Vnitr Lek 1997, 43(4):208-210
[Famotidine in the treatment of gastropathy induced by non-steroidal antirheumatic agents].
- Subkatedra reumatológie IVZ, Piest'any.
Klíčová slova: Anti-Inflammatory Agents, Non-Steroidal, adverse effects, ; Esophagitis, chemically induced, ; Famotidine, therapeutic use, ; Female; Histamine H2 Antagonists, therapeutic use, ; Humans; Male; Middle Aged; Peptic Ulcer, chemically induced,
In an open clinical endoscopically controlled study in 30 consecutive patients with rheumatic diseases complicated by the ulcerative and erosive form of gastroduodenopathy induced by non-steroidal antiinflammatory drugs and oesophagitis, after four weeks treatment with oral famotidine (one dose of 40 mg/day) confirmed a significant improvement of the mean oesophageal (0.67 +/- 1.06 vs. 0.03 +/- 0.18, p rrr 0.01) gastric 2.10 +/- 1.49 vs. 0.63 +/- 0.85, p rrr 0.001) and duodenal mucosal score (1.80 +/- 1.52 vs. 0.43 +/- 0.82, p rrr 0.001). After four weeks treatment 71% lesions (5/7) in the oesophagus were cured, 77% gastric lesions (10/13) and 75% duodenal lesions (9/12). Treatment with non-steroid antirheumatics proceeded.
Keywords: Anti-Inflammatory Agents, Non-Steroidal /adverse effects/; Esophagitis /chemically induced/; Famotidine /therapeutic use/; Female; Histamine H2 Antagonists /therapeutic use/; Humans; Male; Middle Aged; Peptic Ulcer /chemically induced/
Zveřejněno: 1. duben 1997 Zobrazit citaci