Vnitr Lek 1993, 39(10):1003-1007

[Atrial natriuretic factor as a marker of clinical severity in cardiac failure].

I Suchmanová-Lazúrová, R Rybár, I Majercák, G Valocík, E Fedorová, Y Machánová, R Tkácová, D Trejbal
II. interná klinika FN Kosice.

The authors examined plasma levels of the atrial natriuretic factor (ANF) in 26 patients with manifestations of cardiac failure. The ANF levels were high as compared with reference values (21 +/- 16.7 fmol/ml vs. 4.9 +/- 2.1 fmol/ml) and different in relation to individual functional NYHA classes, i.e. the lowest ones were in the second and the highest ones in the fourth class. Concurrently the authors revealed a statistically significant negative exponential correlation between plasma ANF levels and the left ventricular ejection fraction (r = 0.550, p < 0.01) and a bordeline correlation between ANF and the stroke volume (r = -0.45, p = 0.05). The results indicate that the plasma ANF level is a good indicator of severity of cardiac weakness and can be used in clinical work as a prognostic indicator in patients with heart failure.

Keywords: Adult; Aged; Aged, 80 and over; Atrial Natriuretic Factor, blood, ; Biomarkers, blood, ; Female; Heart Failure, blood, ; Humans; Male; Middle Aged; Prognosis

Published: October 1, 1993  Show citation

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Suchmanová-Lazúrová I, Rybár R, Majercák I, Valocík G, Fedorová E, Machánová Y, et al.. [Atrial natriuretic factor as a marker of clinical severity in cardiac failure]. Vnitr Lek. 1993;39(10):1003-1007.
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