Vnitr Lek 1993, 39(10):951-953

[Linkage analysis in pedigrees with Alzheimer's dementia].

I Mazura, R Jirák, F Koukolík
Psychiatrické centrum Praha.

Linkage analysis with three specific DNA markers was carried out on the Alzheimer's dementia pedigrees. The DNA markers used in our study, D21S1/D21S11, D21S13 and D21S16 in the 21q11.2-21q21 regions are localized. The results from different brain DNA samples and from peripheral blood samples of AD families were evaluated by two-point linkage analysis. The linkage between DNA markers and one AD pedigree was observed (D21S1/S11 and D21S13).

Keywords: Alleles; Alzheimer Disease, genetics, ; Genetic Linkage; Genetic Markers; Humans; Pedigree

Published: October 1, 1993  Show citation

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Mazura I, Jirák R, Koukolík F. [Linkage analysis in pedigrees with Alzheimer's dementia]. Vnitr Lek. 1993;39(10):951-953.
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