630
PŘEHLEDOVÉ479422001004388130181216258306358404446
ČLÁNKY525622001003973122176223272
Vztah465833001004375103139177
fibrilace4851330010017357397113129163194228
síní5095330010028438196
a5208330010033
demence525733001003873133169206237271
|5584220010018
183564222001002869104
/36038040010732
Vnitř3680804001074592111139166
Lék.3865804001074184122140
2026;72(3):183-1864025804001074487128170185227270291334355369407446489516555593638
/47088040010732
VNITŘNÍ48058040010746107127172221281301
LÉKAŘSTVÍ5128804001074084130188235279325377399
www.casopisvnitrnilekarstvi.cz42580400107651332012142542953293774274464795215705896176436927117307748128548809159449871007102310631101
https://doi.org/10.36290/vnl.2026.038433244001003865941331631802022234554440010041831024656440010015547911713947974400100287389124167204247293316355396414432470516552594611655688730
Vztah4258400275140241331454582
fibrilace1084840027586154283375440506628728845
síní2006840027599165293359
a24428400275116
demence26068400275123241429547676777894
Petra4251230013764120161204262
Kratochvílová7091230013767110168208271321387443473506569626684
II.42513800133265276
interní524138001332686121175210271296
klinika844138001335178103163188239293
FN11601380013354124
Plzeň1307138001335983129184245
Fibrilace425189001214972130164188213262307357
síní810189001214064120144
(FS)982189001212877126154
je1164189001212475
celosvětově1267189001214595120176216267317351406454504
nejčastější17991890012155107132177227267302352377417441
setrvalá2268189001214091126159211261285334
srdeční2630189001214073130181228284308
arytmie,2966189001214882133171255279330351
která3345189001214784134168217
aktuálně3590189001214996133189238263319370
postihuje39881890012157114154189213269325349401
přibližně4417189001215790115172198221265322373
2–448181890012151100156
%50021890012179
populace.51091890012157114172228253302347397418
Její425203001213789114138
prevalence584203001215790141190239264315372418468
neustále10732030012155107163203238288312364
stoupá1458203001213974129186243293
a17722030012148
očekává18412030012155102152200250298347
se,2209203001214091112
že2342203001214394
okolo24572030012155103158183239
roku2717203001213288136193
205029312030012151102153205
by31572030012157104
jí3282203001212449
mohlo33522030012183139196220277
celosvětově3650203001214494119176216266316350405453503
trpět4174203001213367125177212
kolem44072030012146101126178262
1004690203001215199153
milionů48642030012183108132156212269324
pacientů52092030012157107153177228285425217001213389
(1).53621700121297698118
Demence6762170012166118203254311357407
postihuje11052170012157114154189213270325350401
aktuálně1529217001214895132188237262318369
5–719202170012152104152
%20942170012179
populace21962170012157114172228253301347397
starší2616217001213974124157199223
6028612170012151104
let,2988217001212375109131
v31422170012148
roce3212217001213388135185
205034192170012151103154205
se3647217001213991
očekává37602170012155101151199250297347
ztrojnásobení4129217001214379113169193250299339395453505562586
této4737217001213383118173
hodnoty.49322170012156112170226282316367385
Toto5339217001215099133188
onemocnění4252310012155112163248304350407458514539
vede986231001214898156208
ke1216231001214797
snížení1335231001214096120164215272296
soběstačnosti,1653231001214096154206246281331377433489529564588609
závislosti2285231001214293141166206230286326361385
na26932310012155104
druhé2819231001215790147203255
osobě3096231001215595151209261
a33792310012149
zvýšení3450231001214395146187238295319
celkové3791231001214595120167222270320
mortality.41342310012183139173210260284308342393411
(2)4567231001212879106
V46952310012156
posledních47732310012157114154178230288344369414470
letech5266231001212374109159206262
přibývají425245001215791116174221274324349373
důkazy8292450012156112160210255306
o11662450012155
souvislosti1252245001213996152202227267292348389424448
mezi17312450012183135180204
FS1966245001214997
a20942450012148
zvýšeným2173245001214395147188239296343428
rizikem2632245001213357101126174224309
kognitivního29722450012147102160216241275299349406430489545
úpadku35482450012155113163221269326
a39042450012149
demence.39832450012157108193245302348399420
Cílem4433245001215982109161246
tohoto4709245001213389146202236291
přehledu5031245001215791142199224275334390
je5452245001212476
shrnout425259001214096129186242298333
nejnovější7802590012156107132188244293343367407431
epidemiologické12342590012150108133190242326351407432488545570615663713
údaje,19692590012155113162187238259
patofyziologické22512590012157106140195225277323347403428485542566612660710
mechanismy29832590012184135182238287343367407491538
a35432590012149
možnosti36142590012184140183240296336371395
prevence4031259001215791142191241297343393
tohoto4447259001213388145201235290
vztahu4760259001214894130180236292
na50752590012155104
základě5202259001214393141167216274325
publikovaných4252730012157113170195219266320368417473519563619
studií.1064273001213974129186210234256
Dostupná13392730012166123163197253310366415
data17742730012156104138187
potvrzují,19812730012156113146197232277333357381402
že2403273001214393
FS,2516273001214896118
zejména2654273001214293117201252309357
diagnostikovaná3031273001215680128185241296336371395442496544593649698
ve3748273001214898
středním3865273001214074107158216272295379
věku,4264273001214897145201223
významně4506273001214899145201250333389440
zvyšuje4966273001214394145185241265316
riziko5302273001213256100124171226
jak425287001212473121
celkové,569287001214595120167222270320341
tak934287001213382130
časné1087287001214595135191242
demence.13532870012156107192243300346396417
Důsledná17932870012167123163187239297353402
kontrola22192870012146101158191225280305354
rizikových2597287001213257101125173227276327372428
faktorů3048287001213079127164219253309
a33812870012148
adekvátní34522870012148106157205258307340397421
léčba,3896287001212475122179229251
mohou41702870012183140196253309
toto4502287001213388122177
riziko4702287001213358101126173228
snížit.4953287001214096120164189223245
Klíčová425304001235885111155211261312
slova:758304001234268124174225248
fibrilace1027304001212955112145169192240285334
síní,1382304001213962118141161
demence,15653040012156106190240296341390410
antikoagulace.19963040012148104136159206259308364419442490535584604
The4253290015067134197
relationship6613290015047110145210258293359428483551586655
between13543290015067130178271333396465
atrial18573290015063111160194259294
fibrillation2189329001504783151200234269303368416450517585
and28133290015063132200
dementia30523290015067130231294363410445510
Atrial425349001216193125149197220
fibrillation672349001212956112145169192215263296319374429
(AF)1129349001212888136165
is1321349001212463
the1411349001213388139
most15773490012183138178212
common1816349001214598182265320376
sustained2219349001214094133167216239294345402
cardiac2648349001214594126183206254298
arrhythmia2974349001214880113169215251306389412460
worldwide34613490012174128161185242315339396446
and39343490012148104160
currently41213490012145100133166215271303327374
affecting4522349001214878110160206241265320376
approximately49253490012148105162195249295318402450482531555603
2–4425363001215199154
%5983630012179
of696363001215584
the799363001213489139
population.9573630012157113170226249297329352408463484
Its146036300121245798
prevalence1577363001215790140187236259310365410459
continues2055363001214599155187210265320370410
to2484363001213387
rise,259036300121335695146166
and27753630012148103160
by29543630012157103
around3076363001214881136191246303
2050,33983630012151101152202222
the3639363001213388139
number37973630012155110193250301334
of4150363001215584
patients42533630012157106138161212267300340
with4612363001217498131186
AF48173630012161109
is4945363001212463
expected5027363001215097155206251287336393
to5439363001213387
approach4253770012148105162195249298342397
100840377001215198151
million10093770012183106129152175230286
(1).131337700121287495114
Dementia14453770012166117200251306338361409
currently18723770012145100132165215270302326373
affects2263377001214877109160205240281
5–725623770012151103149
%27293770012179
of2826377001215584
individuals2928377001212378135158206230286341389412451
over33973770012155102151183
the3598377001213388139
age37553770012148104154
of3927377001215484
60,40283770012152104124
and41693770012149104160
its434737700121245697
prevalence4462377001215790139187235258309364409458
is4938377001212362
projected5018377001215790144168218264299348405
to5441377001213387
triple42539100121336689146170220
by6633910012157104
20507853910012151101152202
(2).1005391001212878104122
This11453910012150106130169
disease1332391001215679118169217256307
leads1657391001212374122178218
to1893391001213387
loss1998391001212379118157
of2173391001215584
independence,2275391001212479135186243294350406457512557606626
increased2919391001212479124156206254293344401
need33383910012156106157214
for3570391001213085118
long-term3706391001212378134190222255305337421
care,4145391001214594126176196
and43593910012148104160
higher4537391001215679135190240273
overall48283910012155103152184233256280
mortality.51263910012183138171207256279302335385402
In425405001212479
recent526405001213282128177232265
years,812405001214797145177217238
accumulating1072405001214893136191274329353401433456511567
evidence1661405001215097121178228284329378
has20604050012156104143
suggested2224405001214094150206257296330379436
an26824050012148103
association2807405001214887126181227250298330353408464
between32924050012157108142217267318374
AF36874050012161109
and38184050012148103160
an39994050012148103
increased4124405001212378123156206254293343401
risk454640500121335695142
of4709405001215584
cognitive4814405001214599156211234267290339388
decline52234050012156107152175198254304
and4254190012148103159
dementia.6024190012156106189239295327349397418
The10384190012149105155
aim1211419001214871153
of1382419001215584
this1483419001213388111150
review1651419001213282129152202275
is1944419001212362
to2024419001213386
summarize2128419001213994176259307339362405454
the2600419001213388138
most27564190012183138176210
recent2984419001213282127176231263
epidemiological32654190012150107130186236319342397421475532555599647671
data,39534190012157104136185206
pathophysiological41764190012157106138192247304360405444467521545600656679724772795
mechanisms,49894190012183133178233281336359397480519539
and4254330012148103160
preventive609433001215790140187236292324347396445
strategies1078433001213973106154187236293316366406
underlying15084330012155110167217250274321345400457
this1989433001213388111150
relationship,2163433001213383107154187210265321360415438495514
based27014330012157106145195253
on29784330012155110
published31124330012157113169194216256311361419
studies.3555433001213973128185208258297319
Available38984330012161106155178201249306330380
data43024330012157105137186
confirm4512433001214599154183209242326
that4862433001213388136168
AF,50544330012162110121
particularly51994330012157106138174197242297425447001212472104128175
when6244470012173129180235
diagnosed883447001215680127183239294333383441
in1347447001212479
midlife,14504470012183106163186209239289309
significantly1782447001214063119174197227253297346401434457504
increases2310447001212379124156206254293344383
the2717447001213388138
risk287944700121335695142
of3045447001215584
both31524470012157113146201
overall33774470012154102151184232256279
and36794470012149104160
early-onset3863447001215098131154202233291346385436469
dementia.43564470012156107190241296329352400421
Careful48014470012158106138188218274297
control5122447001214598154187219274298
of5443447001215584
cardiovascular425461001214594126182205260307356395440495518566599
risk104546100121335695142
factors1208461001212978123158212245286
and15154610012148103160
adequate16964610012148105155213267316348397
treatment2115461001213365115163196279329385417
may25534610012184132178
reduce2752461001213382140194239288
this3062461001213388111150
risk.323346100121335696142165
Key4254780012358108158
words:6044780012374130166224266290
atrial915478001214881113137185208
fibrillation,1144478001213056112145169192215263296319374429450
dementia,16164780012156106190240296328351399420
anticoagulation.20574780012149104136159204258307362417441489521544599655676
V5655240010745
poslední626524001075098131149193242289307
době950524001074896145189
bylo1155524001074988108155
provedeno1326524001074976122162204254297345392
větší1734524001074183110144162
množství19125240010773121168204238267310329
studií,2257524001073362109158176194209
které2482524001073868110136178
prokázaly267652400107497612216020242553800107367897137
vztah579538001074079110151199
mezi7955380010773117154173
fibrilací98553800107244393119139157198238257
síní1258538001073452100118
a13935380010740
rizikem145053800107264682101139182255
vzniku1722538001074079128146184232
demence.1971538001074892166210258298341355
Výsledky2343538001074687121139183233271313
těchto2673538001072870111159186232
studií425552001073463111160179197
naznačují,644552001074989127175216257304323342357
že1023552001073779
větší1125552001074184111146164
incidence1312552001071966107126175219267307350
vzniku1684552001074180129147185233
demence1940552001074993166210259299342
je2304552001071963
u23905520010747
nemocných,2460552001074892166214256304342382430445
u4255660010748
kterých496566001073869112138181221269
byla788566001075089109150
fibrilace96156600107244393120139158198239281
síní126656600107335199118
zjištěna140756600107375675107136178227267
ve1698566001074083
věku1805566001074184122170
45–691998566001074485131179221
let224356600107196391
a23575660010741
čím2421566001074059132
déle2577566001074993112156
byly2756566001075089109149
pacienti425580001075091132150194242269288
vystaveni732580001074084118147188228271319338
fibrilaci108858000107244493120139158199239258
síní,136558000107335199118133
tím1517580001072847120
rychleji1656580001072669109157176220239257
u19325800010748
nich1999580001074866107155
docházelo2172580001074998139187227265308327375
k25665800010738
poklesu2623580001074999137158202235282
kognitivních425594001073988139188208237256299349368410459
funkcí.912594001072474123162203222239
U11785940010758
osob1263594001074984133185
nad1475594001075091142
70let1645594001074487108154183
věku1855594001074186125175
se2057594001073480
zdá,2164594001073787129145
že2337594001073781
riziko244559400107274785105144193
vzniku2665594001074282132151190240
demence425608001074994168213262303346
nestoupá798608001074993127157204253303345
výrazněji1170608001074185113155192242287305324
oproti1521608001074899126174202221
běžné1769608001075095133182227
populaci.20226080010750100151200219260301320336
Zvýšené2385608001074988132166211259304
riziko271660800107274683103141189
nalézáme425622001074889108152189231305349
u7956220010748
vzniku864622001074180128147185233
demence1118622001074993167211259300342
vaskulárního1481622001074182116153201220261287336355405453
a19556220010741
smíšeného20176220010734107125160205253297345394
typu,2432622001072770121169185
ne2638622001074892
však2751622001074174116154
u4256360010748
Alzheimerovy493636001075271108156201219293337363410451494
demence1007636001074993166211259299342
(3,136863600107246781
4).146963600107446579
Tyto565650001074276108154
výsledky738650001074184118136180230268311
potvrzuje1068650001074999126169197235284303347
také1433650001072869107150
studie1602650001073362110160178222
španělských1843650001073383124172216236268306349388436
autorů2298650001074188116163190238
prezentovaná2555650001074976119157200248275321425664001074182130171
na621664001074889
kongresu735664001073886134184210253287334
EHRA1094664001074298143198
2025,1317664001074487128172186
která1528664001073869111138180
zkoumala1733664001073674122170243284303344
vztah2102664001074179110152200
fibrilace232766400107244393120139158198239281
síní2633664001073452100119
(FS)2777664001072465105128
a4256780010741
demence493678001075095170215264306349
na869678001074991
rozsáhlé987678001072674111147190239258303
katalánské1317678001073982110152171213262296334378
kohortě.1722678001073987137186214245288304
Bylo2053678001074687107157
sledováno223767800107345398149198239282331380
celkem2644678001074184104142186261
24256920010744
520480692001074486128
839620692001074386128
pacientů765692001074991131150194242268316
ve1098692001074184
věku1198692001074184122170
nad1385692001074889138
451540692001074385
let164169200107196391
po1749692001074999
dobu1864692001074997147196
132076692001074482
let.217469200107196391107
Výsledky2298692001074687121139183233271314
ukázaly,2629692001074785127164207226265277
že3047524001073677
FS3139524001074180
představuje3234524001074975116165197225265303350368411
nezávislý3660524001074890126167206224256274313
rizikový39885240010726448098135181220262
faktor4265524001072364101130176202
demence4482524001074891162205252291333
u48305240010747
pacientů4892524001074989129146189235261308
mladších5215524001077291130178209227266312
703047538001074486
let315453800107196391
(HR3267538001072380125
1,21;341453800107435499139148
P35845380010745
<36515380010753
0,001),3726538001074459103149189207220
zatímco3968538001073678105124198238285
u42745380010748
osob4344538001074881130180
starších4545538001073463104130165183223271
704838538001074385
let494553800107196391
tato505753800107286996143
asociace5222538001074074122163182222263305
významná3047552001074185124174215289338379
nebyla.3453552001074893143183203244261
Nejvýraznější37415520010758103122163207235277315364409428461480
souvislost4247552001073483132174193227246294328358
byla4632552001075090110151
zjištěna480955200107375776109138181230271
u51075520010748
demence5181552001075094169214262304346
s30475660010733
časným3096566001074081113160198272
nástupem3384566001074888120149196245289361
(early-onset3762566001072364103129148187214264312344388415
dementia,4193566001074892164208255282300340355
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při494856600107497594
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před3260580001075076119169
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rokem3564580001072774112155229
věku3810580001074184122170
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této474958000107277098144
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jako538258000107206098145
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pacienti4575594001075091132150194242268287
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CMP,30476080010751121167171
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je3447608001071963
sám3533608001073476149
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sobě3778608001073382132176
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za4396608001073779
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faktor5319608001072466104135181208
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kognitivní3481622001073885135183202230249290339357
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skupině.4684692001073371119169188236280294
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výzkumy5206692001074083122161209283321
MUDr.425740009562112164189200
Petra64374000954078103127164
Kratochvílová82574000954065102127169206249284302320364400437
II.4257520095173449
interní4917520095176084122146190207
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Cit.43897400095466388103
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Lék.481174000953675109125
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Článek45237520095466399142182216
přijat47567520095456986103139164
redakcí:493775200952462107144178213230243
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Článek43417640095466399142182216
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