Vnitr Lek 1990, 36(8):746-752
[Immunologic classification of lymphoid cells based on the detection of membrane phenotype using monoclonal antibodies in patients with T-lymphoproliferative diseases].
- Ustav hematologie a krevní transfúze Praha.
A series of (CD1-CD10) mouse monoclonal antibodies reactive with human T lymphoid cells, in different stages of differentiation, was used for immunological classification of leukaemic cells of 25 patients with T cell lymphoproliferative disorders, using a fluorescence assay. The majority of patients with T-ALL had cells of an immature or early thymic phenotype and patients with T lymphoblastic lymphoma had phenotypes corresponding to different levels of more mature stages of T cell differentiation. Three patients with T-CLL and one patient with mycosis fungoides had mature T cell phenotypes CD3+, CD4-, CD8+, corresponding to cytotoxic/suppressor cell types and one patient with T-CLL had CD3+, CD4+, CD8- phenotype, corresponding to the "helper/inducer" cell type.
Keywords: Adolescent; Adult; Aged; Antigens, CD, analysis, ; Child; Humans; Immunophenotyping; Leukemia, T-Cell, immunology, ; Lymphocyte Subsets; Middle Aged
Published: August 1, 1990 Show citation