Vnitr Lek 1995, 41(7):470-472

[Successful treatment of agranulocytosis caused by carbimazole using recombinant granulocyte-macrophage colony stimulating factor].

A Kreze, A Kuviková, L Laca, S Kompis, M Dobáková, P Babusík, L Matecek, E Pekárová
Interná klinika A Nemocnice F. D. Roosevelta, Banská Bystrica.

The authors describe a patient with hyperthyroidism who developed after three weeks' treatment with carbimazole agranulocytosis and the condition was complicated by septic shock. The authors used for treatment in addition to antibiotics and corticoids, for the first time in their practice, human recombinant granulocyte macrophage colonies stimulating factor (rHuGM-CSF) which produced a very favourable effect. In the meantime the patient was prepared for goitrectomy, operated and discharged in a satisfactory condition to have ambulatory treatment.

Keywords: Agranulocytosis, chemically induced, ; Carbimazole, adverse effects, ; Female; Granulocyte-Macrophage Colony-Stimulating Factor, therapeutic use, ; Graves Disease, drug therapy, ; Humans; Middle Aged; Recombinant Proteins

Published: July 1, 1995  Show citation

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Kreze A, Kuviková A, Laca L, Kompis S, Dobáková M, Babusík P, et al.. [Successful treatment of agranulocytosis caused by carbimazole using recombinant granulocyte-macrophage colony stimulating factor]. Vnitr Lek. 1995;41(7):470-472.
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