1105
PŘEHLEDOVÉ42522001004388130181216258306358404446
ČLÁNKY88722001003973122176223272
Vitamin4253300100436087123183199236
D677330010046
a739330010034
jeho7893300100144987126
klinické9313300100345065103118148183217
využití116433001003574112144159186202
1142132200100285698
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VNITŘNÍ4268040010746106127172220280301
LÉKAŘSTVÍ748804001074185130188236280325378400
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Vnitř1270804001074693112140166
Lék.1456804001074083122140
2025;71(2):108-1141615804001074487129173186227268286329351366403442487516554589628
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www.casopisvnitrnilekarstvi.cz442680400107651332012142542953293774274464795215705896176436927117307748128548809159449871007102310631101
a425620010741
transportován4886200107285598147181231281309340388429472521
portálním1030620010750100128160202222271290365
žilním14166200107375776125144219
systémem165762001073375110140183258303378
a2056620010741
vede211962001074185136181
k2322620010738
rychlému238262001072670111160180224299347
vzestupu27516200107418112442576001073362110160208
koncentrací65076001073885134174217265292319360401420
25(OH)D3108776001074488110168225249306347
a1452760010740
je151076001071963
rovnoměrněji159076001072673114162211284329355404448467486
distribuován209376001074867100129156176225273321362403451
v2562760010740
různých262076001072674111159198238285
tkáních42590001072867110159178219268
organismu.71890001074876125166215235268342391408
Jeho115090001073277126175
podávání1350900010750100151192233275324344
je171890001072064
proto180790001075077125154201
vhodné203390001074190140191240285
zejména234290001073780100174220269310
v2677900010741
určitých274290001074875115134425104001072871112161
specifických612104001073484130172191216237278317361401450
situacích,108910400107335281130172213233274323339
ke1454104001073982
kterým1563104001073870113141184260
patří:1849104001075093121148168184
obezita,2059104001074899145183203232274291
jaterní237610400107206189132160210229
selhání,263110400107347999148189238258274
malabsorpce,4251180010774115135177227262311339390432475491
dysfunkce942118001074990125151201250289329372
CYP2R113401180010752100147190235277
a16431180010741
obecně1710118001074899145187236281
situace,201711800107345382131172214257273
kdy2316118001073887128
je2471118001071964
potřebné25611180010750100128155199250299344
rychlé425132001072772113163183229
dosažení683132001074999134178217261311331
dostatečné1043132001074999135165208237281324374419
saturace1491132001073478106156184227270314
vitaminem183413200107416291134210230280326401
D22641320010759
(34).2352132001072468115137152
Jeho2533132001073177127178
další2739132001075092113147166
nezanedbatelnou425146001074893131175224269320370413441484504553602651
výhodou1099146001074185135184235284333
je1455146001071964
základní1542146001073679118139181231280299
doporučený1864146001074998149199227276318361410449
režim2336146001072770108128203
podávání25611460010750100151193233276325344
jedenkrát425160001071964115160209248277319347
měsíčně.7941600010773118153172213262306322
Kalcitriol565174001074690110152171201229249299319
je912174001072065
aktivní1005174001074282114134176227246
formou1279174001072474102179229279
vitaminu158617400107416291134210230279328
D19421740010760
a20301740010742
přirozeným209917400107517999127176212257307347424
ligandem255117400107193989132181233278354
receptoru425188001072771114158209237285313363
pro815188001075179127
vitamin97018800107416291133209228277
D,1275188001075973
který1375188001073971115142187
zvyšuje1589188001073782127162210230275
střevní189218800107346491136177228247
resorpci2167188001072771106156183235278297
vitaminu249118800107426291134209229278327
D28451880010760
a4252020010740
potlačuje481202001074998124143182222269287330
sekreci827202001073376114141183224242
PTH.1085202001074486143159
Kalcitriol1260202001074486104144162189215234281300
má15762020010773113
krátký1705202001073765105132169211
poločas1932202001074997117164204245277
(5–82225202001072465110155
hodin),2396202001074795144162209230243
a26552020010740
proto2711202001074976122148194
je425216001071964
vhodné515216001074190139189238282
ho824216001074897
podávat948216001075099150191231273300
v12752160010741
denním1342216001074994142191209283
režimu.1652216001072770107127200248265
Vzhledem1943216001074683132151196246290365
k23342160010738
tomu,2399216001072875150197213
že2639216001073679
není2745216001074893141160
formou42523000107247198172221269
vyskytující712230001074184118156199230278297315355374
se1104230001073478
přirozeně120023000107507796122169205248296340
v15582300010741
potravě,1617230001075099126153195234277292
je1927230001071963
nutné2008230001074996124173217
těsné2243230001072870104152196
monitorování24572300010774122171189218264291338378420425244001074867
jeho518244001071963111160
účinnosti.704244001074888107155203251285314332348
Jeho1079244001073175123172
podávání1277244001074999149190229271319337
je1641244001071963
zejména173024400107367998171216264305
indikované2061244001071966116135172220260301350394
u24812440010748
chronické2555244001074088114162210229269307350
hypoparatyreózy425258001074887137186237278305346373416443486535571614
a10582580010741
chronického1119258001074088114161210229269307350398447
selhání158525800107347897145186234252
ledvin1857258001071963113154174222
(35).2098258001072467108131144
Srovnání565272001074267114154203243291310
jednotlivých891272001071963113161209236255273314357396444
forem135127200107247198141214
vitaminu158227200107405987128202220268315
D19132720010758
je1988272001071963
uvedeno2067272001074889132182225273321
v24052720010740
tabulce2462272001072869118166185225267
527462720010744
(4).28062720010724658699
Toxicita4252970013861116177210260293338399
vitaminu861297001386093138199292325389453
D13512970013872
Vitamin56531400107456592133205223269
D8503140010757
má9233140010773113
široké105131400107335176122160202
terapeutické126831400107286995135184228275302320359396438
rozmezí1722314001072672106179222259277
a20153140010740
je2070314001071962
v21483140010740
tomto2203314001072873146172218
smyslu24363140010733105143176194240
lékem269231400107186199141213
bezpečným,425328001074993130179223263310348421436
bez876328001074993130
nutnosti1021328001074894122169217249278296
těsného1332328001072869102149192239287
monitorování16343280010773121168186213259285331370411458476
(s2125328001072455
výjimkou2196328001074082101119191228275322
kalcitriolu).253332800107387998137155182208227274293339360372
Podávání425342001074694145187228271320339
velmi792342001074186106181200
vysokých1019342001074286121171211255296345
dávek1391342001075092133178217
po16353420010751101
dlouhou1764342001075069119168218267317
dobu21083420010750100151201
však2336342001074277120159
může25223420010775124162206
vést2755342001074186121150
k4253560010738
hypervitaminóze481356001074988139184211255275303345419438487536571615
D,1113356001075972
která1203356001073970113139181
se1402356001073479
projevuje1498356001075178125145189230279298342
zejména185835600107378099173218267308
hyperkalcemií,2184356001074887138184210249292311352395469488507522
která2724356001073869112139181
přetrvává425370001075178122151178223266307349
dlouhodobě,801370001075070119169218267319368420466480
a13083700010742
dalšími1377370001075092112145164239258
komplikacemi1662370001073988163214234253292336377421496515
kardiovaskulárními,2204370001073983110159178228269311346384434453495522572591666685701
renálními,425384001072772123165186236255332352368
neurologickými821384001075096146174223244294347367409448493571591
a14403840010742
muskuloskeletálními.15103840010777126161200251271321357396441462508537580600650670747766783
K23213840010747
monitorování23963840010776127178197227276304353396439489509
zásobení425398001073781116166218265315335
organismu787398001075078128170220240274350399
vitaminem121439800107416291134210230280326402
D16443980010760
používáme17313980010752103153191211254297373419
stanovení2178398001073465108158208250295345364
sérových2570398001073580108157199244285335
koncentrací304762001073886135176219268295322364405424
25(OH)D.349362001074489111170228252310324
Mezní3839620010771116153202221
dávky,408262001075091131170213225
jejichž43296200107206483102142191228
dlouhodobé457962001075069118166215264314363414459
překračování506062001075077121159188230270317358400448467
může3047760010774122159202
k3269760010739
hypervitaminóze332876001074887138184211255275303345419438486535571614
D,396276001075972
jsou405476001071953101150
uvedeny422476001074890134184229277316
v4560760010741
tabulce462176001072870120169188229271
3.491276001074560
Při31879000107457190
předávkování330190001075077119169210250289336376418466484
vitaminem38099000107416189130204222270314388
D4221900010758
je430490001071963
nutné439190001074896124172216
ihned463290001071966114159209
přerušit486590001075076119146194227245273
užívání516290001074885104145187235253
vitaminu5439900010741613047104001072869143161209257
D33221040010759
a34001040010740
preparátů3459104001075077120169211237279306354
kalcia383210400107388099139158198
a40491040010741
dostatečná4109104001074997130159201228270312360400
hydratace.4528104001074887135162203231272312355370
Při491710400107457089
hyperkalcemii5025104001074887138182209248290309349392465484502
je3047118001071963
nutné3131118001074996124173217
navíc3369118001074889129148188
řešit3578118001072770103122150
tuto3749118001072876104151
podle3921118001074999149168212
příslušných415411800107497695128147194227275313353401
pravidel,4576118001075077119158178227271290305
tedy4902118001072871121161
i.v.50841180010719357385
podávání5190118001074999149189229271319337
roztoků3047132001072774109140187225273
krystaloidů3343132001073866109143172213232280299349396
bez3761132001075095132
obsahu3916132001074898131173221269
kalcia4207132001073881100140159199
ve4429132001074083
velkém4535132001074184103141184257
objemu4815132001074898117161235282
(dle512013200107247089133
situace527613200107335180128168209251
přibližně304714600107507898148168187225274319
3–63393146001074592140
l)3549146001072045
a36211460010741
podávání36891460010751101152193234277326345
kličkových406114600107386078119158206247292332381
diuretik4469146001075069117145188217236275
k47711460010739
forsírování4837146001072472100135154181229270312361380
diurézy.5244146001075069118145189227271283
V30471600010747
případě312216000107517999151194246291
nedostatečného3441160001075096148198233263306335379422472518568619
účinku4087160001075092111161201251
léčby4366160001071965108159200
a/nebo4594160001074277125171222273
potřebě48951600010751102131159203255302
rychlejší5225160001072772113163183229249283302
úpravy3047174001074897124166206249
kalcemie331617400107388099139182255274318
je3654174001071963
indikované3736174001071967117135173220260302350394
parenterální4150174001075091118161209236278305346365413432
podávání4601174001075099149190230271319338
bisfosfonátů.4959174001074968101126174207232280328369396444459
Při543717400107467190
kritickém304718800107386584111129169206248320
stavu3383188001073362102141189
s35881880010733
nutností3637188001074794122169217249278296
rychlého3949188001072668107154172216263311
snížení427518800107348098134176223241
kalcemie453218800107387998137179251269312
je4860188001071962
nutné4938188001074894122169212
provedení5166188001074976122161204253296343361
hemodialýzy.3047202001074892166215265283324343383421464476
Závěr30472270013862122182238284
Vitamin318724400107466694136209228276
D34882440010758
je3571244001071963
vitaminem365924400107416088130203222270314387
s40712440010734
řadou4130244001072768117166214
důležitých4369244001074996115159196215243286325373
fyziologických4767244001072468106126174193242292310351388431471519
funkcí5311244001072473121158198216
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jeho3105258001072064112160
dostatečný3283258001074997131160201228271312360398
přísun369925800107507695128175223
a39402580010741
dostatečné3998258001074998131160201229271312360404
zásobení4420258001073679112160210255303322
organismu4760258001074774123163211230263336383
je5161258001071963
důležité5242258001074996115159196215243285
pro3047272001075077124
jeho3188272001071963111160
normální3365272001074897124198239258306324
fungování3706272001072473121170219259301349367
a40902720010741
zdravotní4149272001073684111152192239267315334
stav4500272001073463104144
jednotlivců4661272001071963113161210237256274315355403
a50812720010741
celé5139272001074083102146
populace.53022720010750991491983047286001071960100143157
Prevalence3227286001074571114154196215259307347390
deficitu3639286001074993117137177196224272
vitaminu393328600107406088129203222269317
D42722860010758
je4353286001071963
celosvětově4438286001074082102150183225268296343383426
vysoká.4886286001074184118167205247264
Je5172286001073175
jí5269286001072038
proto5329286001075077124151198
věnována3047300001074185134183224266315356
velká3430300001074185105143186
pozornost36433000010750100136184211261310344374
a40443000010741
také4112300001072870109152
v42913000010741
odborné4359300001074999150200227277322
literatuře470730000107203967110137180207256283326
existuje5060300001074485104138167216235280
řada5367300001072669119160
doporučení,3047314001074997147196223272312355403421437
která3506314001073869112138180
se3708314001073478
od3809314001074898
sebe3929314001073478128173
mírně4124314001077492119168212
liší43583140010719387089
ve4469314001074184
strategii457631400107336289131158200250269288
podávání4886314001075099149190229271319338
a52463140010741
podávaných53103140010749981491893047328001074081129166205253
dávkách.3316328001074888128166207247295310
Z36423280010748
praktického3707328001074975116154184202242279322369417
hlediska4140328001074866110159177209246288
je4444328001071962
potřebné4522328001075098125151193242290333
zdůraznit,4871328001073684131156197234282300328344
že5231328001073678
základem53253280010736771151351753047342001074993167
ve3231342001074184
zlepšení3333342001073656100149183227275293
stavu3644342001073463104144192
zásobení3854342001073678112160210255303322
populace4193342001075099149198217257298340
vitaminem455134200107406088129203221269314387
D49563420010758
jsou5032342001071952100148
režimová5198342001072669106126199247288329
opatření3047356001074898139166193236284302
včetně3366356001074180122150198242
dostatečného3625356001074997131160201228271312359404452500
přísunu414235600107507695128175223270
vitaminu442935600107416088129203221269317
D47623560010759
přirozenou483735600107507796122169204247295344392
stravou.524635600107336289130170217265282
To3047370001074285
spolu3150370001073483132152199
s33673700010734
doplněním3419370001074998148167215259307326399
podávání3837370001074998149189229270319337
vitaminu419237000107416189130204222270317
D45283700010758
přípravky460537000107497695145171213253292334
s49583700010733
jeho5010370001071963111160
obsahem5188370001074898132173222266339
dle3047384001074968112
dostupných3184384001074997131160208257306344384432
doporučených3641384001074998148197224272313355403441481529
postupů4195384001075099133162210259307
by4528384001074989
mělo46423840010774118137185
přispět485238400107507796128178222250
ke5127384001073881
zlepšení523438400107365599149182226275293
zásobení3047398001073678111158208252300318
populace3381398001075098148196214254294336
vitaminem373339800107416088128201219267310383
D41333980010757
a42073980010740
ke4263398001073881
zlepšení436039800107365599148181224272290
jejího46663980010719638199149196
zdravotního4879398001073683109150190237264311330379427
stavu.5322398001073362103142190206
PROHLÁŠENÍ48542800974286143197237289331372426447
AUTORŮ:948428009748100142197243296312
Prohlášení127542700984473118164185227260302348369
o1658427009845
původnosti:171642700984793134178225271317350379400419
Práce214942800954063100136173
je233742800951756
původní240742800954487123165209252269
a2690428009536
nebyla274042800954382126161179215
publikována296942800954487131148165198240276313355391
ani33754280095367895
není348442800954382125141
zaslána36404280095326999116152194230
k3885428009533
recenznímu39334280095236198136178211254271336378
řízení43254280095244173111154171
do451042800954386
jiného46104280095173476116158201
média.4826428009565104148165201215
Střet50564270098416997139168
zájmů:52384270098357799167212231
Žádný.48544000954380125168202213
Financování:71643900984161108149195232277318359406427446
Ne.117844000955191104
Poděkování:130043900984590137180221266307348395416435
N/A.175244000955180122139
Registrace190943900984688135156190219248290326368
v2293439009841
databázích:235143900984687116158205247284306342389408
N/A.277644000955180122139
Projednání293243900984573119141183231278319365387
etickou33354390098417192128170214261
komisí:361243900984186155176210231250
N/A.388044000955180122139
LITERATURA426463001234978134189250318368438498567
1.42548000853647
Whistler48448000835795110135158172206227
D.72248000834656
De79048000834580
morbo88148000835895116155193
puerli108648000833876110130145160
anglorum,125748000833269108122159180218275287
quem155648000833774109166
patrio17334800083397192113128165
ideiomate19104800083145286101138196227248281
indigenae22034800083145290104142176214245279
vocant249448000833268100133170191
„the26964800083214279114
rickets“.282148000832136674254900083306385112132141
Journal57949000832562100120158190204
of79749000833756
History8674900083445984106143164197
of107849000833756
Medicine.114849000835488127142173187225259270
1645;5:397-415.143249000833465101133143177187222255287305340370399411
2.42550000853651
McCollum49050000835486127163178193229286
EV,7905000083337078
Simmonds88250000833347104161198236275300
N,119650000834557
Becker126750000833570102131164185
JE,14665000083245769
Shipley15495000083327084122138172203
PG.17655000083367993
An187150000834179
experimetal196450000833465103138159174231265287319333
demonstration231150000833973130168205231253274306327342379417
of274250000833756
the28125000083215993
existence4255100083346580105127161198229262
of70151000833856
a771510008332
vitamin8175100083314668100157172209
which104051000835188103134171
promotes12255100083396096154191213246272
calcium15115100083316378109123160217
deposition.174251000833873111149175189211226263301313
J2069510008324
Biol21075100083365088103
Chem.222451000834077111168181
1922;53:293-298.24195100083346396130141176208219253287319340370404438451
3.42552000853650
Askew4915200083416897131181
FA,6885200083327083
Bourdillon78752000833573110131168183197212249287
RB,10905200083357183
Bruce11885200083365694125158
HM,136252000834499111
Jenkins14895200083245996126141178204
RGC,170952000833579119131
Webster185652000835790128154177210230
TA.21025200083336983
The220152000833271105
distillation23225200083385378101115130144176197211248286
of262452000833756
vitamin26965200083314668100157172209
D.42553000834556
Proceedings4955300083355591123156191230244282320345
of85453000833856
the9245300083225993
Royal103153000833673104136151
Society.119653000833270102116150172205214
1931;B107:76-90.14245300083346496126134169200231263272305336359393428440
4.42554000853650
Windaus48754000835773110148180217242
A,74154000834154
Schenck80754000833264101136173204234
F,105254000833338
von110154000833269107
Werder121954000835890111148182203
F.143354000833338
Uber148354000834482117137
das16325400083387095
antirachitisch17395400083326990105125157189226240262277302333371
wirksame21215400083516686116144177234268
bestrahlungs-produkt2401540008338739912214217521222726430133936538542444548242555000833875104128
aus5675500083326994
7-deoxycholesterin.6755500083345292126164194227258295333348382408430464484499536549
Hoppe-Seylers123855000834481120159194216247281312328362382409
Z1661550008337
Physiological171255000833572102128143180195232271286317349364
Chemistry.209055000834077111168183208231251285294
1936;23985500083346496129141
241100-103.25535500083346595122153188211241272305316
5.42556000853650
Casado4885600083407298130169206
E,70856000833245
Quesada76656000834784119145177216247
JM,10275600083247891
Naves113156000834576107141167
M,131156000835567
et139256000833455
al.14615600083324658
SEIOMM15335600083326478125180234
recommendation17805600083215486123180237272309347379400415452490
on228356000833775
the23715600083226094
prevention24785600083396093125158196216231268306
and279756000833270108
treatment4255700083224276107128185220257278
of71757000833756
vitamin7875700083314668100157172209
D1010570008345
deficiency.10695700083387289106138152186223255288297
Re.13805700083356981
Osteoporos14755700083477396129167206244265301327
Metab181657000835589111143181
Miner.201157000835569106141161171
2021;13:84-89.219657000833467100130138167196207241277299334368378
6.42558000853652
Bergwitz4955800083357192130181197219250
C,76358000834053
Jüppner83458000832562102141180215236
H.108858000834458
Regulation116458000833570110147163195217232270308
of149158000833756
phosphate156558000833978116143182220252274308
homeostasis189158000833876134169208235258291317332358
by226758000833970
PTH,235658000833569114127
vitamin25015800083324870103161176214
D2733580008345
and279758000833170109
FGF-23.42559000833276109131162196209
Annu64959000834179117155
Rev81959000833671103
Med.93759000835590129142
2010;61:91-104.109559000833468100131144180210219254286305335367403416
7.42560000853645
Dominguez48960000834585144159198238276312342
LJ,8496000083326072
Farruggia9406000083326284107146185225241274
M,123260000835569
Veronese13196000083366991129168204232267
N,160560000834458
Barbagallo16816000083366991132165205238254270309
M.200860000835569
Vitamin20966000083355376109168184222
D2337600008345
sources,240060000832766104126158192220234
metabolism,2652600008357931161501902294256100083153057116129
and57561000833271111
deficiency:7076100083387392109141157193231264298313
available10416100083326498113129162202219254
compounds131661000833269128168208246285325352
and168961000833271110
guidelines18216100083387692131167183199238273301
for21436100083185779
its22436100083153866
treatment.23316100083214378111133192228267289303
Metabolites.265561000835490113147187226425620008315305488116130
2021;11:255.57262000833469102134143174202212248283316329
8.42563000853651
Christakos4926300083407797112138160192222259285
S,79263000833345
Dhawan85263000834583115165197235
A,110263000834154
Verstuyf11726300083366888115137174206227
L,141463000833245
et147463000833456
al.15456300083324759
Vitamin16196300083365273106163177214
D:184963000834558
metabolism,192263000835792113145184222237252277334346
molecular228463000835794110144176213228259279
mechanism257963000835792124161193230244270327
of42564000833756
action4956400083326386101138176
and68564000833269107
pleiotropic8066400083395488103140161182219257272304
effects.11246400083335271105137160187200
Physiological133864000833572102128142180195232271286317349364
Reviews.171664000833569101116150200227240
2016;96:365-408.19706400083346798129140175210221256290323344380415450463
9.42565000853649
Keum48965000833569107165
N,66865000834457
Chen73965000834078113151
Q-Y,90465000834771104112
Lee103065000833165101
DH,114565000834590103
et126265000833456
al.13326500083324760
Vitamin14066500083365275107165180218
D1638650008346
supplementation169865000832663102142158192250285323345378400415453491
and220365000833270109
total23266500083225981113129
cancer246965000833164102134168189
incidence2672650008315528510013917321242566000833165
and50866000833270109
mortality63566000835896117142175190205228261
by91566000833870
daily10036600083387085101132
vs.11546600083315872
infrequent1244660008315527193128167205240278299
large15616600083154769107142
bolus17216600083387793131157
dosing189666000833877103118156195
strategies:21096600083264971104126159199214249276288
a2415660008332
metaanalysis246566000835893115148180218250266298325339366
of284966000833756
randomised4256700083215492131169227242268303343
controlled78367000833168107128150187203218253292
trials.1091670008321435890106132145
Br125267000833556
J1324670008324
Cancer.136367000834073111143177198208
2022;127:872-878.158767000833468101136148178208241251286319353374409442476489
10.4256800085367085
Rosen52368000833574100135173
CJ,7106800083406779
Adams80268000834179112170196
JS,10116800083255769
Bikle1094680008335508097132
DD,123968000834692103
et135568000833456
al.14256800083324760
The149968000833271106
nonskeletal161968000833776114141170205220255277310325
affects19586800083325170105137162189
of216168000833756
vitamin22316800083314770102160175213
D:245868000834558
an253068000833169
endocrine261368000833472111149182203219257292
society4256900083266497112147169203
scientific6436900083265974108146168183201218250
statement.9086900083265082104138196231269291304
2012;33:456-492.122769000833468100130143178210222256289323347383417450462
11.4257000085366678
Athanassiou51770000834162100133171203230256271309347
L,87870000833145
Mavragani93770000835487118140173212244283298
CP,12487000083407680
Koutsilieris134270000833572111133161176191206240262277303
M.165970000835569
The174270000833271106
immunomodulatory186270000831573130168206244303341381418433466487524546580
properties24567000083386097137172194218234268295
of276570000833757
vitamin28357000083324842571000832254112127165
D.60671000834556
Mediterr67771000835590130145167201222244
J936710008324
Rheumatol.97671000833573108146204236258295311324
2022;33:7-13.131571000833468101136148183216228261280310340353
12.4257200085366884
Menzes52572000835490128157191218
AR,7597200083417791
Lamb86672000833165122162
MC,104472000835495108
Lavie11687200083316596112147
CJ,13317200083406679
et142672000833456
al.14987200083324760
Vitamin15747200083365275107165180218
D1808720008346
and187072000833270109
atherosclerosis.19957200083325391126148185212244259294315352379394420434
Current24457200083407697119153191213
Opinion267472000834787102140155193232
in42573000831553
Cardiology.4937300083407394132147185201239279311321
2014;29:571-577.82973000833468100131143178212225260294326345379412447453
13.Cashman42574000853668835087400083407399137195227265
KD,7887400083348192
Dowling89574000834583135150165203242
KG,11517400083357892
Škrabáková12577400083326284117157190220257289322
Z,159374000833851
et165974000833456
al.17297400083324760
Vitamin18037400083365375108166181219
D2036740008345
deficiency20957400083397391108140155190228260294
in240374000831452
Europe:24707400083326990127167202215
pandemic?26997400083397211014918442575000835772104130
Am57075000834199
J685750008324
Clin7247500083405570108
Nutr.84775000834583105127137
2016;103:1033-1044.99975000833569100132144174205239250280311344377399430461498535547
14.4257600085366883
Demay51976000834580137169199
MB,72976000835590102
Pittas842760008335497194126152
AG,10067600083418395
Bikle1113760008335507995129
DD,125476000834590100
et136676000833455
al.14337600083324659
Vitamin15037600083365173105162177214
D1728760008346
for17857600083185576
the18737600083215993
Prevention19787600083355588119153190211225263300
of229076000833756
Disease:23577600083456086120151177211223
an259176000833269
Endocrine26727600083326910814517719721242577000833872
Society51177000833270102116150172205
Clinical7307700083405468106120151183198
Practice9427700083355587119142157188221
Guideline.11777700083448196134168183197234269280
J1471770008324
Clin15097700083405469106
Endocrinol162977000833269108145177198213250288303
Metab.194677000835489110142181193
2024;109:1907-1947.215277000833568100131142172203237249279308343375393423453488519524
15.30474800085366883
Giustina31434800083445996122145161198231
A,338648000834155
Bilezikian34544800083355166100130145175192223261
JP,37284800083246064
Adler38054800083417995129150
RA,39684800083357892
et407348000833456
al.41424800083324760
Consensus421548000834076115141176214240277303
statement45314800083264982103137195230268289
on483348000833775
vitamin49214800083324770102160175213
D5147480008345
status52054800083264981103141167
assessment53854800083325885119304749000832651107141178198
and325749000833168106
supplementation:337449000832662100138153187243277314334366387401438475487
whys,387249000835087117143155
whens,403949000834986120157182195
and424549000833168106
hows.436249000833774124150163
Endocrine453649000833269106143175195210247280
Reviews.482849000833568100115148198224237
2024;45:625-654.50764900083346798129140174205216250282316337373405439451
16.30475000085366985
Biasucci31455000083355182109146178209224
G,338250000834357
Donini345250000834584122137175190
V,365550000833544
Cannalire371250000834073111148181196211232266
G.399150000834457
Rickets40615000083365183113147169197
types42715000083225595130157
and444150000833270109
treatment45635000083214377108130188223261283
with48595000083506688126
vitamin49985000083324770102160175213
D5224500008345
and528250000833270109
analogues.54045000083316910230475100083155393130165192205
Nutrients.326851000834482105126142176215236264277
2024;16:416.356151000833468101133145175206218253283314327
17.30475200085366876
Arboleya314152000834162102141157191223256
L,341552000833145
Brana34775200083355790128160
I,365552000831427
Pardo37005200083356788126164
E,388152000833346
et394552000833456
al.40185200083324861
Osteomalacia40965200083477497131170228260276308340355387
in450152000831452
adults:457152000833170108123146173186
a4774520008332
practical48245200083386093125149165196229245
insight5086520008315537994133171192
for52965200083185677
clinicians.539152000833146619911430475300083314678116143156
J3219530008324
Clin32585300083405570108
Med.338153000835590129143
2023;12:2714.353953000833468101136147177207220255288320351364
18.30475400085366985
Gaksch315154000834476107135168206
M,337654000835468
Jorde34635400083246284122157
R,363954000833549
Grimnes37075400083446581138176211238
G,396454000834457
et404054000833457
al.41165400083314760
Vitamin41955400083355274107165180218
D4432540008345
and449654000833270109
mortality:462454000835796117142175190205227261275
individual49185400083145291106139155193231263279
participant52165400083387192117132164179219252290311
data30475500083387092125
meta-analysis318855000835792115147170202240273288320347362388
of359255000833756
standardized36645500083275082121160192213251266295329369
25-hydroxyvitamin40495500083346991130161199220258288322357372395428485501538
D4604550008345
in466555000831552
26916473455000833467101133164
individuals49155500083145291106139155193231263279305
from52365500083184077136
a5388550008332
European54365500083326930475600083215897133165203
consortium.326556000833168107133171193218233270328342
PLOS362256000833566112144
One.378256000834785120133
2017;12:e0170791.393056000833468100129139169199212246282313343376409442474483
19.30475700085366982
Aspelund314357000834169108143159196234273
T,343057000833342
Grübler348557000834466104143159194215
MR,371457000835490104
Smith383257000833290105127165
AV401157000834174
et409957000833456
al.41695700083324760
Effect42435700083325170105137161
of441857000833757
genetically448857000833873111146169184216249264279311
low481357000831453104
25-hydroxyvitamin49305700083346991130161199221258288322357372395428486501539
D5482570008346
on304758000833776
mortality314158000835795117142174190205227261
risk:3420580008321366292107
mendelian354558000835792130170204220235267305
randomization38685800083215492131169227242271305327342380418
analysis430458000833270103118150177192218
in454058000831452
34610580008334
large46635800083144768106141
European48225800083326990127167202234272
cohorts.511258000833269107145167192219233
Nutrients.53635800083458210512614230475900083347294121135
2019;11:74.319759000833468100130143173201210243273286
20.30476000085367287
Manson314960000835487125151190228
JE,33926000083245871
Cook347860000834077115146
NR,36396000083458195
Lee374960000833165101
I-M,38656000083153793107
et398760000833456
al.40586000083324860
Vitamin41346000083355274107165180218
D4367600008345
supplements442760000832664103142158193251286324346373
and481560000833270109
prevention49396000083396195127161199221236274313
of526760000833756
cancer533860000833265103135168190
and304761000833270109
cardiovascular31716100083316485124139177209242268300338353386407
disease.35936100083385379114146173208220
N3828610008345
Engl388861000833371110125
J4028610008325
Med.406861000835489129142
2019;380:33-44.422561000833569101131143178213248261296329351388425437
21.30476200085366982
Martineau314262000835487108133148186221253290
AR,34456200083417791
Jolliffe3549620008324627893108128147181
DA,374362000834685100
Hooper385662000834482121160196217
RI,40866200083355164
et416362000833456
al.42326200083324760
Vitamin43056200083365275107165180218
D4536620008345
supplementation459462000832764103142158193251286324346378400415453492
to509962000832158
prevent51706200083396195127161199221
acute540462000833164101304763000832255
respiratory31196300083215582121136158191212249271305
tract34416300083214376108132
infections:35906300083155372106139163178216255281293
systematic39006300083275986109143201233255270302
review42196300083215587103138189
and442563000833270109
meta-analysis455163000835792114147170202240272288319346361387
of495563000833857
individual50296300083155292107139155194231264279
participant53256300083397293118133165180304764000833972110131
data.31946400083387092124138
BMJ.334764000833590116129
2017;356:i:6583.349164000833468100130139174207242254269281317350384418431
22.30476500085367288
Rasoul31516500083356895133171186
MA,335365000835596111
Al-Mahdi34796500083415779135168206245260
M,375565000835467
Al-Kandari38386500083415779116149187226259280295
H,414965000834457
et422265000833456
al.42946500083314760
Low436965000833269120
serum45056500083266182121178
vitamin46996500083324770103161176214
D4928650008346
status49896500083265082104142168
is517365000831541
associated52306500083315884123155170202224258298
with30476600083516689127
high31916600083385392130
prevalence33396600083386094126159174209247280313
and367066000833270109
early37966600083346687103135
onset394966000833775102137159
of412666000833756
type-142006600083225595131154185
diabetes44036600083385385124160182216242
mellitus466366000835793108123138161199225
in490666000831452
Kuwait.497666000833572123156171194207
BMC520166000833590131
Pediatr.53496600083356910812415630476700083224353
2016;16:95-95.311667000833468100131143173205217252286308343377389
23.30476800085367286
Jacobsen31466800083245687124163189224261
R,342068000833548
Moldovan348168000835492107146183215247285
M,377868000835468
Vaag38586800083356698136
AA,40076800083418397
et411668000833456
al.41856800083314659
Vitamin42566800083365274106163178215
D4484680008345
fortification45416800083185677101116133150182214236251288326
and488068000833169107
seasonality50006800083256091118155193225240255277310
of532368000833655
birth5391680008338547498136
in304769000831553
type31156900083215595131
13261690008334
diabetic33116900083385385124160182197229
cases.:35556900083326491126153166179
D-tect37506900083456991125158182
study.39476900083264987126158168
J4131690008324
Devel417069000834581113147163
Orig43486900083476985123
Health448769000834479111126148187
Dis.46896900083456187101
2016;7:114-119.480569000833468100131143176186216244275298329356386397
24.30477000085367186
Dong314970000834584122161
J-Y,3327700008324477987
Zhang343170000833775107145184
W,363270000835767
Chen371570000834078113151
JJ,38827000083244860
et395870000833456
al.40307000083324760
Vitamin41077000083355274107165180218
D4341700008345
intake44027000083155374107137171
and458970000833270109
risk4714700008321376393
of482370000833756
type48957000083225696131
15042700008335
diabetes:50937000083385385124160182216242255
a5364700008332
meta-analysis54127000083579230477100083225477109147179195227254268295
of335771000833756
observational342971000833777103138160194227249264302341373388
studies.38337100083264987126141176203216
Nutrients.406571000834482105126142176214236264277
2013;5:3551-3562.435871000833468100130141176187222255288319337370403437470483
25.30477200085367388
Kayaniyil315572000833569100133171186219234250
S,342572000833346
Vieth34917200083365388110149
R,366072000833650
Retnakaran37307200083367194132165195229250283321
R,407272000833650
et414272000833457
al.42197200083324861
Association43007200083427096135168183215237252291329
of465072000833757
vitamin47277200083324871104162177215
D4963720008345
with50297200083516689127
insulin51777200083155379117132147185
resistance538372000832155829712330477300083225492125158
and322373000833169109
β-cell33497300083386194128143159
dysfunction35257300083387097117156194226250265303342
in388473000831553
subjects395473000832663102118153185209237
at420873000833254
risk4279730008321376393
for43897300083185678
type44847300083225595131
24632730008334
diabetes.46847300083385385124160182216243256
Diabetes49577300083466193133168190224251
Care.52257300083407394128140
2010;538373000833468100131144
331379-1381.30477400083346798128160193217248278312344354
26.30477500085367187
Kahawara314975000833568107139190222244277
T,344075000833342
Suzuki349675000833370100138168184
G,369575000834457
Inazu37677500083155385114153
T,393475000833342
et399175000833456
al.40627500083314760
Rationale41367500083366890105143182214230264
and441575000833270109
design45397500083387399114153191
of474575000833756
diabetes48167500083385385125160182216243
prevention50747500083386094126160199220235273312
with54017500083506688126
active30477600083326590105138173
vitamin32417600083324871105164179218
D3480760008346
(DPVD):354676000831966102140187206218
a3785760008332
randomised,38387600083215493133172231246273309349362
double-blind,422176000833977116156172208231272288304342382395
placebo-controlled46377600083395688121155195235259293331370392414452468483519559
study.52177600083265089128161171
BMJ540976000833692118
Open.304777000834787122160174
2016;6:e011183.323677000833468100131143179192226262294321349380414426