Vnitr Lek 2008, 54(5):478-481

Mucosal immunity with emphasise on urinary tract immunity and diabetes

J. Krejsek*, M. Kudlová, M. Koláčková, J. Novosad
Ústav klinické imunologie a alergologie Lékařské fakulty UK a FN Hradec Králové, přednosta prof. RNDr. Jan Krejsek, CSc.

Protective immune response in urinary tract is frequently impaired in patients with diabetes. Immunity in this mucosal compartment displays unique characteristics; e.g. absence of physiological microflora and lack of mucus. Pathogens are identified by the PRR receptors expressed on both epithelial and immune cells. Inflammatory response characterised by the acumulation of granulocytes is followed. Both protective and harm characteristics of inflammatory response are inseparable linked and delineated by gene polymorphisms in PRR receptors.

Keywords: diabetes mellitus; mucosal immunity; urinary tract; infection

Received: May 23, 2007; Published: May 1, 2008  Show citation

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Krejsek J, Kudlová M, Koláčková M, Novosad J. Mucosal immunity with emphasise on urinary tract immunity and diabetes. Vnitr Lek. 2008;54(5):478-481.
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