Vnitr Lek 2011, 57(4):339-346

Xerostomia, hyposialia, sicca syndrome - quantitative disturbances of the salivary flow rate

R. Slezák1,*, I. Berglová1,2, J. Krejsek2
1 Stomatologická klinika Lékařské fakulty UK a FN Hradec Králové, přednosta doc. MUDr. Radovan Slezák, CSc.
2 Ústav klinické imunologie a alergologie Lékařské fakulty UK a FN Hradec Králové, přednosta prof. RNDr. Jan Krejsek, CSc.

Diseases od salivary glands may be associated with salivary flow rate disturbances. Production of the saliva is evaluated by sialometric tests. The stress is putted on salivary flow rate disturbances in Sjögren's syndrome, drug-induced and postirradiative sialopathy, and diabetes mellitus. The possibility of the stimulation and substitution of the saliva is discussed.

Keywords: salivary glands; salivary flow rate; hyposialia; xerostomia; sialometry; Sjögren's syndrome; diabetes mellitus; sialogogues

Received: October 8, 2010; Published: April 1, 2011  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Slezák R, Berglová I, Krejsek J. Xerostomia, hyposialia, sicca syndrome - quantitative disturbances of the salivary flow rate. Vnitr Lek. 2011;57(4):339-346.
Download citation

References

  1. Carlson ER, Ord RA (eds). Textbook and color atlas of salivary gland pathology. Diagnosis and management. Ames, Iowa: Wiley-Blackwell Publishing2008.
  2. Mandel L, Surattanont F. Bilateral parotid swelling: A review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002; 93: 221-237. Go to original source... Go to PubMed...
  3. Slezák R, Kudiyirickal MG, Nováková V et al. Stručný přehled nemocí slinných žláz a poruch salivace. Folia Parodontol Bohem 2008; 4: 16-25.
  4. Young W, Khan F, Brandt R et al. Syndromes with salivary dysfunction predispose to tooth wear: Case reports of congenital dysfunction of major salivary glands, Prader-Willi, congenital rubella, and Sjögren's syndromes. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001; 92: 38-48. Go to original source... Go to PubMed...
  5. Grisius MM. Salivary gland dysfunction: A review of systemic therapies. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001; 92: 156-162. Go to original source... Go to PubMed...
  6. Scully C. Drug effects on salivary glands: dry mouth. Oral Dis 2003; 9: 165-176. Go to original source... Go to PubMed...
  7. Turner JR, Sugiya H. Understanding salivary fluid and protein secretion. Oral Dis 2002; 8: 3-11. Go to original source... Go to PubMed...
  8. Ferguson DB. The physiology and biology of saliva. In: deBurgh Norman JE, McGurk M (eds). Color Atlas and Text of the Salivary Glands Diseases, Disorders and Surgery. London: Mosby-Wolfe 1995, 40-48.
  9. Porter SR, Scully C, Hegarty AM. An update of the etiology and management of xerostomia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004; 97: 28-46. Go to original source... Go to PubMed...
  10. Ship JA. Diagnosing, managing, and preventing salivary gland disorders. Oral Dis 2002; 8: 77-89. Go to original source... Go to PubMed...
  11. Field AE, Rostron JL, Longman LP et al. The developmental and initial validation of the Liverpool sicca index to assess symptoms and dysfunction in patients with primary Sjögren's syndrome. J Oral Pathol Med 2003; 32: 154-162. Go to original source... Go to PubMed...
  12. Moore PA, Guggenheimer J, Etzel KR et al. Type 1 diabetes mellitus, xerostomia, and salivary flow rates. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001; 92: 281-291. Go to original source... Go to PubMed...
  13. Pajukoski H, Meurman JH, Halonen P et al. Prevalence of subjective dry mouth and burning mouth in hospitalized elderly patients and outpatients in relation to saliva, medication, and systemic diseases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001; 92: 641-649. Go to original source... Go to PubMed...
  14. Ferguson DB, Carter P. Salivary gland dysfunction. In: deBurgh Norman JE, Mc Gurk M (eds). Color Atlas and Text of the Salivary Glands Diseases, Disorders and Surgery. London: Mosby-Wolfe 1995: 49-57.
  15. Ciferská H, Horák P, Heřmanová Z et al. Sjögrenův syndrom. Intern Med Pro Prax 2006; 10: 423-426.
  16. Nikolov NP, Illei GG. Pathogenesis of Sjögren's syndrome. Curr Opin Rheumatol 2009; 21: 465-470. Go to original source... Go to PubMed...
  17. Merne ME, Syrjänen SM. Detection of Epstein-Barr virus in salivary gland specimens from Sjögren's syndrome patients. Laryngoscope 1996; 106: 1534-1539. Go to original source... Go to PubMed...
  18. Terada K, Katamine S, Eguchi K et al. Prevalence of serum and salivary antibodies to HTLV/1 in Sjögren's syndrome. Lancet 1994; 344: 1116-1119. Go to original source... Go to PubMed...
  19. Ramos-Casals M, Muñoz S, Zerón PB. Hepatitis C virus and Sjögren's syndrome: trigger or mimic? Rheum Dis Clin North Am 2008; 34: 869-884. Go to original source... Go to PubMed...
  20. Amft N, Bowman SJ. Chemokines and cell trafficking in Sjögren's syndrome. Scand J Immunol 2001; 54: 62-69. Go to original source... Go to PubMed...
  21. Azuma M, Motegi K, Aota K et al. Role of cytokines in the destruction of acinar structure in Sjögren's syndrome salivary glands. Lab Invest 1997; 77: 269-280.
  22. Krejsek J, Kopecký O. Ústní dutina a imunitní systém. In: Krejsek J, Kopecký O. Klinická imunologie. 1. vyd. Hradec Králové: Nucleus HK 2004: 317-323.
  23. Vitali C, Bombardieri S, Jonsson R et al. Weisman MH; European Study Group on Classification Criteria for Sjögren's Syndrome. Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 2002; 61: 554-558. Go to original source... Go to PubMed...
  24. Dawson LJ, Holt DJ, Highma SM et al. A comparison of salivary gland hypofunction in primary and secondary Sjögren's syndrome. Oral Dis 2001; 7: 28-30. Go to original source... Go to PubMed...
  25. Skalova S, Minxova L, Slezak R. Hypokalemic paralysis revealing Sjögren's syndrome in a 16-year-old girl. Ghana Med J 2008; 42: 124-128. Go to PubMed...
  26. Martinoli C, Pretolesi F, Del Bono V et al. Benign lymphoepithelial parotid lesions in HIV-positive patients: Spectrum of findings at gray-scale and Doppler sonography. Am J Roentgenol 1995; 165: 975-979. Go to original source... Go to PubMed...
  27. Maynard JD, Challacombe SJ, Schidt M. Sialectasis, Sjögren's, Mikulicz and HIV-associated salivary gland diseases (HIV-SGD). In: deBurgh Norman JE, Mc Gurk M (eds). Color Atlas and Text of the Salivary Glands Diseases, Disorders and Surgery. London: Mosby-Wolfe 1995: 267-283.
  28. Vokurka S. Mukositida dutiny ústní u pacientů po chemoterapii. Kompendium ambulantní medicíny. Med Tribune 2008, 7: 8.
  29. Samarawickrama DY. Saliva substitutes: how effective and safe are they? Oral Dis 2002; 8: 177-179. Go to original source... Go to PubMed...
  30. Amerongen AV, Veerman EC. Saliva - the defender of the oral cavity. Oral Dis 2002; 8: 12-22. Go to original source... Go to PubMed...




Vnitřní lékařství

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.