Vnitr Lek 1995, 41(10):692-695

[G-CSF (Neupogen Roche) in the treatment of patients with chronic aplastic anemia with severe neutropenia].

J Novotný, M Zvarová, L Prazáková, M Jandlová, L Konvicková
Oddĕlení klinické hematologie FN U sv. Anny, Brno.

Aplastic anaemia (AA) of the chronic type with severe cytopenia is very frequently a difficult therapeutic problem. Patients with granulocyte values below 0.5 G/l are threatened by infections, incl. sepsis possibly with a fatal outcome. If the pool of stem cells for granulocytes is not completely exhausted and can respond to growth factors, these patients can be treated either chronically and/or in risk situations (e.g. injury, surgery) with preparations of the type of a recombinant, granulocyte colony stimulating factor (rhG-CSF), or granulocyte and monocyte colony stimulating factor (rhGM-CSF). The authors present a review of diagnostic and therapeutic algorithms in patients with the AA syndrome and summarize their own experience with the preparation Neupogen Roche (rhG-CSF).

Keywords: Anemia, Aplastic, complications, ; Female; Filgrastim; Granulocyte Colony-Stimulating Factor, therapeutic use, ; Humans; Male; Neutropenia, complications, ; Recombinant Proteins, therapeutic use,

Published: October 1, 1995  Show citation

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Novotný J, Zvarová M, Prazáková L, Jandlová M, Konvicková L. [G-CSF (Neupogen Roche) in the treatment of patients with chronic aplastic anemia with severe neutropenia]. Vnitr Lek. 1995;41(10):692-695.
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