Vnitr Lek 1995, 41(12):822-826

[Density of adhesive proteins after oral administration of proteolytic enzymes in multiple myeloma].

A Sakalová, R Kunze, D Holománová, J Hapalová, B Chorváth, M Mistrík, J Sedlák

Klinika hematológie a transfuziológie FN a Subkatedra hematológie a transfuziológie IVZ, Bratislava.

The authors present information on the presence of adhesive proteins on membranes of myeloma and precursor cells isolated from bone marrow and blood from a group of 33 patients examined by fluorescent flow cytometry. They also compare the density of integrins (CD29, CD49e, CD41, CD51 and CD61) and adhesive proteins from the group of "homing" receptors (CD44) and IgG "superfamily" (LFA-1, LFA-3, ICAM-1, N-CAM) and their changes after a single oral dose of a mixture of proteolytic enzymes (Wobe Mugos, Wobenzym, MUCOS Pharma, FRG). The authors observed a significant drop of CD29, CD54 (ICAM-1), CD58 (LFA-3) after Wobe Mugos, CD49, CD51, CD58 after Wobenzyme. The insignificant decline of density of CD44 on cells, as well as of the soluble receptor of CD44 after oral administration of proteolytic enzymes in serum, incl. the mentioned changes of integrins and other adhesive proteins, indicate the importance of enzyme preparations in the supporting treatment of malignant processes.

Keywords: Adjuvants, Immunologic, administration & dosage, ; Administration, Oral; Cell Adhesion Molecules, metabolism, ; Drug Combinations; Humans; Hydrolases, administration & dosage, ; Integrins, metabolism, ; Multiple Myeloma, metabolism, ; Rutin, administration & dosage,

Published: December 1, 1995  Show citation