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www.casopisvnitrnilekarstvi.cz42580400107651332012142542953293774274464795215705896176436927117307748128548809159449871007102310631101
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hmyzí15559800275122310436542608
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jasná3309980027560182286414535
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i17901240027560
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otázky248912400275121211333438565698
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Vachová8371630013770125175240303360418
Ústav4251780013371113150203254
imunologie7021780013326117176237297323383445470525
a12501780013353
alergologie,1327178001335378133169229289315376438463517539
Fakultní18891780013354102153214239275335360
nemocnice22721780013361116208268318378403452505
Plzeň2801178001335882129183244
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Lékařská31451780013352106157211246290341395
fakulta3563178001333286137197222258311
v38981780013353
Plzni,3974178001335983129190215237
Univerzita42341780013371131156209263298347372408462
Karlova47191780013360113149174234286339
Nejzávažnějším4252290012166117142186236284333377434485509549573658
klinickým110222900121477397153177223270321406
projevem1528229001215791146171222271320405
alergie1953229001214872123157214238289
na22622290012155104
hmyzí23862290012155139186232256
jed2662229001212475134
je2815229001212576
život2911229001214367116171204
ohrožující31352290012155112145201244299324348394418
anafylaxe.35722290012149105154183235260309357407428
Evropská4020229001214997131187245285332383
epidemiologická44222290012150108133190242326350406431487544568614661711
data51532290012157106139189
jednoznačně53622290012124751334252430012155110153209257302358408
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že1273243001214292
u13852430012154
dospělých14592430012156111151208259283331375431
osob1909243001215594150207
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hmyzí26542430012155138184229253
bodnutí29272430012156112170225280314338
nejčastější32842430012155106130175224264298348372412435
spouštěč3739243001213996152207247281331377
této4135243001213383116171
závažné4325243001214393140189232288339
systémové4683243001214088128162212296351399448
alergické5151243001214771122155211235280327376
reakce425257001213384133180225275
a7262570012148
předčí800257001215690141199245269
v10952570012148
tomto1169257001213388172206261
ohledu14562570012154111136187245301
i17832570012123
léky1832257001212375123174
a20322570012148
potraviny.21062570012157114148181231278303359406423
Dalším25552570012166115140180204288
projevem2869257001215790146171222271321405
alergie3300257001214873124158215239290
na36162570012155104
jed3746257001212476134
hmyzu39062570012155139186232288
jsou4220257001212464120177
nepřiměřené44222570012156107165199224308359392442499551
velké4998257001214898123171221
lokální5245257001212379128178202258282
reakce425271001213384133180225275
kolem7212710012147102127178263
místa10052710012183107147182232
vpichu12582710012148107131177233289
hmyzu.15682710012155139186232288310
Tyto1899271001215092129184
reakce2104271001213384133180225275
jsou2400271001212465121177
z25982710012143
klinického266227100121477397153177223270320377433
pohledu31162710012157114171195247305361
podstatně34982710012156113172212247297330386438
méně39572710012183135191243
závažné4221271001214293141190235291343
než45852710012155106151
reakce4757271001213283132180225275
systémové,5053271001213988129164214299355403453474
nicméně425285001215579124207258314365
i8092850012123
rozsáhlý852285001213287130171221276300348
lokální1219285001212479127177201256280
otok1518285001215588142190
dokáže17272850012156112160209253303
znepříjemnit2050285001214298149206239263289339423479502536
život2605285001214367116170203
pacienta28282850012156105150174225280313363
na32102850012155103
několik33332850012155106153207232255302
dní.36552850012156111135156
Cílem3831285001215781106157241
tohoto4091285001213388144199232287
sdělení4397285001214097147172222278302
je4719285001212474
seznámit4813285001213990134189238321345379
čtenáře5211285001214480130186234267317
s4252990012140
aktuálními495299001214896133189238262318342427451
diagnostickými976299001215681129186243299339374398444491543628652
a16582990012148
léčebnými1737299001212375121171229286332418442
postupy22092990012157114154189245303350
u25892990012155
pacientů26752990012157106152176227284317373
s30782990012140
alergií3148299001214873124158215239263
na34412990012156105
jed3576299001212475134
hmyzu.37402990012155140186232288310
Tyto4081299001214991129184
postupy42952990012157114154189245303350
závisí4675299001214394141166206230
zcela4935299001214389139164213
zásadně5178299001214394134184242298349
na4253130012155105
charakteru5543130012145101150183233281317368402458
proběhlé1037313001215690146204256313337388
reakce1450313001213383132180225275
a17493130012148
významně18223130012148100146202251336392443
se2290313001213991
liší240531300121244888112
u25413130012156
pacientů26213130012157107152176228284318373
s30193130012140
lokálními3083313001212480128178203259283367391
a34993130012148
systémovými3572313001213988129164214299355403455540564
alergickými4161313001214872124158214238284332383468492
projevy4678313001215791146171222271323
po50253130012157114
bodnutí.51633130012157114172229284318342364
Závažnost4253270012155105153202247303359400434
reakce888327001213383132180225275
rozhoduje1191327001213388131188244302358383434
již165332700121254993
o17743270012155
samotné1857327001214090174230264320372
indikaci2257327001212480137162209259305329
alergologického2615327001214872124157214270295351409433479526576633689
vyšetření,3333327001214899140191226259310366391412
určuje3774327001215588133189214265
volbu40683270012148103128185241
pohotovostní43383270012157114171227260315364419459494550574
protialergické4940327001215791147181205254278329363420444490537587
medikace4253410012183135193217265315361411
a8563410012149
je925341001212476
klíčová102134100121477397142197245294
při1336341001215790115
indikaci1471341001212480137162209259305329
imunoterapie18203410012124108164220276310360394444501526577
hmyzím24173410012156140187233257341
jedem.2779341001212475134185270292
Doporučení30913410012167123181238272329375425481505
pro3617341001215790146
pacienty37833410012157107153177228285318369
s41723410012140
již423234100121244992
proběhlou4345341001215690146204256313337393449
alergickou4815341001214872124158214238284332386443
reakcí5278341001213383133180225249
po4253550012157114
bodnutí5633550012157114172229284318342
jsou930355001212465121177
jasně1132355001212473113169220
definovaná13773550012156108139166222278326376432481
a18823550012149
patří19553550012157107140174198
mezi21783550012183135179204
základní2406355001214394142168216274331355
erudici2785355001215084141198222268292
alergologa.3102355001214872124158214270295352409458480
Problémem3607355001215386142200225276361412497
alergie4128355001214973124158215239290
na44433550012155104
hmyzí45723550012156140186232257
bodnutí48533550012157114172229284318343
však5220355001214888138186
je,543135500121247596
že425369001214393
nelze5383690012155106131175225
předem783369001215790141199250334
vytipovat1137369001214899136160217274322371404
osoby1561369001215595151208256
ohrožené18363690012155112145200243294350401
touto2257369001213387143177232
alergií.2509369001214872123157213237261283
Důvodem28113690012167122171226284335419
je3250369001212475
velmi3345369001214898122206230
vysoká3595369001214899139195243293
prevalence3908369001215790141189238263314370416466
tzv.4393369001213379130148
asymptomatické4560369001214888137222279313368452501534558604651700
senzibilizace5280369001214091147191215425383001215782106130174224270320
k7663830012147
hmyzím8343830012155139186232256341
jedům1195383001212576134190274
v14903830012148
běžné15593830012156108152209260
populaci,18403830012157114172228253302348371393
což2254383001214499142
diskredituje2417383001215681121168203254313337371427451503
přínos2940383001215791116172228268
eventuálního3229383001215099149205239295344368424448506563
preventivního3812383001215791142191241297331355404461485543600
screeningového4432383001214086119170222279303359416472521571627684
vyšetření51363830012148100140192226260310367391
na4253970012155105
tento553397001213383140173228
typ804397001213384143
alergie.970397001214873124158215239290311
Klíčová425414001235885111155211261312
slova:760414001234268125174225248
alergie1032414001214872122155211234284
na13404140012155103
jed1467414001212474132
blanokřídlého1622414001215781129184239287321344400424474530585
hmyzu22314140012155138184229284
(HVA),2539414001212892148205232251
molekulární28144140012183138162213260315339387419475498
diagnostika3336414001215679127183238293333366389436485
(CRD),3845414001212884137204230249
test4117414001213483122156
aktivace4297414001214895131154202250295344
bazofilů46654140012157105149204233259282337
(BAT),5025414001212982142185216235
systémová52844140012139871271612104254280012183139186234
reakce680428001213383131178221270
po9724280012156112
bodnutí11064280012156112169225279313336
(SR),1463428001212875128155174
velká1658428001214897121168217
lokální1896428001212479126175199254277
reakce2194428001213383131178221270
(LLR),2485428001212975122175202221
imunoterapie27274280012124107161217272305354387435492516566
hmyzím33144280012156139184229253336
jedem3671428001212575132183266
(VIT),3958428001212987111162193211
asymptomatická4191428001214887135219276309363447495527550595642691
senzibilizace.4903428001214090146189212269292316339382431476525545
Allergy4254530015077112146210259328396
to8604530015046113
insect10114530015033101157220274322
stings13714530015054101135204272328
–17374530015068
clear1844453001505287150215264
rules,21474530015047115149212268305
but24914530015067135182
also2712453001506398153220
new29714530015067130222
questions32314530015067135198254301336402471526
The4254730012149105155
most5974730012183137176209
serious824473001213989121144199253292
clinical113347300121456790144167211259282
manifestation14334730012182130184207236285324358406438461515570
of2020473001215583
insect2121473001212377116166211245
venom2384473001214796151205288
allergy268947300121487194144176231278
is2984473001212462
life-threatening306347300121244675125158190245277326373405454509532586641
anaphylaxis.37224730012148102150205261306329377423447485506
European42464730012148101133187244294341396
epidemiological46594730012150106130185235318341395418473529552596644667
data53434730012156104136184
clearly425487001214568118166199223270
confirm717487001214498154183209241325
that1063487001213489137169
insect1254487001212378117168213249
stings152448700121407497152208247
are1793487001214880130
the1945487001213388138
most21054870012183138178211
common2338487001214598182265320376
trigger273648700121336589145201251284
of3042487001215484
this3147487001213388111151
severe3319487001214090138187220269
systemic3610487001214088127161211294317362
allergic399448700121487194145178233256301
reaction4317487001213282130175210233288344
in4683487001212378
adults,47834870012148105159183216256277
surpassing5082487001213994126184232272311334389445
even425501001215098147202
medications6495010012183134191214259308340363418474513
and11835010012148104160
foods1365501001212984139197236
in1622501001212479
this1722501001213388111150
regard.1894501001213282139187220276297
Another22125010012161117172204260310343
manifestation25765010012184132187210239290329363412444467522578
of3175501001215585
insect3281501001212378117168214249
venom3551501001214897153208292
allergy386450100121487295145178234281
is4167501001212362
large4250501001212472104160210
local4482501001212378124173196
reaction4700501001213282130175210233288344
around5065501001214881136191246303
the5389501001213388139
site42551500121406296145
of589515001215584
the693515001213388138
insect850515001212479118169214250
sting.111951500121397396152208228
From1367515001214879133217
a16035150012148
clinical167151500121446890146169214262286
point19765150012157113136191224
of2219515001215584
view,2322515001214872123196213
these2554515001213388139178229
reactions2802515001213382131175211234289344383
are3205515001214880130
significantly3355515001213962118173196226252297345401433456504
less3878515001212374113152
serious4050515001213990123146201257296
than4365515001213388136192
systemic4576515001214088127161210294317362
reactions,4957515001213383131176211234289345384405
but53815150012157112146
even425529001215098147202
extensive651529001215097133182238277300348397
local1071529001212479124173197
swelling12915290012139114163187210233288344
can1659529001214493148
bother18305290012157113146201251284
the2137529001213489139
patient22995290012157106138161212267300
for2622529001212984117
several2762529001214090138187220268292
days.30775290012156104150189211
The33115290012149106156
aim3490529001214972155
of3668529001215584
this3775529001213388111150
article3949529001214880116139184207257
is4229529001212463
to4315529001213387
present4425529001215790140179230286318
current47665290012145100132165215271303
diagnostic5092529001215680128183239294333367390435
and4255430012148103160
treatment612543001213466116164196280330386418
procedures1057543001215790145190239297351384434473
for1558543001212984117
patients17025430012157106138161211267299340
with2069543001217498131186
insect2282543001212479118168214249
venom2559543001214897152207291
allergy.287754300121497295146178234282298
These32035430012149106156196246
procedures3476543001215790145190239297351384434473
depend39765430012157107164215271328
entirely43315430012150106138161193243267315
on46735430012155111
the4811543001213388139
nature49775430012155103136191223273
of5277543001215584
the5389543001213388138
reaction425557001213382129174209231286341
and7845570012148102158
vary960557001214896128178
significantly1155557001214062118172195224250294343397429452499
between16725570012156107140215264315370
patients20595570012157105137160210265297337
with2413557001217497130184
local2615557001212378123171194
and28275570012148103159
systemic3003557001214087127160209292315359
allergic337955700121487294144177232255299
sting369655700121397295150205
reactions.3919557001213282129174209231286341380401
The43375570012150106156
severity4510557001213989136185218241274323
of4850557001215584
the4951557001213388138
reaction5106557001213382130174209232286341
is5465557001212362
decisive4255710012156107152175214237286335
for778571001212984117
the913571001213489139
indication1070571001212479136159204252285308363418
of1507571001215584
allergological160957100121487295145178234289313368425448493541565
examination,2192571001215097146229252307355388411466521542
determines27535710012156106140189222306329384434474
the3245571001213388139
selection3402571001214090114165210246269324379
of3800571001215584
emergency39025710012150134184217273323379424473
medication,43945710012183134191214259308340363418474495
and49075710012148103160
is5085571001212463
essential5166571001215090129179235267290338362
in425585001212379
the523585001213388139
indication681585001212379135158203252284307362418
of1118585001215584
venom1222585001214897153208291
immunotherapy.15335850012123106190244300355388443493526575631678694
Recommendations22465850012154105150204288371421477534582614637692748787
for3052585001213085118
patients31895850012157106138161211267299340
who35485850012174130185
have37525850012156104150199
already3971585001214871104154202258306
experienced4296585001215098155206239263313368413462520
an48355850012148104
allergic495858500121487295145178234257302
insect5279585001212378117168214249
sting42559900121407397152208
reaction652599001213383131175211234289345
are1016599001214881130
clearly1166599001214468118166198222270
defined14555990012156107136163218268326
and18005990012148103160
are1979599001214881131
part21295990012157106138174
of2322599001215584
the2426599001213388138
basic25845990012157105144167212
knowledge28155990012147104159232256306364420470
of3304599001215584
an34085990012148103
allergist.353159900121487194145178233256295329351
However,39015990012165121194243291340373389
the4309599001213388139
problem4467599001215790144201225276359
with4846599001217397130185
insect5051599001212378117168213249
sting531959900121397396152208
allergies42561300121487295145178233256306346
is789613001212362
that869613001213388136168
it1055613001212457
is1130613001212362
not12106130012156111143
possible13716130012157113152191214270294345
to1734613001213387
identify1839613001212379130185217240270320
individuals2177613001212479135158207230287341389413452
at2647613001214880
risk274561300121335695142
of2905613001215584
this3007613001213388111150
allergy317561300121487194145177233281
in3474613001212378
advance.35706130012148105153201257301350370
This39586130012150106129168
is4144613001212463
due42256130012156111161
to4404613001213387
the4509613001213388138
very4665613001214897130180
high4863613001215679134190
prevalence5071613001215689139186235258308364409458
of425627001215584
so-called527627001214095129176225248271322379
asymptomatic924627001214888136220277310364447496528551596
sensitization1538627001214090146185208241264307357389412467523
to2079627001213387
insect2185627001212378117168213249
venoms2452627001214897153208292331
in2801627001212379
the2898627001213388139
general30556270012156106162212245294317
population,33916270012156112169225248296329352407463483
which38936270012173129152197252
discredits4163627001215780119164197246304327360401
the4582627001213388139
benefits47396270012157108164214244270303344
of5101627001215584
preventive5203627001215790140188237292425641001213356104154
screening600641001213984117167218273296352408
for1029641001212984117
this1167641001213389112151
type1339641001213383141192
of1552641001215584
allergy.165764100121487295145178234282298
Key4256580012358107156
words:5976580012374129164222263286
hymenoptera9006580012155100183232287341398430478511558
venom1475658001214896151205288
allergy178065800121487193143175230277
(HVA),2074658001212891146202229247
molecular23386580012183137161210255309332379411
diagnostics2766658001215678125180235289328361383427467
(component3250658001212869122205260315370420475506
resolved3773658001213382121175198246294350
diagnostics,4141658001215578125180235289327361383427467487
CRD),46466580012157109175201219
basophil48826580012156104143197253308331354
activation5253658001214892126149196244425672001213355109164
test606672001213381120153
(BAT),776672001212880139182212230
systemic1023672001213987125158207289312356
sting139667200121397294149204
reaction1617672001213281128172207229283338
(SR),1972672001212874126152170
large2160672001212370102156206
local2383672001212377122170193
reaction2593672001213281128172207229283338
(LLR),2948672001212873119171198216
venom3181672001214896151205287
immunotherapy34856720012123105187241295349381435485517565620666
(VIT),4168672001212885109158189207
asymptomatic4392672001214786133216272304357439486518541585
sensitization.4994672001213988143181203236258300349381403457512533
MUDr.425740009562112164189200
Martina64374000956299122150167210247
Vachová,90774000954176113156199235273287
Ph.D.12127400095408297150162
Ústav42575200955079105142178
imunologie62075200951783125168212230273318335374
a1011752009537
alergologie,10657520095365493117160203221264309326366379
Fakultní146175200953770105148165190234250
nemocnice172975200954382148192229272289325363
Plzeň21107520095405689127170
a2298752009536
Lékařská235275200953674109147170201235273
fakulta26427520095215993136153179216
v2875752009536
Plzni,29297520095405689133150164
Univerzita311075200955093110147186209244262287324
Karlova345175200954078102120163199237
VACHOVAM@fnplzen.cz42576400954184129179233274317380439461505550567600639682697733767
Cit.43947400095466388103
zkr:45147400095336792108
Vnitř463974000954183100125149
Lék.480674000953674109125
2025;71(6):353-358494974000953977114154166203239256294314327367405442466503540579
Článek45267520095466399142182216
přijat47597520095456986103139164
redakcí:494075200952462107144178213230243
28.52017520095397792
7.531175200953945
2025537475200953977115154
Článek43777640095466399142182216
přijat46107640095456986103139164
po479176400954488
recenzích:48977640095246299137180214231267310323
1.523876400953949
9.530576400953951
2025537476400953977114154