Vnitr Lek 1992, 38(9):921-929

[The favorable effect of hydrolytic enzymes in the treatment of immunocytomas and plasmacytomas].

A Sakalová, M Mikulecký, D Holománová, D Langner, K Ransberger, G Stauder, M Mistrík, S Gazová, I Chabronová, M Benzová

I. interná klinika Fakultnej nemocnice, Bratislava.

At present attention is focused on research of biomodulating influences on tumorous processes, in particular inhibition of metastatic spread of tumors. In the aetiopathogenesis an important part is played by immune complexes, interaction of cytokines. The authors tested the supporting effect of hydrolytic enzymes in plasmocytoma and immunocytoma. The enzymes were administered along with cytostatic preparations according to the MOCCA pattern. They recorded a more rapid onset and longer persistence of remissions, a marked decline of total proteins, paraproteins, beta-2-microglobulin. Complications associated with paraprotein (hyperviscosity syndrome, nephrotic syndrome, peripheral angiopathy) improved. A combination of chemotherapy and enzymatic treatment proved effective and suitable, in particular for patients with interferon intolerance.

Keywords: Chymotrypsin; Drug Combinations; Humans; Hydrolases, therapeutic use, ; Pancreatic Extracts, therapeutic use, ; Papain, therapeutic use, ; Paraproteinemias, therapy, ; Plasmacytoma, therapy, ; Rutin, therapeutic use, ; Thymus Extracts, therapeutic use, ; Trypsin

Published: September 1, 1992  Show citation