Vnitr Lek 1992, 38(8):814-821
[Fructose metabolism disorders and infusions].
- Biochemický ústav. Lékarská fakulta MU, Brno.
The authors give an account of views regarding the use of non-glucose energy sources in parenteral nutrition during the immediate post-load period/serious operations, severe injuries). Attention is devoted to the metabolic pathway of fructose and its disorders. In hereditary fructose intolerance an infusion of D-fructose or D-glucitol (= sorbitol) can induce life threatening hypoglycaemia (unless glucose is administered concurrently). According to some views, in subjects with this intolerance the organism is threatened also by hepatic and renal failure; their development may be independent on hypoglycaemia. Fructose and D-glucitol (sorbitol) therefore should not be administered by the parenteral route. This view is supported by cases where hereditary fructose intolerance could not be revealed from the case-history and clinical manifestations. Some countries have already eliminated fructose and D-glucitol (sorbitol) from their pharmacopoeias.
Keywords: Food, Formulated, adverse effects, ; Fructose, administration & dosage, ; Fructose Metabolism, Inborn Errors, metabolism, ; Humans; Parenteral Nutrition, adverse effects, ; Sorbitol, administration & dosage,
Published: August 1, 1992 Show citation