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lékové666255001212375123178226276
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zaměřené1179255001214393178229262312369421
na16202550012155104
diabetes1744255001215781130187239274324365
mellitus21292550012183135160184208242298338
2.2487255001215174
typu2581255001213384142199
a28002550012148
jejich2868255001212476101125171227
jednotliví3115255001212475134190246280304328377402
zástupci,3537255001214394134169225283329353375
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na33622690012155104
strategii3485269001213973106155188238295318342
léčby.3846269001212474120177224240
Dřívější4106269001216699123171221245284308
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role4820269001213287111162
HbA1c50012690012165122183517727700713054
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na6352830012155104
kombinaci7582830012147101185242267322371416440
léčby1217283001212374120177224
a14612830012148
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role1897283001213288112163
metforminu20802830012182133167200255289373397452507
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v31652830012147
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léčby3522283001212475121178224
nově37662830012155111158208
zachyceného3993283001214393138194240284334390441497553
pacienta45652830012157106151175226282315364
modifikována49482830012183139197220250277324378426475531579
jeho425297001212476132189
kardiovaskulárním642297001214797130188212268316365406453510534583616673697782
a14522970012148
renálním1528297001213384141190214270294379
profilem.1935297001215791146176204228279364386
Ten2349297001215095151
pak25292970012157106154
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jeho3148297001212475132188
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kardiovaskulárních4729297001214797130187212268316365405453509534583616673697743799
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by9933110012157105
měl11273110012184135160
být13173110012157104141
léčen1488311001212475122171228
s17463110012139
pomocí18153110012157114199255301325
inhibitorů2170311001212380136160218242276331365422
SGLT226213110012150115164208261
a/nebo2912311001214885139190248305
agonistů32473110012148105161218242282317372
receptorů3649311001213384130180238273328362418
GLP-1.40973110012164113167197244261
Zahájení43873110012156106162211236287344368
léčby4785311001212374121178226
těmito5041311001213383167191226281
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na10863250012156105
hladině1215325001215580129187211267318
HbA1C15583250012165123184173533300713062
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na20683250012156105
tom,2197325001213388173195
zda24163250012143100149
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užívají2956325001215599123172222247271
metformin,32513250012183135169202258292377401457479
či3754325001214569
nikoliv.3847325001215680128182207231281298
Ústup41693250012165104139195253
od44463250012155113
léčby4584325001212375121179226
perorálními48343250012157109143199233282307363387471495
léky5354325001212375123174
s4253390012139
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rizikem882339001213256100124171220304
hypoglykemie12063390012155101159216273297345393442526550601
je1826339001212575
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rysem2738339001213384124175259
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dekády,34013390012156107154204261310326
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akcelerovaný3948339001214895139189214265298353401450506552
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nahradit.14033530012155104160194243301325359381
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léčebné2043353001212475121171229286337
preparáty2400353001215790141199249282331365415
a28353530012148
možnosti29033530012183139182239295335370393
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chirurgie37833530012145101125158214248304328379
též4182353001213383127
umožňují43293530012155139195238294350374398
efektivní4747353001215081132180217241290347371
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míry4253670012183108141193
obezity.6413670012155113165209233268318336
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přináší1310367001215791115171220260285
aktuální1618367001214896133188237262318342
pohled19833670012157114171195247305
na23113670012156105
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léčby2809367001212475122179227
tohoto3059367001213388145201235290
onemocnění.33723670012155112163248304351407458515539561
Klíčová425384001235885111155211261312
slova:758384001234268124174225248
diabetes1027384001215680127184235269318357
mellitus,14063840012183133157181204237292331352
kardiovaskulární1779384001214796129185208263310359398444500523571604660683
onemocnění,24833840012155111161245300345401451506530550
hypoglykemie,30553840012155100158214271294342389438522545595615
obezita,36913840012155112163206230263312333
HbA1c.4045384001216512218342193920071305442753840012121
Treatment4254090015067108171236283384447516563
of10274090015065114
type11794090015046116185248
214654090015072
diabetes15764090015067101166235298346408464
mellitus20784090015099162197231266313382437
–25384090015068
a26444090015064
current27304090015052120169218281350397
view31654090015066100163255
of34584090015066114
the36114090015046115178
different38284090015067101149199262312375444491
drug43574090015068117184253
classes4648409001505287152208263326381
and4254230015063132201
strategies6644230015054100150213261323392427489545
for12474230015047115163
their14494230015046115178213262
use17494230015067122185
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drug629443001215687142197
classes843443001214467114152191240279
targeting1139443001213280112167216249271326381
type1537443001213281138188
217424430012151
diabetes1810443001215678125181231263312350
mellitus21784430012182132155177200232286324
and25194430012148102158
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representatives3324443001213382138170219257307362393441473495543591630
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the4887443001213387137
last5041443001212370108141
105199443001215197
years5313443001214795142174213
in425457001212379
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the1979457001213388139
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the2679457001213388138
treatment2841457001213366116164196279330386418
strategy.3283457001213973106154187236293341357
The36644570012149106156
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therapy1093471001213389139172220277323
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the1626471001213388138
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metformin,23954710012183134167199254287371394449470
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renal1971485001213383138186210
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if3169485001212453
positive32424850012157113152175208231280329
or3591485001215588
at3699485001214881
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risk401048500121335695142
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should5243485001213995150205228285
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SGLT210854990012149114161204257
inhibitors1363499001212479134157214237271325358398
and/or17824990012148104160195246279
GLP-120824990012165112165195240
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HbA1C564513001216512318373952100713062
levels829513001212474122171195234
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metformin.26995130012183134168199254287371395450471
The31985130012150107157
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oral4143513001215588137161
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feature1935527001212979127160215247297
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these5299527001213388138178228
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possibilities23575410012156112152191214270294317340373396446486
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surgery3341541001213994126182232265315
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it4120541001212457
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influence5139541001212378107134188239294339388
the425555001213388139
level585555001212374121171195
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obesity.9065550012155112163202225258308325
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article1441555001214981117140185208258
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an21035550012149104
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perspective27045550012157108141181238289335370393441490
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strategies3786555001214074106155187237293317367406
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this4352555001213388111150
disease.4524555001215679118169217256306326
Key4255720012358108158
words:6045720012374130166224266290
diabetes915572001215680127184235269318357
mellitus,12945720012183133157181204237292331352
cardiovascular1667572001214594126182205260308356395440495519567599
disease,2287572001215780119169217257307327
hypoglycemia,26355720012156101159215271295342386435519542590611
obesity,32675720012155112163202225258308324
HbA1c.3612572001216612318337865800071305438425720012121
Zatímco565608001074890116135208248294
diabetes876608001074867107156201228270304
mellitus11966080010773117136155173200248281
1.1493608001074455
typu1564608001072870120168
(DM1T)1748608001072482151190227255
je2019608001071963
od2098608001074797
stanovení2211608001073463104151199239282330348
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stále425622001073463105125169
léčen621622001071964105148197
s8456220010734
pomocí9056220010750100175224266285
inzulinu1217622001071967105154173192240288
či1532622001074059
jeho1618622001071964113162
analog,1807622001074189131150199250266
tak2099622001072870109
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schémata1119636001073476126172247289318360
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místo2167636001077695129159207
volby2402636001074190111162202
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léčbě2701636001072065107158204
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letech176065000107206492135177225
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do1058664001074997
klinické118066400107385977125144184222265
praxe1470664001074976118158201
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nových2016664001074997137180220268
lékových2309664001071963101149189232272320
skupin,2654664001073371119169188236251
především425678001075076119169213254288306380
GLP-1831678001075696142168207
analog1064678001074189129148197247
a13376780010741
inhibitorů1404678001071967115133183202230277304352
SGLT2,1782678001074298138175220235
které2043678001073869112138181
kromě2250678001073867114188232
pozitivních2508678001075099134154182200241291309349397
hypoglykemizujících3047608001074988140190241261301341385460479517566585604645665705754
účinků3829608001074889108157196245
mají41016080010775116136155
i42836080010719
pozitivní43296080010750101137157185205247297316
vliv467260800107416180122
na4821608001074991
kardiovaskulární4939608001073882109158177226267310344382431451492519569588
a30476220010741
renální3108622001072669117158177225243
systém3371622001073374108137180254
organismu3644622001074875123164212231263337384
(1,404862200107246374
2).414262200107446679
V31876360010746
článku3252636001074059100148186234
jsou3505636001072052101149
v36736360010741
úvodu3734636001074789136186234
popsány3987636001075099149183224272311
jednotlivé4317636001072064114162210237256275316359
medikamenty46966360010773118168186224266340384432459502
či5217636001074059
lékové5295636001071963102149189232
skupiny,3047650001073471119169188236275286
ve3351650001074184
druhé3453650001074975124172216
jeho3687650001071963111160
části3864650001074182115144163
pak4045650001075091129
zmíněna41926500010736111129177221269310
aktuální4520650001074179110158198217265283
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strategie5368650001073463901313047664001072870120139183
jejich324766400107196382100141189
využívání3453664001074083132169188229271319337
v38076640010741
terapii.386566400107287097138188207226241
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účinky5126664001074788106154192235
léků5378664001071963101149
ani3047678001074190108
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