509
HLAVNÍ506722001005185134178232252
TÉMA533422001003981147194
Nevyužitý261533001005187123161200232247274313
potenciál294433001003776102137175206221255271
inovativní32313300100155291127162188205241279295
léčby35423300100155081119155
diabetu37133300100375387125161188227
2.395633001003349
typu402133001002564102140
–4177330010038
náklady423233001003671106122157195232
na448033001003771
zbytné456833001003068104133171207
kardiorenální47913300100346993131146185209244282317332370385
komplikace519233001003472132170186201235271301335
|5584220010018
509564222001003480123
/35938040010732
Vnitř3670804001074592111139166
Lék.3855804001074184122140
2025;71(8):509-5144015804001074487128172185226267286328350365409452497527569608647
/47078040010732
VNITŘNÍ48058040010745106127171220280301
LÉKAŘSTVÍ5127804001074084130188235280325377399
www.casopisvnitrnilekarstvi.cz42580400107651332012142542953293774274464795215705896176436927117307748128548809159449871007102310631101
https://doi.org/10.36290/vnl.2025.092433544001003865941331631802022234557440010041831024659440010015547911713948004400100287389124167204247293316355396414432470516552587605649691728
Nevyužitý42598002751522703935266547598249141045
potenciál15479800275123249339456585686752873939
inovativní25639800275611883144365566467128389651032
léčby3672980027560179280409535
diabetu42512400275123189310439557648776
2.127812400275132200
typu15551240027585216345472
–207512400275125
náklady227712400275122243370438560689817
na317112400275122244
zbytné34921240027599228353447576695
kardiorenální425150002751212423354635296557478659941115118113091376
komplikace18781500027512124343055962569181893810391156
Tomáš4251890013760116211270318
Doležal1,7651890013776140171229282341371113219000803611671890013729
Klára1218189001376799157199256
Lamblová1,14971890013756115210276307371427485197419000803620091890013729
Kateřina20601890013767126166224267296361419
Chadimová1,25021890013765129187253283378442498556305119000803630851890013729
Barbora31361890013766125167232296338396
Decker1,35541890013776135185245302345389619000803639311890013729
Bohdana39821890013766130195261319384442
Kubešová2,44461890013768130196255303367424481492619000803649641890013729
Iva425204001373190147
Piljarová3,595204001376493123154213255319375433102720500803610642040013729
Klára1115204001376799157199257
Koubková4,13942040013767129193259319382438496189020500803619282040013729
Michal19792040013793124174239297327
Kostern5,23282040013768129177217276318382271020500803627462040013729
Anastasie27972040013772136194242283341389420478
Halas1329720400137761351652232713564205008036
1Institut425220007833456219001332687129166191227287323
pro802219001336398158
zdravotní9832190013347109144197248307342403428
ekonomiku14342190013355107165226286378403454514
a19722190013353
technology2048219001333690140200260320346407468521
assessment2592219001335395138193236279369425485520
(iHETA)3136219001333155127180237296326
2Sanofi4252350078334592340013354107168228259288
s.r.o.,770234001334467103121180201224
Praha1018234001335893146206258
3NovoNordisk4252500078334592490013372133184243316376412474499541592
s.r.o.,1074249001334467103121181202225
Praha1322249001335893146206259
4Boehringer4252650078334592640013360120176237272297358419474509
Ingelheim992264001332687148203229289344369460
spol.14752640013344106167193215
s17132640013344
r.o.,1780264001333654113134157
Praha1961264001335893146206258
5AstraZeneca4252800078334572790013367112149184237297351412467517570
Czech10502790013364113167217277
Republic13502790013360115177237299325350399
s.r.o.,1772279001334467103121181202225
Praha2020279001335993146206259
V4253300012156
ČR5023300012158112
významně6343300012149100146203252336392444
roste1099330001213288128163213
prevalence1333330001215791142190240264316372418468
diabetu1822330001215781130187239274330
2.2173330001215173
typu2267330001213384143199
a24873300012148
pro2556330001215791146
budoucí27233300012157114171227284330354
udržitelnost30983300012155112146191216250300325381437477512
nákladů36313300012156105152179227285341
na39933300012155104
léčbu4118330001212475122179235
komplikací43743300012147102186244269293341391437461
je4856330001212475
důležitá49523300012157112136188232256291340
včasná53133300012148931431834253440012155105
léčba553344001212375121179228
podle8043440012157114172197248
evidence-based1075344001215099124181233289335385420479528569620678
medicine17763440012184135194218264288344395
v21943440012148
souladu2265344001214096153177226284339
s26273440012140
guidelines.26903440012156112136194245270294350401442464
Aktuální31773440012162109146202251276332356
konsenzus35563440012147101158198250306350406447
léčby4026344001212375121179226
diabetu4275344001215781130187239274330
2.4628344001215173
typu4724344001213384143199
je4946344001212576
vedle5045344001214898157181232
cílení530134400121446895146203227
na4253580012156105
glykemickou560358001215681129178228313337383431485542
a11323580012149
váhovou1211358001214898154211259314370
kontrolu16123580012147102159192226281307363
zaměřen2005358001214394178230263314370
primárně2406358001215791115200249283340391
na28283580012155104
snižování2963358001213996120164219268317374398
kardiorenálního3391358001214798131189213269303354411460485541565624680
rizika4101358001213358102126174224
moderními43563580012183140198250284341365449474
skupinami4860358001214088144202227283332417441
léčiv5331358001212476122146196
s4253720012140
dostatečnou4853720012156112152187237270320367423479535
evidencí1040372001215098123181232288334358
–14183720012150
GLP-114883720012164113167198244
agonisty17523720012148105161217241281316367
a21393720012148
SGLT222073720012149114163207260
inhibitory.2487372001212480136160218242276331365416433
Analýza29403720012162118167191239285336
pacientských32963720012157107152176227284317359406457502558
administrativních38743720012148106190214270294334369402452485509558615639685741
dat46353720012156105139
814794372001215199
20449063720012152103156
pojištěnců50823720012157114139163203238288344390445
zdravotních425386001214399132181228283316372396441496
pojišťoven9413860012156113137161200235289337387443
OZP,14033860012168121173183
RBP16063860012153108162
a17883860012148
ZPS,18553860012155108157179
u20533860012155
kterých2127386001214784133167218262317
byla24643860012156103128176
v26603860012148
letech2727386001212474108158204260
2019–202330063860012151102149195248296346395447
alespoň3472386001214872123163220276332
dvakrát38243860012156105153201235284317
vykázána4161386001214899147196240291346395
diagnóza4575386001215680128185241296338389
E114983386001214997139
(diabetes5141386001212882106154212263297347387
2.425400001215174
typu)520400001213384142199225
a7664000012149
jsou836400001212464120177
na10344000012155104
antidiabetické11604000012148104137161219243292350402436460506553603
farmakoterapii,1784400001213080113198247295349383433467517574599623645
ukázala24504000012155103153197248273322
velmi2793400001214898123207231
nízkou3045400001215680124172226283
penetraci33494000012157109165217251285334380404
těchto3774400001213384130186220275
lékových4070400001212375123178226277322378
skupin4470400001213987143201225282
u47734000012155
pacientů,48494000012157107153176228284318373395
kteří5265400001214784135168193
ji5479400001212448
mají4254140012183132157181
dle631414001215681132
guidelines7874140012156112136194245270294350402442
dostat.12544140012156112152187237271293
Celých15714140012158108133181226282
8518784140012151102
%20054140012179
ASCVD21084140012161112171231299
diabetických2431414001215781130187239274298344391442487543
pacientů29994140012157106152176227284317373
je3396414001212576
bez34964140012157109154
optimální36744140012155113147171255304329385409
léčby,4107414001212475122179227244
stejně4375414001214075125150206257
tak4657414001213383130
764812414001215199
%49364140012179
pacientů50394140012157107153177228284318374
se5437414001214091
srdečním425428001213972129180227282306390
selháním835428001213990115171220275299383
a12384280012148
741306428001215196
%14224280012179
pacientů15204280012157107152176227283316372
se1911428001214091
zjištěným202242800121426791131165215271318402
CKD.24444280012158112180199
Systém2662428001215095135170220304
zdravotního29854280012143100133183230284318374398456511
pojištění35164280012157113138162202236286342366
tak3902428001213382130
na40514280012156104
aterosklerotických4175428001214881131165220260307333384418473507531576623674719774
komplikacích49694280012147101185243268291339389434458503559
ztrácí425442001214379113162208232
každoročně685442001214797142199255289345391447498
4121211442001215298143
mil.13764420012184108132154
Kč,1558442001215499121
na17074420012156105
srdečním1840442001213972130181228284308392
selhání2260442001214091116172221277302
2112590442001215198141
mil.27534420012184108132154
Kč/rok2935442001215498136167223271
a32344420012148
u33104420012155
chronického33934420012145101134190247271317364414471527
onemocnění39484420012155112163248304350407458514538
ledvin4514442001212475134183208264
je4806442001212476
finanční4910442001212956112161218263320344
ztráta5282442001214379113162196246
způsobena4254560012143101157197253312364420469
suboptimální917456001214095153210268302326410459484540564
farmakoterapií1504456001212979113197247294349383433467516574599623
27021504560012151101151
mil.23234560012184108132154
Kč/rok.2500456001215499136167223271295
Klíčová425473001235885111155211261312
slova:758473001234268124174225248
diabetes1027473001215680127184235269318357
2.1406473001215172
typu,1499473001213383141196217
suboptimální1737473001214094151207264297320403451475530553
farmakoterapie,2311473001212978111194243289343376425458506563587637657
administrativní29894730012148105188211267290329363395444476499547604627
data36374730012156104137186
plátců,3844473001215781129161205260280
orgánové4146473001215587143191246302349398
komplikace.45654730012147101184241265288335384429478498
Unrealized4254980015081149198261326361395451513582
potential10454980015067134182245313361395460495
of15784980015066114
innovative17304980015033102170237302366414448515577
therapies23454980015046115178228291360394457512
for28964980015047114163
type30974980015047117185248
233844980015072
diabetes34944980015067102166235298346409464
–39964980015069
the41034980015046115178
economic43204980015061115182250317417452505
burden48644980015067135184252316384
of4255120015066114
preventable5775120015068117180245306375422488556591654
cardiorenal12705120015052117166235269336385448517581616
complications19245120015053119219288323357411476523558625693749
In425532001212479
the525532001213388138
Czech6845320012158102152198253
Republic,9575320012154105162217274298321366387
the1364532001213388139
prevalence1523532001215790140187236259309365410459
of2002532001215584
type2107532001213383140191
223195320012151
diabetes2390532001215780128184235269318357
is2768532001212362
significantly2850532001214063119174197227253298346402434457505
increasing.3375532001212378123156206254293316371427448
For38435320012149103136
the3999532001213388139
future4158532001212985118173205255
sustainability4434532001213994133167216239294342399422445468502551
of5006532001215584
treatment5110532001213366115163196279330385418
costs425546001214497136169209
related651546001213382105153185233290
to958546001213386
complications,1061546001214598180236260282326374406429483538576597
timely1675546001213356138187211258
treatment1950546001213365114161193275325380412
based23795460012156104143193249
on26455460012155110
evidence-based2772546001215096120176225280324373405463511549599655
medicine34455460012182132189211255278332382
and38445460012148102158
in4020546001212377
accordance4114546001214892135188221276323378422470
with4602546001217396128183
clinical480254600121446789144166211259281
guidelines51015460012155109132188237261283338387426
is425560001212362
essential.504560001214988127176231263285332355376
The8975600012149105154
current1068560001214599131163212267299
consensus1384560001214497152190240295333387425
on18265600012155110
type1953560001213382139189
221595600012151
diabetes2227560001215679126181232264313352
treatment2596560001213365114161193275325379411
focuses3024560001212983128182221270309
not33505600012155110142
only35095600012154109132179
on37055600012154109
glycemic3832560001215578124168216298321365
and42145600012148102158
weight43895600012173122145200254286
control4692560001214597152184216270293
but50025600012157111144
primarily5163560001215689112194241273296319365
on4255740012154109
reducing550574001213381137191235257311366
cardiorenal932574001214592124179201255287335390437459
risk140857400121325593139
using1563574001215593115169224
modern18045740012182136192241273327
drug2148574001215687142197
classes2361574001214467114152190239278
with2655574001217396128182
sufficient2854574001213992120152177221243292347378
evidence3249574001214996119174223278322370
–36355740012150
GLP-137015740012164111162191235
receptor3953574001213281125173229261314346
agonists43165740012147102156210233271304343
and46765740012148102157
SGLT248505740012148111158200251
inhibitors.5118574001212377131153209232264317349388409
An4255880012161116
analysis5655880012148104152175222262285324
of913588001215484
administrative10205880012148105188212267290329363395444476499548597
patient16405880012157106139162212267300
data19635880012157105137186
from2173588001212962117201
81,2042397588001215299114167218270
insured2691588001212379118172205254312
individuals3026588001212479135159207231287342390414453
of3502588001215584
the3610588001213388138
health37725880012156106154178211266
insurance4061588001212479118172205253309354403
companies4487588001214599182239288343366416456
OZP,49665880012169121173183
RBP,51725880012154109162171
and53675880012148103160
ZPS,4256020012155107155176
who6196020012173128183
had8196020012156103159
the996602001213387138
E111151602001214996137
(type1305602001212959108166216
215396020012151
diabetes)1607602001215779127183234267316355379
diagnosis2004602001215679126182237291330353392
recorded2413602001213382127181213269319376
at2806602001214880
least2904602001212373121160193
twice31156020012133108132176225
between33576020012157107140216265315371
2019–202337456020012151101147192245291341389440
and42026020012148103159
are4379602001214780129
undergoing45266020012154109165215248303358381436491
antidiabetic50356020012148103135157214236284340391424447491
pharmacotherapy,4256160012157113161193277325370424457512562595644700747763
revealed1206616001213382130179227251301358
very1582616001214998131181
low1781616001212479152
penetration19516160012157108164214248280329361384439495
of2464616001215584
these2567616001213388138178228
drug2814616001215688144200
classes3032616001214568116155194245284
among33356160012148131186242298
patients36516160012157106139162212267300340
who,40106160012173129184204
according4232616001214893137190223279303358414
to4664616001213387
guidelines,47706160012155110133190240264287342393432453
should5242616001213995150205228285
be4256300012157108
receiving554630001213383128177201249273328384
them.959630001213489139223244
A4256440012161
full514644001213085109132
856746440012151101
%8036440012180
of911644001215584
diabetic1023644001215679127184235268291336
patients13876440012157106138161212267300340
with1755644001217498131186
ASCVD19696440012161111169227295
are2292644001214881130
without2450644001217498131186241296330
optimal28086440012155112145168251299322
treatment,3159644001213365115163196279329385417438
as3625644001214988
are3741644001214881130
763900644001215198
%40266440012179
of4133644001215584
patients42456440012157106139162212268300340
with4614644001217397130185
heart48276440012156106154187223
failure5078644001212978101124179211261
and53676440012149104160
74425658001215196
%5406580012179
of637658001215584
patients7406580012157106138161211267299340
diagnosed1099658001215679127183238293333383440
with1558658001217497130186
CKD.17626580012158111179197
The19786580012149106156
health21536580012155106154177210265
insurance2437658001212378118172204253308353402
system2858658001213988127161210294
thus3171658001213388142182
loses3371658001212479118169208
CZK35986580012158114168
4123784658001215196141
million39436580012184107130153176231287
annually42486580012149104159214262285308356
due46226580012157112162
to4802658001213488
atherosclerotic4908658001214881136186219274313358381432465519552575620
complications,425672001214599182239263286331379412435490546585606
CZK10576720012158114167
2111250672001215298139
million/year14156720012184107130153176231287322369419467499
due19406720012157111162
to2128672001213387
heart22416720012155106154186222
failure,2489672001212978101125179212262282
and27976720012148103160
CZK29836720012158114167
27031766720012152100149
million/year33516720012183107130153176231287322369418466499
due38766720012156111161
to4063672001213387
suboptimal4176672001214094151207264297320403451475
pharmacotherapy46776720012157113161193277325370423456511562595643700746
in5449672001212479
chronic4256860012145100132187243266310
kidney757686001214671128183234280
disease.1058686001215780119170218257307327
Key4257030012358108158
words:6047030012374130166224266290
type915703001213383141192
211287030012151
diabetes,1200703001215780128185236269318358379
suboptimal1600703001214094151206264297320403451474
pharmacotherapy,20957030012157113161194278326371424457512563596644701747763
payer28797030012157106152201234
administrative31347030012148105188211266289329362395443476499547596
data,37527030012156104137185206
organ3980703001215487143191246
complications.4248703001214498182238262285330379411434489545584605
MUDr.425740009562112164189200
Tomáš64374000953775141178208
Doležal,86874000955296114153187224241255
Ph.D.11417400095408297150163
Institut4257520095176090116133158201227
pro66975200954469111
zdravotní79775200953276100137173215240283300
ekonomiku111575200953873115159202268285319362
a1495752009536
technology154975200952463100143186229247290335371
assessment19387520095366696136166196261301344368
(iHETA)23247520095213888126166208229
dolezal@iheta.org42576400954487105144177215233291308351391416453468511535578
Cit.43917400095466388103
zkr:45117400095336792108
Vnitř463674000954183100125149
Lék.480374000953674109125
2025;71(8):509-514494674000953977114154166203239256294315328368406446473511546581
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