201234259275308343371385
Expert449757000833366107143165190
Rev470857000833672105
Clin48345700083405671110
Immunol.496557000831574133172210250266279
2023526557000833570104139
Jul-54255700083256379102
-Dec;19(8):939-948.304758000832168103136149179209228262280292327360393417452488523537
19.30475900085366881
Kai31415900083356882
M,323659000835467
Vion33165900083355188126
PA,34555900083357185
Boussouar355359000833573110136162200238269290
S,385659000833244
et391359000833355
al.39815900083314659
Eosinophilic40525900083337096110148185224262277292307338
granulomatosis44035900083375891128165180218275307328365391406431
polyangiitis48475900083387692123156193232247261283298324
(EGPA)51835900083195195130167185
complicated53815900083316712530476000083395570101134156190229
with32936000083516689127
periaortitis,34376000083387495111143181203227242265280306319
precipitating37736000083396094127142181197219252274289327366
role41566000083215874109
of428160000833857
dupilumab?435560000833875114130145183241273312337
A4709600008341
case47676000083316490125
report49096000083215594133154179
a5105600008332
review51536000083215587103138189
of535960000833756
the54326000083226095
literature.3047610008315305286107140162200221255267
RMD333061000833590136
Open.348261000834786122160173
2023367161000833468101136
Sep;9(3):e003300.382261000833267107119154174207224236271306342376409443479492
20.30476200085367287
Caminati315062000834073131146184216238253
M,341862000835568
Buhl350262000833573111126
R,364462000833549
Corren37086200083407799121155193
J,391662000832436
et396862000833456
al.40396200083324861
Tezepelumab41156200083326393127166202217255313345384
in451562000831452
patients45826200083397294109144182203231
with48296200083506688126
allergic4971620008331476297118156171203
and519062000833169109
eosinophilic5314620008334739911415219030476300083397792107122154
asthma.32176300083315881119177210223
Allergy.34556300083415772107128166198208
2024367863000833469101133
May;79(5):1134-1145.382763000835487117131163197216250268280310337367403426456484515548560
doi:44026300083387692104
10.1111/all.15986.45216300083356679109137165192214244260275288319349381416451465
21.30476400085367082
Chagas314464000834078110149181208
GCL,336764000834484116129
Xavier351164000833971102118153174
D,370064000834556
Gomes377164000834483141176203
L,398964000833145
et404964000833456
al.41206400083324760
Effects41956400083335271105138162190
of440064000833756
Tezepelumab44716400083336393127166202217255313345384
on487064000833776
Quality496164000834785117133148170204
of518064000833756
Life52516400083324766101
of536764000833756
Patients54386400083366730476500083223771109130158
with32176500083516688126
Moderate-to-Severe,335665000835492132166187220242275298320357380411446478512533567579
Uncontrolled394865000834381113149187209230267283298332371
Asthma:43326500083416992130187219231
Systematic45766500083326289112145203235256271303
Review489265000833570102117152203
and510765000833270109
Meta-Analysis.5228650008355891121441662072452773047660008315477488115128
Curr31906600083407798120
Allergy33256600083415772107128166198
Asthma35386600083416992130188221
Rep.377466000833570109122
2023391166000833469101136
Jun;23(6):287-298.406366000832462100111146181199233251263298331364383414448483496
22.30476700085367288
Wechsler314967000835791123161188203238259
ME,342167000835588101
Ruddy353667000833573112151183
MK,373367000835490104
Pavord38516700083356798136158196
ID,40606700083156172
et414567000833456
al.42156700083324760
Efficacy4289670008332506886118151183216
and451967000833270109
Safety46416700083336685119142175
of483067000833756
Itepekimab49006700083153771110146176192250282321
in523567000831553
Patients53016700083356789104139177199226
with30476800083516689127
Moderate-to-Severe318968000835593132167189222243277300323360383414449482516537571
Asthma.37756800083416992131188221234
N4024680008345
Engl408468000833371110125
J4224680008325
Med.426468000835489129142
2021442168000833569102133
Oct456968000834780104
28;385(18):1656-1668.46886800083356880115150184202233264282294324355389423447478509544580593
23.30476900085377591
Chan316069000834181114154
R,333669000833651
Stewart34096900083335591144178200226
K,365769000833651
Misirovs373069000835673100116138177210238
R,399069000833751
et406369000833559
al.41436900083334963
Targeting42286900083336385125161185201240281
Downstream453169000834687140180207232254290323383
Type493669000833462104141
25099690008335
Cytokines51566900083417096135167184224260288
or546669000833861
Upstream304770000834585113137159194227287
Epithelial33557000083347490114153189206221254271
Alarmins36477000083425892114174190229256
for39257000083185780
Severe402670000833370103139161196
Asthma.42437000083427195135194228242
J4506700008325
Allergy45527000083425974110133172205
Clin47797000083405672111
Immunol491270000831574134173212252268
Pract.52027000083365791125150164
2022538770000833571105141
Jun;10(6):1497-1505.304771000832462100112142173193226244256286317350383402433463497531543