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FARMAKOLOGICKÝ42522001003983129195242289338373423469489529576625
PROFIL106522001004388139179198233
Osilodrostat4253300100477792107146185209248277304341367
https://doi.org/10.36290/vnl.2026.05142544001003865941331631802022236484400100418310274944001001554791171398904400100287389124167204247293316355396414432470516552594611655690718
Osilodrostat4259800275151255321387513642734861964105211751264
Michal4251370013793124174239297327
Kršek1,7751370013767110158216277105013800803610851370013729
Marta11361370013793152194236295
Šimůnková214531370013759891842483133724354915492001138008036
1III.42515300783345615200133265278101
interní581152001332686121175210271296
klinika901152001335178103163188239293
–12171520013355
klinika1295152001335279104164189240294
endokrinologie16121520013355116178238289327352412472498559620646700
a23361520013353
metabolismu,24121520013392147183237298359385410453543603626
1.3061152001335673
lékařská3158152001332681132186221265316370
fakulta3551152001333285136197222258311
a38861520013353
Všeobecná39621520013361105160220283338388449501
fakultní4486152001333286137197222258319344
nemocnice48531520013361116207268317378403451505
v4251670013353
Praze501167001335993146193248
2YourComm,4251830078334571820013360113173209274332424515537
s.1018182001334366
r.1108182001333653
o.1184182001336182
Cushingův4252330012157111150205229284340395444
syndrom888233001213987144200233288371
(CS)1278233001212884134162
je1459233001212474
onemocnění15532330012154110160244299345400450506529
způsobené21012330012143100155195250307358414464
nadměrnou25852330012154103159242293326382437492
autonomní30962330012148103136190246301385440464
produkcí3579233001215689144201256303347370
kortizolu39682330012147100134170193236291315370
a43572330012148
jeho4424233001212475130186
působením46292330012156111151206263314370393477
na51252330012155103
buňky,52472330012156111167214264280
tkáně425247001213379128183233
a6772470012147
orgány743247001215487142190245290
lidského1052247001212346103142188237293347
těla.1418247001213382106153175
Klinický1611247001215479102157180225271321
obraz19512470012154111144192235
CS22052470012157107
je2331247001212474
velmi2423247001214897121203226
komplexní26682470012146100183239263313360416439
a31262470012147
bezprostředně31922470012156107150207239294333367399449506561611
ohrožuje38212470012155110143197239294317367
své4207247001213988137
nositele43632470012154109148171204253278328
na47092470012155103
životě.4831247001214265113167200249268
Morbidita51182470012179134167224248304328361409
a4252610012148
mortalita4952610012184140174211261285309343393
pacientů9102610012157107153177228285318374
s13062610012139
aktivním1368261001214895132156206263287371
CS17612610012158109
je1893261001212475
oproti19902610012155113147203237261
referenční2273261001213384114166199250307353409433
populaci27282610012157114172229253302348372
až3122261001214892
čtyřikrát3237261001214481131166190238273322356
vyšší,36152610012148100140180204226
zejména3863261001214394119203255311360
v42462610012148
důsledku43162610012156112152176228286334390
kardiovaskulárních4728261001214797131188212268316366406454510534583617674698743799
příčin,425275001215791115161184241262
ale717275001214872124
pacienty8702750012157107152176227284317368
ohrožuje12682750012154111145200243299324375
řada1673275001213282139188
dalších18912750012156105130169194239295
komplikací.22152750012147102187244269293341391437461483
Navíc27272750012166115163188233
existují2989275001215099123164198254279303
důkazy,33212750012157112160210255306323
že3673275001214394
zvýšená3796275001214394146187238295344
morbidita41692750012183139173231256314338372422
a46202750012148
mortalita46972750012184140174211261285309343393
přetrvává5119275001215791142176210262311359408
mnoho4252890012183140196253309
let756289001212475109
i8882890012123
po9332890012157114
úspěšné1070289001215595152204245301352
léčbě.1444289001212475122179231252
Léčba1718289001214798144202252
CS19922890012158109
musí21232890012183139180203
být23492890012157104141
časná2513289001214494134190239
a27742890012149
komplexní.28452890012147102186244269320369425450471
Ve33392890012155103
všech3464289001214889140187243
situacích372928900121406398153203248272318374
s41252890012140
přetrvávající4187289001215791142176210262311359408433457503527
nadprodukcí47362890012155104162220254309368423471516540
kortizolu52982890012147101135172196425303001214398124179
musíme6273030012184140180204288340
normalizovat9903030012155111145230279304328371427475525558
jeho1571303001212576133189
produkci.1783303001215791146205260308353377398
Zde22053030012155111163
má23913030012183133
své2547303001213989139
místo27103030012183107147182237
farmakologická2970303001213080113198247295349374431488512558606656
léčba.3649303001212475122179229251
Perorální4253170012153101134189222270294349372
přípravek815317001215789113170202251297346394
Isturisa122731700121236397151184207247295
s15403170012140
účinnou15983170012155100123178233288343
látkou1959317001212472104151204260
osilodrostat2237317001215594117140195252285339378412461494
(kódově2749317001212875128185240288337
označen3104317001215496152200244293349
LCI699)34713170012147102125177227279305
je3794317001212475
indikován3887317001212378135158204258305354409
k43143170012147
léčbě4379317001212374119176226
endogenního46233170012150106163218274325380435458516571
Cushingova521231700121581111502052282834253310012156111158206
syndromu649331001213987143200232287370425
u10913310012155
dospělých11643310012157112151207258281329372427
pacientů.16093310012157105150173223279311365386
Jeho2012331001213788143198
účinnost22283310012155100123178233287327360
a26063310012148
bezpečnost26723310012157108151208258304359414453487
byla31763310012157103127175
a33693310012148
je3435331001212474
ověřována35273310012155102151182237284332387435
v39803310012148
programu4045331001215790144201233282365419
klinických448233100121477295150173217263314357412
studií4912331001214073128185208231
LINC5160331001214771136195
1–7.5372331001215298144155
Studie425345001214981136192215266
fáze713345001212978121172
III90734500121244872
sledovaly1001345001213963113170225273321345392
účinnost14153450012155100123178233289328362
i17993450012123
bezpečnost18453450012157107151208259304360415454488
osilodrostatu.2355345001215594117140195253285340379413462494549570
Údaje29473450012165121169193243
in3213345001212378
vitro3314345001214872105137192
ukazují,35283450012155102151195250273297317
že3868345001214292
ani39833450012148103126
osilodrostat4131345001215595117141196253286340379413462495
ani46483450012148103127
jeho4797345001212474130185
hlavní5005345001215579127173229252
metabolit528034500121831341672164253590012157113137160193
neinhibují6383590012156106130185240263320375399422
enzymy10803590012151106149199283329
a14293590012149
transportéry,1498359001213366114169208265321354390439472522538
které2057359001214682132165214
se2292359001213990
podílejí24023590012157113170194219269293316
na27393590012155103
metabolismu28623590012184134168217273329353376415498553
léčiv,3435359001212474120143191207
v36623590012148
klinicky373135900121477295150173218264315
relevantních4066359001213382106157204253308340396419463519
koncentracích.46053590012147101156201250306338371419464487532587608
Lékové5233359001214797144198245294
interakce425373001212379111160193242288332381
se827373001214090
nejeví9383730012156106130180228252
pravděpodobné.1211373001215790138185240291348403461516573629679699
Nejvážnějším19313730012166117141189238281336387411450473556
nežádoucím25083730012156106149199256311366411434517
účinkem30473730012155100123178224273357
v34253730012148
klinických349437300121477295150174218265315359414
studiích3929373001214074129185208232276331
byla42813730012157104128176
adrenální44783730012148105137187243291314369393
insuficience.4892373001212378117172201227272295345401446495515
Klíčová425390001235885111155211261312
slova:758390001234268124174225248
antikortikosteroidy,10273900012148103136159205259292328351398451491525574607661685741789805
Cushingův18533900012158111151206229284340395443
syndrom,2317390001214088144201234288372393
Cushingova27313900012158111150206229284340395442491
choroba,32433900012145100155188242299348369
osilodrostat.3633390001215595117141196253286340379413462495516
Osilodrostat4254150015083138172207274343392459514561626674
Cushing’s4254350012158111150206229284340361397
syndrome844435001214088144201233288371422
(CS)1287435001212985135162
is1470435001212463
a15544350012149
disease1624435001215780119169217256307
caused1953435001214493148187237295
by22694350012157103
excessive2394435001215097141190229269291340389
autonomous28044350012149103136190246301385440495535
production3360435001215790144202256301337360415471
of3852435001215584
cortisol3958435001214498131167190229284308
and42884350012148103160
its447043500121235697
effects4588435001215080113163209244285
on48944350012155111
cells,5026435001214594118141180201
tissues524943500121335695134189239278
and4254490012148103160
organs607449001215587143191246285
of914449001215584
the1019449001213489139
human11804490012155110193241296
body.14984490012157112170217234
The17534490012150106157
clinical193144900121456891146169214263286
feature2239449001212979127160215247297
of2558449001215484
CS26634490012158108
is2793449001212362
very2876449001214998131181
complex3078449001214599183239263314361
and34604490012149104160
directly3642449001215679112162207243266313
threatens3977449001213388120170218251300356395
the4393449001213389139
lives455344900121244795144184
of4758449001215584
its486444900121235697
carriers.4982449001214594126160183233266307328
Morbidity53314490012181136169425463001215781137160193243
and6974630012148103160
mortality8854630012183139172207256280303336386
of1299463001215584
patients14114630012157106138161212267300340
with1780463001217397130185
active1993463001214993129152200249
CS22704630012159108
is2407463001212362
up24974630012156112
to2637463001213488
four2753463001212984139172
times2953463001213356139190230
higher3211463001215578134190240273
than3512463001213388136192
in3732463001212379
the3839463001213388139
reference4006463001213382112162195245301346395
population,44294630012157113170226249297330353408463484
mainly49414630012184132155210234281
due52504630012157112162
to5440463001213387
cardiovascular425477001214593125181204258305353392437491515562594
causes,1037477001214593147186236275296
but13514770012157111144
patients15134770012157105137160210265297338
are1868477001214880130
at2016477001214880
risk211447700121325594140
of2272477001215584
a23734770012148
number24394770012155110192249299332
of2789477001215483
other2890477001215587142192224
complications.3132477001214598181238261284328377409432486542580602
In3751477001212479
addition,38484770012148104160183216239293349369
there4235477001213388138171220
is4473477001212362
evidence4552477001215098121177227283327376
that4946477001213287135167
increased5131477001212378123155204252291341398
morbidity4254910012183139172229252309332365415
and8614910012149104160
mortality10434910012183138171207256280302336385
persist14504910012157108141181204243277
for1748491001212985117
many18874910012183131187232
years2140491001214897145177218
even2379491001215098147203
after2603491001214877114163196
successful2820491001214094139183232271310341397420
treatment.3261491001213366116164196280330386418439
Treatment3722491001214976126174207290340396428
of4172491001215584
CS42774910012158108
must44064910012184139178212
be46394910012157108
early4768491001215099131155202
and49924910012148103160
comprehensive.51734910012145991822392723224255050012155105160199221269318338
In780505001212479
all87650500121487194
situations98850500121396294149196228251306361399
with1405505001217396129184
persistent16065050012157107140180202241275323379410
overproduction20345050012155101150182239272326382437481516539593648
of2700505001215583
cortisol,2801505001214498130166188227282305326
we31445050012173122
must32845050012183137176209
normalize35115050012155109142225273296318361410
its393950500121235696
production,4052505001215790144200255299334357411466487
where45565050012174129179211261
pharmacological48345050012157112160192275323367420444498555577622670693
treatment425519001213366115164196279330385418
has8645190012155103143
its102851900121235697
place.1146519001215781129174223243
The4255330012150106157
oral604533001215588137160
product787533001215790144201256301336
Isturisa114653300121246397152185208247296
with1465533001217497130185
the1673533001213388139
active1835533001214893128151199248
substance2106533001214094151190224273328373422
osilodrostat2551533001215594117140195252285340379413462494
(code3068533001212870123181231
LCI699)33225330012147102125177227279305
is3650533001212362
indicated3735533001212479135158203252284334391
for4149533001212984117
the4289533001213388138
treatment4450533001213366115163196279330385418
of4890533001215584
endogenous49975330012150106163218274325380435491530
CS4255470012158108
in557547001212378
adult6595470012148105159183216
patients.8995470012156105138161211267299340361
Its128454700121235797
efficacy1405547001215080112138183232277326
and17555470012148103160
safety1939547001213988117168201251
have22145470012155103150199
been24375470012156107158214
and26755470012148103160
are2859547001214880130
being30135470012157108131186242
verified3279547001214897130154183209259317
in3619547001212479
the3722547001213388138
clinical388454700121456891146169214263286
trial419454700121336689137160
program4378547001215790145201234282365
(LINC476754700121297598164222
1–7).5013547001215198144172191
Clinical5227547001215881104160183227276300
studies425561001214073128185208258298
phase7475610012157113160200250
III102156100121244871
verified1116561001214897130154183209260317
the1457561001213388138
efficacy1619561001215080112139183232277326
and19695610012148104160
safety2153561001214089118168201251
of2428561001215584
osilodrostat.2536561001215594117140195252285339379413461494515
In3075561001212479
vitro3178561001214872105137192
data33945610012156104137185
indicate3603561001212479135158203252284334
that3960561001213489137169
neither41535610012155106129162218268301
osilodrostat4478561001215494117140195252285339379412461494
nor49955610012156111144
its516356100121235697
major52845610012183131155210243
metabolite4255750012183134167216273329353376409458
inhibit911575001212378134157213237270
enzymes12095750012150106149199283333373
and16105750012148103160
transporters1797575001213366114170209265321354390439472512
at2337575001214881
clinically244657500121446890146169214262286309356
relevant2830575001213382106157204253308340
levels.3198575001212474122171195234255
Drug34815750012166100155211
interactions3720575001212378111160193241286322345400455494
do42425750012156112
not43815750012156111144
appear45525750012149105162214262294
likely.487457500121234693142166213230
The51315750012150106157
most53165750012183138177211
serious425589001214090123147202257296
adverse7425890012149105154203236276326
event1090589001215097146202235
was13465890012173122161
adrenal15285890012148105137187243291314
insufficiency.1864589001212378117172201234260305328378434479528545
Key4256060012358108158
words:6046060012374130166224266290
anticorticosteroids,9156060012148103136159204257290326349394448487521570603658681738777798
Cushing’s17346060012158111151206229284340361397
syndrome,2153606001213987144200233288371422442
Cushing’s26166060012158111150205229284340361397
disease,3034606001215780119169218257307327
osilodrostat.3382606001215594117141196253285340379413462495516
Cushingův4256610013856119171235267331395459522
syndrom9846610013850113177242288351444
a14656610013858
jeho1545661001383190154217
etiopatogeneze17996610013856101135197261322367429493552616676727786
Cushingův565678001075197130178197245294341382
syndrom971678001073374123173199246320
(CS)1315678001072473116140
je1478678001071963
onemocnění1565678001074796140214262304352396444462
způsobené2051678001073686134167216266311359403
nadměrnou2477678001074989139212256283332380428
autonomní425692001074188117163212260334382401
produkcí843692001074976123173221259298317
kortizolu1176692001073886113144162199246266313
a15066920010741
jeho1563692001072064112160
působením1740692001075098131179229274322341414
na2171692001074889
buňky,2277692001074997145183226238
tkáně2531692001072866109157201
a27486920010741
orgány28066920010748753047664001074990138176
lidského324266400107193786119157200248297
těla355766400107287089130
a37056640010741
první3765664001074976120169188
podrobný3971664001075099149176223273321360
popis4349664001075099149168201
onemocnění4569664001074796140214262304352396444462
podal5050664001074999149189208
Harvey5277664001075797124168211251
Cushing3047678001075196128175193240288
v33516780010740
roce3407678001072672113154
19323577678001074380121161
(1).37546780010723627992
Jedná3862678001073073123170209
se4087678001073377
o41806780010747
vzácné4243678001074078119159206249
onemocnění4508678001074795138211258299346389436454
s49786780010733
odhadovanou5027678001074796143183232279318359406453501
incidencí3047692001071967107126175219267308326
2–33394692001074487128
nové3542692001074897137180
případy374369200107507696145187236276
na4040692001074889
141496920010744
0004205692001074489135
0004351692001074490136
obyvatel4507692001074898137182223250293312
a48406920010741
149016920010744
rok4966692001072673112
(2,509869200107246782
3).520169200107446578
Pokud5300692001074591130178227
prof.42574000954468111132145
MUDr.588740009562112164188200
Michal80574000956280116159195213
Kršek,10357400095406596135170186
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