Vnitr Lek 2006, 52(4):339-347

Primary prevention of ischemic heart disease in middle-aged men living in Prague: Results of twenty-year research

F. Boudík1,*, J. Reissigová2, K. Hrach2, M. Tomečková1,2, J. Bultas1, Z. Anger1, M. Aschermann1, J. Zvárová2
1 II. interní klinika 1. lékařské fakulty UK a VFN, Praha, přednosta prof. MUDr. Aleš Linhart, DrSc.
2 EuroMISE centrum-Kardio, Ústav informatiky Akademie věd ČR, Praha, ředitelka prof. RNDr. Jana Zvárová, DrSc.

Introduction:
Ischemic Heart Disease (IHD) represents the most frequent cause of mortality and morbidity in the Czech Republic. The aim of this study is to analyze long-term mortality of cardiovascular disease (CVD), identify its predictors and verify the validity of Framingham risk function for Czech patients.


Design and methods:
The twenty-year study (STULONG) of primary prevention of risk factors of atherosclerosis in 1419 men aged 38 to 53 years living in Prague was started in 1975.

Results: CVD mortality analysis showed a higher risk of death for heavy smokers vs. non-smokers or light smokers (p < 0.0001), hypertensive patients vs. patients with normal blood pressure (p < 0.0001), men with hypercholesterolemia vs. men with normal cholesterol level (p = 0.0432), and a lower risk for university graduates vs. men with elementary education (p = 0.0006). Between 1980 and 1984, age-specific CVD mortality rates of men from STULONG study were higher (p = 0.0132) than national CVD mortality rates; between 1985 and 1994, they were insignificantly lower. Framingham risk function underestimated absolute ten-year risk of IHD in all risk quintiles (p < 0.0001) with discrimination of 63%.

Conclusion:
CVD mortality observed within STULONG study was significantly affected by known risk factors (hypertension, smoking, hypercholesterolemia, lower education); Framingham risk function underestimated absolute ten-year risk of IHD.

Keywords: primary prevention of Ischemic Heart Disease; Cardiovascular disease

Received: January 17, 2006; Published: April 1, 2006  Show citation

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Boudík F, Reissigová J, Hrach K, Tomečková M, Bultas J, Anger Z, et al.. Primary prevention of ischemic heart disease in middle-aged men living in Prague: Results of twenty-year research. Vnitr Lek. 2006;52(4):339-347.
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