437
12020122001002864109
|350220010018
VNITŘNÍ4268040010746106127172220280301
LÉKAŘSTVÍ748804001074185130188236280325378400
/11948040010731
Vnitř1270804001074693112140166
Lék.1456804001074083122140
2026;72(2):120-1221615804001074487129171186227271292335357372409446489519558595639
/22998040010732
www.casopisvnitrnilekarstvi.cz442680400107651332012142542953293774274464795215705896176436927117307748128548809159449871007102310631101
FARMAKOLOGICKÝ42522001003983129195242289338373423469489529576625
PROFIL106522001004388139179198233
Kombinační42533001004381141179195232267298336351
léčba7923300100155081120155
rosuvastatin9633300100236291129165201230257293320336373
+1352330010038
perindopril14063300100377397113150189228266290306322
–1744330010038
další17983300100377288116132
krok19463300100335997132
k2094330010033
prevenci21443300100376196132167205235250
kardiovaskulárních24113300100336993131146185220255284319357372407431470485515553
onemocnění298033001003876111171210241278314352367
https://doi.org/10.36290/vnl.2026.02542544001003865941331631802022236484400100418310274944001001554791171398904400100287389124167204247293316355396414432470516552594611655692727
Kombinační4251120027514126344957864377189399411221188
léčba16901120027561179281410531
rosuvastatin229811200275872133174445706897948821005109411611289
+363411200275132
perindopril381311200275124242335400527656782911100310681134
–42513800275125
další62713800275123245311416482
krok118613800275121215342468
k173113800275121
prevenci190013800275123215334457571700801867
kardiovaskulárních2844138002751212423354635296547768961001112712551320144215351662172818281957
onemocnění42516400275121248367554680781909102811571223
Jiří425203001374575118147
Vítovec595203001376998138201258314365
I.425218001332650
interní498218001332686121175210271296
kardioangiologická8182180013351105140202227287340400462487547573633695720769819873
klinika1714218001335279104164189240293
Lékařské20312180013352106157211246290341394
fakulty2449218001333285136197222258312
MU27852180013388158
a29672180013353
FN30432180013353123
u31902180013360
sv.3274218001334397114
Anny34112180013368128188238
v36722180013353
Brně3749218001335995156211
Ústav4252330013371113150203254
farmakologie702233001333285121212265316374400461522548602
a13282330013353
toxikologie1404233001333695145170221280306366428453508
Farmaceutické19352330013354102137229281330384444480505554604658
fakulty2616233001333285136197222258312
MU,29522330013388158178
Brno3153233001336096157217
Kombinace4252840012154109194252277333382429479
statinu934284001214075125158183239295
a12592840012149
inhibitoru1338284001212380136161218243277333367423
ACE17922840012161118167
představuje1989284001215891142201241276326374431456507
moderní25272840012183140198250284341365
terapeutický2922284001213484118168226278334369393439486538
přístup3490284001215791116156191247305
k38252840012147
současné3903284001213996152198248289345396
léčbě4330284001212375122179231
hypercholesterolemie45922840012155102161213247293349405430482523558608642698723775859884935
a4252980012148
arteriální504298001214882119170204229278303359383
hypertenze,9182980012156102161214248285336393437489510
tedy1458298001213384143192
dvou16802980012157107162218
hlavních1929298001215680130177235259305362
rizikových2321298001213358102126174229278330375432
faktorů2783298001212980128165220254311
kardiovaskulárních3125298001214797131189213269318368408456513537587620678702748804
onemocnění39602980012155112164249305352409461517542
(KVO).4532298001212983144213240260
Fixní4822298001214973121178203
kombinace50552980012147102187246271327376423473
rosuvastatinu425312001213388128183232281321356405438462518573
a10183120012148
perindoprilu10863120012157108142166222280335393427451475531
umožňuje16363120012155139195238294349374425
komplexní20803120012147101186243268319367423447
prevenci2547312001215790141189239295341365
KVO29313120012154115182
u31333120012155
pacientů32083120012157106151175226282316371
s35993120012139
vysokým3658312001214899139195243294379
či4057312001214468
velmi4145312001214898122206230
vysokým4395312001214899139195243294379
rizikem.4794312001213257100124172221305327
Výhodou51413120012156104161217275331387
této425326001213383118173
kombinace6213260012147101186244268325374419469
je1113326001212476
nejen12123260012155107131183239
synergický1474326001214089146198232288312358406457
účinek19543260012155101125181232280
na22573260012156105
snížení2385326001213995119163214271295
krevního2703326001214782133181238263321377
tlaku3103326001213357106154210
a33363260012148
hladin3407326001215580129186211267
lipidů,3697326001212347105129187243264
ale3984326001214873124
i41313260012123
zlepšení4177326001214368119177217268325349
adherence45493260012148106162214248298355401451
k50233260012147
léčbě5092326001212475122179231
díky5346326001215681130182
jednoduššímu425340001212475133189244302357397436460544599
dávkování.10443400012156104151199254301350406430451
Článek1515340001215781130185236284
shrnuje1819340001213995128184239264314
farmakologické2153340001212978112196244292346371426483507553600649
vlastnosti2822340001214772121160195251306346381404
obou32463400012155112168224
složek,3490340001213963119161212260284
výhody3793340001214899156211269317
fixní4130340001212956103159183
kombinace,43333400012146100184242266322370416465486
klinické483834000121477396152176221268318
indikace5175340001212379136160207257302352
a4253540012148
praktické496354001215791141188225249295343393
aspekty912354001214888145198246283334
jejího1269354001212475100124183239
použití15313540012157114170214238272296
v18513540012148
interní1922354001212379113163197254278
praxi.2223354001215791140189214235
Klíčová425371001235885111155211261312
slova:758371001234268124174225248
rosuvastatin,1027371001213387127181229278317351400432455510531
perindopril,15793710012157108141165220277332389422445469489
fixní2089371001212956102158181
kombinace,22923710012146100184241264319367412461481
dyslipidemie,27943710012157104144167190247270327377461484534554
hypertenze,33693710012156101159210243279328384427477497
adherence,38873710012148105160211244293349394443463
prevence4371371001215790140187237292337386
KVO.47783710012155114181200
Fixed425396001506497164226294
combination7583960015052118219287322390455502537604672
of14683960015066114
rosuvastatin16213960015047115170238305368424471536583618687
and23463960015063132201
perindopril25853960015067130180213282350418486535569604
–32113960015068
the33173960015047116179
next35343960015067130197246
step38193960015054100163232
in40893960015033101
cardiovascular42293960015052117166235269336401465520574642676741791
disease50583960015067102157220285340403
prevention4254100015067116180245306375422457524592
The4254300012149105154
combination596430001214497180235258313360391414468523
of1136430001215482
a12354300012148
statin1300430001213972120152175229
and15464300012148102157
an17214300012147101
ACE18394300012161116163
inhibitor2019430001212377132154210233265318350
represents2386430001213382138170219258307362393433
a28364300012148
modern29014300012182137193242274329
therapeutic3247430001213387137169216272322377409431475
approach37394300012148104160192246294338392
to4148430001213285
the4250430001213387137
simultaneous4404430001213961143197220252300354404459513551
management49724300012183130184232287336418468523554
of425444001215583
hypercholesterolemia5264440012155100157208240284338393417466505539588620674698748831853901
and14444440012148103159
arterial1621444001214779115164196219267290
hypertension19284440012156101158208241276325380419441496551
–24964440012150
the2564444001213287137
two27184440012133109162
main28984440012183130153208
risk312344400121335695141
factors3281444001212978122157210243283
for3581444001212984116
cardiovascular3715444001214493125180203258304352391435490513560592
disease4325444001215679117167215254303
(CVD).4646444001212883141208234252
The49154440012150105155
fixed-dose5088444001212955101149206238296351389439
combination425458001214599182239263318366398421476532
of975458001215584
rosuvastatin1077458001213387126181229278317351400432455510
and16054580012148104160
perindopril17834580012157108141165220276332389422445468
provides2269458001215790145192216272323362
comprehensive2649458001214599182239272322377428484523545594643
prevention3310458001215790139187236292324347402458
of3786458001215584
CVD38884580012158116183
in4089458001212479
patients41864580012157106138161211267299340
at4544458001214881
high4643458001215578134189
or4850458001215588
very4956458001214897130181
high5155458001215578134189
risk.536245800121335796142165
This4254720012150106129168
combination619472001214599182239263318366398421476532
offers1177472001215584116167200240
synergistic1443472001213987144194227283306345379402447
effects1915472001215080113163209244285
on22254720012155111
blood2362472001215781136191249
pressure2636472001215790140180219273306355
and30174720012148104160
lipid3203472001212447103127183
levels,3412472001212474122171195234255
and36924720012149104160
its387847200121245797
simplified4001472001214062146202226249279305355412
regimen4439472001213383139162246296352
improves48164720012124107164197251298347387
patient52294720012156105138161211267299
adherence.4254860012148105160211243293349394443463
This9104860012150106130169
article1101486001214881117140184208258
summarizes1381486001214094177261309341365408458497
the1900486001213389139
pharmacological20614860012157113161194277326370424448503560583628677700
properties2783486001215790145202253286322345395434
of3240486001215584
both33464860012157113146201
agents,35694860012148104154210242283304
the3895486001213389139
rationale4056486001213381114137192248296319370
and44484860012148103160
benefits46304860012157108164214244270303344
of4996486001215584
their5102486001213489139163195
fixed5319486001213056102151209
combination,425500001214599182239263318366398421476532553
clinical99950000121456891146169214263286
indications,1306500001212479136159203252285308363418457479
and18065000012148103160
practical1987500001215790138183218242286335358
considerations2367500001214498154193216272323355404436460515570609
for2997500001213085118
internal3136500001212378111160193249297320
medicine34775000012184134192215260282338388
practice.3886500001215790139183219242287336356
Key4255170012358108158
words:6055170012375131166225267290
rosuvastatin,918517001213387127181229278317351400432455510531
perindopril,14725170012157108141164219276331388421445468488
fixed-dose1983517001212955102151208240299354394444
combination,2450517001214498182239262317365398421476532552
dyslipidaemia,30255170012156104144167190246270327375425509532580601
hypertension,36485170012156101159210243279328384423446501557577
adherence,42485170012148105160211244293349394443463
cardiovascular4734517001214493126182205260307355395440494518566598
prevention.5355517001215790140425531001214897153185208263319340
Úvod4255770013874137198262
Kombinace565594001074592166216235283324364407
statinu990594001073463104131150198246
a12545940010741
inhibitoru1314594001071866114133182202230276303352
ACE16845940010753102144
představuje1846594001075077120170203232273313361380424
moderní22895940010773122172216243291310
strategii261859400107336289130158200250269287
pro425608001075076123
pacienty565608001075091132150194242269311
se893608001073478
současnou987608001073482130171212245293341389
hypertenzí1393608001074886137182208239281330366386
a17956080010741
dyslipidemií.1853608001074989123141160209228277321395413432447
Tato2317608001074277104150
fixní248460800107244382131149
kombinace2650608001073885159209228425622001074887127168
cílí6096220010740587896
na720622001074888
dva823622001074989129
zásadní968622001073677110151199246264
rizikové124762200107274581100137183222264
faktory1527622001072364102132177203245
kardiovaskulárních1788622001073879105152170217256297329366413431471497545562601648
onemocnění2452622001074795138210258298345388435453
a4256360010741
přináší48663600107507796144184218236
nejen742636001074993112155204
aditivní966636001074190109137156197246264
efekt1251636001074367111149180
na1451636001074889
snížení1560636001073482100137180228246
rizika,182763600107264682101139182197
ale2045636001074160104
i21696360010719
zlepšení2208636001073756100150183227275294
adherence2522636001074190139183209252300341383
díky425650001074866104146
zjednodušenému58665000107365597146193240288334366409456499570617
dávkovacímu1218650001074887126164209248289328346418464
režimu.1697650001072668104122194240255
Fixní196765000107415997144162
kombinace2144650001073783156204222269308347389
rosuvastatinu254865000107267210415019023026229033042566400107284795142
a5886640010741
perindoprilu650664001075094121140188238286336363382401448
tak1119664001072869107
rozšiřuje1247664001072774109145163189238256300
terapeutické156866400107287197139188233281309328368406449
možnosti20386640010774122158207255289318336
prevence2395664001075077120161204252293335
KVO2751664001074595154
u4256780010748
polymorbidních493678001074998118158233281308358377427475493533581
pacientů1094678001075091132150194242269317
s14316780010733
vysokým1484678001074184118166205248322
rizikem.182667800107264682102139182256272
Perindopril30475770013867126172204268333396460506538571
Perindopril3187594001074687114132180229277327354372390
je3602594001072063
inhibitor3690594001071967115133182201228275301
angiotenzin-konvertujícího4016594001074289139157205231274322358377424452491538586626668695725773791809849867917965
enzymu5006594001074492128171246293
(ACE),5324594001072476125166191204
který3047608001073868110135177
blokuje3241608001075068116153201219262
přeměnu3519608001075076118191234281327
angiotenzinu3863608001074188137154201228269317353371418465
I43446080010719
na4380608001074888
angiotenzin4485608001074088136154201227269316352371418
II4919608001071937
–49736080010745
silný503460800107345169116154
vazokonstriktor.5204608001074182118164202248296304762200107346288106143173218244256
Tím3322622001074261133
snižuje347562200107338098133180198241
periferní3736622001075094119138161203229277294
cévní4050622001074081121169187
rezistenci,4256622001072769105124155184225272312330344
krevní4620622001073865107147195212
tlak485262200107284685123
a49946220010741
sekreci5054622001073477114141184224242
aldosteronu,5315622001074159107155187304763600107286994139187233247
přičemž330863600107497593131172244279
zvyšuje3602636001073678120152198216258
hladiny3874636001074866105153170217254
vazodilatačního4142636001074080116162210228245284310350389436453501548
bradykininu.4704636001075075115163202240259305322369415429
Perindopril5148636001074585110128175223269318344362379
má30476500010774114
prokázané3179650001074975121159201237278325369
orgánově3566649001105182134179230281325370
protektivní3953649001105284135166211257291313359410433
účinky4403649001105191114165210257
–46776500010745
zpomaluje4740650001073686134207247265312330372
remodelaci5130650001072769142189239282300340379397
myokardu,30476640010774111158196237263310356371
zlepšuje344266400107375598147180226244287
endoteliální3753664001074491140187213255273291330348395413
funkci4190664001072472119156195212
a44276640010741
chrání4492664001074087113153200218
ledviny.4734664001072063112152171218255266
Po5025664001074590
perorálním5140664001074993119165191232250297314387
podání3047678001074995143181227244
je3304678001071960
rychle3378678001072666104149166208
absorbován,3599678001074088119165190237284322361407421
maximální40336780010772111148166236274292337354
koncentrace4400678001073782128167207252277302341379420
dosahuje4833678001074894125165210255272314
asi516067800107407188
za5261678001073676
153506780010743
hoprof.540667800107489442574000954468111132145
MUDr.588740009562112164188200
Jiří805740009528456886
Vítovec,9087400095415884125162200237252
CSc.,117774000954684121136150
FESC134474000953774112158
I.42575200951732
interní4747520095176084122146190207
kardioangiologická6987520095347296139156199236279324341384401445489506543577614
klinika13307520095345269112129163201
Lékařské154875200953675109147171201235274
fakulty18397520095215993136153179217
MU2073752009563113
a2203752009536
FN225775200953787
u2362752009542
sv.24227520095306778
Anny251875200954690133167
v2703752009536
Brně275775200954064108147
jiri.vitovec@fnusa.cz42576400951734587590124141166208244283320378400444487517554569605640
Cit.43997400095466388103
zkr:45197400095336792108
Vnitř464474000954183100125149
Lék.481174000953674109125
2026;72(2):120-122495474000953977114152166203242261300320333367400439466501534574
Článek44987520095466399142182216
přijat47317520095456986103139164
redakcí:491275200952462107144178213230243
21.51737520095397585
11.52757520095397081
2025537375200953978115155
Článek43477640095466399142182216
přijat45807640095456986103139164
po476176400954488
recenzích:48677640095246299137180214231267310323
27.52087640095397683
1.530876400953950
2026537576400953978115153