1468
HLAVNÍ506722001005185134178232252
TÉMA533422001003981147194
Hyperurikemie437133001004885124159184222246262297331391406441
a4828330010034
metabolický487833001005995122158196235251266296331369
syndrom526333001002865104142166205265
|5584220010018
23564222001003672
/36968040010732
Vnitř3773804001074592111139166
Lék.3958804001074184122140
2025;71(1):18-234118804001074487128172185226267286325343357395434462501545
/47088040010731
VNITŘNÍ48058040010746106127172220280301
LÉKAŘSTVÍ5127804001074185130188236280325378400
www.casopisvnitrnilekarstvi.cz42580400107651332012142542953293774274464795215705896176436927117307748128548809159449871007102310631101
PROHLÁŠENÍ4855500974286143197237289331372426447
AUTORŮ:94855009748100142197243296312
Prohlášení12755400984473118164185227260302348369
o165854009845
původnosti:17165400984793134178225271317350379400419
Práce21495500954063100136173
je23375500951756
původní24075500954487123165209252269
a269055009536
nebyla27405500954382126161179215
publikována29695500954487131148165198240276313355391
ani3375550095367895
není34845500954382125141
zaslána3640550095326999116152194230
k388555009533
recenznímu3933550095236198136178211254271336378
řízení4325550095244173111154171
do45105500954386
jiného4610550095173476116158201
média.482655009565104148165201215
Střet5056540098416997139168
zájmů:5238540098357799167212231
Žádný.4856700954380125168202213
Financování:7166600984161108149195232277318359406427446
Ne.11786700955191104
Poděkování:13006600984590137180221266307348395416435
N/A.17526700955180122139
Registrace19096600984688135156190219248290326368
v229366009841
databázích:23516600984687116158205247284306342389408
N/A.27766700955180122139
Projednání29326600984573119141183231278319365387
etickou3335660098417192128170214261
komisí:36126600984186155176210231250
N/A.38806700955180122139
LITERATURA42699001234978134189250318368438498567
1.42511600853547
Yanai48511600833563101132147
H,64411600834356
Adachi71211600834078109140178192
H,91611600834456
Hakoshima98411600834475105141167204219275307
M,130311600835467
et138211600833355
al.14491160083314658
Molecular152011600835391106140172209224255276
Biological18081160083354986102139178192223256270
and209111600833168106
Clinical22091160083405469106120151183198
Understanding241911600834480119153173200222254291330344381419
of285111600833655
the4251260083215994
Pathophysiology5311260083356688125163202240270297311349364402441473
and101612600833269108
Treatments11361260083324983114136193228265286314
of146212600833756
Hyperuricemia153012600834475115150171209229245276309366381413
and195512600833269108
Its20751260083153764
Association21521260083406894132164178210231246284322
with24861260083506688125
Metabolic262412600835488110143181220235250281
Syndrome,42513600833261100138159196253288299
Cardiovascular7371360083397292130145182214246272304341356388409
Diseases11581360083456086120152178212239
and140913600833269108
Chronic15291360083407798134172187218
Kidney17601360083345089126161192
Disease.19641360083456086120152178212224
Int22011360083145273
J2286136008324
Mol232313600835492107
Sci.2443136008332647891
2021;22,9221.254613600833468100131139174208220253285319350360
2.42514600853652
El49214600833348
Ridi5551460083355190105
R,67514600833549
Tallima739146008333617691106164196
H.95014600834558
Physiological102314600833573103130145183199237277292324357372
functions14101460083185795127151167205243269
and169514600833169108
pathogenic18191460083387193131169209244282297329
potential21631460083397899133171193208240256
of243414600833756
uric25051460083375974106
acid:26261460083326479118130
A2772146008341
review.2828146008320544251560083324782133144
J584156008325
Adv62415600834179112
Res.7511560083367097111
2017;8:487-493.87715600833468100130139175187221257290309345379411424
3.42516600853651
Sorensen4901660083327192126165191226264
LB.7681660083326881
Role8631660083357489124
of100216600833756
the10721660083226095
intestinal11811660083155374108135158173211244259
tract14541660083224376108133
in160116600831452
the16671660083226095
elimination17761660083345065123138176208230245283322
of211216600833756
uric21821660083385974106
acid.23031660083316479118131
Arthritis24481660083416287125146162184199226
Rheum.268816600833573108146204217
1965;8:694-706.42517600833464100134144180192227261297320351384420433
4.42518600853651
Hisatome4941860083445985119140177235271
I,78218600831427
Ichida8261860083154785100139171
K,101418600833550
Mineo108118600835470108143181
I,128018600831427
et132418600833456
al.13971860083324861
Guidelines14751860083438197135170186201239274301
for17931860083185677
Management188718600835587125158197232289325363384
of228818600833757
Hyperuricemia236218600834476116151172211232248280313371386418
and279718600833270109
Gout42519600834482121143
3rd58319600833561819600491234
Edition.6681960083337186108124162200213
Gout89719600834382120143
Uric10551960083446580112
Nucleic118319600834482114130164180211
Acids.14101960083417287126152166
2020;44(Supplement):1-40.159119600833569101136148183220240271309348387403438496531569591610622651670707743755
5.42520600853650
Merriman49320600835490111133148206238276
TR,7872060083326983
Dalbeth8882060083457793132167190228
N.113320600834558
The120920600833272107
genetic133320600833873111146169184216
basis15662060083397299113140
of172320600833757
hyperuricaemia179720600833868108144165203225240272305340398413445
and226020600833169108
gout.238620600833876114137150
Jt.25542060083244660
Bone263120600833674113148
Spine.279620600833371874252160083387385
2011;78,35-40.52521600833468100128136169202215251284306342378391
6.42522600853652
Simmonds49222600833247105163201240279305
HA,81222600834485100
McBride92722600835487122144159198233
MB,117522600835591103
Hatfield12942260083447698117134169185224
PJ,15332260083355467
et161522600833456
al.16862260083324760
Polynesian17622260083357187119158193220235267305
women208222600835088146182220
are23172260083325387
also24192260083324773112
at254622600833253
risk2615226008320366292
for27222260083185678
hyperuricaemia2815226008338684252360083397495134155170202235270328343375
and82023600833270109
gout94923600833876114137
because110523600833975107140178204239
of136423600833756
a1440236008332
genetic149223600833873111146168183215
defect17272360083387392127159183
in193023600831553
renal20022360083215593126141
urate21632360083375891113146
handling.232923600833870108147162177215254267
Br261623600833657
J2693236008324
Rheumatol.27372360083357310814642524600835790111148164177
1994;33:932-937.6182460083346499135147182215226261294327347382415447453
7.42525600853645
Dalbeth4832560083457793132167189227
N,72325600834558
Merriman79425600835489110132147205237275
T.108225600833342
Crystal11372560083406094121144177192
ball13422560083397287102
gazing:145725600833870100115153192204
New167425600834580131
therapeutic18182560083215994115148187223261283298330
targets21612560083225475113148170198
for23722560083185677
hyperuricaemia246225600833868108144165203224240272304339397412444
and42526600833270109
gout.54926600833876115137150
Rheumatology.71526600833573108146204236258295311349389421431
2009;48:222-226.116126600833468104140152187223235271305340360391426460473
8.42527600853652
Caulfield49227600834073110126143160195211250
MJ,7562760083558193
Munroe86327600835593131152189225
PB,11022760083367183
O’Neill120027600834760106141156172187
D,140127600834657
et147227600833457
al.15432760083324860
SLC2A9161827600833364102138180214
is184727600831440
a1902276008332
high-capacity19492760083375291129151185218257290322337360394
urate23572760083375992113147
transporter25192760083224376114140179218240264298319
in285327600831553
humans.42528600833875133165203230243
PLoS68428600833566103135
Med.83428600835590129143
2008;5,e197.99228600833468104140152187198234263294326333
9.42529600853649
Enomoto49229600833370109167205227264
A,77329600834155
Kimura84529600833552109147168201
H,106329600834557
Chairoungdua113829600833977110125146183221259298337375407
A,156229600834155
et163429600833457
al.17082960083324760
Molecular178529600835593109144176214229262283
identification20852960083155388126148163181198230263285300338376
of247929600833756
a2552296008332
renal26012960083215593125141
urate27592960083375891113147
anion4253060083327085123161
exchanger6023060083346596134167205244279300
that9173060083226092114
regulates10463060083215595132148180201235262
blood13233060083395593132171
urate15103060083375891113146
levels.16723060083154982116132158171
Nature18593060083447798136157192
2002;417:447-452.206630600833468104137149184215244254288325357376413445479491
10.4253160085356881
Woodward51731600835691128166216247267303
OM,83131600834699112
Köttgen9533160083347091114150183220
A,118331600834154
Coresh12473160083397595128153189
J,144731600832334
et149231600833354
al.15573160083314557
Identification16253160083145285121141155172189219250271285321358
of199431600833654
a2059316008331
urate21013160083365688108140
transporter,22523160083214173109134171208228252284304312
ABCG2,257531600834075114154187198
with27843160083496485121
a425326008331
common46732600833166123179216253
functional7303260083185692123145160196233264278
polymorphism10193260083387590120177214234272309323348404
causing14333260083316399124137174211
gout.165532600833774111132144
Proc18103260083345489121
Natl19413260083447596110
Acad206232600834070102139
Sci.2212326008332637789
2009;106:10338-10342.231132600833467101135147175205239251279309341372405427456486518552583594
11.4253360085366678
Li52033600833147
S,58433600833245
Sanna64633600833265103141173
S,83633600833345
Maschio89833600835587114146184199237
A,115233600834155
et122433600833456
al.12973360083314760
The137433600833271106
GLUT9149733600834476118153187
gene170133600833873111146
is186433600831440
associated19213360083325885123156171203225259298
with22363360083506689127
serum23803360083266182120178
uric25753360083375874106
acid26973360083326480118
levels2832336008315504253460083326682108
in54834600831452
Sardinia6163460083326586124140177192224
and85634600833270109
Chianti9803460083407893125163184200
cohorts.119534600833168107145167191219232
PLoS144334600833566103135
Genet.159434600834379117152174187
2007;3:e194.179734600833468104137147182193227257287323336
12.4253560085356782
Vitart5203560083355173105126150
V,68235600833544
Rudan73835600833572110142179
I,93035600831426
Hayward96935600834375105158190211248
C,122935600834052
et129435600833355
al.13613560083314659
SLC2A9143235600833263100135176210
is165435600831540
a1706356008332
newly175035600833771122137168
identified19303560083155387124145160178194228267
urate22093560083375890111144
transporter23663560083214274112137175214235259292312
influencing26913560083145168851221561934253660083314684123
serum5643660083266182120178
urate7573660083385992113147
concentration,91936600833269107139173211233254287309324362400413
urate13473660083385992114147
excretion15103660083346596118152174189227266
and179136600833270109
gout.191536600833876115137150
Nat20813660083447799
Genet.219536600834479117152174188
2008;239836600833468104140152
40:437-442.25653660083357084118151183201238275307320
13.4253760085366883
Matsuo52637600835487109136174212
H,75637600834457
Takada8313760083326091124163195
T,104537600833241
Ichida11043760083154785100139171
K,129337600833550
et136137600833456
al.14353760083324760
Common151337600834077135193232270
defects18013760083387392127159183211
of203037600833757
ABCG2,210537600834177117159194206
a2329376008332
high-capacity23793760083385392130152186219258291323338360394
urate2791376008337599242538600832255
exporter,49638600833465105144165190224245255
cause76638600833264102128163
gout:94538600833876114137150
A1111386008341
function-based11673860083195795127152167205243266306339365400440
genetic162238600833873111146169184216
analysis185438600833169102117149176191217
in208638600831553
a2154386008332
Japanese22023860083245695128166201228263
population.248038600833978118156171203225240278317330
Sci28253860083336580
Transl4253960083335083121147162
Med.60339600835489129142
2009;1,5ra11.76039600833468105140153183192227247280310337347
14.4254060085377186
Yuan,53340600833672105144158
H.;7124060083455972
Yu,8054060083367286
C.;9124060083415468
Li,10014060083324861
X.108340600833954
et115840600833558
al.12374060083324862
Serum13204060083336991131190
Uric15314060083456683116
Acid16684060083427490130
Levels181940600833267100135152179
and201940600833271111
Risk21524060083365279110
of228340600833858
Metabolic236240600835692115149189229245261294
Syndrome:26774060083336410414416620442541600835894106
A552416008342
Dose-Response61541600834685112148171209245272312351390417453
Meta-Analysis108941600835590113146169211250283299331359374400
of151041600833858
Prospective15894160083355694121161197230255271304339
Studies.19494160083325493132148183210224
J2194416008325
Clin22404160083405671109
Endocrinol237041600833372111150184205221260299315
Metab.270641600835591113147187200
2015;100:4198-4207.42542600833468100130141171202239252286316347382404441473507540546
15.4254360085366883
Choi52543600834078116131
HK,6734360083448094
Ford7844360083327091129
ES.9304360083326680
Prevalence10264360083355690122155171205244276309
of135243600833756
the14254360083226095
metabolic153643600835893115148187226242257289
syndrome18414360083275998137158195254289
in214643600831553
individuals22154360083155392107140155194232264279305
with25374360083516689127
hyperuricemia.2680436008338691091441652044254460083213668102160175207220
Am66144600834199
J775446008324
Med.81444600835590129143
2007;120:442-447.97244600833468104137147177207241254288325358378415452484490
16.4254560085366985
Hjortnaes5254560083445997119144182214249276
J,81645600832436
Algra8664560083415796117150
A,103045600834155
Olijhoek1100456008347637893131169205235
J,135045600832436
et140145600833456
al.14714560083324860
Serum15464560083326789127185
uric17454560083385974106
acid18664560083326479118
levels19984560083155082116132158
and217145600833169108
risk2294456008321366292
for24014560083185677
vascular24934560083326591123161176209230
diseases273745600833854801151474254660083266188
in52846600831553
patients5964660083397294109143182203231
with8424660083516689127
metabolic98446600835893115148187226242257289
syndrome.12884660083265997136158195253288300
J1604466008324
Rheumatol.164346600833674109147204237259296311324
2007;198346600833468104137146
34:1882-1887.21454660083346981111142178211232262293329362368
17.4254760085366876
Takahashi5184760083336191124162195221259274
S,80847600833346
Yamamoto87047600833565123155213251273310
T,119647600833342
Tsutsumi12544760083335592114142179237252
Z,152347600833750
et159047600833456
al.16624760083324861
Close17394760083405593120155
correlation19104760083316890112146161194215231269307
between22334760083397597150184220258
visceral25074760083324874106140161194209
fat27334760083185173
accumulation28234760083316442548600833169127164180212234249287325
and76648600833270109
uric8904860083375874106
acid10114860083326479118
metabolism114448600835893115148187226242257283341
in150048600831552
healthy156848600833772104120142180211
men.179448600835792131144
Metabolism195348600835590112145184223239254280337
1997;46:1162-1165.23064860083346499132142177213225255283314347368398426457491503
18.4254960085366985
Facchini5264960083326294125163178216231
F,77249600833338
Chen82649600834078113151
YD,9924960083358293
Hollenbeck11004960083448298113148186225261294324
CB,14394960083407688
et154349600833456
al.16144960083324760
Relationship16904960083357086118139155193231258295310349
between20554960083387496149184219257
resistance2328496008320548196122145178216248282
to262549600832259
insulin-26994960083155379116132147184207
-mediated42550600832180115154169201223257296
glucose7365060083395491124160187222
uptake,9735060083387799132162196208
urinary11965060083375874112144165199
uric14105060083385974106
acid15325060083316479118
clearance,16655060083314681113134167205237271283
and196350600833270109
plasma20875060083395587113171203
uric23065060083375873105
acid24275060083316479118
concentration.2560506008331681061381722102322532863083234255160083377689
JAMA52951600832464120162
1991;266:3008-3011.70651600833465100132140175209244257292326363398421453488519547556
19.4255260085366982
Wang52652600835789127166
J,71152600832436
Qin76652600834763100
T,88552600833342
Chen94652600834078113151
J,111652600832436
et117152600833456
al.12465260083324760
Hyperuricemia132552600834476116151173211232248280313371386418
and176252600833270109
risk1890526008321366292
of200152600833857
incident20775260083145284100138173211233
hypertension:232952600833768108144165189223261288302340379391
A2739526008341
systematic2799526008326588542553600832255113146167183215
review6555360083215587103137189
and85953600833270109
meta-analysis98353600835792115148170202240273288320347362388
of138653600833757
observational145853600833777103138160194227249264302341373389
studies.18625360083264987126141176203216
PLoS209453600833566103135
ONE224553600834792125
2014;9,e114259.238653600833468100131143178188224253281312345380412423
20.4255460085367287
Johnson52854600832462101139165204242
RJ,7855460083366375
Kang87554600833569107146
DH,103654600834691103
Feig11555460083326681120
D,129154600834556
et136254600833457
al.14345460083324760
Is151054600831440
there15665460083226095116150
a1731546008332
pathogenetic17795460083387193131170209244282317339355387
role21815460083215874109
for23055460083195678
uric23985460083375974106
acid25205460083316479118
in265354600831553
hypertension2721546008338681081441654255560083225593120135173211
and65155600833270109
cardiovascular7765560083316485123138176208241268300338353385406
and119855600833169108
renal13225560083205493125140
disease?14785560083385379114146172207232
Hypertension.172555600834576116152173198231270296311349387400
2003;41:1183-1190.214155600833468104137149183214222252280311345367397425455491504
21.4255660085367082
Berger5225660083357192130165186
L,72256600833245
Yü78256600833571
TF.8685660083326673
Renal95556600833570109141156
function11265660083185795127151166204243
in138356600831553
gout.145056600833876115137150
IV.16155660083155161
An169056600834179
analysis178456600833270102117149176191217
of201656600833756
52420875660083346799
gouty220056600833876115137171
subjects238556600832664103118153186210238
including26375660083155385100138177192230269
long-term4255760083155391130153175209230289
follow-up729576008318567287125176198237276
studies.10215760083264987126141176203216
Am125257600834199
J1367576008324
Med.140657600835590129142
1975;59:605-613.15645760083346497130140176208221256292326348385416445458
22.4255860085367288
Feig5325860083326682120
DI,6715860083466174
Madero76458600835587126161182220
M,100358600835468
Jalal10905860083245672104119
DI,12285860083456174
et132158600833456
al.13965860083324861
Uric14765860083436480112
acid16075860083326479118
and174458600833270109
the18725860083226095
origins19865860083375974113128166193
of219858600833756
hypertension.227358600833868108144165190224262288303341379392
J2685586008324
Pediatr.2728586008335681081231554255960083224353
2013;162:896-902.49459600833468100130141171202236248283317353376411447480492
23.Mazzali425606008536728751460600835486115146179195209
M,73660600835467
Hughes81660600834481120157192218
J,104760600832436
Kim109560600833551108
YG,12166060083357790
et131960600833456
al.13876060083324760
Elevated14596060083334782114146168201240
uric17126060083375873105
acid18296060083326479117
increases19596060083145283104138170196230257
blood22296060083385491130169
pressure24106060083396094120147183204238
in266160600831452
the27256060083226094
rat28326060083205374
by42561600833970
a510616008332
novel55761600833876108142158
crystal-independent7306160083325387114137170185207223261300335375410448487522560582
mechanism.132761600835792125163195233249275332346
Hypertension.168861600834476116151172197231269295310348387400
2001;38:1101-1106.210361600833468104136145180214226256284315347366396424456491505
24.4256260085367186
Uedono52562600834478118156195233
H,77262600834456
Tsuda8426260083335592131163
A,101962600834155
Ishimura1088626008314407893151189210243
E,134462600833346
et140462600833456
al.14746260083314760
Relationship15476260083367186119140156194232258296311350
between19116260083397496150184219258
serum21826260083266183121179
uric23746260083375974106
acid24946260083326479118
levels26256260083155082117132158
and279762600833270109
intrarenal425636008315537495128150184222254269
hemodynamic71063600833772130169208240279311369384416
parameters.11416360083397293126184219241275296324337
Kidney14946360083345190128163194
Blood17046360083355189128167
Press18866360083365690117144
Res20456360083357097
2015;215863600833468100130140
40:315-322.23146360083347083118149179201234266301313
25.4256460085367287
Mallat52864600835487102117150171
SG,7156460083327790
Al82064600834157
Kattar8926460083356990115148169
S,107664600833345
Tanios11376460083326098113151178
BY,13306460083367078
et142464600833456
al.14956460083324861
Hyperuricemia,157164600834476116151173211232248280313371386418431
Hypertension,201864600834475115151172197231269295310348386399
and243264600833270109
Chronic25576460083397798136174189221
Kidney2793646008335529142565600833873104
Disease:5446560083466187122154181216228
An78865600834079
Emerging88265600833390125146185200238277
Association11746560083416995134166181213235250288327
Curr15166560083407798120
Hypertens165165600834476116151173197231269295
Rep.196265600833570109122
2016;18,74.209965600833468100131144174205218252282295
26.4256660085367187
Schröder52866600833265103124161201236257
K,80166600833449
Vecchione86666600833568101132170185223261296
C,117866600834053
Jung124766600832462100139
O,140166600834758
et147566600833456
al.15476660083324760
Xanthine162366600833871109130168183221256
oxidase18956660083376883122154181216
inhibitor21266660083155391106145161183220242
tungsten23836660083226098137163186220258
prevents26576660083396094127161199221248
the4256760083226095
development53367600833873105139155193232291326364385
of93167600833757
atherosclerosis10016760083315391126147185211244259294315352379394420
in143467600831452
ApoE149967600834180119153
knockout166567600832969107140170207245268
mice194667600835772104138
fed20976760083185292
a2202676008332
Western-type224767600835790117140174195234256279312352388
diet.26486760083385388110123
Free27846760083325286122
Radic42568600833568107122154
Biol5956860083355088104
Med.71468600835590130143
2006;41:1353-1360.87268600833468104140152187217226256286319352374404434469504517
27.4256960085367180
Ma52369600835487
M,62869600835568
Wang71569600835788126165
L,89969600833145
Huang96269600834482114152191
W,117269600835767
et125769600833456
al.13326960083314760
Meta-analysis141069600835489112145167199237270285317344359385
of181369600833757
the18886960083226095
correlation20016960083316890112146161193215231269307
between23266960083397597150184220258
serum26026960083266183121179
uric27996960083375874106
acid4257060083326479118
level5587060083155082116132
and70570600833270109
carotid8307060083316485122144159198
intima-media1043706008315537490147180202261296336351383
thickness.14417060083226075107137176211238265278
PLoS173570600833566103135
ONE188570600834793126
2021;16,e0246416.202770600833468101132140170202214250285318350386422453484497
28.4257160085367288
Ji52871600832439
X,58271600833952
Leng64971600833266104143
XY,8077160083387684
Dong90671600834584123162
Y,108371600833543
et114171600833457
al.12137160083324760
Modifiable128871600835593133148165182214254270304
risk1608716008320366292
factors17157160083185284108145167194
for19247160083185678
carotid20177160083316485122144159198
atherosclerosis:22317160083315391126147185211244259294315352379394420432
A2679716008341
meta-273571600835792114147170
-analysis4257260083215391123139171198212239
and67972600833270109
systematic8037260083265986109143201233255270302
review.11207260083215587103138189200
Ann133572600834179117
Transl14677260083335083121148163
Med.164572600835590129142
2019:7,632.180372600833468100130143176182218251284296
29.4257360085367285
Men52673600835490128
P,66973600833540
Punzo72473600833573111140177
G.91773600834357
Uric9907360083446580112
acid:11187360083316479118130
Bystander12637360083366895118151189228263284
or156273600833859
culprit16377360083316984123145160183
in183573600831553
hypertension190373600833868108144165190223262288303341379
and229873600833169108
progressive24227360083396097137158192219246260293327
renal27657360083205593125140
disease?4257460083385379114146173208233
J.67374600832437
Hypertens.72574600834476116151172197231269295309
2008;26:2085-2092.104974600833468105140152187221233268302338372394425459494527540
30.4257560085367287
Cheng52475600834077112150188
X,72575600833851
Liu7897560083314683
T,88575600833241
Ma93875600835587
L,103775600833245
et109575600833456
al.11637560083324760
Prothrombotic12357560083355693114152173210268306345366382413
effects16617560083345372106138162189
of186375600833756
high19327560083375291128
uric20737560083375873105
acid21907560083326479117
in232075600831452
mice238575600835771103136
via25347560083324779
activation26257560083326488103135168189204242280
of42576600833757
MEF2C-dependent49776600835488120154194207247282322357395434469507529
NF-κB10417660083457899132169
pathway12257660083397294132182215246
by148676600833970
upregulating15717660083387798132172209225257279294332371
let-7c.1957766008315507292123151164
Aging21377660083417994132171
2020;12:17976-17989.232376600833569101136148179208221251280314346378402433462495530565576
31.30471160085366981
Yisireyili3142116008335517792113147179195210225
M,338011600835568
Hayashi346211600834476107140167205220
M,369511600835568
Wu377711600835794
H,388411600834457
et395511600833456
al.40251160083314760
Xanthine409811600833871109130168184221256
oxidase43681160083376883122154181216
inhibition45971160083155391106145161183198236275
by488511600833970
febuxostat49691160083185392130161199225248281303
attenuates5286116008331537711114918721930471260083225582
stress-induced31501260083264971105132158179195233272310342376416
hyperuricemia,358612600833868108144165203225240272306364379411424
glucose40311260083385391123160187222
dysmetabolism,42731260083387097155190212245284323339354380438451
and474412600833270109
prothrombotic48741260083386097119157179216274314352374390422
state53161260083264982104138
in547412600831553
mice.304713600835772104138150
Sci32131360083326479
Rep330813600833570109
2017;7:1266.343313600833468100129139172182212242275311324
32.30471460085356984
Nishizawa31431460083445883120134162194244275
T,343014600833240
Taniura34821460083325995110146166198
T,369214600833240
Nomura374414600834380137173194225
S.398114600833244
Effects40371460083325069102134157183
of423214600833655
febuxostat42991460083185189126156192218240272292
on460314600833774
platelet-derived46881460083385384105138153186208226266299320334366399437
microparticles513714600835670101122158196228248272286317332365391
and304715600833168106
adiponectin31651560083316984122159197231262286300337
in351415600831451
patients35771560083387091105139176197224
with38121560083506587124
hyperuricemia.394815600833666105139160197217232263296352367398410
Blood43701560083355087125163
Coagul.454515600833975107145182196208
Fibrinolysis47651560083324684105120157194209240266280306
2015;26:887-892.50821560083346798127137171204215249283315333368401433445
33.30471660085367186
Jia31501660083243971
Z,323816600833851
Zhang330616600833775107145184
X,350716600833852
Kang357516600833569107146
S3738166008332
et378716600833456
al.38601660083324760
Serum39371660083326788127185
uric41381660083375974106
acid42611660083326479118
levels43961660083144981116131157
and457016600833270109
incidence4696166008314528499138173211243277
of499016600833756
impaired506316600831572112145160181215254
fasting53341660083195278102117155194
glucose30471760083385492124161188223
and329117600833270110
type34211760083225696132
23574176008334
diabetes36291760083385385125161183217244
mellitus:389417600835793109124139162200226239
A4154176008341
meta-analysis421517600835893116149172204242275290322350365391
of462717600833757
cohort470417600833269108146168193
studies.49171760083275088128143178205219
Diabetes51561760083466294133169192226253
Res54291760083367198
Clin30471860083405570108
Pract.31701860083355689121145159
2013;101,88-96.334418600833468100130141171203235244280315338373408422
34.30471960085367185
Lv314419600833159
Q,321419600834659
Meng,328419600835487124162173
F,346819600833237
He351619600834477
FF,36041960083326368
et368319600833355
al.37491960083314557
High38171960083445895132
serum39601960083255979116172
uric41431960083375771102
acid42561960083316276114
and438119600833168105
increased44971960083155182102135165191224262
risk4770196008321356089
of487019600833755
type49361960083215392126
25073196008334
diabetes:51181960083375182120154175208233245
A5374196008340
systemic54251960083265783304720600832255112126158
review32182060083215586101135186
and341820600833169107
meta-analysis353920600835792113145167199236268282313340354379
of393220600833756
prospective40022060083385996122160195227250265297330
cohort434620600833268106143164188
studies.45482060083264986124139173199212
PLoS477420600833565102133
ONE492120600834792124
2013,50592060083346899128139
8,521220600833547
e56864.527320600833468101136171206218
35.30472160085367186
Doshi315121600834584111148164
M,333321600835468
Takiue34192160083326090107144179
Y,361621600833544
Saito36782160083326580103140
H,383621600834457
et391121600833456
al.39852160083324860
The406421600833271106
increased41882160083155385106140172199234273
protein44802160083386097119153168206
level47042160083155082116132
of485421600833756
URAT1492821600834480123152186
was513221600835083110
observed526021600833777103138159194228268
in304722600831554
obesity/metabolic312222600833778114142157180214238296332354388428468484500532
syndrome367522600832760100140161199259295
model399122600835897137173189
mice.420122600835874107141154
Nucleosides437622600834584117132168207235250290325353
Nucleotides475022600834584117133168208230246286321349
Nucleic512022600834584117132168184216
Acids.53572260083427490129156170
2011;30:1290-1294.304723600833468100128136171205219248278312348372403433467503515
36.30472460085367288
Miao315124600835470102140
Z,330724600833851
Yan337424600833565103
S,349324600833245
Wang355424600835789127166
J,373624600832436
et378824600833456
al.38602460083324760
Insulin39362460083155379117132147185
resistance4137246008321558196122146178216249282
acts44352460083326488116
as456724600833258
an464124600833270
independent47272460083155392127166201240279314352373
risk5116246008321366392
factor52242460083195284109145167
exacerbating5407246008334669830472560083316586126159181196234274
high-purine33412560083385392130153193231252268306341
diet37032560083385388110
induced38342560083145292129161195235
renal40892560083215594126141
injury42512560083155368105127161
and443225600833270110
knee456225600833069104140
joint47222560083155469107129
gouty487125600833877115138171
lesions.5063256008315507792130168195208
Inflamm5292256008315537087120178236
Res.30472660083357097111
2009;58:659-668.317326600833468104140152188222234269303336359396432467481
37.30472760085367079
Leyva31422760083316697132165
F,332227600833339
Wingrove337627600835774111150172209241275
CS,36662760083407487
Godsland376827600834483122149164196234273
IF,40572760083144753
et412627600833456
al.41972760083324760
The427327600833272107
glycolytic43952760083385385117153169201226241273
pathway46842760083387193131182214245
to494527600832158
coronary50192760083316889127165197218253
heart528727600833772104125150
disease:54532760083385330472860083266193120155167
A3229286008341
hypothesis.328628600833768108147168207242268283309323
Metabolism362428600835590112145184223239254280338
1998;47:657–662.397728600833464100135147181214224259293326359396431465477
38.30472960085367288
Chen315329600834078113151
S,332229600833245
Yang338529600833564102141
H,354429600834457
Chen361929600834077112151
Y,378729600833644
et384929600833356
al.39232960083314760
Association40002960083416996134167182214236251289327
between43452960083397497150184219258
serum46202960083266183121179
uric48172960083375873105
acid49402960083326479118
levels50762960083155082116132158
and525129600833270109
dyslipidemia5378296008338709711212730473060083395493128186201233
in329830600831452
Chinese33683060083407792130165192227
adults:361330600833271108123146174186
A3817306008341
cross-sectional38753060083315390117143164191226259283298336375407422
study43153060083264987126158
and449130600833170109
further46173060083185778103141176197
meta-analysis.483230600835792115147170202240272288320347361388401
Medicine.525130600835489129144176191229264276
2020;99,e19088.304731600833468101135148184219229264294324360395431444
39.30473260085367185
Goli31453260083448298113
P,327132600833640
Riahi33243260083365183121136
R,347332600833650
Daniali353632600834577115130162178193
SS,37423260083326577
et383232600833457
al.39023260083314760
Association39753260083416995134166181213235250288327
of431532600833756
serum43843260083276283121179
uric45763260083375874106
acid46953260083326479118
concentration482632600833168107139172211232254287308324362400
with52393260083516689127
components537932600833168126304733600833977116151189211238
of330233600833756
pediatric337533600833874114129161182204220252
metabolic364333600835792115147187226241256288
syndrome:39483360083265997136158195253288301
A4265336008341
systematic43233360083265885108142200232254270301
review46413360083215587103137189
and484633600833270109
meta-analysis.497133600835893115148170203241273288320347362388402
J5389336008324
Res54303360083357097
Med304734600835490129
Sci.3191346008333658093
2020;25,43.330034600833468101135148183218229264296309
40.30473560085367489
Kelishadi31513560083356985100126164196235250
R,341635600833549
Mansourian348035600835587125152190228249265297335
M,383035600835468
Heidari-Beni39133560083447994133165186202224261296334349
M.427735600835569
Association43613560083416995133166181213235250288327
of470335600833756
fructose47743560083194179111135172199234
consumption502335600833168106133170228267289304342381
and541935600833270109
components304736600833168126166204243278316337365
of343036600833857
metabolic350536600835893115148187226242257289
syndrome38123660083265897136157195253288
in411836600831553
human418936600833875133165203
studies:44113660083264987126141176202215
A4644366008341
systematic47033660083265986109143201233255270302
review50233660083215587103138189
and523036600833270109
meta-535736600835893115148170
-analysis.30473760083215391123139171198212239252
Nutrition.331437600834583105127143165180218257270
2014;30:503-510.359937600833468100131143178213226261295328350384415447459
41.30473860085366981
Jamnik314538600832456114152167197
J,336038600832436
Rehman341338600833570109166199237
S,366738600833245
Blanco37303860083355183121153190
Mejia393738600835590105120152
S,410638600833346
et416938600833456
al.42423860083324860
Fructose43203860083325290122146183210245
intake45823860083155374107137172
and477138600833270109
risk4897386008321366292
of500638600833857
gout508038600833877115137
and523538600833169108
hyperuricemia:5361386008337681081433047396008321608298130165224239272285
A3353396008341
systematic34153960083276087111146205238260276308
review37443960083215689105141193
and395839600833271110
meta-analysis409039600835893116150173206244277293326353369395
of450639600833858
prospective45853960083396199126166202236261276310344
cohort495039600833270109148170195
studies.51673960083265088128144179207221
BMJ540939600833692118
Open.304740600834787122160174
2016;6,e013191.323640600833468100131143179192227263294324355386418427
42.30474160085367085
Ng314541600834583
HY,32414160083447987
Lee334041600833265100
YT,34534160083357179
Kuo354541600833571109
WH,3667416008357102114
et379341600833456
al.38624160083314658
Alterations39334160083415677110131163184199236274300
of424541600833856
Renal431441600833570107139153
Epithelial44804160083337186107145179194208240254
Glucose47474160083445996127163189224
and498341600833270108
Uric51044160083436479110
Acid52264160083417287125
Transporters5363416008333508211914530474260083387696120153173199
in325742600831451
Fructose33194260083325188119142178203237
Induced35674260083155289126157189228
Metabolic380642600835488109140178216231245276
Syndrome.40934260083326198136156192249283294
Kidney43984260083355088124158189
Blood45984260083354986124162
Press47714260083355588113139
Res.49214260083356994107
2018;43:1822-1831.50394260083346798127139172204214243272305338358387417450480488
43.30474360085367388
Dalbeth31564360083467995135171194233
N,341043600834659
House349043600834584123150186
ME,369743600835589103
Gamble382143600834578137177194229
GD,407143600834592103
et419543600833558
al.42744360083324861
Population-specific435743600833573113152168201223239278317341368408444478493512529562
influence4940436008315537289127163202235269
of523043600833858
SLC2A9530943600833365104141184218
genotype304744600833874113151174208249285
on335344600833776
the34504460083226196
acute356744600833265103126160
hyperuricaemic374844600833869110146168207228244277310345404420452
response42214460083215583122162201227263
to450544600832259
a4585446008332
fructose46384460083194180113137175202237
load.48964460083155487127141
Ann505744600834281119
Rheum519744600833675110149207
Dis.54254460083466288102
2013;72:1868-1873.304745600833468100130141174209221251282317353375406437470504517
44.30474660085367490
Hallfrisch31524660083447692107126148164190222260
J.342846600832436
Metabolic347946600835590112145184223239254286
effects37804660083345473107140164192
of398746600833757
dietary40594660083385388110143164198
fructose.42724660083194179111135172199234246
FASEB453446600833270104136172
J.472146600832437
1990;477346600833464100135148
4:2652-2660.49364660083354782116149182203234267303338351
45.30474760085357083
Van314247600833565102
den325547600833871108
Berghe33754760083346889125162196
G.358247600834356
Fructose:36504760083325188119142177203237249
Metabolism391047600835387109140178216231245270326
and424847600833168105
shortterm43654760083256299120143167199220276
effects46534760083335270104135158185
on484947600833774
carbohydrate49354760083306282121158195225262282314335368
and531447600833168106
purine54314760083387530474860083203572106
metabolic316548600835791112144183220236250281
pathways.34584860083387091129178210240266279
In374948600831552
Metabolic381348600835387109141179217232247278
Effects41034860083325069102134158184
of429948600833756
Dietary43674860083445993115147167200
Carbohydrates,45794860083397192130168206236273294326347380406418
Macdonald500948600835485117153191228260274312
I,533348600831527
Vrana53724860083355587124155
A,304749600834155
Eds,31154960083337197110
Progress32384960083355693133154188215241
in349249600831553
Biochemical35584960083355189121159194252267299332347
Pharmacology,391849600833673105126185217249286302340380412422
Karger,43534960083356889127162184193
Basel,45594960083366995130146158
Switzerland,47304960083338398121151185207222255293332344
1986;21:pp.1-32.508749600833465100135147182214222261301313344363395428440
46.30475060085367489
An315250600834179
Emerging324650600833391126147185200238277
Association.35385060083416996134167182214236251289327341
Curr38945060083407697119
Hypertens402950600834475115151172197231269295
Rep.433950600833671110122
2016;18:74.447750600833468100131143173204217250280293
47.30475160085366978
Zhang313751600833775106144182
W,333151600835766
Doherty341051600834583121155176200233
M,365551600835467
Bardin37355160083356788125140177
T,392451600833341
et397851600833355
al.40455160083324759
EULAR411751600833274106148184
evidence43135160083336580119153190222255
based45805160083397197131170
recommendations47635160083205486122179236271308347378400414452490515
for52915160083185576
gout.537951600833876113135148
Part30475260083356788112
II:31725260083153043
Management.322852600835486124156195230288323361382396
Report363652600833671110148170194
of384352600833757
a3913526008331
task39575260083225481111
force40815260083185577108141
of423552600833857
the43055260083215994
EULAR441252600833376108151186
Standing46115260083335486124163178216255
Committee487952600834077135192207230254288323
for52155260083185677
International5305526008315537410812916720030475360083223774112144160
Clinical32195360083405570107122154186202
Studies34335360083335391130145179206
Including36515360083155385100137176191228267
Therapeutics393153600833271106127159198233271293308340367
(ESCISIT).43115360083185185125140172186220241252
Ann457653600834078116
Rheum470553600833573108145202
Dis.49205360083456186100
2006;65:1312-1324503253600833468104140152187221231261291321351371401431463495
48.30475460085367490
Khanna315654600833574106145182215
D,339054600834656
Fitzgerald34665460083324770100138173195228243282
JD,37675460083247081
Khanna386854600833574106144182215
PP,41025460083357075
et419654600833456
al.42725460083324760
2012435154600833469100130
American450154600834199134155171202235273
College47945460083407793108143182217
of503054600833857
Rheumatology510654600833674109147205237259296312350389422
guidelines30475560083387691130165180195233268295
for33575560083195678
management345055600835890128160199234292327365387
of385255600833857
gout.392455600833877115137151
Part40905560083356788113
1:421855600833443
Systematic42765560083336390113147205237259274306
nonpharmacologic459755600833876115154192225246304337369406422460499514546
and515955600833270109
pharmacologic52835560083397710913118922130475660083316884122162177209
therapeutic32715660083226095116149188224262284299331
approaches361856600833271110132169202234272307334
to396756600832259
hyperuricemia.404156600833868108144165203225240272306364379411424
Arthritis44815660083416286125146161184199225
Care47225660083397294128
Res.48655660083357097111
2012;64:1431-1446499156600833468100130142178215227256288320351370401432469505
49.30475760085367285
Sattui31475760083326587111149165
SE,33265760083336578
Gaffo34195760083447796115153
AL.35875760083417286
Treatment36885760083335084116138196231269290
of399357600833857
hyperuricemia406557600833768108143165203224240272305363378410
in449057600831553
gout:455857600833876114137150
Current47235760083407698119153191213
therapeutic49515760083226095116149188224261284299331
options,52975760083377799114152191217230
latest30475860083154668101128150
developments321058600833872104138153191230287322359381408
and363058600833269108
clinical3751586008330456098112144176191
implications.395558600831471110126140172204226241278316342355
Ther432358600833271105126
Adv446258600834078110
Musculoskelet.458558600835491117149186201239265295328344378400413
Dis50105860083456086
2016;51095860083346799129141
8,145-159.52635860083344677107140161192221253264
50.30475960085367287
Kanbay315159600833568107146179209
M,337759600835468
Siriopol3461596008332476884122161200216
D,369359600834656
Nistor37665960083446086109146167
I,395059600831427
et399359600833457
al.40665960083324760
Effects41425960083335271105138162190
of434859600833756
allopurinol44215960083314762100140178199215252291307
on474459600833776
endothelial483659600833472111149171209244260275307322
dysfunction:51745960083387097117156194226250266304342354
A3047606008341
meta-analysis.310360600835893115148170202241273288320347362388402
Am352060600834199
J3634606008324
Nephrol.367460600834479119157178215231244
2014;39:348-356.393460600833468100131143178211224259294330353386418453466
51.30476160085367082
Xin31456160083385391
W,325261600835767
Mi333461600835570
S,342061600833245
Lin34806160083324785
Z.358061600833851
Allopurinol36476160083415671109149187208224262300316
therapy39796160083215994116149188219
improves421461600831472111133170202236263
vascular44926160083326591124161177209230
endothelial473861600833472111149171209244260275307322
function50756160083195795128152167205243
in533461600831552
subjects54026160083266310230476260083154981104131
at319062600833153
risk3255626008320356090
for33576260083185576
cardiovascular34456260083306283120135172203235261293329344376396
diseases:38536260083385278112143169203229241
A4106626008341
meta-analysis415962600835690112144166197234266281312338352378
of454962600833755
randomized46166260083215390128165223237266299337
controlled496662600833066104125146182197212246284
trials.5263626008321425788103128141
Cardiovasc5416626008340729230476360083385391123156183215
Ther.327763600833372107128139
2016;343163600833468100131143
34:35906360083346981
441-449.368763600833471101120157193227238
52.30476460085377389
Cicero31586460083415790124146185
AFG,336464600834276121135
Pirro3521646008336517395134
M,367664600835670
Watts376764600835991114139168
GF,39566460083457985
et406364600833457
al.41426460083324862
Effects42256460083345373108142167195
of444264600833858
Allopurinol45216460083425874113154194216232271310327
on486964600833878
Endothelial496864600833473113152175214250267282315331
Function:53216460083337010914316818430476560083387993
A3170656008342
Systematic32436560083336594119155215250273290324
Review359865600833673107125162216
and384465600833373114
Meta-Analysis398865600835794118153177221261295312346375392420
of443865600833859
Randomized452865600833671111152193254271302338380
Placebo-Controlled49386560083365387121157199240265310349390413437476494510547589
Trials.3047666008333506597113139152
Drugs321566600834567105144170
2018;78:99-109.340066600833569101132144177210222257293316347379414425
53.30476760085367186
Alem,31466760083415691149162
M.M.332167600835468124138
Allopurinol34726760083415772110149187209224262300316
and380167600833270109
endothelial392367600833472111149171209244259274306321
function:42576760083195795127151167204243255
A4525676008341
systematic45796760083265885108142200232254269301
review48936760083215587103137188
with50946760083516689127
meta-analysis5234676008357921141471692022402723047686008315477488115
of317768600833756
randomized32496860083205391130169227242271305345
controlled360968600833168107128150187203218253292
trials.3917686008321435890106132145
Cardiovasc40786860083397294132147185217250276308
Ther.440268600833272107128138
2018;36,e12432.455668600833468100131143178212225260290320352384417429
54.30476960085367388
Zhang315169600833876108146185
T,335169600833342
Pope340869600833572112147
JE.35716960083245770
Cardiovascular36576960083407394132147185217250276309346362394415
effects40886960083345372107139163191
of429569600833756
urate-lowering43676960083375891113146169186224275309331346384423
therapies48066960083215994116149188203238265
in508669600831553
patients51546960083397294109144182203231
with54016960083506688126
chronic30477060083316990128166181213
gout:327570600833877115137151
A3441706008341
systematic34977060083265986109143201233255270302
review38157060083205487102137188
and401870600833270109
meta-analysis.414370600835792114147170202240272288319346361387401
Rheumatology455970600833674109147204237259296311350389421
2017;499670600833468100129139
56:1144-1153.51507060083346881111138169206229260288318351363
55.30477160085367185
Bredemeier31477160083355791130165223258273308329
M,349171600835468
Lopes357371600833169108144171
LM,375871600833187101
Eisenreich38737160083334774109147168202217249287
MA417471600835597
et428571600833456
al.43567160083324760
Xanthine443071600833971109130169184222256
oxidase47017160083376783122154181216
inhibitors49317160083155391106145160183220241269
for52147160083185678
prevention5306716008339609412716119930477260083223775113
of317472600833756
cardiovascular32437260083316485124139177209242268300338354386407
events:366372600833466101139160188200
A3877726008340
systematic39317260083265885108142200232254270301
review42467260083205487102137188
and444772600833270109
meta-analysis456972600835893115148170203241273288320347362388
of497072600833757
randomized50407260083215492131169227242271305345
controlled5398726008331681073047736008322438096111146186
trials.3248736008322435991106132146
BMC340973600833590131
Cardiovasc35557360083407394132148185217250277309
Disord.38807360083456086125146184198
2018;18:24.409373600833468100131143173204217252284296
Další46037620011061108131169193
literatura481476200110244779125158204236287320366
u51997620011051
autora5269762001104597129179212258
a41207720011046
na4184772001105298
www.casopisvnitrnilekarstvi.cz430177200110671372082272673143524034574805185656186416737057587818048528989459781016104910971121114311841226