654
PŘEHLEDOVÉ42522001004388130181216258306358404446
ČLÁNKY88722001003973122176223272
Virové4253300100436084123158193
hepatitidy:63433001003773111146172188215231270306323
Novinky97333001005291126142180214252
v1242330010035
diagnostice12933300100375287125163202231258274305339
a1648330010034
léčbě16983300100155081119155
37220622001003466104
|350220010018
VNITŘNÍ4268040010746106127172220280301
LÉKAŘSTVÍ748804001074185130188236280325378400
/11948040010731
Vnitř1270804001074693112140166
Lék.1456804001074083122140
2025;71(6):372-3761615804001074487129173186227268286328351365410450493519559600640
/23008040010731
www.casopisvnitrnilekarstvi.cz442680400107651332012142542953293774274464795215705896176436927117307748128548809159449871007102310631101
https://doi.org/10.36290/vnl.2025.07042544001003865941331631802022236484400100418310274944001001554791171398904400100287389124167204247293316355396414432470516552587605649680725
Virové4259800275140207300426548663
hepatitidy:1165980027512224137049158164773780393210601131
Novinky23739800275151277399464592719852
v33029800275121
diagnostice3470980027512318931043956769379688595110521169
a47169800275116
léčbě4879980027560179281410528
Petr4251370013764120161204
Husa,6511370013776141189248277
Petr9501370013764121162204
Husa11771370013775140188247
ml.14461370013795125154
Klinika425152001336087111172197247301
infekčních749152001332686118173224271332357405465
chorob12381520013349109169205265327
FN15881520013354124
Brno1735152001336095156217
a19751520013353
LF20511520013352105
MU21791520013388159
Brno2361152001336095156217
Virové425203001215580113168215264
hepatitidy7092030012155105162211244268301325381429
představují1157203001215790140197237271320367423447470
i16472030012123
v16892030012148
21.1756203001215197114
století1889203001213974128152203237260
závažný2168203001214393139188232287333
zdravotnický2520203001214399132181227281315370394439485536
problém.3075203001215690145202226277360382
V34762030012155
rámci3551203001213281164209232
České38032030012157106146193242
republiky4064203001213383140195252277300347398
představují4481203001215689139197236270319366422446470
v49702030012148
současnosti5037203001213994150195244283338394433467491
největší4252170012155107132181231266307331
problém784217001215791147205230281366
opakované11782170012155113163210265313363419470
lokální1677217001212379128178202258282
epidemie19872170012151109133191242327351402
virové2417217001214873107162210260
hepatitidy27062170012155107165214248272306330388436
A,3170217001216185
narůstající32832170012156105138195235270320344368414438
počet37492170012157114160210245
případů4022217001215790115173222280336
akutní4386217001214896152186243267
hepatitidy46812170012155107165215248272306330388436
E51452170012150
a52232170012148
léčba5299217001212475122179229
virové425231001214873106162210260
hepatitidy7072310012156107165215249273307331388437
C11662310012158
u12472310012155
uživatelů1324231001215599124173222256306331387
drog.1733231001215690145203225
Od19802310012169128
května2130231001214799149183240289
202524412310012151102152204
je2667231001212576
k27652310012147
dispozici2834231001215781121179235278303349372
nový32292310012155111160211
doporučený34622310012157113171228262318364414471517
postup40022310012157113154189244302
Evropské4326231001215098132188246286334384
asociace4732231001214888145191215264310360
pro5114231001215791147
studium52832310012139741301882124252450012155139
jater586245001212473107157191
(EASL),799245001212877141192239268287
který1108245001214784134168220
v13492450012148
některých14192450012156107155192242276328373429
ohledech18692450012155112137188246298344400
mění22912450012183135191215
přístup2528245001215791115155190246304
k28542450012147
diagnostice2922245001215781130187243299339374398444494
a34382450012148
léčbě3508245001212475121179231
virové3761245001214872106161210260
hepatitidy40432450012155106165214248272306330387436
B.4501245001215476
Virová4599245001215681115170218268
hepatitida48892450012155106165214248272306330387437
D53472450012167
se5436245001213991
zatím425259001214394127151235
v6842590012148
podmínkách7552590012157114172256281337385435481537
naší13152590012156105145169
republiky1507259001213384142198256281305352404
vyskytuje19342590012148100140188239277333357409
velmi2366259001214898123207231
vzácně,2621259001214894145190247298319
a29632590012149
to3035259001213388
především3146259001215791142200251300340364449
u36182590012155
cizinců.3696259001214569113137193239295317
V40362590012156
případě4115259001215791115173223280331
superinfekce4470259001213995152205238263319349400449493543
viru5037259001214872106162
hepatitidy52232590012155106165214248272425273001213357115163
D6132730012167
(HDV)705273001212893161216249
na9792730012155104
chronickou11082730012145101134190247271316364419475
infekci1608273001212379109161209253277
virem1910273001214873107157242
hepatitidy21772730012155107165215248272306330388436
B26382730012155
(HBV)2717273001212994149205237
se2979273001214091
jedná3095273001212576134190239
o33592730012155
vůbec34392730012148105162214261
nejrychleji37252730012155107132165217262318342393418442
progredující4192273001215791147204238289347403428452497521
virovou4738273001214873106162210265321
hepatitidu50842730012156107165215249273307331388444
do4252870012156112
jaterní560287001212473107157191248272
cirhózy855287001214468102158215257308
a11862870012148
hepatocelulárního12572870012155107165215248303350400425481505554587644668727783
karcinomu,2062287001214797131176200256312397453475
a25592870012148
proto2630287001215791146180235
je2888287001212475
potřeba29862870012157114148181232290340
věnovat3348287001214898155211259309342
diagnostice3713287001215680129186242299339374398443493
infekce4229287001212380110161209254304
HDV45552870012165133189
velkou4766287001214899124171226282
pozornost.50712870012157113156212246303359399434456
Prvním425301001215284135191215297
léčivem741301001212374119142190239322
účinným1082301001215499122177232278361
proti1462301001215689144177200
HDV16813010012164130185
je1884301001212475
bulevirtid19773010012157112135186233257290326349405
(BLV),2401301001212881129178209228
což2648301001214498140
je2807301001212474
syntetický2900301001213987143175224258281326372422
lipopeptid,3341301001212347103159216267323357380436457
skládající3817301001213986111159215263287310355378
se4214301001213989
ze4322301001214292
474433301001215198
aminokyselin45503010012147130153208263310360400450475498553
z51213010012143
domény51833010012155110193243299344
preS1425315001215689138187233
velkého676315001214896121167215271326
proteinu1020315001215689144176225249304358
HBsAg,13973150012164118157217272293
který1708315001214783132164214
se1941315001213989
váže2049315001214796139188
na22563150012155102
specifický2377315001213995146192215244270315361411
receptor2807315001213282127176232266319352
(sodium3178315001212865120177200254337
taurocholate3534315001213281135167222267322377401448481530
cotransporting4083315001214497130162211266304361416449485508563619
polypetide47203150012156112136183240291325348404454
–51933150012149
NTCP),52613150012164115170222248267
což425329001214599143
je588329001212475
primární683329001215791115199249282339363
transportér1066329001213366116172212270326360397447481
konjugovaných15673290012147102159183239296352400449506552597653
žlučových2240329001214367123169223271323368424
kyselin2684329001214798139190215239295
na29993290012156104
bazolaterální31233290012157107151207232281314365399448472529553
membráně,36963290012183134219277311360416468489
a42053290012148
tím4273329001213357141
brání4434329001215791140197221
stupu4675329001213974130188244
HDV49393290012165133189
do51483290012156112
hepatocytu.52803290012155107165215425343001213388134184222277299
BLV7443430012154102152
je916343001212475
první1011343001215790142199223
schválený1254343001213985141188237261312369415
antivirový16893430012148104137161210234268323371422
lék2131343001212375122
pro2273343001215791146
léčbu2439343001212374121178234
hepatitidy26923430012156107165214247271305329386435
D31463430012167
u32333430012154
pacientů33073430012157106152176227283316372
s36983430012140
kompenzovaným37583430012146101185242294351394450498547603649734
jaterním4512343001212472106156189246270354
onemocněním.48863430012154111162246302348404455512535619641
Počet4253570012153107154204238
hlášených691357001215580129169220277323368424
případů1143357001215790115173222280336
akutní1506357001214996153187243267
hepatitidy18013570012155107165215248272306330388436
E22653570012149
v23423570012148
České24183570012158107148195245
republice2691357001213384142198256281305351401
byl31193570012157104130
v32763570012148
letech3352357001212475109160206262
2016–202136423570012151102150198252300351401448
většinou4118357001214898132174198254310366
kolem45123570012147102127178262
200–25048023570012151103157211259311362
případů5192357001215690115172222280335
ročně.425371001213388135191242263
V7153710012156
roce798371001213388135185
202210103710012152103152204
došlo12423710012156112152177233
k15023710012147
nárůstu15773710012155104138194234269325
na19293710012156105
3192061371001215198144
a22333710012148
v23083710012149
letech2384371001212475109160206262
202326743710012151102152204
a29053710012148
202429813710012151102152201
dokonce32103710012156112160215272318368
na36053710012156105
684,37373710012151105159180
resp.3944371001213384124182203
66241743710012151105155
případů4357371001215690115172222280335
akutní4720371001214896152186243267
hepatitidy50143710012156107165215248272307331388437
E54783710012149
ročně.425385001213388134189240260
Tento705385001214994150183238
trend962385001213366117173230
bude12123850012156112169220
s14523850012139
velkou1511385001214797122169223279
pravděpodobností1810385001215690139186242293350407465520578634690730764788
pokračovat26183850012156113160195244290344392441474
i31113850012124
nadále31543850012155104161210234285
(2593458385001212979130179
hlášených3656385001215580128168219275321366421
případů4097385001215690114171221278333
do44493850012157112
konce45813850012146101157203252
dubna48533850012156111168225273
2025).51463850012151102151202230249
Co54143850012158112
je425399001212475
toho519399001213388144200
příčinou,738399001215790114159183238294350371
není11293990012155106162186
zatím1334399001214393126150233
definitivně15873990012156107137164219243277301349406457
určeno,2063399001215588133182238294314
ale2396399001214872123
je2539399001212475
velmi2633399001214898122205229
pravděpodobné,2882399001215690139186242292350406464519577633684705
že3606399001214393
tento3719399001213282138171226
nárůst39643990012155104137193232267
souvisí4250399001214095151200225264288
se4557399001214091
zvýšenou4667399001214394145185236292348403
prevalencí5090399001215690140188237261312368414437
infekce425413001212380110161209254304
HEV7524130012165115174
u9494130012155
rezervoárových1027413001213384128179213265320370403459507559604660
zvířat.1710413001214395119156205238261
Klíčová425430001235885111155211261312
slova:758430001234268124174225248
hepatitida10274300012156106163212244267300323380428
A,1476430001216184
hepatitida15814300012156106163212245268301324380428
B,2031430001215475
hepatitida21274300012155106163212244267300323380428
C,2576430001215880
injekční2678430001212378101152199242298321
uživatelé3020430001215598121170218251300324374
drog3415430001215789144201
(PWID),3637430001212881165189256282301
hepatitida39594300012155106163212244267300323380428
D,4408430001216785
bulevirtid,45144300012157112135186233257290326349405426
hepatitida49614300012156106163212244267301324380428
E.5410430001215072
Viral4254550015077112161224258
hepatitis:7224550015067130199263311346393428483519
News12804550015082145237291
in16104550015033101
diagnosis17494550015068102167235304371426460516
and23034550015064132201
therapy25424550015046115179228291360427
Viral425475001215680113161185
hepatitis6354750012155106163211244267300323362
remains1022475001213383166214237293332
a13794750012148
serious1452475001213990123146201257296
health17734750012155106154177210265
problem2063475001215790145202226276360
in2448475001212379
the2552475001213388138
21st2715475001215298132166
century.2906475001214594149182236269319336
In3267475001212479
the3371475001213388139
Czech35354750012158102152198253
Republic,38134750012154104162217274298321366387
the4225475001213388138
biggest4388475001215781137193243283317
problems4730475001215689144201225275359398
currently51534750012145100132165215271303326374
are425489001214881130
repeated583489001213282139190238271320377
local988489001212378124173196
epidemics12114890012150107131187238321345389430
of1668489001215584
viral1779489001214872105153176
hepatitis19834890012155106163211244267300323362
A,2372489001216184
an24834890012148104
increasing2614489001212378123156206254293316371427
number30684890012156110194250301334
of3429489001215584
cases3540489001214594133183223
of3790489001215584
acute3901489001214893148181230
hepatitis41584890012156106163212245268301324363
E,4548489001214970
and46454890012149104160
the4833489001213388138
treatment4998489001213366116164196280330386418
of5443489001215584
viral425503001214872104153176
hepatitis6235030012155106163211244267300323362
C10065030012158
in1086503001212378
drug1186503001215688144200
users.1407503001215595145178218240
Since1668503001214972127172221
May19115030012180129174
2025,21065030012152102151201221
new23485030012155106179
recommended2548503001213383129182266349400455512562620
procedures3189503001215790144190239296351383433473
from3683503001212963117201
the3905503001213388139
European40655030012149103136190247298346402
Association44885030012161102141196242265313345368423479
for4988503001213085117
the5127503001213388138
Study5287503001214980135192240
of425517001215584
the529517001213388139
Liver688517001214770118167200
(EASL)908517001212877139189236263
have11915170012155103150199
been14105170012157108159214
available,1644517001214995144167190238295319369389
which20535170012173129152197252
in2325517001212379
some2423517001214095179229
respects2672517001213383122179230276311351
change30435170012145100148204260310
the3373517001213388139
approach35315170012149105162195250299343398
to3949517001213388
the4056517001213489139
diagnosis4215517001215680127183239294333356395
and46305170012148103160
treatment4810517001213366115163196279330385418
of5248517001215484
viral5352517001214871104152176
hepatitis4255310012155106163212244267300323362
B.811531001215475
Viral909531001215681113161185
hepatitis11175310012156106163212244267301324363
D15035310012167
is1593531001212362
still167953100121397396119143
very1845531001214897130180
rare2049531001213281113163
in2235531001212479
the2337531001213389139
Czech24995310012158103153199254
Republic,27765310012154104161217274298321365386
occurring31865310012155100144199231264288343399
mainly36085310012184132155210234281
in3912531001212479
foreigners.4014531001212984117167191247302352385426447
In4484531001212479
the4587531001213388138
case4749531001214593132183
of4955531001215584
superinfection5062531001214094151202235259314343393439425545001213356111167
with611545001217498131186
hepatitis8175450012155106163211244267300323362
D11995450012166
virus1285545001214872104160199
(HDV)1504545001212892159213245
on17685450012155111
the1898545001213389139
chronic2057545001214499132186242265310
hepatitis23875450012155106163211244267300323362
B27695450012154
virus2843545001214872104159199
(HBV)3061545001212993147202233
infection,3314545001212378107157203238261317372393
it3727545001212356
is3803545001212362
the3885545001213388139
fastest-progressing4043545001212978117151201240274302360393448504537587626665688743799
viral4862545001214872104153176
hepatitis50585450012155106163212244267300323362
to5440545001213387
liver42555900121244795144177
cirrhosis623559001214568100133189244283306345
and9895590012149104160
hepatocellular11715590012155106163211244298344393417440494518566598
carcinoma,1790559001214594126171194249304387436457
and22685590012148103160
therefore2449559001213388139172221251306339389
great2859559001215689138187219
attention3099559001214881116166221254277332387
must35085590012183138177211
be37405590012157108
paid38695590012157106129185
to4076559001213387
the4184559001213388139
diagnosis4344559001215679127183239294333356395
of4760559001215584
HDV48655590012165132187
infection.5073559001212379107158203239262317373394
Bulevirtide4255730012154109133183231255287323346402453
(BLV)900573001212982129179210
is1133573001212362
a12185730012148
synthetic1288573001214088145177232282316339384
lipopeptide,1694573001212447103159216267324358381437488507
consisting2224573001214598154193216255289312367423
of2670573001215584
472776573001215299
amino28975730012149132155210265
acids3185573001214893116172212
from3419573001212963117201
the3642573001213489139
preS13804573001215789139188234
domain40605730012157112196244267322
of4404573001215584
the4511573001213388139
large4672573001212472104160210
HBsAg49055730012165119158219274
protein,5201573001215790145178227251306327
which4255870012174130153198253
binds706587001215781136193232
to967587001213387
a10825870012148
specific1159587001213996147193216245272317
receptor1504587001213383128177235268322355
(sodium1887587001212966122179202257340
taurocholate2256587001213382136169224269325380404452485534
cotransporting2818587001214599132165213269308364420453489512568624
polypeptide34705870012157113137185243294351384407464515
–40135870012150
NTCP)40915870012166117173225251
on43705870012155111
the4509587001213389139
surface4676587001214095127160209254303
of5007587001215584
liver511958700121244796145178
cells,5325587001214594118141180201
thereby425601001213388139172221278325
preventing770601001215790140187236292324347403459
HDV12496010012165132187
from1456601001212963117201
entering16776010012150106138187220244299355
the2052601001213489139
hepatocyte.22116010012156106163212245299344394430480500
BLV27316010012154102151
is2902601001212463
the2985601001213388139
first314460100121295688128162
approved33276010012148104162195249296345403
antiviral37506010012148103136159207231263312335
drug4106601001215688144200
for4326601001213085117
the4464601001213388138
treatment4623601001213365115163196279330385418
of5061601001215584
hepatitis51656010012156106163212244267301324363
D4256150012167
in513615001212378
patients6136150012156105138161211267299340
with974615001217397130185
compensated1181615001214498182238289345384433466515572
liver177461500121244795144177
disease.1972615001215780119169218257307327
The4256290012150106157
number6096290012155110193250301334
of970629001215584
reported1082629001213282139195228264313371
cases1480629001214594133183223
of1730629001215584
acute1841629001214993148181231
hepatitis20996290012156106163212244267300323363
E24896290012149
in2566629001212378
the2672629001213388138
Czech28386290012158102152198253
Republic31186290012154105162217274298321366
was35116290012174122161
mostly37006290012183138177211235282
around4009629001214981136191246303
200-25043396290012152102155189236287337
cases4703629001214594133183223
per49536290012157108141
year5122629001214796144177
from5326629001212963117201
2016-2021.4256430012151101148195229275326374421437
In886643001212479
20229906430012151101150200
and12156430012148103160
202313996430012151102150201
and16246430012149104161
2024,18096430012151101150198219
there2052643001213388139172221
will2298643001217397120143
be24666430012157108
an25986430012148103
increase2726643001212378123156205253293343
to3093643001213388
3193205643001215197142
and33716430012149104160
68435566430012151103156
and37366430012149104161
66239216430012151104153
cases4098643001214594133183223
of4345643001215584
acute4453643001214993148181231
hepatitis47086430012155106163212244267300323362
E50956430012149
per51686430012157108141
year,5333643001214897145177193
respectively.425657001213383122178230275311334382431455502519
This9656570012150106129168
trend1155657001213365115171227
is1403657001212463
likely148765700121244793142166214
to1722657001213387
continue1830657001214599154187210265320370
(2592221657001212978129177
reported2419657001213383140196229264314371
cases2811657001214594133183223
by30556570012157103
the3179657001213489139
end33396570012150106163
of3523657001215584
April36286570012161118151175198
2025).38476570012151101150201228246
Key4256740012358108158
words:6046740012374130166224266290
hepatitis9156740012156106163212244267300323362
A,1299674001216184
hepatitis14046740012155106163212244267300323362
B,1788674001215474
hepatitis18846740012155106163211244267300323362
C,2267674001215881
persons23696740012157108141181236292331
who27216740012174130185
inject2927674001212379102152198233
drugs3181674001215789145201240
(PWIDs),3442674001212981165190256296321339
hepatitis38026740012156106163212245268301324363
D,4186674001216785
bulevirtide,42926740012157112135186233257290326349405455475
hepatitis47896740012155105163211244267300323362
E.5172674001214971
prof.42574000954468111132145
MUDr.588740009562112164188200
Petr80574000954078103127
Husa,95074000955093123160175
CSc.114274000954684121136
Klinika4257520095405975118135169207
infekčních6497520095176081120154190233249285328
chorob99575200953679122146189233
FN124675200953787
Brno135175200954064108151
a1520752009536
LF157475200953573
MU1664752009563113
Brno179475200954065108152
husa.petr@fnbrno.cz42576400954385115153167213253278302360382426471495539582596632667
Cit.43987400095466388103
zkr:45187400095336792108
Vnitř464374000954183100125149
Lék.481074000953674109125
2025;71(6):372-376495374000953977114154166203239256294314327367403442465502538574
Článek45567520095466399142182216
přijat47897520095456986103139164
redakcí:497075200952462107144178213230243
3.523175200953953
6.530175200953954
2025537375200953977115154
Článek43777640095466399142182216
přijat46107640095456986103139164
po479176400954488
recenzích:48977640095246299137180214231267310323
1.523876400953949
9.530576400953951
2025537476400953977114154