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PŘEHLEDOVÉ42522001004388130181216258306358404446
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pohledu75733001003877115130166204242
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24018922001003675121
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CKD.1708132001075196155169
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časných676146001074081115162201241289
známkách984146001073685126199237280320368
CKD1371146001075296156
a15461460010741
CHSS16061460010751108148189
je1814146001072063
třeba189714600107285497147188
aktivně2105146001074078109128169218262
pátrat,2386146001075092119146187214231
pacient2636146001075091132150194242269
je565160001071963
v6481600010740
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stadiu950160001073463104153172219
onemocnění1189160001074897141214263304352396444463
často1672160001074081114143190
asymptomatický.1882160001074074115189239267313387428455474514552595607
3.304762001074459
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doporučení355062001074997147197224272312355403421
říkají,39936200107264585127146165180
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gliflozin42956200107496886110132181216235283
by459962001075089
měl4710620010773117136
dostávat486862001074997130159201241282309
společně519862001073483132152196237285329
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inhibitorem324276001071967115133183202230277304347420
RAAS3684760010745100155198
a3903760010741
statinem396676001073362103131149197241315
každý430376001073880117165206
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s4821760010733
CKD487676001075196155
až505376001074178
na515276001074889
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výjimky.370490001074184104122196234276288
Česká401790001075194128165208
verze424990001074184111149192
doporučení446690001074997147197224272312355403421
byla491290001075089109149
publikována508690001075098148167186223271311353401441
v31871040010741
tomto3247104001072875149176223
časopise3489104001074082115163213233265310
před3818104001075077119170
340071040010744
roky4071104001072673112155
(22).4246104001072366110132146
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gliflozinem342911800107496887111133182217236284329403
by3858118001075089
měla39731180010774118138178
trvat417811800107275498140167
až4371118001074179
do4476118001074997
konečného4600118001073885134178219267312360409
stadia5035118001073463104154173213
selhání527411800107347897145186234253
ledvin,3187132001071963113154174222237
tj.344413200107284763
do3526132001074998
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na4017132001074989
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nebo4400132001074892142191
do4611132001074997
transplantace472813200107285496144177226246287335361403443486
ledviny.5233132001072064114155174222261273
5.3047146001074559
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gliflozinu355114600107507089114138187224244293342
se3921146001073480
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dlouhodobého4639146001075069119169218268320370421468517567
poklesu52341460010750101141162208243291
funkce3187160001072473121158198240
ledvin,3447160001071963113154174222237
nikoliv3704160001074867104152171190231
podle3954160001075099149168212
jejích418616000107196382100140188
akutních4394160001074179127155204222262310
a47241600010741
přechodných4785160001074976119160208257307355393433481
změn.52861600010736110154202218
PROHLÁŠENÍ48519000974387144199239292335376430452
AUTORŮ:954190009749101143200245299316
Prohlášení128618900984573119166187229263305352373
o1674189009845
původnosti:173518900984693134179227274320354383404423
Publikace217419000954082127144161195233269308
byla24981900095447997133
zpracována264719000953378102139176218254291334371
s3034190009529
využitím307919000953775119152169195212277
uvedené337219000954380119163203246286
literatury3674190009517335997121158183226249288
a3978190009536
nebyla403019000954383127163181217
publikována426319000954487132150166200243279316359396
ani46751900095367996
zaslána478719000953270100117153197233
k5036190009534
recenznímu50861900095236299137180213257274340382
řízení4852020095244174112156172
do67520200954387
jiného7792020095173477117160203
média.1000202009565105150167203218
Střet12352010098426998141170
zájmů:142120100983679100169215234
Žádný.167320200954380125168202213
Financování:190420100984161108149195232277318359406427446
Ne.236720200955191104
Poděkování:248820100984590137180221266307348395416435
N/A.294120200955180122139
Registrace309720100984688135156190219248290326368
v3481201009841
databázích:353920100984687116158205247284306342389408
N/A.396420200955180122139
Projednání412020100984573119141183231278319365387
etickou45232010098417192128170214261
komisí:480020100984186155176210231250
N/A.506820200955180122139
LITERATURA426225001234978134189250318368438498567
1.42524200853547
Foreman4842420083326889122179211248
KJ,7442420083346273
Marquez82924200835486106143180214243
N,108424200834456
Dolgert11522420083458398136170191214
A,137924200834054
et144524200833355
al.15122420083314658
Forecasting15822420083326990123155187212235250287325
life1919242008314294781
expectancy,201224200833464103138169193225262293326335
years23592420083316495116142
of251324200833756
life2581242008314294781
lost,26742420083155278100113
and279924200833168107
all-cause425252008332476284118151189215250
and69125200833270109
cause-specific81625200833164102128163186213252288320336353370402
mortality123425200835896118142175191206228262
for15122520083185678
250160625200833469103
causes172525200833164102128163190
of193125200833757
death:200425200833873105127165177
reference21972520083215574108130164202234268
and248125200833270109
alternative26062520083324769103124163195217232265299
scenarios4252620083265892130162184199237264
for7022620083185678
2016-4079326200833468100131154191227
for10332620083185678
19511242620083346498
countries123526200833168106145166187203238265
and151326200833170109
territories.1635262008321557698114136173195210245272285
Lancet.193326200833265103135169191205
2018;392(10159):2052-2090.215126200833468100131143178211244262294325357387419437449484518552585606637671706742754
2.42527200853652
Ehrenkranz4932720083337091126164194216249287317
JR,8252720083256175
Lewis91627200833165116132158
NG,109027200834589103
Kahn120927200833468106144
CR,13692720083407690
Roth14742720083367496134
J.162427200832437
Phlorizin:16772720083357288126147163192208246258
a1951272008331
review.19982720083215587103138189200
Diabetes22142720083456193132167190223250
Metab248027200835590112145184
Res26802720083357097
Rev.279327200833570103113
2005;21(1):31-38.42528200833468104138149184216231262277289324355374406440454
3.42529200853652
Jörgens4952920083246385124160199226
V.73929200833545
The80229200833373109
roots9292920083205898120149
of109629200833757
SGLT117129200833277110140
inhibition:13292920083155392108148164187203242281294
Laurent-Guillaume164129200833165104125160199221242289328343359375408446505541
de220029200833873
Koninck,229129200833573113128167200231246
Jean25552920083246092131
Servais27042920083336890126159175202
Stas4253020083325488115
and55730200833270110
Freiherr6843020083325287103142177199222
Josef9233020083246390126146
von108530200833270109
Mering.121130200835590112129167207221
Acta14483020083417398132
Diabetol.15973020083456194134170193231247261
2019;56(1):29-31.187530200833468101132145181216236268283296332367391424456466
4.42531200853652
Zinman4953120083385492151184223
B,73631200833548
Wanner80331200835789128167202224
C,104531200834054
Lachin11173120083326699137153192
JM,13273120083248094
et143931200833457
al.15143120083324862
Empagliflozin,159431200833391131165204220236254271310339355394407
Cardiovascular20203120083397395134150188221255282315353369402424
Outcomes,246231200834786110141179238273301315
and279531200833270110
Mortality42532200835494116141175191206230264
in70632200831453
Type77632200833261101137
2930322008334
Diabetes.9813220083456294134170193228255270
N1267322008345
Engl132932200833271111127
J1472322008325
Med.151332200835591131145
2015;373(22):2117-2128.167432200833469102133144180212247266301336355367403435464494513545577608642656
5.42533200853651
Heerspink49833200834480116138166206222261292
HJL,81233200834470103117
Stefánsson9513320083335589109143182209237276315
BV,12883320083357282
Correa-Rotter139233200834077100122157190213251290313338372394
R,180833200833651
et188033200833458
al.19593320083324862
Dapagliflozin204333200834578118152192208224242259298327344382
in244733200831554
Patients25233320083356790106141180203231
with27763320083516790129
Chronic42534200834078100138177193226
Kidney6683420083345291130165198
Disease.8823420083466289124157184220233
N1132342008344
Engl119334200833371111127
J1337342008324
Med.137734200835591131145
2020;383(15):1436-1446.153834200833569103138151187222257276308339358370401433466501525557589626663677
6.42535200853652
Nuffield49135200834482101119136171187226
Department73135200834581120153175199257293331353
of109835200833656
Population116835200833572111150165198220235273312
Health149435200834479111127149187
Renal169535200833570109141157
Studies18663520083325391131146181208
Group;208835200834365102141180192
SGLT2229435200833277109138174
inhibitor24823520083155391106145161184221243
Meta-273935200835489111144167
-Analysis42536200832162100133149181208223250
Cardio-Renal6883620083407395133148187210247283321353369
Trialists‘1071362008332506698114129156179207220
Consortium.130536200834077115142181202227243281338352
Impact167136200831572112145177202
of188736200833756
diabetes19573620083385386125161183217244
on221536200833776
the23053620083215995
effects24143620083335372107139164192
of262036200833756
sodium269036200832664104120157215
glucose4253720083385492125162189225
co-transporter-26643720083316993116138171210237276316338363397419440471
inhibitors11493720083155392108147163186224246274
on143737200833776
kidney15283720083294686124160192
outcomes:17343720083377699130168226262290303
collaborative20513720083316885101133173213235268291307340374
meta-analysis244037200835793115149172205243276292324352367394
of284837200833857
large4253820083154870108144
placebo-controlled5863820083385588121155195235259293331370392414452469484520560
trials.1163382008322446093109136150
Lancet.133038200833165104137171194208
2022;400(10365):1788-1801.155538200833469102138151186223260280312345378414448467480510540574610634665697733766776
7.42539200853644
Abdul-Ghani48239200834179118155170192238276308345360
MA,85439200835496110
DeFronzo97639200834580112132168206235272
RA,12603920083357791
Norton136439200834482103127163201
L.157839200833144
Novel163539200834482113147162
hypothesis181039200833767106144166204238264279304
to212739200832158
explain219739200833465104119151166203
why241339200835088118
SGLT2254339200833276108136171
inhibitors272739200831451891041421574254020083215778104
inhibit5414020083145188102140155177
only7304020083367488119
30-508614020083346790123156
%1029402008351
of109140200833756
filtered1158402008317344870102123156194
glucose13644020083375288120155181215
load15914020083155284122
in172440200831552
humans.178740200833774130161198224237
Diabetes.20364020083445990128162184217243255
2013;62(10):3324-3328.23034020083346798127137172205221252282300311345377409440462493525557589602
8.42541200853753
Hostetter50041200834584112136170193218253275
TH,7964120083338093
Olson9114120083476491130170
JL,11024120083245772
Rennke119541200833672111150181216
HG,143241200834591105
Venkatachalam155841200833670109140174197230263302336351385444
MA,202341200835598113
Brenner21574120083365893132171207229
BM.240741200833693107
Hyperfiltration25354120083457811915617719821523125427631033234842542200833776
in51842200831553
remnant58842200832155113151183221243
nephrons:84942200833772111150171208247273286
a1152422008332
potentially12024220083387799133171192208240255270302
adverse152242200833170103137159186221
response17604220083215582121160198225260
to203742200832259
renal21134220083215593125141
ablation.22724220083317186119140156194232245
Am253542200834199
J2652422008324
Physiol.269342200833573104131145183199212
1981;241(1):F85-F93.4254320083346499131139174206237252283298310343376410432466500532545
9.42544200853650
Brenner4924420083355792131170205227
BM,73644200833591105
Meyer85844200835490122157179
TW,105444200833394105
Hostetter117644200834483110134168191216251273
TH.14664420083327993
Dietary15754420083466297120154176210
protein18024420083396199122156172210
intake20294420083155376109140175
and222144200833170110
the23484420083216096
progressive24604420083396199140161196224251267300335
nature2812442008337704254520083226082117
of55845200833757
kidney6314520083304786125161193
disease:8404520083385481116149176212225
the10814520083226096
role11934520083215975111
of132045200833757
hemodynamically139345200833773132171211244283316375391423457473489521
mediated193045200835793133149182204239279
glomerular22254520083385493152188210249265298319
injury25604520083155469108129164
in274045200831553
the28094520083226196
pathogenesis4254620083397295134173213248287323351366393
of83546200833757
progressive9094620083396199140161196224251267300335
glomerular12614620083385493152188209248264297319
sclerosis15974620083265975111133171198214241
in185546200831453
aging,19254620083327287126166179
renal21214620083215695128144
ablation,22824620083327288121144160198237251
and255046200833270110
intrinsic2677462008315547698114153180195228
renal4254720083215594127143
disease.5854720083385481116149176212225
N827472008344
Engl88847200833371111127
J1032472008324
Med.107247200835591131145
1982;307(11):652-659.123347200833565101135148184219253270302331346358394429463484522556589601
10.4254820085356984
MacKay,52248200835486118152186216226
Eaton7624820083326486123161
M.,9364820083536780
MacKay,103048200835385117152185216226
Lois12694820083316883109
Lockard139248200833067100130163184222
and162748200833169108
Addis,174848200834078117132158171
T.193248200833242
FACTORS198748200833269108143189225259
WHICH2259482008357101117157201
DETERMINE247348200834578113147182236252297330
RENAL28164820083356842549200834485117
WEIGHT.55649200835790105150194229238
American80849200834098133154170202235273
Journal109549200832462100121160192208
of131749200833656
Physiology-Legacy138649200833573103130145183199238277309331364399438470503536
Content193649200833976115136170208230
September217949200833267107129163220259295316
192825094920083346497131
86(2):45926544920083336988122140152186219252
11.4255020085366780
Lindner,5255020083314786126165200222233
A.,7785020083415669
Charra,86750200834079112134156190204
B.,10915020083354962
Sherrard,117350200833371107129151185207246259
D.145250200834557
J.,15295020083253851
&1600502008339
Scribner,16595020083336688104144183219241251
B.193050200833649
H.200050200834458
(1974).20785020083185181115146164176
Accelerated227450200834173105139155191213246269303344
atherosclerosis263850200833154931281501882162494255120083155072110138153180
in62251200831453
prolonged6925120083386199115154193233268309
maintenance101751200835891107145167202241274312345380
hemodialysis.141351200833874132171212227260276309336352379393
N1823512008344
Engl188451200833371111127
J2028512008324
Med.206951200835490130144
1974;290(13):697-701.22305120083346598129142178212249269301332350363399433467486518552584595
12.30472420085366986
Nohria315624200834584124147164197
A,337524200834157
Hasselblad345424200834478106134170187228245279319
V,379524200833646
Stebbins38632420083335591131172189228256
A,414124200834157
et422024200833458
al.43002420083324863
Cardiorenal43852420083407497136153192215251290324341
interactions:47482420083145477112134169202228245284324352365
insights5136242008314548198138177200229
from53872420083194281141
the30472520083226198
ESCAPE316325200833268110154191224
trial.3406252008321446194111126
J3550252008324
Am3592252008341100
Coll37102520083407996113
Cardiol.38412520083407496136152192209223
2008;51(13):1268-1274.408325200833469107144157194226243276307326339370401436473497529561595627641
13.30472620085367086
Mullens315626200835494110127163203230
W,340926200835768
Abrahams350026200834182105139179212272299
Z,382226200833852
Francis38972620083325388127161177205
GS,41242620083447892
et423926200833458
al.43192620083324963
Importance440526200831474114154177203238277311346
of477326200833758
venous485426200833167106146186213
congestion509026200833169109150186214239255295335
for54472620083195881
worsening304727200835089112141177216232271312
of337427200833758
renal34482720083205595128145
function36082720083195998131157173212252
in387527200831554
advanced394527200833172106140179212247288
decompensated424827200833874108146206246283322350384407442483
heart474627200833874107129155
failure.4917272008318536986124147182195
J5128272008324
Am5168272008341100
Coll52832720083407895112
Cardiol.5410272008340749730472820083385594111126
2009;53(7):589-596.319128200833469107143158194229248284305318355391426451487520557572
14.30472920085367087
Ronco315629200833575115148187
C,336529200833954
Haapio344129200834477111152169208
M,367129200835469
House376229200834484123151187
AA,397129200834185101
Anavekar409429200834180114147183214249272
N,438829200834458
Bellomo44682920083367289106145205245
R.473429200833652
Cardiorenal48072920083407597137153193216251291324341
syndrome.517029200832660100140163202261298311
J5503292008324
Am3047302008341100
Coll31653020083407996113
Cardiol.32963020083407496136152192209224
2008;52(19):1527-1539.353830200833469107144157194228247280312331344376407442476496528560594629641
15.30473120085367086
Griffin31493120083446784104128145184
M,335031200835469
Rao343531200833670110
VS,35613120083367085
Ivey-Miranda36623120083154984117141198215237272311352385
J,406431200832437
et411831200833457
al.41923120083324863
Empagliflozin427131200833392132167207224240261280320349366406
in469331200831554
Heart476431200834480113136162
Failure:4942312008333648097136158194208
Diuretic516631200834562101124159183200233
and541531200833272112
Cardiorenal30473220083407497136153192215251290324341
Effects.34063220083325275111145171200215
Circulation.36393220083405779112151168201224241280320335
2020;142(11):1028-1039.399232200833470104139154185218252270303332348362393426460495519551584619653666
16.30473320085367188
Go315933200834484
AS,32663320083417791
Chertow338033200834080116139165203256
GM,3659332008344100115
Fan379833200833263102
D,392433200834557
McCulloch400533200835488131169186202242276315
CE,43443320083407489
Hsu445633200834472110
CY.45903320083407888
Chronic470233200834079102140180197230
kidney49563320083294787127164197
disease51763320083385582119152180217
and541633200833271112
the30473420083226299
risks3169342008321396798129
of332234200833758
death,340434200833875109132173187
cardiovascular36153420083316689129146186219254283317356373407430
events,406934200833468105145168197212
and430534200833272113
hospitalization.444134200833879107148165189224241258289324348365405445460
N4924342008346
Engl499334200833373114131
J5147342008325
Med.519634200835591133148
2004;536734200833571109147161
351(13):1296-1305.304735200833469101117150182200214245276312349373406437473508522
17.30473620085366979
van314636200833266105
der32713620083387497
Velde33873620083367087127164
M,357036200835569
Matsushita365936200835488111141179207246263286321
K,399936200833551
Coresh406936200834079102137165205
J,429336200832438
et435036200833458
al.44273620083324963
Lower451036200833170122158181
estimated47103620083346287104163196220255296
glomerular50253620083385594154191213253270303326
filtration53703620083193653769913430473720083223979119
rate31893720083215679115
and332837200833271112
higher34643720083385495135172195
albuminuria36823720083324990130190207246286309326360
are40653720083325591
associated41803720083326088128163180213237272314
with45173720083516893133
all-cause4673372008332496690125160199227264
and496137200833272113
cardiovascular50973720083326689129146186220254283317356373407430
mortality.304738200835797120146180197213237272284
A3352382008341
collaborative34133820083327087104137178218241276299315349385
meta-analysis381938200835794117151175209248282299332360377404
of424438200833758
high-risk43233820083375494133157181198225256
population460038200833979120160176210233250289329
cohorts.495038200833169109149172198227242
Kidney52133820083355393132169202
Int.5435382008315557892
2011;79(12):1341-1352.304739200833470103132142176211231264295315328359391427459479512543577612626
18.30474020085367188
Rasalam31534020083357097132149182242
R,341240200833651
Sindone34814020083324988128168208244
A,374340200834156
Deed381740200834682119160
G,399540200834458
Audehm407140200834180120156196255
RG,43444020083358196
Atherton445840200834163103139162188226266
JJ.47424020083244963
State48234020083335589112148
of498840200833858
precision50644020083396297131148175192231271
medicine53534020083579313415130474120083314887123
for31894120083195881
heart328941200833774107129155
failure3463412008319547087126148184
with36664120083506791131
preserved38164120083386197125161184220256297
ejection41324120083345086120146163202242
fraction43934120083184276110135152191231
in464341200831554
a4716412008332
new476741200833774126
therapeutic49124120083226198120155195232271295312346
age.527641200833273109123
ESC541841200833267109
Heart304742200834481114136162
Fail.3228422008332637996110
Published335642200833574115132148176215251292
online36664220083387894111150186
January38704220083255898137170193228
23,41164220083347184
2025.421842200833470104140154
doi:10.1002/ehf2.1520543904220083387894108139172186218251288323351384423444478492524556590626661
19.30474320085367085
Chandramohan314943200834079113152193215250309349389422462
D,362843200834557
Simhadri370243200833349108148181222244261
PK,39804320083357188
Jena408543200832460100133
N,423543200834559
Palleti43114320083366986102138162179
SK.45074320083326885
Strategies46094320083325578112135170211228264292
for49184320083195881
the50164320083216197
Management513043200835589128162202239298334374397
of304744200833758
Cardiorenal31234420083407497136153192215251290324341
Syndrome348244200833263104144167205265301
in380244200831454
the38744420083216197
Acute398944200834174113137172
Hospital418044200834483111152169193227244
Setting.44424420083326992118135174214229
Hearts.468944200834481114136162192207
2024;491444200833469104137150
5(3):329-348.50824420083345388107120157191226251285322359374
20.30474520085367390
Katz31544520083357093125
SD.32964520083337992
In340545200831454
search34764520083266296118151190
of368345200833758
euvolemia375845200833473107146163200259275309
in408445200831454
heart415545200833774107130156
failure.4328452008318536986125147183196
JACC454145200832466106146
Heart470445200834480114136162
Fail.4883452008333648097111
2014;2(3):306-307.501145200833470103135149185204239257271307343380405439475509516
21.30474620085367185
Tada315546200833362103136
A,331546200834156
Burkhoff33954620083357497129170210230254
D,367246200834558
Naser375346200834579107143166
JA,39424620083246681
et404746200833457
al.41284620083324863
Dapagliflozin421446200834579120154195212228249268308338355394
Enhances463146200833372112146185219254282
Arterial49374620083416389125147164198215
and517546200833271112
Venous531046200833670110150189217
Compliance304747200834078138179196212246285319354
During342347200834585108125164205
Exercise365047200833367102125157174201237
in391047200831554
Heart398647200834581114137163
Failure4171472008333648097136158194
With43874720083587599139
Preserved45484720083355793121157180216252293
Ejection48634720083334986120145162201241
Fraction:51274720083325387121147163203242256
Insights5406472008314548198304748200833877100130
From31954820083325392151
the33654820083216197
CAMEO-DAPA348048200834084141176225250298339377415
Trial.39134820083335269102119133
Circulation.40644820083405779112151168201224241280320335
2024;150(13):997-1009.441748200833470104137150182213249270303334353366403439474494526559596633645
22.30474920085367491
Viklický31574920083365385103119153184219
O,339549200834760
Ryšavá34744920083356997132165199
R,369249200833551
Tesař37614920083336593128150
V,393049200833646
Rychlík399549200833569102142159175208
I,422249200831429
Prázný42694920083355892123163195
M,448349200835469
Češka457149200834075103134169
R,475949200833651
Haluzík48294920083447894133164181214
M.506249200835470
Expertní515049200833367108145167194233250
stanovisko54184920083275185304750200833877111128155187225
ke329050200832965
spolupráci337250200832667107124163204227261295311
diabetologů37015020083385488128165189227244284325364
a4082502008332
internistů41315020083155477112135175191219244283
s4431502008326
nefrology44755020083377494118156174213254287
v4780502008331
péči482950200833875109126
o4972502008337
nemocné502750200833774133173207246283
s5327502008326
chronickým5371502008331709313130475120083385487119154214
onemocněním327951200833877114173213247286323362379438
ledvin.37355120083155192126143182197
Vnitr39505120083367491115138
Lek.41065120083316798114
2022;68(7):426-431.423851200833570104140154191228249285306319355389424449487521553564
Připravujeme34257700462187305393573691863101911981284144817151880
pro34261000421173280445
diabetology8506100042117324440257372984110071088125414181579
29.32072100340155306374
ledna7477210034079224389551697
Olomouc1580721003781912694156347809251040
12.32075000340155293371
února74475000340162323481588732
Plzeň161275000378153230354487634
12.32077900340155293371
května74477900340156310449552715862
Praha174177900378153249390536676
2026312630001202476103014671954
diabetologie478375100884262100142179205246266306347367404
pro484175700884270111
praxi496575700884370107145165
29.48837710051234758
1.495177100512334
20264995771005123477094
CENTRAL482077600391936597897120137
PARK4967776003918375776
FLORA505477600391632567598
OLOMOUC48967790043254572103130156179
4.kongres48327430093414868743009015489174400873876116156182218248
diabetologie297973100884262100142179205246266306347367404
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PARKHOTEL309375600391737567699124141159176
PLZEŇ3126759004320406384111
3.kongres30287230093413063723009015308672400873876116156182218248
diabetologie355070900884262100142179205246266306347367404
pro360771600884270111
praxi373171600884370107145165
12.36487290051234558
5.371672900512335
20263761729005123477094
OREA3571734003922426082
HOTEL366473400392145638198
PYRAMIDA3773734003917365578106116139160
PRAHA3692737004320436995120
1.kongres36007010093413633702009015365670200873876116156182218248