Vnitr Lek 1997, 43(5):298-301

[Clinical findings in individuals with the factor V Leiden mutation].

M Matýsková, Z Vorlová, I Hrachovinová, A Buliková, J Zavrelová, M Slechtová

Oddĕlení klinické hematologie FNsP, Brno-Bohunice.

Leiden mutation of the coagulation factor V is the most frequent known congenital risk factor of thrombophilia. The authors examined a group of 440 subjects with thrombosis in the case- or family-history. The mutation was found in 146. In 94 thrombotic manifestations were recorded in the case-history, five women were examined because of repeated abortions. 52.74% carriers of FVL had venous thrombosis of the lower extremities and pelvis in their case-history, 19.18% had pulmonary embolism in the case-history. In 27.40% during the initial manifestations of thrombosis no other risk factor of thrombosis was detected. In 10.27% the first thrombosis developed after an injury or operation. In 22.22% women the thrombosis was manifested during pregnancy or the puerperal period. Due to the high incidence of this defect screening of the resistance to activated protein C should be an integral part of examination of thrombophil conditions.

Keywords: Adolescent; Adult; Aged; Child; Child, Preschool; Factor V, genetics, ; Female; Humans; Infant; Male; Middle Aged; Mutation; Pregnancy; Pregnancy Complications, Cardiovascular; Thrombophilia, genetics, ; Thrombosis, genetics,

Published: May 1, 1997  Show citation