447
HLAVNÍ506722001005185134178232252
TÉMA533422001003981147194
Nevyužitý261533001005187123161200232247274313
potenciál294433001003776102137175206221255271
inovativní32313300100155291127162188205241279295
léčby35423300100155081119155
diabetu37133300100375387125161188227
2.395633001003349
typu402133001002564102140
–4177330010038
náklady423233001003671106122157195232
na448033001003771
zbytné456833001003068104133171207
kardiorenální47913300100346993131146185209244282317332370385
komplikace519233001003472132170186201235271301335
|5584220010018
51156422200100346291
/35938040010732
Vnitř3670804001074592111139166
Lék.3855804001074184122140
2025;71(8):509-5144015804001074487128172185226267286328350365409452497527569608647
/47078040010732
VNITŘNÍ48058040010745106127171220280301
LÉKAŘSTVÍ5127804001074084130188235280325377399
www.casopisvnitrnilekarstvi.cz42580400107651332012142542953293774274464795215705896176436927117307748128548809159449871007102310631101
a425620010741
mírně49062001077492119168212
roste72662001072673107136178
zastoupení92962001073678111140187235285330378396
GLP-1134962001075797142169207
agonistů158062001074191139188206239268316
(3,3–5,019206200107246681125171214228272
%).221762001076687101
Nejvíce2342620010757101120161181221263
vzrostla262962001074180107154188217236276
penetrace42576001075095143187215242283324366
SGLT281176001074298138175220
inhibitorů105076001071967115134183202230277304352
(7,4–17,014227600107246874118165204240246291
%).173376001076688101
Na56590001075799
obrázcích68390001074899127170208248267308357
21059900010744
až112390001074078
41221900010743
vidíme128490001074061111130205250
farmakoterapii,15539000107246794169211250298326369397439490510529545
která211890001073869113140183
byla232090001075090111152
v2491900010741
roce255190001072775117160
2023273090001074488130175
vykázána425104001074287129173213258308351
u8061040010749
diabetiků884104001075071114166213243264304355
s12681040010735
diagnózou1332104001075071114166216267305354405
srdečního1767104001073462113160203254274327378
selhání/HF2174104001073581102153196246267301362406
(Obr.2609104001072586139168182
2),282110400107456984
chronického425118001074089117165215235276315359409458
onemocnění912118001074897143218267310359404453473
ledvin/CKD1413118001071965116158179228262312358418
(Obr.1860118001072484135163177
3)2065118001074466
a21591180010742
aterosklerotického2229118001074169113140189223262284329356404433453494533577627676
kardiovaskulárního425132001073983110160181230272316351390440460502530581601653703
onemocnění/ASCVD1157132001074899145220271314364409459479513562607660710771
(Obr.1957132001072485137166179
4).216513200107456882
Penetrace2276132001074690140186215243287329373
SGLT226781320010742100142180227
inhibitorů425146001071968117136186206235283311360
u8051460010747
HF872146001075799
pacientů,991146001074992133153198247274323339
která1350146001073870113141183
by1553146001074990
měla16621460010774119139180
být1862146001075090122
co2004146001074087
nejvyšší,2111146001074893113155199234268287303
je2434146001071964
jen2518146001071964113
34,32650146001074490105151
%.2821146001076684
Obdobná4251600010760112163212263313355
situace80816000107335382131172214257
je1093160001072064
u11851600010748
CKD1261160001075297158
pacientů,1447160001074992134153198247275324340
kde1815160001073888133
jsou1976160001071953102151
SGLT2i2155160001074299141178224243
vykázány2426160001074085124168206249298338
jen2792160001071964113
u4251740010747
34,7490174001074489104148
%6561740010766
populace740174001074998149197217258299341
a10991740010741
GLP-11158174001075696142169208
RA13841740010745100
jen1501174001072064112
u16311740010747
9,9169617400107445799
%.1813174001076684
Nejhorší19151740010757101121169218245279298
je2231174001071964
situace231217400107345381129170211254
u25841740010747
ASCVD2649174001075396148196256
pacientů,304762001075092134153198247275323340
kde341262001073887132
jsou356962001071953102151
GLP-1374562001075798144171211
agonisté398162001074191140190209243273316
vykázáni432262001074185125168206249298318
jen466562001071964113
u4803620010748
7,848766200107445197
%4999620010766
nemocných509062001074893168217259308348388437
a3047760010741
SGLT2i310976001074299141178224242
u3373760010747
21,334427600107448496141
%3605760010766
pacientů.369376001074992133153197246274323339
Modelování30471020012583135188237261314363412464488
(ne)zabráněných3564102001252978127154197247299335384436485538588629680
komplikací4273102001254899179231256280329379420444
diabetu4746102001255175123175224261313
Promítnutím3187118001074469115187205232279325352370442
výsledků3644118001074082115132175224260307
prognostických3966118001074975121169216263295323341380417458497543
klinických452511800107375774121138177214256294341
studií4881118001073361108155173191
do5087118001074895
populace5197118001074997146193211250289330
diabetiků3047132001074968108158202230249287335
v34051320010741
ČR3469132001075297
byly3589132001075089109149
získány376113200107365688126168216255
počty4039132001075099140170213
zabráněných4275132001073779128155197245289337376415463
událostí4762132001074797137156205238267286
při507113200107507796
současné5190132001073482130171212245293337
míře3047146001077492121164
využití3235146001074084132169188216235
doporučovaných3493146001074998148197224272313359399441489527567615
antidiabetik4132146001074089115134183202242292337365383421
a45771460010741
rovněž4641146001072774114163207244
modelována49081460010774123173217236284324366414455
ideální53861460010719681123047160001074160108126
situace,319316000107335179127168209251266
kdyby3478160001073887127177217
bylo3714160001075089109157
příslušnými389116000107497695128147194227275313388406
lékovými4317160001071963101148189232306325
skupinami4661160001073472120169189236277351369
léčeno5050160001071963104146194243
1005312160001074484129
%54611600010766
vhodných3047174001074190138188236275314362
diabetiků.3429174001074968108157202230249287335350
20191313354001104793140187
Počet442314447121104896137182212
pacientů442291347121105296137158204254284334
08513460011047
56913360011047
000757336001104793140
10645325001104793
000758325001104693140
15645315001104793
000758315001104693140
20645304001104793
000758304001104693140
25645293001104793
000758293001104693140
30645283001104793
000758283001104693140
35645272001104793
000758272001104693140
40645261001104793
000758261001104693140
45645251001104793
000758251001104693140
50645240001104793
000758240001104693140
55645230001104793
000758230001104693140
60645219001104793
000758219001104693140
20202214354001104793140187
20213114354001104793140187
20224014354001104793140187
20234914354001104793140187
70,69752390079336780114
%1102239007952
72,118512350079336780114
%1978235007952
75,227592300079336780114
%2886230007952
78,036502260079336780114
%3777226007952
79,545562260079336780114
%4683226007952
20,747012950079336780114
%4828295007952
20,547493040079336780114
%4876304007952
18,648683110079336780114
%4995311007952
17,049773180079336780114
%5104318007952
8,450643250079334780
%5158325007951
5,051593310079334780
%5253331007951
2,052513370079334780
%5345337007951
0,253483430079334780
%5442343007951
20,137952970079336780114
%3922297007952
20,838523060079336780114
%3979306007952
17,539673140079336780114
%4094314007952
13,740723220079336780114
%4199322007952
7,041643290079334780
%4258329007951
4,742533350079334780
%4347335007951
1,943483410079334780
%4442341007951
0,344533320079334780
%4547332007951
19,428932970079336780114
%3020297007952
20,929533060079336780114
%3080306007952
17,530633130079336780114
%3190313007952
11,031523190079336780114
%3279319007952
5,732593250079334780
%3353325007951
4,333553320079334780
%3449332007951
1,834283370079334780
%3522337007951
0,335403440079334780
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18,419932980079336780114
%2120298007952
20,820523090079336780114
%2179309007952
18,121573170079336780114
%2284317007952
8,822573300079334780
%2351330007951
4,123483380079334780
%2442338007951
3,624613290079334780
%2555329007951
1,625493370079334780
%2643337007951
0,426413440079334780
%2735344007951
70,610923000079336780114
%1219300007952
21,211653100079336780114
%1292310007952
18,212583180079336780114
%1385318007952
7,413583320079334780
%1452332007951
3,314653240079334780
%1559324007951
3,415453300079334780
%1639330007951
1,516283370079334780
%1722337007951
0,417383430079334780
%1832343007951
Metformin96137100865894117138177200260277317
Inzuliny14123710086175788127144161200233
SU180837100863582
DPP4204737100864886124161
SGLT2i238337100863581115144181198
GLP-1276337100864680118139175
RA295437100863882
Thiazolidindiony32103710086367592126157196212229270286326366383422462495
Glinidy38423710086476380120137177211
Inhibitory42013710086175797113154171195233257292
střevních45083710086295376111145185202234274
glukosidáz47973710086405796130169197214254289319
Obr.4252010011362114150173
1.625201001135478
Vývoj731202001074582122167184
uhrazené932202001074591117160195232279317
antidiabetické1265202001074592117135180198243288327354372409445483
terapie176420200107266388131177195233
v20142020010737
letech206820200107185683119157203
2019–20232287202001074282119154201240280319359
56,043104460090387792130
%4456446009059
79,547914460090387792130
%4937446009059
17,047914610090387792130
%4937461009059
20,747914770090387792130
%4937477009059
20,547914920090387792130
%4937492009059
18,647915070090387792130
%4937507009059
8,448105230090385492
%4918523009059
5,048105380090385492
%4918538009059
2,048105540090385492
%4918554009059
0,248105690090385492
%4918569009059
Metformin133544600906098123145185209272289331
Podíl454942200924282125145164
v4728422009238
celém47824220092337190129192
vzorku499042200923871113140178220
pacientů463043100924482115134173216242284
s4929431009232
DM24976431009251113153
SGLT2i145846200903785120151189207
Inzuliny14194780090186092133151168210244
SU157849300903785
DPP4149350800905090129168
GLP-1137452400904884123145183
RA157352400904086
Thiazolidindiony11465400090377896132164204222239281299340382400441482517
Glinidy14475560090486683125142185220
Inhibitory70657100901860102119162179204244269306
střevních10285710090295478115151193210244285
glukosidáz132957100904259100135176206224266302334
34,333214620090387792130
%3467462009059
31,231734770090387792130
%3319477009059
20,827024930090387792130
%2848493009059
18,225825080090387792130
%2728508009059
7,020715240090385492
%2179524009059
3,119015400090385492
%2009540009059
2,418595550090385492
%1967555009059
0,117585710090385492
%1866571009059
Obr.4254050011362114150173
2.625405001135481
Farmakoterapie733405001073983108180225262306332368394437482501539
vykázaná1288405001073878114159194239285330
u16344050010746
populace1696405001074591137183201246284320
pacientů2032405001074591129147185231256301
s23504050010731
HF2397405001075494
+25074050010753
DM225774050010756124164
46,743106440090387792130
%4456644009059
79,547916440090387692130
%4937644009059
20,747916590090387792130
%4937659009059
17,047916740090387792130
%4937674009059
18,647916900090387792130
%4937690009059
20,547917050090387792130
%4937705009059
8,448107210090385492
%4918721009059
5,048107360090385492
%4918736009059
2,048107520090385492
%4918752009059
0,248107670090385492
%4918767009059
Metformin133564400906098123145185209272289331
Podíl454962000924282125145164
v4728620009238
celém47826200092337190129192
vzorku499062000923871113140178220
pacientů463062900924482115134173216242284
s4929629009232
DM24976629009251113153
SGLT2i145866000903785120151189207
Inzuliny14196760090186092133151168210244
SU157869100903785
DPP4149370600905090129168
GLP-1137472200904884123145183
RA157372200904086
Thiazolidindiony11467380090377896132164204222239281299340382400441482517
Glinidy14477540090486683125142185220
Inhibitory70676900901860102119162179204244269306
střevních10287690090295478115151193210244285
glukosidáz132976900904259100135176206224266302334
34,736556600090387792130
%3801660009059
25,531586750090387792130
%3304675009059
23,930576910090387792130
%3203691009059
22,129677070090387792130
%3113707009059
9,922997220090385492
%2407722009059
5,720707380090385492
%2178738009059
3,719567540090385492
%2064754009059
0,217587690090385492
%1866769009059
Obr.4256100011362114150173
3.625610001135479
Farmakoterapie732610001073983108180225262306332368394437482501539
vykázaná1287610001073878114159194239285330
u16336100010746
populace1695610001074591137183201246284320
pacientů2031610001074591129147185231256301
s23496100010731
CKD2396610001074890147
+25596100010753
DM226296100010756124164